JP7822597B2 - チロシンキナーゼ阻害剤耐性ｅｇｆｒ変異を有するがん細胞に対する抗腫瘍活性を有する化合物 - Google Patents

チロシンキナーゼ阻害剤耐性ｅｇｆｒ変異を有するがん細胞に対する抗腫瘍活性を有する化合物

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JP7822597B2
JP7822597B2 JP2021561677A JP2021561677A JP7822597B2 JP 7822597 B2 JP7822597 B2 JP 7822597B2 JP 2021561677 A JP2021561677 A JP 2021561677A JP 2021561677 A JP2021561677 A JP 2021561677A JP 7822597 B2 JP7822597 B2 JP 7822597B2
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cancer
egfr
mutations
tki
mutation
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JP2022529016A (ja
JP2022529016A5 (enExample
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ジャクリーン ロビショー
モニーク ニルソン
ジョン ブイ． ヘイマッハ
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The University of Texas System
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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JP2021561677A 2019-04-17 2020-04-16 チロシンキナーゼ阻害剤耐性ｅｇｆｒ変異を有するがん細胞に対する抗腫瘍活性を有する化合物 Active JP7822597B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962835354P 2019-04-17 2019-04-17
US62/835,354 2019-04-17
PCT/US2020/028547 WO2020214831A1 (en) 2019-04-17 2020-04-16 Compounds with anti-tumor activity against cancer cells bearing tyrosine kinase inhibitor resistant egfr mutations

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JP2022529016A JP2022529016A (ja) 2022-06-16
JP2022529016A5 JP2022529016A5 (enExample) 2023-04-24
JP7822597B2 true JP7822597B2 (ja) 2026-03-03

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US (1) US20220193074A1 (enExample)
EP (1) EP3955928A4 (enExample)
JP (1) JP7822597B2 (enExample)
KR (1) KR20220003546A (enExample)
CN (1) CN113784718A (enExample)
CA (1) CA3132816A1 (enExample)
WO (1) WO2020214831A1 (enExample)

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MX2021010265A (es) 2019-02-26 2021-09-23 Janssen Biotech Inc Terapias de combinacion y estratificacion de pacientes con anticuerpos anti-egfr/c-met biespecificos.
US12629375B2 (en) 2019-03-29 2026-05-19 Board Of Regents, The University Of Texas System Compounds with anti-tumor activity against cancer cells bearing HER2 exon 21 insertions
MY208668A (en) 2019-05-14 2025-05-23 Janssen Biotech Inc Combination therapies with bispecific anti-egfr/c-met antibodies and 3rd generation egfr tyrosine kinase inhibitors
US11850248B2 (en) 2019-05-14 2023-12-26 Yuhan Corporation Therapies with 3rd generation EGFR tyrosine kinase inhibitors
BR112022015140A2 (pt) 2020-02-12 2022-10-11 Janssen Biotech Inc Tratamento de pacientes que têm mutações de salto do éxon 14 de c-met
WO2023129667A1 (en) 2021-12-30 2023-07-06 Biomea Fusion, Inc. Pyrazine compounds as inhibitors of flt3
CN120265328A (zh) * 2022-11-03 2025-07-04 德州大学系统董事会 用于非小细胞肺癌的检测和治疗的方法
CN115998743B (zh) * 2023-01-16 2024-05-28 威尚（上海）生物医药有限公司 喹唑啉类化合物在克服奥希替尼耐药中的用途

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WO2018094225A1 (en) 2016-11-17 2018-05-24 Board Of Regents, The University Of Texas System Compounds with anti-tumor activity against cancer cells bearing egfr or her2 exon 20 mutations
WO2018156812A1 (en) 2017-02-22 2018-08-30 G1 Therapeutics, Inc. Treatment of egfr-driven cancer with fewer side effects

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CN107530434A (zh) * 2015-04-23 2018-01-02 免疫医疗有限公司 非小细胞肺癌egfr突变阳性的联合疗法

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2018094225A1 (en) 2016-11-17 2018-05-24 Board Of Regents, The University Of Texas System Compounds with anti-tumor activity against cancer cells bearing egfr or her2 exon 20 mutations
WO2018156812A1 (en) 2017-02-22 2018-08-30 G1 Therapeutics, Inc. Treatment of egfr-driven cancer with fewer side effects

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Title
Cancer Res. Treat.，2018年，50(3)，pp.835-842，DOI: https://doi.org/10.4143/crt.2017.303
Cell，2018年，7，212, page 1-16
Clinical Cancer Research，2015年，21(23)，pp.5305-5313
Clinical Cancer Research，2016年，22(13)，pp.3281-3285
Lancet Oncol.，2015年，16，pp.830-838
Rapid Commun. Mass Spectrom.，2013年，27，pp.1183-1195，DOI: 10.1002/rcm.6559
Signal Transduction and Targeted Therapy，2019年03月，4(5)，page 1-10，https://doi.org/10.1038/s41392-019-0038-9

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Publication number Publication date
CA3132816A1 (en) 2020-10-22
EP3955928A1 (en) 2022-02-23
JP2022529016A (ja) 2022-06-16
EP3955928A4 (en) 2023-05-31
WO2020214831A1 (en) 2020-10-22
KR20220003546A (ko) 2022-01-10
CN113784718A (zh) 2021-12-10
US20220193074A1 (en) 2022-06-23

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