JP2936456B2 - Liquid-tight sealing method and blood purification device - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a liquid-tight sealing method and a blood purification apparatus, and more particularly, to a liquid-tight seal between a casing main body and a lid member of a blood purification apparatus. The present invention relates to a liquid-tight sealing method and a blood purification apparatus which is extremely easy to manufacture and does not generate residual blood therein.

[0002]

2. Description of the Related Art Conventionally, a casing body provided with a bundle of hollow fibers and a lid member provided at an end of the casing body and having a blood outlet are provided. In the blood purifier, the seal between the casing main body and the lid member includes a seal ring interposed between the casing main body and the lid member when the lid member is attached to an end of the casing main body. It was common to do this.

[0003] However, silicone seal rings, which are frequently used as seal rings, have high reliability but are expensive, which is one of the reasons why the manufacturing cost of a blood purifier cannot be reduced. Was.

As a sealing method that does not use such a seal ring, a method of ultrasonically welding a casing body and a lid member has been put to practical use. In this method, an end of a casing body cylindrical body and a lid member attached to the end of the casing main body are fused by ultrasonic waves.

[0005] However, according to this method, sealing is performed considerably outside the region where the hollow fiber bundle is opened on the end face of the casing body, so that the residual blood remains outside the region where the hollow fiber bundle is opened. There is a problem that occurs.

As a method for preventing such residual blood, an annular convex portion is provided on the inner surface of the lid member facing the casing body, and this is brought into contact with the end surface of the sealing material. A method of ultrasonically fusing the end portion with the lid member has been proposed.

However, according to this method, it is necessary to bring the end face of the sealing material in which the hollow fiber bundle opens into contact with the annular convex portion of the lid member without a gap, and the sealing in which the hollow fiber bundle opens is required. Extremely high precision is required for cutting when forming the end face of the material, and there has been a problem that conventional equipment cannot cope with this. In some cases, a gap is formed between the end face of the sealing material and the annular convex portion of the lid member, and there is a problem that blood coagulation occurs in the gap.

[0008] The present invention has been completed based on such circumstances. That is, an object of the present invention is to solve the above problems. SUMMARY OF THE INVENTION It is an object of the present invention to provide a liquid-tight sealing method capable of extremely easily liquid-tightly sealing a space between a casing body and a cover member of a blood purification apparatus. Another object of the present invention is to provide a blood purification apparatus which is extremely easy to manufacture and does not generate residual blood therein.

[0009]

According to the first aspect of the present invention, there is provided a casing body cylinder for sealing a hollow fiber bundle with a sealant so that the hollow fiber bundle has an opening end face. the one end opening of the casing main body formed by fixed to one opening of the body, have a blood outlet inlet, provided on the inside surface
Annular lid member ing by filling the adhesive in the groove is attached,
The end face of the casing body cylinder and / or the end face of the sealing portion formed by the sealant, wherein the outer region of the hollow fiber bundle and the lid member are annularly sealed with an adhesive. The invention according to claim 2 is to fix the hollow fiber bundle to one end opening of the casing body cylindrical body with a sealant in a state where the cut open end face of the hollow fiber bundle is opened. A casing body having a sealing portion, and an adhesive which has a blood outlet and is attached to an end of the casing body, and is filled in an annular groove provided on an inner surface of the casing body. A blood purification apparatus comprising: a lid member adhered to an end surface of a cylindrical body and / or an end surface of the sealing portion and in a region where no hollow fiber membrane is present.

Hereinafter, the present invention will be described in detail.

(Casing Body) The casing body in the method or apparatus of the present invention is obtained by fixing the hollow fiber bundle to one end opening of the casing body cylindrical body with a sealant so as to have a cut opening end face of the hollow fiber bundle. Become.

That is, the casing body according to the present invention comprises a casing body cylinder having an opening at one end, a hollow fiber bundle housed inside the casing body cylinder, and a hollow fiber bundle for the casing body. A sealing portion fixed with a sealing agent so as to have a cut opening end surface at one end opening of the cylindrical body.

There is no particular limitation on the casing body cylinder as long as it can accommodate a hollow fiber bundle inside and has an opening at one end to which a lid member described later can be attached. A well-known cylinder body for a casing main body, which is employed in the blood purification apparatus described above, can be suitably employed. However,
In a normal case, a suitable casing body cylinder is a cylinder having openings at both ends.

The material constituting the casing main body cylinder is not particularly limited, but, for example, polycarbonate, polystyrene, acrylonitrile and styrene in relation to a sealant for fixing the hollow fiber membrane to the end opening. And the like, polymethyl methacrylate, ABS resin, AB resin, and the like. However, the material constituting the casing main body cylinder is not limited to the above-described example, and other ordinary polymer materials and metal materials can be appropriately used.

The hollow fiber membrane constituting the hollow fiber bundle is not limited by characteristics such as the material and shape thereof.
For example, as the material, cellulose, cellulose diacetate, cellulose triacetate, etc., cellulose derivatives such as cellulose ethers, polyamide derivatives,
Examples thereof include polyester derivatives, methacrylic or acrylic polymers such as polymethyl methacrylate, polyvinyl chloride polymers such as polyvinyl chloride, polyurethane, and polyolefins such as polyethylene and polypropylene. The outer diameter of the hollow fiber membrane is usually about 10 to 600 μm.

The sealant is not particularly limited as long as the hollow fiber bundle can be fixed to the casing body cylinder, and is itself used for fixing the hollow fiber bundle in a conventional blood purification apparatus. A conventionally known sealant can be suitably used. Specifically, for example, a curable polymer composition such as a polyurethane resin, a silicone resin, and an epoxy resin can be suitably used. Among them, a polyurethane resin and an epoxy resin can be preferably used particularly in view of the relationship with an adhesive described later. When these are adopted as a sealant, as an adhesive described later,
Polyurethane-based adhesives, epoxy-based adhesives, and the like with less resin sink after curing can be suitably used, and have advantages such as extremely excellent sealability and adhesiveness.

With this sealing agent, the hollow fiber membrane is fixed to the one end opening of the casing body cylindrical body so as to have a cut open end face of the hollow fiber bundle. In other words, the end surface of the sealing portion formed by the sealant is exposed at one end opening of the casing body cylindrical body, and the end of each hollow fiber in the hollow fiber bundle is open at the end surface of the sealing portion. The hollow fiber bundle is fixed to the one end opening of the casing body cylindrical body in a state where the cut opening end surface of the hollow fiber bundle and the end surface of the sealing portion are flush with each other.

The method of fixing the hollow fiber bundle so as to have the cut open end face is not particularly limited as long as it can be fixed in such a state as a result. For example, one end opening of the casing body cylindrical body is sealed with a sealant. After fixing the hollow fiber bundle, the sealing agent is cut together with the hollow fiber bundle at a predetermined position, thereby exposing the cut opening end face of the hollow fiber bundle.

By fixing the hollow fiber bundle with a sealant, an end face of the casing body cylindrical body and / or an end face of the sealing portion formed by the sealant are formed at one end opening of the casing body. Is done. As its mode,
The end face of the casing main body cylinder and the end face of the sealing portion may be flush, or the end face of the sealing portion may slightly project from the end face of the casing main body cylinder, An aspect in which only an end face of the sealing agent is formed on the surface by covering the end face of the casing body cylindrical body with the agent may be adopted.

(Lid Member and Mounting Thereof) The lid member according to the present invention is mounted on the opening at one end or both ends of the casing body cylinder. The lid member according to the present invention has a blood outlet and an inner surface facing an end surface of the casing body cylinder and / or an end surface of a sealing portion formed by the sealant, and is provided for the casing body. It is formed so that it can be attached to the end opening of the cylindrical body ,
An annular groove for filling the adhesive is provided on the inner side surface .

[0021] The blood outlet port introduces blood into or draws blood from the space where the cut open end face of the hollow fiber bundle fixed with the sealant opens. The position at which the blood outlet is provided in the cover member is not particularly limited as long as blood can be introduced or drawn out, but is preferably provided at the center of the inner surface of the cover member.

The method of attaching the lid member to the end opening of the casing main body is not particularly limited as long as it can be attached. For example, the outer peripheral surface of the end opening of the casing main body cylinder is provided. A male screw portion may be provided, and a lid member having a female screw portion formed on an inner peripheral surface thereof may be screwed into the male screw portion. Alternatively, the male screw portion may be provided at an end opening of a casing body cylindrical body having no screw portion. Alternatively, a method of simply fitting a lid member having no screw portion may be used. Particularly preferable is a method of screwing the male screw portion and the female screw portion. According to this method, the sealing with the adhesive described later can be particularly easily and reliably performed.

(Sealing or Adhesion) In the liquid-tight sealing method of the present invention, the end surface of the casing main body cylinder and / or the end face of the casing main body cylinder formed at the opening at one end or both ends of the casing main body cylinder. An annular surface provided on the end surface of the sealant and the inner surface of the lid member
The groove is sealed in a region outside the region where the cut opening end face of the hollow fiber bundle exists (hereinafter, may be referred to as an “outside region”) by bonding in a ring shape with an adhesive.

In the method of the present invention, the method of sealing in an annular shape with an adhesive is such that the adhesive after bonding surrounds the existing area and the end face of the casing body cylinder and / or the sealing. There is no particular limitation as long as it is present on the end face of the stop.

As a method of such sealing or bonding , for example, a method of filling an adhesive in an annular groove provided on the inner surface of the lid member and mounting the adhesive on a casing body cylindrical body, etc. Can be mentioned.

[0026] As embodiments of the coating of the adhesive, the lid
An embodiment may be such that an annular groove, for example, an annular groove or an annular concave portion is formed on the inner surface of the member, and this is filled with an adhesive.

The sealing with the annularly formed adhesive is performed at the same time that the lid member is mounted on the casing body cylinder, that is, the lid member is mounted on the casing body cylinder. It is desirable that the curing of the adhesive is completed almost at the same time as the completion of the sealing, and the sealing is completed. However, the mounting and the bonding may be performed by independent operations. After the mounting and the bonding, another processing such as ultrasonic welding may be performed.

The adhesive in the present invention is not particularly limited as long as the lid member and the end surface of the casing body cylinder and / or the end surface of the sealing portion can be adhered. For example, a urethane adhesive, An epoxy adhesive or the like can be suitably used. Among these, the type with less resin sink after curing is particularly preferable.

The adhesive in the present invention may be the same composition as the sealing agent or a composition of a completely different kind. Preferably, the same composition as the sealing agent is employed. When an adhesive which is the same kind of composition as the sealing agent is adopted, the sealing portion and the adhesive are well adapted to each other, so that the end surface of the casing body cylindrical body and / or the end surface of the sealing portion and An extremely good seal between the lid member is achieved. Further, there is an advantage that the types of materials that come into contact with blood can be reduced, and the antithrombotic properties are improved. In this case, even if the composition is not completely the same as the composition of the sealing agent, it is sufficient that each component is common to some extent.

The bonding in the present invention may be performed after the sealant is completely cured, or may be performed before the sealant is completely cured. In particular, it is preferable to perform the bonding before the sealing agent is completely cured, because the sealing agent and the adhesive are well blended to achieve an extremely good sealing.

According to the blood purification apparatus of the present invention, similarly to the method of the present invention, the end face of the casing body cylindrical body and / or
Alternatively, it can be manufactured by bonding the end surface of the sealing portion formed by the sealing agent and the lid member with the adhesive.

[0032]

According to the liquid-tight sealing method of the present invention, an expensive seal ring such as a silicone ring is not used, and
By an extremely simple operation of attaching the lid member to the casing main body, the end opening of the casing main body cylinder and the lid member can be sealed in a liquid-tight manner.

Further, according to the liquid-tight sealing method of the present invention, the sealing is performed relatively near the region where the hollow fiber bundle exists on the end face of the casing body cylindrical body and / or the end face of the sealing portion. The generation of residual blood in the non-existent region of the hollow fiber bundle on the end face of the casing body cylinder and / or the end face of the sealing portion is prevented.

In the blood purification apparatus of the present invention, the end face of the casing body cylindrical body and / or the end face of the sealing portion where the hollow fiber bundle is not present and the cover member are annularly sealed with the adhesive. Therefore, good liquid tightness is maintained without using a seal ring. In addition, since the end surface of the casing body cylindrical body and / or the end surface of the sealing portion and the inner surface of the lid member are fixed by the adhesive, the lid member is not easily detached.

Furthermore, since the seal is made relatively near the end area of the hollow fiber bundle on the end face of the casing body cylinder and / or the end face of the sealing portion, the end face of the casing body cylinder and / or Alternatively, generation of residual blood on the end face of the sealant is prevented.

[0036]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the present invention will be described in detail with reference to embodiments.

(Embodiment 1) FIG. 1 is a sectional view schematically showing the vicinity of an opening at one end of a casing body cylinder in a blood purification apparatus according to an embodiment of the present invention. FIG. 1 shows one end of the blood purification apparatus. This blood purification device 1a has a casing body 2, a lid member 3, and an adhesive 4.

The casing main body 2 includes a casing main body cylinder 5, a hollow fiber bundle 7 including a plurality of hollow fiber membranes 6 housed inside the casing main body cylinder 5, and a hollow fiber bundle 7. At the end opening 8 of the casing body cylinder 5.

The casing body cylindrical body 5 is a cylindrical body having openings at both ends, and a cover member mounting portion 10 having a male screw portion for mounting the cover member 3 on the outer peripheral surface of the opening 8 at both ends. Having. In the drawing, reference numeral 11 denotes a dialysate discharge / intake pipe for introducing or discharging a dialysate or the like into a space formed by the inner peripheral surface of the casing body cylinder 5 and the outer peripheral surface of the hollow fiber membrane 6. .

Both ends of the hollow fiber bundle 7 are connected to the sealing portions 9 at both end openings 8 of the casing body cylinder 5.
It is fixed by.

The sealing portion 9 has an end face 13 formed inside the end face 12 of the casing body cylinder 5 and flush with the end face 12 of the casing body cylinder 5. 13 has a cut open end face 14 of the hollow fiber bundle 7.

In this embodiment, the sealing end face 13 having such a cut opening end face 14 was formed as follows. That is, the hollow fiber bundle 7 is housed so that both ends of the hollow fiber bundle 7 project slightly outward from the end surface 12 of the casing main body cylinder 5, and the hollow fiber bundle 7 is closed at one end opening 8 of the casing main body cylinder 5. After fixing the hollow fiber bundle 7 with a sealing agent, a sealing portion 9 formed of the sealing agent is fixed to the hollow fiber bundle 7 on a surface coinciding with the end surface 12 of the casing main body cylinder 5. And by cutting the same.

FIG. 2 is a perspective view showing an opening of one end of the casing main body cylinder 5. In FIG. 2, a two-dot chain line L
The area where the cut opening end face 14 on the sealing end face 13 is present is the area where the hollow fiber bundle is present, and is outside of this area and the end of the casing body cylinder 5. The area inside the outer periphery of the section is the outside area of the hollow fiber bundle 7.

[0044] Figure 2, or it, the lid member 3 indicates a state of not being mounted on an end portion of the casing body accommodating cylinder 5.
The male screw portion for mounting the lid member 3 in the lid member mounting portion 10 is not shown in FIG.

The cover member 3 includes an annular groove 15, a blood outlet 16, a mounting portion 17 for mounting to an end opening of the casing main body cylinder 5, and a casing main body 5. An end face and / or an inner face 18 facing the end face 13 of the seal.

The blood outlet 16 is connected to the inner surface 18.
Is formed at the center of the frame.

The mounting portion 17 has a function of mounting the lid member 3 to the opening of the casing main body cylinder 5, and a screw portion formed on the lid member mounting portion 10 of the casing main body cylinder 5. Is provided on the inner peripheral surface thereof.
The lid member 3 in this embodiment is mounted by screwing into the lid member mounting portion 10 of the casing body cylinder 5.

Near the outer periphery of the inner surface 18 of the lid member 3
At the side 19, it is the same as surrounding the central axis.
Two annular protrusions 20 arranged in a circle are formed.
I have. The outer annular protrusion 20a located on the outside has a flat end.
Inner annular protrusion 20b having a surface portion 21 and located inside
Is sharply formed. The outer protrusion 20a
Is attached to the end surface 12 of the casing body cylinder 5
It is fixed with the flat part 21 in contact with it,
The tip of the inner protruding portion 20 b is formed on the sealing end face 13.
In contact with or close to the region where no hollow fiber membrane exists
It is fixed in a state. When formed in this manner, more reliable sealing or liquid-tight sealing is achieved, and the lid member 3 and the casing body cylinder 5 are particularly firmly bonded to each other. Inconvenience such as loosening of the member 3 can be prevented.

In this embodiment, the bonding is performed by the annular groove 1
After the adhesive 4 is filled in the casing 5 and before the adhesive 4 is cured, the lid mounting portion 1 of the casing body cylinder 5 is formed.
This is done by attaching the lid member 3 to the cover. That is, when the lid member 3 is attached to the opening of the casing body cylinder 5, the adhesive 4 filled in the annular groove 15 formed on the inner side surface 18 of the lid member 3 and the sealing end surface 1 3 and are you contact. Then, the inner surface 18 of the lid member 3 and the sealing end face 1 3 is adhered by curing the adhesive 4 in this state.

In this state, the adhesive 4 adheres the lid member and the non-existing region with an annularly formed adhesive surface.

In this embodiment, the attachment of the cover member 3 to the casing main body cylinder 5 and the bonding between the outer region of the hollow fiber bundle of the sealing end face 13 and the cover member are performed by the liquid-tight seal of the present invention. It is also an example of a method .

[0052]

[0053]

[0054]

[0055]

[0056]

[0057] adhesion between the end face 13 of the lid member 3 and the casing main body cylindrical body 5 and / or sealing portion definitive in this embodiment, the outer protrusions 20a and the inner protrusion 20b
The adhesive 4 is loaded in a heaped state into the annular groove 15 formed therebetween, and the lid member 3 is attached to the casing body cylindrical body 5 at the end opening while the adhesive 4 is not cured. ing. By this bonding, the outer surface of the hollow fiber bundle and the lid member 3 on the end face 12 of the casing body cylindrical body and / or the end face 13 of the sealing portion are sealed with the annularly formed adhesive 4. You.

[0058] (Example 2) liquid-tight sealing method in this invention, it is also possible to carry out in the manner shown in FIG. 3, also, the blood purification apparatus in this invention, as shown in FIG. 3 It may be a device.

[0059] In the end opening 8 of the casing body accommodating cylinder 5 definitive in this embodiment, the sealing end surface of the sealing portion 9 by the sealing portion 9 covers the end face 12 of the cylindrical body 5 for the casing main body Only 13 is exposed on the surface.

[0060] The lid member 3 definitive in this embodiment, the annular groove 2
2. A mounting portion 17 for mounting at a blood outlet (not shown) and an opening of the casing body cylinder 5.
And an inner surface 18 facing the sealing end surface 13.

In the vicinity of the inner peripheral surface of the mounting portion 17 on the inner side surface 18, an annular shape having a diameter larger than the inner diameter of the casing body cylinder 5 and smaller than the outer diameter of the casing body cylinder 5 is provided. A protrusion 24 is formed.

In this embodiment, the annular projection 2
The adhesive 4 is annularly loaded into a space formed between the mounting portion 4 and the upper end of the inner peripheral surface of the mounting portion 17. Although the filling amount of the adhesive 4 is not particularly limited, when the cover member 3 is mounted on the casing main body cylinder 5, the annular projecting portion 24, the inner peripheral surface of the mounting portion 17, and the sealing end surface are formed. It is desirable that the amount of the adhesive is substantially sufficient to fill the space surrounded by 12 with no gap.

[0063] Also Oite Example, the lid member 3, mounting unit 1
7 has an internal thread 23 on the inner peripheral surface thereof, and is attached to the casing main body cylinder 5 by screwing into a male thread formed on the lid member mounting section 10 of the casing main body cylinder 5. You.

By this mounting, adhesion between the region where the hollow fiber bundle does not exist on the sealing end surface 13 and the inner surface 18 of the lid member is achieved. At the same time, a liquid-tight seal is formed between them.

The embodiments of the present invention have been described above. The present invention is not limited to the above embodiment. To summarize the above embodiments, there at the end face of the sealing portion formed of a fixed to one end opening of the casing body accommodating cylinder with a sealing agent of the hollow fiber bundle in a state of opening the cut open end of the middle hollow fiber bundle Then, the outer region of the hollow fiber bundle or the opening end surface of the casing body and the inner surface of the lid member are bonded with an adhesive filled in an annular groove provided on the inner surface of the lid member. Is important.

[0066]

According to the present invention, it is possible to provide a liquid-tight sealing method in which the space between the casing body and the cover member of the blood purification apparatus can be sealed very easily in a liquid-tight manner.

According to the present invention, it is possible to provide a liquid-tight sealing method capable of maintaining a sufficient liquid-tightness without using a seal ring and achieving a seal by an extremely simple operation. it can.

According to the liquid-tight sealing method of the present invention, there are also the following advantages. That is, in the conventional blood purification apparatus, in order to reliably maintain the connection between the casing body cylinder and the lid member for a long period of time, after the casing body cylinder and the lid member are mounted, the casing body cylinder In contrast to the necessity of an operation of bonding the cylinder and the lid member, the liquid-tight sealing method of the present invention can extremely easily perform liquid-tight sealing, and furthermore, the end face of the casing body cylinder. Since the end face of the sealant and the inner surface of the lid member can be bonded and fixed, there is an advantage that the bonding operation as a separate step in the related art becomes unnecessary.

According to the present invention, it is possible to provide a blood purification apparatus which does not generate residual blood therein and is extremely easy to manufacture.

According to the present invention, sufficient liquid-tightness can be maintained without using a seal ring, the production is extremely easy, and the conventional problems such as the generation of residual blood inside. Can be provided.

When the same kind of composition as used in the sealing agent is used as the adhesive used for the seal,
The types of materials with which blood comes in contact can be reduced, and antithrombotic properties are improved.

[Brief description of the drawings]

FIG. 1 is a cross-sectional view schematically showing a blood purification apparatus according to one embodiment of the present invention.

FIG. 2 is a schematic perspective view showing the vicinity of an end opening of a casing main body cylinder in the blood purification apparatus of the first embodiment.

FIG. 3 is a sectional view schematically showing a blood purification apparatus according to another embodiment of the present invention .

[Explanation of symbols]

1 ... blood purification device, 2 ... casing body, 3
..Cover member, 4 adhesive, 5 cylinder body for casing body, 6 hollow fiber membrane, 7 hollow fiber bundle, 8
・ Opening of casing body cylinder, 9 ・ ・ ・ Sealing part, 1
0: lid member mounting part, 11: dialysate lead-in / out tube, 1
2 ... end face of casing body cylindrical body, 13 ... sealing end face, 14 ... cutting opening end face, 15 ... annular groove , 1
6 ... blood outlet, 17 ... mounting part, 18 ...
Inner side surface, 19 ... Near outer periphery , 20a ... Outer protrusion, 20b ... Inner annular protrusion, 21 ... Flat portion,
22 ... annular groove, 23 ... female screw part, 24 ... annular protrusion.

Claims (2)

(57) [Claims] 1. A blood lead-in port is provided at one end opening of a casing main body in which a hollow fiber bundle is fixed to a one end opening of a casing main body cylindrical body with a sealant so as to have a cutting opening end face of the hollow fiber bundle. have a adhesive within an annular groove provided on the inner surface
Fitted with a lid member ing filled, and the outer region and the cover member of the hollow fiber bundle to a end surface of the sealing portion formed by the end face and / or the sealant of the casing body accommodating cylinder, A liquid-tight sealing method characterized by sealing in an annular shape with an adhesive. 2. A casing body having a sealing portion formed by fixing the hollow fiber bundle to one end opening of the casing body cylindrical body with a sealant with the cut open end face of the hollow fiber bundle being opened, An adhesive which has an entrance and is attached to an end of the casing main body and is filled in an annular groove provided on an inner surface of the casing main body. A blood purification apparatus, comprising: a lid member adhered to an end surface and a region where no hollow fiber membrane is present.