JPH01139069A - Medical composition - Google Patents
Medical compositionInfo
- Publication number
- JPH01139069A JPH01139069A JP62299086A JP29908687A JPH01139069A JP H01139069 A JPH01139069 A JP H01139069A JP 62299086 A JP62299086 A JP 62299086A JP 29908687 A JP29908687 A JP 29908687A JP H01139069 A JPH01139069 A JP H01139069A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- medical composition
- granules
- bone mineral
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 22
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 24
- 239000008187 granular material Substances 0.000 claims abstract description 17
- 238000002156 mixing Methods 0.000 claims abstract description 6
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 17
- 239000011707 mineral Substances 0.000 claims description 17
- 241001465754 Metazoa Species 0.000 claims description 16
- 108010045569 atelocollagen Proteins 0.000 claims description 15
- 239000000834 fixative Substances 0.000 abstract description 5
- 108090000623 proteins and genes Proteins 0.000 abstract description 5
- 102000004169 proteins and genes Human genes 0.000 abstract description 5
- 238000011109 contamination Methods 0.000 abstract description 4
- 230000003204 osmotic effect Effects 0.000 abstract description 3
- 244000052616 bacterial pathogen Species 0.000 abstract description 2
- 231100000419 toxicity Toxicity 0.000 abstract description 2
- 230000001988 toxicity Effects 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract 2
- 239000002245 particle Substances 0.000 description 11
- 239000007864 aqueous solution Substances 0.000 description 8
- 239000000463 material Substances 0.000 description 6
- 239000000243 solution Substances 0.000 description 5
- 238000011049 filling Methods 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 2
- 208000032544 Cicatrix Diseases 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 231100000241 scar Toxicity 0.000 description 2
- 230000037387 scars Effects 0.000 description 2
- YLZOPXRUQYQQID-UHFFFAOYSA-N 3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-1-[4-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]piperazin-1-yl]propan-1-one Chemical compound N1N=NC=2CN(CCC=21)CCC(=O)N1CCN(CC1)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F YLZOPXRUQYQQID-UHFFFAOYSA-N 0.000 description 1
- WTFUTSCZYYCBAY-SXBRIOAWSA-N 6-[(E)-C-[[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]methyl]-N-hydroxycarbonimidoyl]-3H-1,3-benzoxazol-2-one Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)C/C(=N/O)/C1=CC2=C(NC(O2)=O)C=C1 WTFUTSCZYYCBAY-SXBRIOAWSA-N 0.000 description 1
- 208000017234 Bone cyst Diseases 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 1
- AFCARXCZXQIEQB-UHFFFAOYSA-N N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CCNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 AFCARXCZXQIEQB-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 210000001909 alveolar process Anatomy 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 210000001847 jaw Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
- Dental Preparations (AREA)
Abstract
Description
【発明の詳細な説明】
［産業上の利用分野コ
この発明は、アテロコラーゲン水溶液に動物骨無機質の
顆粒を混合してなる医療用組成物に関するものである。DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to a medical composition comprising an aqueous atelocollagen solution mixed with animal bone mineral granules.
［従来の技術］
この発明の医療用組成物の一成分であるｐＨが約６、５
〜８．０’ｔ’、カッ重量浸透圧濃度が約２５０〜３２
０ｍＯｓｍ／ｋｇＨ２Ｏであるアテロコラーゲン水溶液
（以下、′アテロコラーゲン水溶液」という）は、昭和
６２年特許出願公告第３７０２０号公報に記載されてい
る。[Prior Art] One component of the medical composition of the present invention has a pH of about 6.5.
~8.0't', Kak weight osmolarity is about 250-32
An aqueous atelocollagen solution (hereinafter referred to as 'aqueous atelocollagen solution') having a concentration of 0 mOsm/kgH2O is described in Patent Application Publication No. 37020 of 1988.
もう一方の成分である動物骨無機質は、例えば昭和６２
年特許出願公告第２１５４３号公報に記載の人工骨を構
成する成分として知られている。The other component, animal bone mineral, is
It is known as a component constituting an artificial bone described in Patent Application Publication No. 21543.
また、燐酸系のＣａ塩、コラーゲンおよびたんばく固定
剤を含む人体硬組織用修復材も知られている（昭和６１
年特許出願公開第２４６１０７号）。In addition, a repair material for human hard tissue containing phosphoric acid-based Ca salt, collagen, and protein fixative is also known (1981).
2007 Patent Application Publication No. 246107).
［解決すべき問題点］
上記の人工骨は、生体に対する適合性がすぐれているも
のの、一定の形状を有するため、その用途は骨移植材料
に限られており、いわゆる抜歯痕のごとき不定形な部位
への充填材としては適していない。[Problems to be solved] Although the artificial bone described above has excellent compatibility with living organisms, its use is limited to bone graft materials because it has a fixed shape, and it is not suitable for use in irregularly shaped bones such as so-called tooth extraction scars. It is not suitable as a filler for the site.
また、上記の人体硬組織用修復材では、ゲルタールアル
デヒドの如き毒性のあるたんばく固定剤が用いられてお
り、しかもこのたんばく固定剤は修復材の使用直前に添
加されるため、病原菌による汚染のおそれもあり、満足
できるものではない。In addition, the above-mentioned repair materials for human body hard tissues use toxic protein fixatives such as geltaraldehyde, and since these protein fixatives are added immediately before use of the repair materials, pathogenic bacteria can There is also a risk of contamination, which is not satisfactory.
［問題点を解決するための手段］
この発明は、抜歯痕、骨欠損部への充填とか、歯周疾患
、顎骨的嚢胞、顎堤吸収の処置等に適した医療用組成物
の提供を目的としてなされたものである。[Means for Solving the Problems] The purpose of the present invention is to provide a medical composition suitable for filling tooth extraction scars, bone defects, treating periodontal diseases, jaw bone cysts, alveolar ridge resorption, etc. This was done as a.
この発明の組成物は、アテロコラーゲン水溶液に動物骨
無機質の顆粒を混合することにより製造きれる。The composition of this invention can be manufactured by mixing animal bone mineral granules with an aqueous atelocollagen solution.
アテロコラーゲン水溶液は、例えば昭和６２年特許出願
公告第３７０２０号公報に記載の方法によって製造する
ことができる。The atelocollagen aqueous solution can be produced, for example, by the method described in Patent Application Publication No. 37020 of 1988.
もう一方の成分である動物骨無機質の顆粒は、例えば昭
和６２年特許出願公告第２１５４３号公報記載の方法に
よって製造した動物骨無機質を常法により粉砕機等で微
粉砕したのち篩別することにより製造できる。The other component, animal bone mineral granules, can be obtained by, for example, finely pulverizing animal bone mineral produced by the method described in Patent Application Publication No. 21543 of 1988 using a crusher, etc., and then sieving it. Can be manufactured.
アテロコラーゲン水溶液中のアテロコラーゲンの濃度は
特に限定きれないが、通常０．１〜１０％程度、より好
ましくは１〜５％程度である。Although the concentration of atelocollagen in the atelocollagen aqueous solution cannot be particularly limited, it is usually about 0.1 to 10%, more preferably about 1 to 5%.
また、動物骨無機質の顆粒の粒子径も特に限定されない
が、通常１００〜２０００μ程度が適当である。Furthermore, the particle size of the animal bone mineral granules is not particularly limited, but is usually about 100 to 2000 microns.
アテロコラーゲン水溶液と動物骨無機質の顆粒との混合
割合は、得られる組成物の使用目的にもよるが、通常１
：５ないし５：１（重量比）で所期の目的に合った組成
物が得られる。The mixing ratio of the atelocollagen aqueous solution and the animal bone mineral granules depends on the intended use of the resulting composition, but is usually 1.
:5 to 5:1 (weight ratio), a composition suitable for the intended purpose can be obtained.
この発明の組成物は、ゲル化を防止するため、１０℃以
下の低温で保存するのが好ましい。The composition of this invention is preferably stored at a low temperature of 10° C. or lower to prevent gelation.
［効果］
この発明で用いられるアテロコラーゲン水溶液は、生体
と同じ浸透圧であり、体温程度に加温するとゲル化する
性質を有し、生体適合性に極めてすぐれている。[Effects] The atelocollagen aqueous solution used in the present invention has the same osmotic pressure as that of a living body, has the property of gelling when heated to about body temperature, and has extremely excellent biocompatibility.
また、動物骨無機質の顆粒は、生体の微細な構造をその
ま〜維持しており、生体との親和性が高い。In addition, the animal bone mineral granules maintain the fine structure of the living body and have a high affinity with the living body.
この発明の組成物では、アテロコラーゲンが動物骨無機
質粒子間の連結剤として作用するため、たんばく固定剤
を必要としない、したがって、組成物自体の毒性のおそ
れや、使用時の汚染のおそれもなく、安全性にすぐれて
いる。そして、使用前にはペースト状であり、体温によ
り短時間でゲル化するため、充填部位からの漏出もなく
、不定形部位への充填材として扱い易く、しかも生体適
合性にすぐれており、硬組織欠損部への充填材として極
めて有用である。In the composition of this invention, since atelocollagen acts as a linking agent between animal bone mineral particles, a protein fixative is not required. Therefore, there is no risk of toxicity of the composition itself or contamination during use. , has excellent safety. Since it is in a paste form before use and gels in a short time due to body temperature, it does not leak from the filling site and is easy to handle as a filling material for irregularly shaped areas.It is also highly biocompatible and hard. It is extremely useful as a filling material for tissue defects.
［実施例］
この発明の組成物の製造例を参考例および実施例により
以下に説明する。[Example] Production examples of the composition of the present invention will be explained below using Reference Examples and Examples.
参考例１
斯鮮な牛大腿骨の海綿部を数ｃｍ角に切断し、水中で煮
沸し、骨髄などを除去する。これを１％水酸化ナトリウ
ム水溶液および１％過酸化水素水溶液にそれぞれ１時間
ずつ浸漬したのち、充分に水洗し、乾燥する。これを６
００℃で加熱して有機物を除去し、さらに１１００℃で
３．５時間焼成したのち、乳鉢で破砕し、ボールミルに
より粒子の角を落とした。これを篩により分級し、水洗
、乾燥して、粒子径３００〜６００μおよび６００〜１
０００μの牛骨無機質の顆粒を得た。Reference Example 1 The spongy part of a fresh bovine femur is cut into pieces several cm square and boiled in water to remove bone marrow and the like. This was immersed in a 1% aqueous sodium hydroxide solution and a 1% aqueous hydrogen peroxide solution for 1 hour each, then thoroughly washed with water and dried. This is 6
After heating at 00°C to remove organic matter and further baking at 1100°C for 3.5 hours, the particles were crushed in a mortar and the corners of the particles were removed using a ball mill. This was classified using a sieve, washed with water, and dried to obtain particle sizes of 300-600μ and 600-1.
000μ of bovine bone mineral granules were obtained.
実施例１
２％アテロコラーゲン水溶液と粒子径１０００μの動物
骨無機質の顆粒とを２＝１．１：１．１：２（重量比）
の割合でそれぞれ混合して、ペースト状の組成物を得た
。Example 1 2% atelocollagen aqueous solution and animal bone mineral granules with a particle size of 1000μ 2 = 1.1:1.1:2 (weight ratio)
A paste-like composition was obtained by mixing them in the following proportions.
実施例２
２％アテロコラーゲン水溶液と粒子径６００〜１０００
μの動物骨無機質の顆粒とを２＝３．１：１．１：２（
重量比）の割合でそれぞれ混合して、ペースト状の組成
物を得た。Example 2 2% atelocollagen aqueous solution and particle size 600-1000
μ of animal bone mineral granules and 2=3.1:1.1:2 (
A paste-like composition was obtained by mixing them in the following proportions (weight ratio).
実施例３
粒子径３００〜６００μの動物骨無機質の顆粒を用いて
、実施例２と同様にして、３種のペースト状の組成物を
得た。Example 3 Three types of paste-like compositions were obtained in the same manner as in Example 2 using animal bone mineral granules having a particle size of 300 to 600 μm.
実施例４
粒子径３００μの動物骨無機質の顆粒を用いて、実施例
１と同様にして、３種のペースト状の組成物を得た。Example 4 Three types of paste-like compositions were obtained in the same manner as in Example 1 using animal bone mineral granules with a particle size of 300 μm.
実施例５
４％アテロコラーゲン水溶液と粒子径６００〜１０００
μの動物骨無機質の顆粒とを２＝３（重量比）の割合で
混合して、ペースト状の組成物を得た。Example 5 4% atelocollagen aqueous solution and particle size 600-1000
μ of animal bone mineral granules were mixed in a ratio of 2=3 (weight ratio) to obtain a paste-like composition.
実施例６
４％アテロコラーゲン水溶液と粒子径３００〜６００μ
の動物骨無機質の顆粒とを２：３（重量比）の割合で混
合してペースト状の組成物を得た。Example 6 4% atelocollagen aqueous solution and particle size 300-600μ
and animal bone mineral granules at a ratio of 2:3 (weight ratio) to obtain a paste composition.
Claims (1)
５０〜３２０ｍＯｓｍ／ｋｇＨ＿２Ｏであるアテロコラ
ーゲン水溶液に動物骨無機質の顆粒を混合してなる医療
用組成物。pH is about 6.5 to 8.0 and osmolarity is about 2
A medical composition prepared by mixing animal bone mineral granules with an aqueous atelocollagen solution having a concentration of 50 to 320 mOsm/kgH_2O.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62299086A JP2509955B2 (en) | 1987-11-27 | 1987-11-27 | Hard tissue defect filling material |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62299086A JP2509955B2 (en) | 1987-11-27 | 1987-11-27 | Hard tissue defect filling material |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH01139069A true JPH01139069A (en) | 1989-05-31 |
| JP2509955B2 JP2509955B2 (en) | 1996-06-26 |
Family
ID=17867992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62299086A Expired - Lifetime JP2509955B2 (en) | 1987-11-27 | 1987-11-27 | Hard tissue defect filling material |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2509955B2 (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55155643A (en) * | 1979-05-23 | 1980-12-04 | Koken Kk | Artificial bone and its preparation |
| JPS6028936A (en) * | 1983-07-27 | 1985-02-14 | Koken:Kk | Atherocollagen aqueous solution and its preparation |
| JPS62268563A (en) * | 1986-04-22 | 1987-11-21 | コラ−ゲン コ−ポレ−シヨン | Bone mallow/collagen/inorganic matrix for repairing defect of bone, its preparation and method for repairing defect of bone using the same |
-
1987
- 1987-11-27 JP JP62299086A patent/JP2509955B2/en not_active Expired - Lifetime
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55155643A (en) * | 1979-05-23 | 1980-12-04 | Koken Kk | Artificial bone and its preparation |
| JPS6028936A (en) * | 1983-07-27 | 1985-02-14 | Koken:Kk | Atherocollagen aqueous solution and its preparation |
| JPS62268563A (en) * | 1986-04-22 | 1987-11-21 | コラ−ゲン コ−ポレ−シヨン | Bone mallow/collagen/inorganic matrix for repairing defect of bone, its preparation and method for repairing defect of bone using the same |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2509955B2 (en) | 1996-06-26 |
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