JP7830350B2 - 膵神経内分泌腫瘍の検出 - Google Patents

膵神経内分泌腫瘍の検出

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Publication number
JP7830350B2
JP7830350B2 JP2022567116A JP2022567116A JP7830350B2 JP 7830350 B2 JP7830350 B2 JP 7830350B2 JP 2022567116 A JP2022567116 A JP 2022567116A JP 2022567116 A JP2022567116 A JP 2022567116A JP 7830350 B2 JP7830350 B2 JP 7830350B2
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Japan
Prior art keywords
seq
nos
conjugated
bind
methylation
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Active
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JP2022567116A
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English (en)
Japanese (ja)
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JP2023524740A5 (enExample
JP2023524740A (ja
Inventor
エー． アルクイスト，デヴィッド
ビー． キシェル，ジョン
アール． テイラー，ウィリアム
ダブリュー． マホーニー，ダグラス
マジュムデル，ショウナク
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Mayo Clinic in Florida
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Mayo Clinic in Florida
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Publication of JP2023524740A publication Critical patent/JP2023524740A/ja
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Priority to JP2026034032A priority Critical patent/JP2026094340A/ja
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Publication of JP7830350B2 publication Critical patent/JP7830350B2/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00—Reactions characterised by treatment of reaction samples
    • C12Q2523/10—Characterised by chemical treatment
    • C12Q2523/125—Bisulfite(s)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/164—Methylation detection other then bisulfite or methylation sensitive restriction endonucleases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2022567116A 2020-05-04 2021-05-04 膵神経内分泌腫瘍の検出 Active JP7830350B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2026034032A JP2026094340A (ja) 2020-05-04 2026-03-04 膵神経内分泌腫瘍の検出

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063019751P 2020-05-04 2020-05-04
US63/019,751 2020-05-04
PCT/US2021/030635 WO2021226071A2 (en) 2020-05-04 2021-05-04 Detecting pancreatic neuroendocrine tumors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2026034032A Division JP2026094340A (ja) 2020-05-04 2026-03-04 膵神経内分泌腫瘍の検出

Publications (3)

Publication Number Publication Date
JP2023524740A JP2023524740A (ja) 2023-06-13
JP2023524740A5 JP2023524740A5 (enExample) 2024-05-15
JP7830350B2 true JP7830350B2 (ja) 2026-03-16

Family

ID=78468349

Family Applications (2)

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JP2022567116A Active JP7830350B2 (ja) 2020-05-04 2021-05-04 膵神経内分泌腫瘍の検出
JP2026034032A Pending JP2026094340A (ja) 2020-05-04 2026-03-04 膵神経内分泌腫瘍の検出

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2026034032A Pending JP2026094340A (ja) 2020-05-04 2026-03-04 膵神経内分泌腫瘍の検出

Country Status (8)

Country Link
US (1) US20230167506A1 (enExample)
EP (1) EP4146678A4 (enExample)
JP (2) JP7830350B2 (enExample)
KR (1) KR20230005845A (enExample)
CN (1) CN115551880A (enExample)
AU (1) AU2021268631A1 (enExample)
CA (1) CA3172143A1 (enExample)
WO (1) WO2021226071A2 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8673555B2 (en) 2008-02-15 2014-03-18 Mayo Foundation For Medical Education And Research Detecting neoplasm
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
EP2971179B1 (en) 2013-03-14 2019-01-09 Mayo Foundation for Medical Education and Research Detecting neoplasm
US10301680B2 (en) 2014-03-31 2019-05-28 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasm
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
WO2016160454A1 (en) 2015-03-27 2016-10-06 Exact Sciences Corporation Detecting esophageal disorders
JP6871926B2 (ja) 2015-08-31 2021-05-19 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチＭａｙｏ Ｆｏｕｎｄａｔｉｏｎ ｆｏｒ Ｍｅｄｉｃａｌ Ｅｄｕｃａｔｉｏｎ ａｎｄ Ｒｅｓｅａｒｃｈ 胃の新生物を検出すること
CA3002196C (en) 2015-10-30 2024-05-14 Exact Sciences Development Company, Llc Multiplex amplification detection assay and isolation and detection of dna from plasma
AU2017260630B2 (en) 2016-05-05 2023-07-13 Exact Sciences Corporation Detection of lung neoplasia by analysis of methylated DNA
AU2018211956B2 (en) 2017-01-27 2024-06-20 Exact Sciences Corporation Detection of colon neoplasia by analysis of methylated DNA
AU2018374176B2 (en) 2017-11-30 2024-12-12 Exact Sciences Corporation Detecting breast cancer
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
CA3127329A1 (en) 2019-01-24 2020-07-30 Mayo Foundation For Medical Education And Research Detecting endometrial cancer
JP7799607B2 (ja) 2019-10-31 2026-01-15 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ 卵巣癌の検出
US20250333782A1 (en) * 2022-03-31 2025-10-30 Illumina, Inc. Compositions including aqueous amine borane complexes and polynucleotides, and methods of using the same to detect methylcytosine or hydroxymethylcytosine
WO2025194302A1 (zh) * 2024-03-18 2025-09-25 深圳华大基因股份有限公司 差异化甲基化区域组合及应用
WO2026024692A1 (en) * 2024-07-24 2026-01-29 Guardant Health, Inc. Direct methylation single-base resolution sequencing of enriched unmethylated dna

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005512499A (ja) 2000-09-01 2005-05-12 エピゲノミクス アーゲー 進行中の疾病または特定の疾病の発病素質の診断
WO2018160576A1 (en) 2017-02-28 2018-09-07 Mayo Foundation For Medical Education And Research Detecting prostate cancer
JP2019520037A (ja) 2016-04-14 2019-07-18 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチＭａｙｏ Ｆｏｕｎｄａｔｉｏｎ ｆｏｒ Ｍｅｄｉｃａｌ Ｅｄｕｃａｔｉｏｎ ａｎｄ Ｒｅｓｅａｒｃｈ 高度膵異形成の検出

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090077685A1 (en) * 1998-06-16 2009-03-19 Buehler Robert E Nucleic acid molecules and other molecules associated with plants
CA2519456A1 (en) * 2003-03-17 2004-09-30 Michael G. Goggins Aberrantly methylated genes in pancreatic cancer
EP2097538A4 (en) * 2006-12-07 2011-11-30 Switchgear Genomics TRANSCRIPTION REAGULATION ELEMENTS OF BIOLOGICAL PATHS, TOOLS AND METHODS
WO2012175562A2 (en) * 2011-06-21 2012-12-27 University Of Tartu Methylation and microrna markers of early-stage non-small cell lung cancer
US10106854B2 (en) * 2012-06-14 2018-10-23 Aarhus Universitet Biomarkers for prostate cancer
US20140349856A1 (en) * 2013-03-15 2014-11-27 Biotheranostics, Inc. Neuroendocrine Tumors
EP3189156B1 (en) * 2014-08-08 2020-10-07 AIT Austrian Institute of Technology GmbH Thyroid cancer diagnosis by dna methylation analysis
US10370726B2 (en) * 2016-04-14 2019-08-06 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasia
WO2019010429A1 (en) * 2017-07-07 2019-01-10 The Trustees Of The University Of Pennsylvania METHODS OF DIAGNOSING PANCREATIC CANCER
US10648025B2 (en) * 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005512499A (ja) 2000-09-01 2005-05-12 エピゲノミクス アーゲー 進行中の疾病または特定の疾病の発病素質の診断
JP2019520037A (ja) 2016-04-14 2019-07-18 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチＭａｙｏ Ｆｏｕｎｄａｔｉｏｎ ｆｏｒ Ｍｅｄｉｃａｌ Ｅｄｕｃａｔｉｏｎ ａｎｄ Ｒｅｓｅａｒｃｈ 高度膵異形成の検出
WO2018160576A1 (en) 2017-02-28 2018-09-07 Mayo Foundation For Medical Education And Research Detecting prostate cancer

Also Published As

Publication number Publication date
EP4146678A2 (en) 2023-03-15
JP2026094340A (ja) 2026-06-09
WO2021226071A2 (en) 2021-11-11
CN115551880A (zh) 2022-12-30
CA3172143A1 (en) 2021-11-11
US20230167506A1 (en) 2023-06-01
WO2021226071A3 (en) 2021-12-09
KR20230005845A (ko) 2023-01-10
AU2021268631A1 (en) 2023-01-05
JP2023524740A (ja) 2023-06-13
EP4146678A4 (en) 2025-08-27

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