JP7875802B2 - ｃ－Ｋｉｔ変異を発現する細胞およびその使用 - Google Patents

ｃ－Ｋｉｔ変異を発現する細胞およびその使用

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Publication number
JP7875802B2
JP7875802B2 JP2022533605A JP2022533605A JP7875802B2 JP 7875802 B2 JP7875802 B2 JP 7875802B2 JP 2022533605 A JP2022533605 A JP 2022533605A JP 2022533605 A JP2022533605 A JP 2022533605A JP 7875802 B2 JP7875802 B2 JP 7875802B2
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cells
car
kit
certain embodiments
antigen
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JP2023504560A (ja
JP2023504560A5 (enExample
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プラサッド エス． アドゥスミリ，
ユチュアン ション，
Original Assignee
メモリアル スローン－ケタリング キャンサー センター
スローン － ケタリング・インスティテュート・フォー・キャンサー・リサーチ
メモリアル ホスピタル フォー キャンサー アンド アライド ディジージズ
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4254—Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
    • A61K40/4255—Mesothelin [MSLN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/10—Protein-tyrosine kinases (2.7.10)
    • C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/55—Lung
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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  • Health & Medical Sciences (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2022533605A 2019-12-03 2020-12-03 ｃ－Ｋｉｔ変異を発現する細胞およびその使用 Active JP7875802B2 (ja)

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JP2025165386A JP2026017553A (ja) 2019-12-03 2025-10-01 ｃ－Ｋｉｔ変異を発現する細胞およびその使用

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US201962943032P 2019-12-03 2019-12-03
US62/943,032 2019-12-03
PCT/US2020/062992 WO2021113432A1 (en) 2019-12-03 2020-12-03 Cells expressing c-kit mutations and uses thereof

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JP2023504560A JP2023504560A (ja) 2023-02-03
JP2023504560A5 JP2023504560A5 (enExample) 2023-12-04
JP7875802B2 true JP7875802B2 (ja) 2026-06-18

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US (1) US20230051518A1 (enExample)
EP (1) EP4069730A4 (enExample)
JP (2) JP7875802B2 (enExample)
CN (1) CN115210254A (enExample)
AU (1) AU2020395175A1 (enExample)
CA (1) CA3163872A1 (enExample)
IL (1) IL293598A (enExample)
WO (1) WO2021113432A1 (enExample)

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US12419913B2 (en) 2019-02-08 2025-09-23 Dna Twopointo, Inc. Modification of CAR-T cells
US20250283041A1 (en) * 2022-05-25 2025-09-11 Albert Einstein College Of Medicine Methods for producing red blood cells
EP4540287A1 (en) * 2022-06-20 2025-04-23 CRISPR Therapeutics AG Chimeric antigen receptor specific to cd117
WO2025117266A2 (en) * 2023-11-27 2025-06-05 Albert Einstein College Of Medicine Method of producing self-renewing erythroid cells from human progenitor cells
CN118725143B (zh) * 2024-07-15 2025-12-02 上海交通大学医学院附属瑞金医院 靶向kit d816v突变衍生抗原的tcr及应用

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US10093701B2 (en) * 2012-09-07 2018-10-09 University Of Miami Fusion proteins for promoting an immune response, nucleic acids encoding same, and methods of making and use thereof
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Title
Cem AKIN et al.，"Analysis of the surface expression of c-kit and occurrence of the c-kit Asp816Val activating mutation in T cells, B cells, and myelomonocytic cells in patients with mastocytosis"，Experimental Hematology，2000年02月，Vol. 28, No. 2，p.140-147，DOI: 10.1016/s0301-472x(99)00145-9
HONGYO T et al.，"Specific c-kit mutations in sinonasal natural killer/T-cell lymphoma in China and Japan."，Cancer research，2000年05月01日，Vol. 60, No. 9，p.2345-7
Marcia L. TAYLOR et al.，"The Kit-activating mutation D816V enhances stem cell factor-dependent chemotaxis"，Blood，2001年08月15日，Vol. 98, No. 4，p.1195-1199，DOI: 10.1182/blood.v98.4.1195
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EP4069730A4 (en) 2023-11-01
US20230051518A1 (en) 2023-02-16
CA3163872A1 (en) 2021-06-10
EP4069730A1 (en) 2022-10-12
WO2021113432A1 (en) 2021-06-10
JP2023504560A (ja) 2023-02-03
JP2026017553A (ja) 2026-02-04
IL293598A (en) 2022-08-01
AU2020395175A1 (en) 2022-07-07
CN115210254A (zh) 2022-10-18

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