JP6509981B2 - Hollow fiber membrane module and method of manufacturing hollow fiber membrane module - Google Patents

Description

  The present invention relates to a hollow fiber membrane module and a method of manufacturing the same.

  Conventionally, a hollow fiber membrane module is used for the purpose of water purification, hemodialysis and the like. In the hollow fiber membrane module, a hollow fiber membrane bundle is accommodated in a cylindrical case called a column. Both ends of the hollow fiber membrane bundle are fixed by a sealing member fixed to the inner circumferential surface of the column. Further, lid members called headers are attached to both ends of the column.

  The hollow fiber membrane bundle is fixed to the sealing member in a state of being brought close to the central axis side of the column. The outer edge side of the sealing member where the hollow fiber membrane is not distributed is used as a sealing area for preventing the leakage of the treatment liquid. For example, an O-ring is disposed on the outer edge side of the sealing member, and the O-ring is sandwiched between the header and the sealing member to prevent liquid leakage to the outer diameter side from this.

  For example, in patent documents 1-4, the leak of the liquid to the outside diameter side from the contact part concerned is prevented because a header contacts directly on a sealing member, without passing through O ring. For example, a cylindrical projection (cylindrical projection) is provided on the inner surface of the header, that is, the surface facing the column opening. The tip of the cylindrical projection is brought into contact with the sealing member to prevent liquid leakage from the contact point to the outer diameter side.

JP, 2008-93518, A Patent No. 4369840 Japanese Utility Model Publication No. 6-30202 JP, 2013-6018, A

  By the way, in order to secure stable sealing performance without the intervention of the O-ring, it is preferable that the tip of the cylindrical projection be bited into the sealing member. At this time, for example, as shown in FIG. 10, in the case where the tip cross section of the cylindrical protrusion 100 has a rectangular shape, a large pressure is required to cause the sealing member 102 to bite in compared with the case of a pointed shape. As a result, stress may concentrate on the corners of the rectangular shape, and a crack may occur in the sealing member 102.

  Furthermore, if the header 104 directly abuts on the sealing member 102, the header 104 will be close to the sealing member, particularly in the abutment area. As a result, it is difficult for the liquid to flow in the same area, which may lead to retention.

  Therefore, the present invention provides a hollow fiber membrane module capable of suppressing insufficient sealing and cracking of the sealing member when sealing between the header and the sealing member, and suppressing retention of liquid in the sealing region. The purpose is to

  The present invention relates to a hollow fiber membrane module. The module comprises a column, a hollow fiber membrane bundle, a sealing member, and a header. The column is configured in a cylindrical shape. The hollow fiber membrane bundle is accommodated in the column. The sealing member is filled between the hollow fiber membranes at both ends of the hollow fiber membrane bundle and fixed to the inner circumferential surface of the column in a state where the hollow fiber membrane bundle is brought close to the central axis of the column. Headers are attached to both ends of the column. The cylindrical protrusion which can contact | abut with the exposure surface outer peripheral side in which a hollow fiber membrane bundle is not distributed among the exposed surfaces which oppose a header of a sealing member is provided in the surface facing the sealing member of a header. The cylindrical protrusion is formed in a cross-sectional mountain shape that is expanded from the top end of the tip. Cylindrical projections are formed such that the inner diameter side slopes of the cross section are open relative to the radial direction line of the column as compared to the outer diameter side slopes.

  In the above invention, the opening angle which is an angle formed by the inner side slope and the outer side slope of the cross-sectional mountain shape may be an obtuse angle.

  Further, in the above invention, the opening angle of the cross-sectional mountain shape may be 120 ° or more and 145 ° or less.

  Further, in the above invention, the opening angle of the cross section may be 139 °.

  In the above-mentioned invention, curved surface processing may be given to the skirt side of the slope on the inner diameter side of the mountain-shaped section.

In the above invention, the previous end vertex of the cylindrical projections may be a R-plane.

  The present invention also relates to a method of manufacturing a hollow fiber membrane module. The hollow fiber membrane module comprises a cylindrical column, a hollow fiber membrane bundle accommodated in the column, and hollow hollow fiber membrane bundles at both ends of the hollow fiber membrane bundle in a state in which the hollow fiber membrane bundle is moved toward the central axis of the column. A sealing member filled between the yarn membranes and fixed to the inner circumferential surface of the column, and a header attached to both ends of the column. The cylindrical protrusion which can contact | abut with the exposure surface outer peripheral side in which a hollow fiber membrane bundle is not distributed among the exposed surfaces which oppose a header of a sealing member is provided in the surface facing the sealing member of a header. The cylindrical projection is formed in a cross-sectional mountain shape that is expanded from the top end of the tip, and the cylindrical projection is formed such that the inner slope on the inner side of the cross section is open relative to the radial line of the column compared to the outer slope. In manufacturing the hollow fiber membrane module, when attaching the header to the column, the cylindrical projection is made to bite into the heated and softened sealing member.

  According to the present invention, by forming the cylindrical protrusion of the header into a mountain-shaped cross section expanded from the top end of the tip, it is possible to easily bite into the sealing member at a lower pressure than in the case of a rectangular cross section. Insufficient sealing or cracking of the sealing member can be suppressed. Furthermore, by forming the slope on the inner diameter side of the cross section of the cylindrical protrusion to be open relative to the radial direction line of the column in comparison with the outer diameter side slope, it is possible to suppress the retention of liquid in the seal region.

It is a side sectional view which illustrates the hollow fiber membrane module concerning this embodiment. It is a figure which illustrates the expanded section of the column end of the hollow fiber membrane module concerning this embodiment. It is a figure explaining the shape of the header of the hollow fiber membrane module which concerns on this embodiment. It is a graph which shows the relationship between welding energy and the biting depth to a sealing member according to projection shape. It is a graph which shows the relationship between the largest pressurization value and the biting depth to a sealing member according to protrusion shape. It is a graph which shows the relationship between welding energy and the penetration depth to a sealing member according to taper angle. It is a graph which shows the relation between the maximum pressurization value and the biting depth to a sealing member according to taper angle. It is a figure explaining the shape of the header of the hollow fiber membrane module which concerns on another example of this embodiment. It is a figure which illustrates the expanded section of the column end of the hollow fiber membrane module concerning another example of this embodiment. It is a figure which illustrates the expanded section of the column end of the hollow fiber membrane module concerning a prior art. It is a figure explaining the shape of the comparative example manufactured in order to obtain | require the relationship between welding energy and the biting depth to a sealing member, and the relationship between the largest applied value and the biting depth to a sealing member.

  FIG. 1 illustrates a side cross-sectional view of a hollow fiber membrane module 10 according to the present embodiment. The hollow fiber membrane module 10 includes a column 12, headers 14 A and 14 B, a hollow fiber membrane bundle 16, and a sealing member 18. The hollow fiber membrane module 10 is used, for example, as a filtration device for removing fine particles of raw water. The hollow fiber membrane module 10 is also used as a so-called dialyzer for hemodialysis.

  In addition, although the example which uses the hollow fiber membrane module 10 as a dialyzer is given in the following description, it does not restrict to this form.

  The column 12 is a cylinder that accommodates the hollow fiber membrane bundle 16. The column 12 is formed of, for example, a cylinder made of a resin material such as polycarbonate. The dialysate inlet port 20 and the dialysate outlet port 22 are formed on the column 12 so as to protrude radially from the cylinder near both longitudinal ends thereof. The dialysate is supplied into the column 12 from the outside through the dialysate inlet port 20. In addition, the dialysate is discharged from the inside of the column 12 to the outside through the dialysate outlet port 22.

  The hollow fiber membrane bundle 16 is accommodated in the column 12 and fixed at its both ends by a sealing member 18. Further, the openings at both ends of the hollow fiber membranes constituting the hollow fiber membrane bundle 16 are open (not filled with the sealing member 18), and the blood from one end opening to the other end opening of the hollow fiber membranes Flows.

  The hollow fiber membrane is composed of, for example, a thin tube having a circular cross section with a thickness of about 5 to 150 μm and an inner diameter of about 100 to 500 μm. It is more preferable that the thickness of a film | membrane base material is about 30-50 micrometers and an internal diameter is about 200-250 micrometers among the said range. In addition, the membrane base of the hollow fiber membrane is made of, for example, a semipermeable membrane made of a hydrophobic polymer, which is mainly composed of a polyester resin and a polysulfone resin. Here, the polyester resin may be, for example, a polyarylate resin having a repeating unit represented by the following formula (1).

In Chemical Formula (1), R ¹ and R ² are lower alkyl groups having 1 to 5 carbon atoms, and they may be the same or different.

  Further, the above-described polysulfone-based resin may be, for example, a polysulfone resin having at least one of a repeating unit represented by the following formula (2) and a repeating unit represented by the following formula (3).

In Chemical Formula (2), R ³ and R ⁴ are lower alkyl groups having 1 to 5 carbon atoms, and they may be the same or different.

  The film-forming stock solution for spinning these hydrophobic membrane substrates has a mixing weight ratio (A / B) of polyester resin (A) and polysulfone resin (B) in the range of 0.1 to 10 It is prepared by making it melt | dissolve in the organic solvent so that the total amount (A + B) of both resin may become a ratio of 10 weight%-25 weight%.

  The hollow fiber membrane has been described as being composed of a semipermeable membrane made of a hydrophobic polymer mainly composed of a polyester resin and a polysulfone resin, but the present invention is not limited to this, and a polyester resin Alternatively, the membrane base may be formed of a single polysulfone resin.

  The sealing member 18 is also called a potting material, and is made of, for example, a thermosetting resin such as polyurethane, a phenol resin, or an epoxy resin. When the headers 14A and 14B are attached to the column 12, the sealing member 18 may be heated and softened in order to make the cylindrical projection 26 easily bite into the sealing member 18. For example, the sealing members 18 having a rubber hardness of about 95 before heating are made less than 87 by heating, and the headers 14A and 14B are attached to the column 12. The said rubber hardness is measured by the method defined, for example by JISK6253.

  The sealing member 18 seals both end openings of the column 12 in a state where the end opening of the hollow fiber membrane bundle 16 is opened. The sealing member 18 is filled so as to fill the gaps of the individual hollow fiber membranes of the hollow fiber membrane bundle 16. In addition, the sealing member 18 adheres to the inner circumferential surface in the vicinity of the openings at both ends of the column 12 to prevent the dialysate in the column 12 from leaking out from the openings at both ends of the column 12.

  The sealing member 18 also has a function as fixing means for fixing both ends of the hollow fiber membrane bundle 16 to the column 12. In this fixing, the sealing member 18 fixes the hollow fiber membrane bundle 16 in a state where the hollow fiber membrane bundle 16 is brought close to the central axis C side of the column 12. For example, the hollow fiber membrane bundle 16 is fixed in a state of being moved closer to the central axis side than the sealing region constituted by the sealing member 18 and the headers 14A and 14B. The sealing area refers to an area where the tip of the cylindrical projection 26 of the header 14A, 14B bites into the sealing member 18.

The end enlarged sectional view of column 12 is illustrated by FIG. Although an enlarged view on the side of the header 14A is illustrated here, the header 14B also has a similar structure. As described above, since the hollow fiber membrane bundle 16 is brought closer to the central axis C side of the column 12 (it is brought closer to the central axis side than the sealing region constituted by the sealing member 18 and the headers 14A and 14B) The stopper member 18 is divided into an inner peripheral area 18A in which the hollow fiber membrane bundle 16 is distributed and an outer peripheral area 18B in which the hollow fiber membrane bundle 16 is not distributed.

  Of the exposed surface 24 of the sealing member 18 facing the header 14A, the blood having undergone substance exchange from the hollow fiber membrane bundle 16 is from the surface on the inner peripheral region 18A side (exposed surface inner peripheral side 24A). It is derived.

  Further, the outer peripheral region 18B of the sealing member 18 functions as a sealing region for preventing the leakage of the processing liquid (blood) to the outer diameter side of the column 12. That is, of the exposed surface 24 of the sealing member 18 facing the header 14A, the surface on the outer peripheral region 18B side (exposed surface outer peripheral side 24B) abuts on the cylindrical protrusion 26 of the header 14A, and the tip thereof is inside Configured to bite into. Thereby, the leakage of the liquid to the outer diameter side from the contact point is prevented.

  The headers 14A and 14B are a fluid passing means for introducing blood from the outside and discharging the blood to the outside. The headers 14A and 14B are attached so as to cover the openings at both ends of the column 12. That is, the headers 14A and 14B are provided with a lid 28 facing the end of the column 12, and a side peripheral wall 30 provided on the outer periphery of the lid 28 and having an inner diameter larger than the outer diameter of the end of the column 12. As will be described later, headers 14A and 14B are attached to both ends of the column 12, and ultrasonic welding is performed around the side peripheral wall 30, so that a part of the outer peripheral wall of the column 12 and a part of the side peripheral wall 30 are welded. 32 are formed (see FIG. 2). Thus, the headers 14A and 14B are fixed to the column 12. The end portions of the side peripheral wall 30 and the longitudinal direction (the column central axis C direction) of the column 12 may be brought into contact with each other and welded to each other.

  A port (opening) 34 is provided at the center of the lid 28 of the headers 14A, 14B. The port 34 includes an outer cylindrical portion 36, and a thread 38 is formed on the inner peripheral surface thereof. During hemodialysis, the thread formed on the outer peripheral surface of a joint (not shown) provided at the tip of a tube for removing blood from the patient or returning blood to the patient and the thread 38 of the port 34 are screwed Together, they are combined.

  Further, in the lid portion 28 of the headers 14A and 14B, a cylindrical protrusion 26 protruding toward the sealing member 18 is formed on the surface 40 facing the sealing member 18. The cylindrical protrusion 26 is provided at a position facing the exposed surface outer peripheral side 24B of the sealing member 18 when the headers 14A and 14B are attached to the column 12. As described later, in the welding step of fixing the headers 14A and 14B to the column 12, the headers 14A and 14B are inserted into the column 12 (inserted). In this process, the cylindrical protrusion 26 abuts on the exposed outer peripheral side 24 B of the sealing member 18. When pressure is further applied to insert the headers 14A and 14B, the tip of the cylindrical protrusion 26 bites into the sealing member 18. As a result, blood leakage from the contact point to the outer diameter side is prevented.

As illustrated in FIG. 2, the cylindrical protrusion 26 is formed into a mountain-shaped cross section that is widened from the top end toward the facing surface 40. By making the cross-sectional mountain shape, it is possible to cause the tip of the cylindrical protrusion 26 to bite into the sealing member 18 at a low pressure as compared to the cross-sectional rectangular shape. In addition, since the contact surface between the sealing member 18 and the cylindrical projection 26 spreads in the process of biting in, the pressing force is relaxed. Note that-edge vertices of the cylindrical projection 26 may be a R-plane. For example, R may be 0.2 mm. -Edge vertices With R plane, it is stress generated in the sealing member 18 when the bite is distributed, it is possible suppress the crack generation of the sealing member 18.

  Referring now to FIG. 3, the opening angle γ of the cylindrical protrusion 26, that is, the angle between the inner slope 26A and the outer slope 26B may be an obtuse angle. For example, if the acute angle is used, the cylindrical protrusion 26 may be thin and it may be broken in the process of biting into the sealing member 18, but if it is an obtuse angle, the possibility of such bending may be reduced. Further, the obtuse angle improves the followability of the contact surface of the sealing member 18 having elasticity with the cylindrical protrusion 26. In other words, the sealing member 18 is easily deformed along the shape of the cylindrical protrusion 26. Sealability is improved.

  For example, the opening angle γ of the cylindrical protrusion 26 may be 120 ° or more and 145 ° or less. More preferably, as described in FIG. 6 and FIG. 7 described later, the opening angle γ may be 139 °.

  Further, the cylindrical protrusion 26 according to the present embodiment is formed so that the inner diameter side slope 26A of the cross-sectional mountain shape is opened with respect to the radial direction line R of the column 12 as compared with the outer diameter side slope 26B. By opening the inner diameter side slope 26A, the space between the exposed surface outer peripheral side 24B and the inner diameter side slope 26A is opened, and the flow of the liquid (blood) flowing in the region is secured.

  For example, as illustrated in FIG. 3, an angle β between the inner diameter side slope 26A and the radial direction line R of the column 12 is 30 °, and an angle α between the outer diameter side slope 26B and the radial direction line R is 11 ° and As described above, the cylindrical protrusion 26 itself has a substantially isosceles triangle in cross section, but the inclination of the center line (shown by a broken line) with respect to the column central axis C makes the angle β of the inner diameter side slope 26A be the outer diameter side. It is configured to be larger than the angle α of the slope 26B.

  4 and 5 show a comparative example of the hollow fiber membrane module 10 according to this embodiment, that is, the hollow fiber membrane module 10 in which the cylindrical protrusion 26 has a mountain-shaped cross section, and the conventional hollow fiber membrane module in which the protrusion is rectangular in cross section. It is done. Referring to FIG. 4, the horizontal axis represents welding energy [J], and the vertical axis represents the depth [mm] of the protrusion biting into the sealing member 18. The welding energy refers to energy for melting the inner peripheral surface of the side peripheral wall 30 of the headers 14A and 14B and the outer peripheral surface of the column 12. Generally, the higher the welding energy, the more easily the molten surface melts, and the pressure when inserting the headers 14A and 14B into the column 12 is more likely to be applied to the contact surface between the cylindrical protrusion 26 and the sealing member 18. Become. Therefore, qualitatively, under the same pressure, the higher the welding energy, the deeper the bite depth.

  In FIG. 4, the cylindrical protrusion according to the present embodiment is shown by a marker with “taper 101 °”. The angle with respect to 101 ° indicates the angle ε (α + 90 °) of the outer diameter side slope 26B with respect to the central axis C of the column 12, as shown in FIG. Moreover, the marker shown as "flat ○ .. 0 mm" by FIG. 4, FIG. 5 shows the comparative example on which the prior art was reflected. The comparative example has a rectangular protrusion, and as its cross-sectional shape, one having a length of 0.5 mm, 1 mm, 1.5 mm and 2 mm in contact with the sealing member 18 as shown in FIG. There is.

  In comparison of FIG. 4 and FIG. 5, the pass value of the penetration depth of the protrusion into the sealing member 18 is set to a value exceeding 0.1 mm, and the penetration depth of 0.1 mm or less is rejected. When the inventors of the present invention conducted experiments in setting the pass value of the biting depth, when the biting depth exceeds 0.1 mm, the contact between the protrusion and the sealing member 18 from the contact point to the outer diameter side There was no liquid leakage confirmed. From this, the pass line of the penetration depth as described above is set.

  With reference to FIG. 4, the cylindrical protrusion 26 (taper 101 °) having a cross-sectionally mountain-like shape according to the present embodiment obtains a pass value in the biting depth at any welding energy except in the case where a crack occurs in Table 1 described later. It is understood that you are doing.

  FIG. 5 is a graph when the horizontal axis is the maximum pressure value. The vertical axis shows the biting depth of the protrusion into the sealing member 18 as in FIG. As shown in this example, the cylindrical protrusion 26 (taper 101 °) having a cross-sectional chevron in the present embodiment is compared with the conventional rectangular protrusion except in the case where a crack in Table 1 described later occurs. It is understood that it is possible to dig into the pass value at a low pressure value.

  The data on which the graphs of FIGS. 4 and 5 are based are shown in Table 1 below. In addition, the cell in which the numerical value is not described in the amount of biting shows the example in which the amount of biting was unknown due to the occurrence of a crack. In the graphs of FIG. 4 and FIG. 5, in the following tables, the plots for which the bite amount is unknown are omitted.

Further, in Table 1 and Table 2 described later, the welding energy and the maximum pressure value indicate not the set values but the actually output values. For example, in the process of inserting the headers 14A and 14B into the column 12, the peak power [W] and the fusion distance are set for the welding machine. At this time, the welding horn is moved while oscillating until the output (welding power) of the welding horn reaches the peak power or until the set distance is reached. The maximum deposition energy and maximum pressure values obtained in this process are shown in Table 1. The amount of bite is the hollow fiber membrane module 10 after welding.
Was broken (deployed) and measured.

As shown in Table 1 above, the cylindrical protrusion 26 having a mountain-shaped cross section according to the present embodiment is insufficient in sealing (a biting depth of 0.1 mm or less) or less than the protrusion (rectangular protrusion) applied to the prior art It is understood that the percentage of cracks in the sealing member 18 is low. Further, the encroachment ease, that is, the value of “amount of biting / maximum pressure value” is, except for data in which a crack is generated, a cylindrical protrusion having a mountain-shaped cross section according to the present embodiment in comparison with a comparative example reflecting the prior art 26 is getting bigger. That is, the cylindrical protrusion 26 having a mountain-shaped cross section according to the present embodiment can earn a biting amount with a smaller pressure than in the conventional case.

  Next, test results when variously changing the shape of the cylindrical protrusion 26 having a mountain-shaped cross section according to the present embodiment are shown using FIG. 6 and FIG. 7. The horizontal axis of FIG. 6 indicates the welding energy [J], and the horizontal axis of FIG. 7 indicates the maximum pressure value [N]. The vertical axis indicates the bite depth [mm] in each case.

In this example, referring to FIG. 3, examples of the opening angle γ of the cylindrical protrusion 26 are 120 °, 130 °, 139 °, and 145 °, respectively. The legend on the left side of the figure shows the angle ε formed by the central axis C of the column 12 and the outer diameter side slope 26B. That is, ε = 95 ° (() corresponds to γ = 145 °, ε = 101 ° (◆) corresponds to γ = 139 °, and ε = 110 ° (▲) corresponds to γ = 130 °, ε = 120 ° (●) corresponds to γ = 120 °. The relationship with α <β in FIG. 3 is maintained for any of these examples except the example of ε = 120 ° .

  6 and 7, white plots (プ ロ ッ ト, Δ, □, etc.) show an example in which the sealing member 18 has a crack. It is understood that although the crack has occurred in any of the examples, the pass depth is obtained with the exception of one example. The original data of FIGS. 6 and 7 are shown in Table 2 below.

  The relationship between the pressure value and the amount of biting in the case of Table 2 above, in particular, for ε = 101 ° (γ = 139 °), is almost in direct proportion, and the adjustment of the amount of biting is compared with other examples. It is easy. From such ease of processing, it is preferable to set the opening angle γ of the cylindrical protrusion 26 to 139 °.

<Another example of the present embodiment>
Another example of the hollow fiber membrane module 10 according to the present embodiment is illustrated in FIGS. 8 and 9. In this example, curved surface processing is performed on the bottom side of the inner side slope 26A having a mountain-shaped cross section. When the straight lines cross each other, a so-called smear portion is formed, which may cause liquid retention. By subjecting the portion to curved surface processing, liquid (blood) can be smoothly distributed.

  Also in the cylindrical projection 26 according to FIGS. 8 and 9, the angle β between the inner diameter side slope 26A and the radial direction line R of the column 12 is from the angle α between the outer diameter side slope 26B and the radial direction line R. It is formed to be large. Further, an angle γ formed by the inner side slope 26A and the outer side slope 26B is formed to be an obtuse angle.

DESCRIPTION OF SYMBOLS 10 hollow fiber membrane module, 12 columns, 14A, 14B header, 16 hollow fiber membrane bundle, 18 sealing member, 18A inner peripheral side area of sealing member, 18B outer peripheral side area of sealing member, 24B exposed surface outer peripheral side, 26 Cylindrical projection, 26A inner diameter slope, 26B outer diameter slope.

Claims (5)

With a cylindrical column,
A hollow fiber membrane bundle housed in the column;
A sealing member which is filled between the hollow fiber membranes at both ends of the hollow fiber membrane bundle and fixed to the inner circumferential surface of the column in a state where the hollow fiber membrane bundle is moved toward the central axis of the column; ,
Headers attached to each end of the column;
Equipped with
Of the exposed surface of the sealing member facing the header, a cylindrical protrusion capable of coming into contact with the outer surface of the exposed surface where the hollow fiber membrane bundle is not distributed, on the surface of the header facing the sealing member. Is provided,
The cylindrical protrusion is formed in a cross-sectional mountain shape which is expanded from the top end tip,
The cylindrical projection is formed such that the inner diameter side slope of the cross section has an opening relative to the radial direction line of the column compared to the outer diameter side slope ;
An opening angle which is an angle formed by the inner diameter side slope and the outer diameter side slope of the cross-sectional mountain shape is 120 ° or more and 145 ° or less.
Hollow fiber membrane module. A hollow fiber membrane module according to claim 1, wherein
The hollow fiber membrane module , wherein the opening angle of the cross section is 139 ° . A hollow fiber membrane module according to claim 1 or 2, wherein
A hollow fiber membrane module in which a curved surface process is applied to a skirt side of the inner diameter side slope of the cross-sectional chevron. A hollow fiber membrane module according to any one of claims 1 to 3 , which is:
The hollow fiber membrane module , wherein the tip of the cylindrical protrusion is an R surface . A cylindrical column, a hollow fiber membrane bundle accommodated in the column, and hollow fiber membranes at both ends of the hollow fiber membrane bundle in a state where the hollow fiber membrane bundle is moved toward the central axis of the column And a header attached to both ends of the column, the sealing member facing the sealing member on the surface of the header A cylindrical protrusion capable of coming into contact with the outer peripheral side of the exposed surface where the hollow fiber membrane bundle is not distributed among the exposed surfaces of the stopper member facing the header is provided, and the cylindrical protrusion has a mountain shape in cross section expanded from the tip apex A hollow fiber membrane module manufacturing method, wherein the cylindrical protrusion is formed such that the inner diameter side slope of the cross-sectional mountain shape is opened relative to the radial direction line of the column compared to the outer diameter side slope, ,
When attaching the header to the column, the cylindrical protrusion is made to bite into the heated and softened sealing member;
Method of manufacturing hollow fiber membrane module.