CN113784718A - 对携带酪氨酸激酶抑制剂抗性egfr突变的癌细胞具有抗肿瘤活性的化合物 - Google Patents

对携带酪氨酸激酶抑制剂抗性egfr突变的癌细胞具有抗肿瘤活性的化合物 Download PDF

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CN113784718A
CN113784718A CN202080032255.XA CN202080032255A CN113784718A CN 113784718 A CN113784718 A CN 113784718A CN 202080032255 A CN202080032255 A CN 202080032255A CN 113784718 A CN113784718 A CN 113784718A
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cancer
tki
egfr
mutations
mutation
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J·罗比丘
M·尼尔森
J·V·海马赫
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The University of Texas System
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CN202080032255.XA 2019-04-17 2020-04-16 对携带酪氨酸激酶抑制剂抗性egfr突变的癌细胞具有抗肿瘤活性的化合物 Pending CN113784718A (zh)

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US201962835354P 2019-04-17 2019-04-17
US62/835,354 2019-04-17
PCT/US2020/028547 WO2020214831A1 (en) 2019-04-17 2020-04-16 Compounds with anti-tumor activity against cancer cells bearing tyrosine kinase inhibitor resistant egfr mutations

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CN115998743A (zh) * 2023-01-16 2023-04-25 威尚（上海）生物医药有限公司 喹唑啉类化合物在克服奥希替尼耐药中的用途

Families Citing this family (7)

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MX2021010265A (es) 2019-02-26 2021-09-23 Janssen Biotech Inc Terapias de combinacion y estratificacion de pacientes con anticuerpos anti-egfr/c-met biespecificos.
US12629375B2 (en) 2019-03-29 2026-05-19 Board Of Regents, The University Of Texas System Compounds with anti-tumor activity against cancer cells bearing HER2 exon 21 insertions
MY208668A (en) 2019-05-14 2025-05-23 Janssen Biotech Inc Combination therapies with bispecific anti-egfr/c-met antibodies and 3rd generation egfr tyrosine kinase inhibitors
US11850248B2 (en) 2019-05-14 2023-12-26 Yuhan Corporation Therapies with 3rd generation EGFR tyrosine kinase inhibitors
BR112022015140A2 (pt) 2020-02-12 2022-10-11 Janssen Biotech Inc Tratamento de pacientes que têm mutações de salto do éxon 14 de c-met
WO2023129667A1 (en) 2021-12-30 2023-07-06 Biomea Fusion, Inc. Pyrazine compounds as inhibitors of flt3
CN120265328A (zh) * 2022-11-03 2025-07-04 德州大学系统董事会 用于非小细胞肺癌的检测和治疗的方法

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WO2018094225A1 (en) * 2016-11-17 2018-05-24 Board Of Regents, The University Of Texas System Compounds with anti-tumor activity against cancer cells bearing egfr or her2 exon 20 mutations
WO2018156812A1 (en) * 2017-02-22 2018-08-30 G1 Therapeutics, Inc. Treatment of egfr-driven cancer with fewer side effects

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CN107530434A (zh) * 2015-04-23 2018-01-02 免疫医疗有限公司 非小细胞肺癌egfr突变阳性的联合疗法

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WO2018094225A1 (en) * 2016-11-17 2018-05-24 Board Of Regents, The University Of Texas System Compounds with anti-tumor activity against cancer cells bearing egfr or her2 exon 20 mutations
WO2018156812A1 (en) * 2017-02-22 2018-08-30 G1 Therapeutics, Inc. Treatment of egfr-driven cancer with fewer side effects

Non-Patent Citations (1)

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YOSHIHISA KOBAYASHI，ET AL.: "EGFR Exon 18 Mutations in Lung Cancer: Molecular Predictors of Augmented Sensitivity to Afatinib or Neratinib as Compared with First- or Third- Generation TKIs", CLINICAL CANCER RESEARCH, vol. 21, no. 23, pages 5305 - 5313, XP093040178, DOI: 10.1158/1078-0432.CCR-15-1046 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115998743A (zh) * 2023-01-16 2023-04-25 威尚（上海）生物医药有限公司 喹唑啉类化合物在克服奥希替尼耐药中的用途
CN115998743B (zh) * 2023-01-16 2024-05-28 威尚（上海）生物医药有限公司 喹唑啉类化合物在克服奥希替尼耐药中的用途
WO2024153256A1 (zh) * 2023-01-16 2024-07-25 威尚（上海）生物医药有限公司 喹唑啉类化合物在克服奥希替尼耐药中的用途
GB2641652A (en) * 2023-01-16 2025-12-10 Weishang Shanghai Bio Pharmaceutical Co Ltd Use of quinazoline compound in overcoming Osimertinib drug resistance

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EP3955928A1 (en) 2022-02-23
JP2022529016A (ja) 2022-06-16
JP7822597B2 (ja) 2026-03-03
EP3955928A4 (en) 2023-05-31
WO2020214831A1 (en) 2020-10-22
KR20220003546A (ko) 2022-01-10
US20220193074A1 (en) 2022-06-23

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