JP7825631B2 - 細胞外小胞の分泌を促進する細胞外小胞分泌促進剤、およびその用途 - Google Patents

細胞外小胞の分泌を促進する細胞外小胞分泌促進剤、およびその用途

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Publication number
JP7825631B2
JP7825631B2 JP2023554511A JP2023554511A JP7825631B2 JP 7825631 B2 JP7825631 B2 JP 7825631B2 JP 2023554511 A JP2023554511 A JP 2023554511A JP 2023554511 A JP2023554511 A JP 2023554511A JP 7825631 B2 JP7825631 B2 JP 7825631B2
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secretion
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JPWO2023063284A5 (https=
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Inventor
孝広 落谷
智史 山元
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THEORIA SCIENCE INC.
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THEORIA SCIENCE INC.
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141—MicroRNAs, miRNAs

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
JP2023554511A 2021-10-11 2022-10-11 細胞外小胞の分泌を促進する細胞外小胞分泌促進剤、およびその用途 Active JP7825631B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2021166634 2021-10-11
JP2021166634 2021-10-11
PCT/JP2022/037768 WO2023063284A1 (ja) 2021-10-11 2022-10-11 細胞外小胞の分泌を促進する細胞外小胞分泌促進剤、およびその用途

Publications (3)

Publication Number Publication Date
JPWO2023063284A1 JPWO2023063284A1 (https=) 2023-04-20
JPWO2023063284A5 JPWO2023063284A5 (https=) 2024-07-01
JP7825631B2 true JP7825631B2 (ja) 2026-03-06

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JP2023554511A Active JP7825631B2 (ja) 2021-10-11 2022-10-11 細胞外小胞の分泌を促進する細胞外小胞分泌促進剤、およびその用途

Country Status (4)

Country Link
US (1) US20250270564A1 (https=)
EP (1) EP4417693A1 (https=)
JP (1) JP7825631B2 (https=)
WO (1) WO2023063284A1 (https=)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013118606A1 (ja) 2012-02-08 2013-08-15 独立行政法人産業技術総合研究所 マラリアの予防または治療薬及びそのスクリーニング方法
WO2020204161A1 (ja) 2019-04-04 2020-10-08 日産化学株式会社 細胞外小胞の分泌を促進するための組成物
WO2021095842A1 (ja) 2019-11-15 2021-05-20 国立大学法人 東京大学 バーコード化された細胞外小胞のライブラリー

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021166634A (ja) 2020-04-10 2021-10-21 株式会社アイシン 車両用シート装置

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013118606A1 (ja) 2012-02-08 2013-08-15 独立行政法人産業技術総合研究所 マラリアの予防または治療薬及びそのスクリーニング方法
WO2020204161A1 (ja) 2019-04-04 2020-10-08 日産化学株式会社 細胞外小胞の分泌を促進するための組成物
WO2021095842A1 (ja) 2019-11-15 2021-05-20 国立大学法人 東京大学 バーコード化された細胞外小胞のライブラリー

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
KIM M. J. et al.，J. Leukoc. Biol.，2018年，Vol.103 No.5，pp.885-895
NOVAK K.，Nat. Rev. Cancer，2002年，Vol.2，p.890-891
SHEN W. et al.，Exp. Cell Res.，2018年，Vol.362 No.2，pp.370-377
尾野亘，みにれびゅう マイクロRNAと転写因子相互作用による脂質代謝制御，生化学，2015年，Vol.87, No.6，p.733-735

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WO2023063284A1 (ja) 2023-04-20
EP4417693A1 (en) 2024-08-21
JPWO2023063284A1 (https=) 2023-04-20
US20250270564A1 (en) 2025-08-28

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