JP7830321B2 - ミオシンモジュレーターによる治療方法 - Google Patents

ミオシンモジュレーターによる治療方法

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Publication number
JP7830321B2
JP7830321B2 JP2022526496A JP2022526496A JP7830321B2 JP 7830321 B2 JP7830321 B2 JP 7830321B2 JP 2022526496 A JP2022526496 A JP 2022526496A JP 2022526496 A JP2022526496 A JP 2022526496A JP 7830321 B2 JP7830321 B2 JP 7830321B2
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JP
Japan
Prior art keywords
subject
dose
week
mabacamten
treatment
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JP2022526496A
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English (en)
Japanese (ja)
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JP2023501453A (ja
JP2023501453A5 (https=
Inventor
カールソン，ティモシー
リオ，カルロス エル デル
エム エデルバーグ，ジェイ
フェルナンデス，サラ
パトリック ヘンツェ，マーカス
ヤンフェイ マー，グレイス
マクドウェル，ロバート
エドワーズ ミーリフ，マシュー
セーナート，エイミー
ジェイ セミグラン，マーク
エル ランプル，キャシー
ジャン，デイビッド
ワイ デサイ，ミリンド
ニッセン，スティーブ
ファン，リャン
ランビン，ジョセフ
イン リィ，ワン
エル オーベル，ダニエル
エドマンド ケイン，ブライアン
チャールズ セール，ルイ
Original Assignee
マイオカーディア，インク
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Publication of JP2023501453A5 publication Critical patent/JP2023501453A5/ja
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2022526496A 2019-11-10 2020-11-10 ミオシンモジュレーターによる治療方法 Active JP7830321B2 (ja)

Applications Claiming Priority (19)

Application Number Priority Date Filing Date Title
US201962933517P 2019-11-10 2019-11-10
US62/933,517 2019-11-10
US201962933970P 2019-11-11 2019-11-11
US62/933,970 2019-11-11
US201962935922P 2019-11-15 2019-11-15
US62/935,922 2019-11-15
US202063001473P 2020-03-29 2020-03-29
US63/001,473 2020-03-29
US202063002302P 2020-03-30 2020-03-30
US63/002,302 2020-03-30
US202063006701P 2020-04-07 2020-04-07
US63/006,701 2020-04-07
US202063022573P 2020-05-10 2020-05-10
US63/022,573 2020-05-10
US202063059143P 2020-07-30 2020-07-30
US63/059,143 2020-07-30
US202063064450P 2020-08-12 2020-08-12
US63/064,450 2020-08-12
PCT/US2020/059893 WO2021092598A1 (en) 2019-11-10 2020-11-10 Methods of treatment with myosin modulator

Publications (3)

Publication Number Publication Date
JP2023501453A JP2023501453A (ja) 2023-01-18
JP2023501453A5 JP2023501453A5 (https=) 2024-01-09
JP7830321B2 true JP7830321B2 (ja) 2026-03-16

Family

ID=75849342

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022526496A Active JP7830321B2 (ja) 2019-11-10 2020-11-10 ミオシンモジュレーターによる治療方法

Country Status (13)

Country Link
US (1) US20230158027A1 (https=)
EP (1) EP4054588A4 (https=)
JP (1) JP7830321B2 (https=)
KR (1) KR20220113387A (https=)
CN (1) CN114945372A (https=)
AU (1) AU2020378197A1 (https=)
BR (1) BR112022008641A2 (https=)
CA (1) CA3157629A1 (https=)
CL (1) CL2022001217A1 (https=)
IL (1) IL292840A (https=)
MX (1) MX2022005465A (https=)
TW (1) TW202134259A (https=)
WO (1) WO2021092598A1 (https=)

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DK3645002T3 (da) 2017-06-30 2024-12-16 Amgen Inc Fremgangsmåder til behandling af hjertesvigt med hjerte-sarkomer-aktivatorer
MA53491A (fr) 2018-08-31 2021-09-15 Cytokinetics Inc Inhibiteurs de sarcomes cardiaques
HUE069154T2 (hu) * 2020-01-28 2025-02-28 Assia Chem Ind Ltd A mavakamten szilárd állapotú formái és eljárás elõállításukra
MX2023002024A (es) * 2020-08-28 2023-05-10 Myokardia Inc Métodos de tratamiento con modulador de miosina.
DK4243825T3 (da) 2020-11-12 2025-12-01 Amgen Inc Omecamtiv mecarbil til behandling af hjerteinsattsvigt hos udvalgte patientgrupper
CN115461052B (zh) * 2020-11-25 2023-12-22 深圳信立泰药业股份有限公司 Arb代谢产物与nep抑制剂的复合物预防和/或治疗肾病的药物用途
CN117083275A (zh) 2021-03-04 2023-11-17 赛特凯恩蒂克公司 心脏肌节抑制剂
CN112939876A (zh) * 2021-03-10 2021-06-11 杭州科巢生物科技有限公司 Mavacamten的晶型I及其制备方法
WO2022189599A1 (en) * 2021-03-12 2022-09-15 Sandoz Ag Crystalline forms of mavacamten for the treatment of hcm
PT4370116T (pt) * 2021-07-16 2025-03-14 Cytokinetics Inc Regimes de administração de aficamten para o tratamento da cardiomiopatia hipertrófica obstrutiva
WO2023102452A1 (en) * 2021-12-02 2023-06-08 Tenax Therapeutics, Inc. Use of a combination of levosimendan and an sglt-2 inhibitor to treat heart failure
CN116410143A (zh) * 2021-12-29 2023-07-11 杭州奥默医药股份有限公司 一种多取代脲嘧啶衍生物及其制备方法和应用
CA3248508A1 (en) 2022-04-13 2023-10-19 Assia Chemical Industries Ltd. SOLID STATE FORMS OF MAVACAMTEN AND THEIR PREPARATION METHOD
EP4514355A1 (en) * 2022-04-26 2025-03-05 MyoKardia, Inc. Methods of administering myosin inhibitors
JP2025534288A (ja) 2022-09-26 2025-10-15 エッジワイズ セラピューティクス， インコーポレイテッド １，４－ジヒドロキナゾリノン化合物およびその使用
WO2024097284A1 (en) * 2022-11-02 2024-05-10 MyoKardia, Inc. Mavacamten and derivatives thereof for use in treating atrial dysfunction
EP4688756A1 (en) 2023-03-27 2026-02-11 Edgewise Therapeutics, Inc. Quinazoline dione compounds and uses thereof
WO2024206339A1 (en) 2023-03-27 2024-10-03 Edgewise Therapeutics, Inc. Quinolinone amide compounds and uses thereof
IT202300016653A1 (it) 2023-08-03 2025-02-03 Olon Spa Processo per preparare mavacamten e intermedio di processo.
WO2025046606A1 (en) 2023-08-26 2025-03-06 Micro Labs Limited Granules of mavacamten for oral administration
WO2025096779A2 (en) * 2023-11-01 2025-05-08 Bristol Myers Squibb Company Methods of treatment with a myosin inhibitor using protein levels

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GB0908193D0 (en) * 2009-05-13 2009-06-24 Albright Patents Treatment of disease state
SMT202000071T1 (it) * 2013-06-21 2020-03-13 Myokardia Inc Composti di pirimidinadione contro le condizioni cardiache
EP3399907A4 (en) * 2016-01-04 2019-08-28 Aventusoft, LLC SYSTEM AND METHOD FOR MEASURING HEMODYNAMIC PARAMETERS FROM THE HEADLAPPING SIGNALS
CA3071948A1 (en) * 2017-08-04 2019-02-07 MyoKardia, Inc. Mavacamten for use in the treatment of hypertrophic cardiomyopathy

Non-Patent Citations (3)

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Annals of Internal Medicine，2019年04月30日，Vol.170, No.11，pp.741-748
ClinicalTrials.gov archive: NCT02842242, [2024/10/23検索]，2019年04月16日，https://clinicaltrials.gov/study/NCT02842242?term=NCT02842242&rank=1&a=15&tab=history
JACC，2018年03月20日，Volume 71, Issue 11，p.644

Also Published As

Publication number Publication date
MX2022005465A (es) 2022-08-08
EP4054588A1 (en) 2022-09-14
CA3157629A1 (en) 2021-05-14
BR112022008641A2 (pt) 2022-09-13
TW202134259A (zh) 2021-09-16
AU2020378197A1 (en) 2022-05-26
KR20220113387A (ko) 2022-08-12
CL2022001217A1 (es) 2023-01-13
WO2021092598A1 (en) 2021-05-14
US20230158027A1 (en) 2023-05-25
JP2023501453A (ja) 2023-01-18
CN114945372A (zh) 2022-08-26
IL292840A (en) 2022-07-01
EP4054588A4 (en) 2023-12-13

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