JP7902192B2 - 質量分析によるインスリン様増殖因子ｉバリアントの同定及び定量 - Google Patents

質量分析によるインスリン様増殖因子ｉバリアントの同定及び定量

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Publication number
JP7902192B2
JP7902192B2 JP2023556942A JP2023556942A JP7902192B2 JP 7902192 B2 JP7902192 B2 JP 7902192B2 JP 2023556942 A JP2023556942 A JP 2023556942A JP 2023556942 A JP2023556942 A JP 2023556942A JP 7902192 B2 JP7902192 B2 JP 7902192B2
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igf
sample
variants
mass
ions
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JP2024515443A (ja
JP2024515443A5 (cg-RX-API-DMAC7.html
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モトリキン，イエフゲン
クラーク，ナイジェル
マクファール，マイケル，ジェイ．
ウー，ゼングル
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クエスト ダイアグノスティックス インヴェストメンツ エルエルシー
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/65—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
JP2023556942A 2021-03-19 2022-03-18 質量分析によるインスリン様増殖因子ｉバリアントの同定及び定量 Active JP7902192B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163163502P 2021-03-19 2021-03-19
US63/163,502 2021-03-19
PCT/US2022/020906 WO2022198020A1 (en) 2021-03-19 2022-03-18 Identification and quantitation of insulin-like growth factor-i variants by mass spectrometry

Publications (3)

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JP2024515443A JP2024515443A (ja) 2024-04-10
JP2024515443A5 JP2024515443A5 (cg-RX-API-DMAC7.html) 2025-03-12
JP7902192B2 true JP7902192B2 (ja) 2026-08-07

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JP2023556942A Active JP7902192B2 (ja) 2021-03-19 2022-03-18 質量分析によるインスリン様増殖因子ｉバリアントの同定及び定量

Country Status (7)

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US (2) US12222354B2 (cg-RX-API-DMAC7.html)
EP (1) EP4308923A4 (cg-RX-API-DMAC7.html)
JP (1) JP7902192B2 (cg-RX-API-DMAC7.html)
KR (1) KR20230169172A (cg-RX-API-DMAC7.html)
CN (1) CN117178188A (cg-RX-API-DMAC7.html)
CA (1) CA3212218A1 (cg-RX-API-DMAC7.html)
WO (1) WO2022198020A1 (cg-RX-API-DMAC7.html)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117589997B (zh) * 2023-10-09 2025-11-21 融智生物科技（青岛）有限公司 Igf-1变体的定量检测方法
CN117589998B (zh) * 2023-10-09 2025-11-18 融智生物科技（青岛）有限公司 胰岛素样生长因子i变体的定量检测试剂盒

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030027216A1 (en) 2001-07-02 2003-02-06 Kiernan Urban A. Analysis of proteins from biological fluids using mass spectrometric immunoassay
JP2007532882A (ja) 2004-04-07 2007-11-15 ジェネンテック・インコーポレーテッド 抗体結合体の質量分析
JP2017503862A (ja) 2014-01-12 2017-02-02 アイジーエフ オンコロジー、 エルエルシー インスリン様成長因子−１および上皮増殖因子を含む融合タンパク質およびそのバリアントならびにその使用
CN109957000A (zh) 2017-12-14 2019-07-02 南开大学 一种促进细胞增殖的多肽衍生物及其制备方法及应用
US20210041462A1 (en) 2009-11-05 2021-02-11 Quest Diagnostics Investments Incorporated Quantitation of insulin-like growth factor-i and insulin-like growth factor-ii with high-resolution mass spectrometry

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080064044A9 (en) 1995-05-23 2008-03-13 Nelson Randall W Analysis of insulin-like growth factors from biological fluids by the use of affinity-based mass spectrometric methods
JP2008511838A (ja) 2004-08-30 2008-04-17 テルシカ・インク インシュリン様成長因子欠乏疾患の診断及び治療のための方法及び装置
EP1674113A1 (en) 2004-12-22 2006-06-28 F. Hoffmann-La Roche Ag Conjugates of insulin-like growth factor-1 (IGF-1) and poly(ethylene glycol)
ES2453108T3 (es) 2007-08-06 2014-04-04 Orion Genomics, Llc Nuevos polimorfismos de un único nucleótido y combinaciones de polimorfismos nuevos y conocidos para determinar la expresión específica de alelo del gen IGF2
EP2396429B1 (en) 2009-02-11 2015-05-27 Orion Genomics, LLC Combinations of polymorphisms for determining allele-specific expression of igf2

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030027216A1 (en) 2001-07-02 2003-02-06 Kiernan Urban A. Analysis of proteins from biological fluids using mass spectrometric immunoassay
JP2007532882A (ja) 2004-04-07 2007-11-15 ジェネンテック・インコーポレーテッド 抗体結合体の質量分析
US20210041462A1 (en) 2009-11-05 2021-02-11 Quest Diagnostics Investments Incorporated Quantitation of insulin-like growth factor-i and insulin-like growth factor-ii with high-resolution mass spectrometry
JP2017503862A (ja) 2014-01-12 2017-02-02 アイジーエフ オンコロジー、 エルエルシー インスリン様成長因子−１および上皮増殖因子を含む融合タンパク質およびそのバリアントならびにその使用
CN109957000A (zh) 2017-12-14 2019-07-02 南开大学 一种促进细胞增殖的多肽衍生物及其制备方法及应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MOTORYKIN et al.，MON-487 Simultaneous Monitoring of 13 IGF-1 Variants in a Clinical Mass Spectrometry Assay，Journal of the Endocrine Society，2019年，Vol.3/Issue Supplement_1, MON-487，PP.1-2

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US20220299524A1 (en) 2022-09-22
EP4308923A1 (en) 2024-01-24
BR112023018869A2 (pt) 2023-12-05
US12222354B2 (en) 2025-02-11
EP4308923A4 (en) 2025-01-08
JP2024515443A (ja) 2024-04-10
CN117178188A (zh) 2023-12-05
US20250155448A1 (en) 2025-05-15
WO2022198020A1 (en) 2022-09-22
KR20230169172A (ko) 2023-12-15
CA3212218A1 (en) 2022-09-22

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