JP7796044B2 - Ｃｄ７０特異的融合タンパク質を使用したｔｃｒリプログラミングのための組成物及び方法 - Google Patents

Ｃｄ７０特異的融合タンパク質を使用したｔｃｒリプログラミングのための組成物及び方法

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JP7796044B2
JP7796044B2 JP2022567556A JP2022567556A JP7796044B2 JP 7796044 B2 JP7796044 B2 JP 7796044B2 JP 2022567556 A JP2022567556 A JP 2022567556A JP 2022567556 A JP2022567556 A JP 2022567556A JP 7796044 B2 JP7796044 B2 JP 7796044B2
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sequence
seq
cells
tcr
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JP2023524811A (ja
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ホフマイスター，ロバート
グティエレス，ダリオ
コラード，アンドルー
ラジョイ，ジェイソン
アシュミノヴァ，ヴァニア・イー
ロフグレン，マイケル
ワット，エミー
マッカーシー，デリック
ティグ，ロバート
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ティーシーアール２ セラピューティクス インク．
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    • A—HUMAN NECESSITIES
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K39/0011—Cancer antigens
    • A61K39/001136—Cytokines
    • A61K39/001138—Tumor necrosis factors [TNF] or CD70
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
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    • A61K40/4232—Tumor necrosis factors [TNF] or CD70
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C12N15/09—Recombinant DNA-technology
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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JP2022567556A 2020-05-05 2021-05-05 Ｃｄ７０特異的融合タンパク質を使用したｔｃｒリプログラミングのための組成物及び方法 Active JP7796044B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US202063020196P 2020-05-05 2020-05-05
US63/020,196 2020-05-05
US202063129718P 2020-12-23 2020-12-23
US63/129,718 2020-12-23
US202163147618P 2021-02-09 2021-02-09
US63/147,618 2021-02-09
US202163171751P 2021-04-07 2021-04-07
US63/171,751 2021-04-07
PCT/US2021/030973 WO2021226289A2 (en) 2020-05-05 2021-05-05 Compositions and methods for tcr reprogramming using cd70 specific fusion proteins

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JP2023524811A JP2023524811A (ja) 2023-06-13
JP2023524811A5 JP2023524811A5 (https=) 2024-05-15
JP7796044B2 true JP7796044B2 (ja) 2026-01-08

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US (1) US20240252641A1 (https=)
EP (1) EP4146233A4 (https=)
JP (1) JP7796044B2 (https=)
KR (1) KR20230020421A (https=)
CN (1) CN115989033B (https=)
AU (1) AU2021268953A1 (https=)
BR (1) BR112022022353A2 (https=)
CA (1) CA3177488A1 (https=)
IL (1) IL297916A (https=)
MX (1) MX2022013956A (https=)
WO (1) WO2021226289A2 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3298033T5 (pl) 2015-05-18 2023-10-30 TCR2 Therapeutics Inc. Kompozycje i zastosowania medyczne do reprogramowania TCR z zastosowaniem białek fuzyjnych
US20240117002A1 (en) * 2020-12-23 2024-04-11 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
US20250255960A1 (en) * 2022-01-19 2025-08-14 Hrain Biotechnology Co., Ltd. Anti-cd70 nanoantibody and use thereof
WO2023177821A2 (en) * 2022-03-16 2023-09-21 Myeloid Therapeutics, Inc. Binding domains and methods of use thereof
KR20260018068A (ko) * 2023-05-26 2026-02-06 에디타스 메디신, 인코포레이티드 Cd70 발현을 표적화하는 crispr 관련 방법 및 조성물
CN121299119B (zh) * 2025-12-15 2026-03-06 信纳克(北京)生化标志物检测医学研究有限责任公司 噬血细胞综合征克隆性免疫细胞检测试剂组合物及其应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014504148A (ja) 2010-10-27 2014-02-20 ベイラー カレッジ オブ メディスン Ｔ細胞をｃｄ７０陽性悪性腫瘍に仕向けるためのキメラなｃｄ２７受容体
JP2018515123A (ja) 2015-05-18 2018-06-14 ティーシーアール２ セラピューティクス インク． 融合タンパク質を用いたｔｃｒの再プログラミングのための組成物及び方法
WO2018152181A1 (en) 2017-02-14 2018-08-23 Kite Pharma, Inc. Cd70 binding molecules and methods of use thereof
JP2019536452A (ja) 2016-11-22 2019-12-19 ティーシーアール２ セラピューティクス インク． 融合タンパク質を用いたｔｃｒの再プログラミングのための組成物及び方法
WO2020060593A1 (en) 2018-09-21 2020-03-26 Harpoon Therapeutics, Inc. Conditionally active receptors

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170335281A1 (en) * 2014-03-15 2017-11-23 Novartis Ag Treatment of cancer using chimeric antigen receptor
US11173179B2 (en) * 2015-06-25 2021-11-16 Icell Gene Therapeutics Llc Chimeric antigen receptor (CAR) targeting multiple antigens, compositions and methods of use thereof
KR20180075689A (ko) * 2015-11-23 2018-07-04 트르스티스 오브 보스톤 유니버시티 키메라 항원 수용체에 관한 방법 및 조성물
US10392442B2 (en) * 2015-12-17 2019-08-27 Bristol-Myers Squibb Company Use of anti-PD-1 antibody in combination with anti-CD27 antibody in cancer treatment
WO2019067805A1 (en) * 2017-09-27 2019-04-04 University Of Southern California NEW PLATFORMS FOR CO-STIMULATION, NEW CAR DESIGNS AND OTHER IMPROVEMENTS FOR ADOPTIVE CELL THERAPY
GB201800649D0 (en) * 2018-01-16 2018-02-28 Argenx Bvba CD70 Combination Therapy
CN112020518A (zh) * 2018-02-01 2020-12-01 辉瑞公司 靶向cd70的嵌合抗原受体
CA3111087A1 (en) * 2018-08-29 2020-03-05 Nanjing Legend Biotech Co., Ltd. Anti-mesothelin chimeric antigen receptor (car) constructs and uses thereof
WO2021133959A2 (en) * 2019-12-24 2021-07-01 TCR2 Therapeutics Inc. Compositions and methods for gamma delta tcr reprogramming using fusion proteins
WO2022006451A2 (en) * 2020-07-02 2022-01-06 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins and pd-1 antibodies
US20240117002A1 (en) * 2020-12-23 2024-04-11 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
WO2022150831A1 (en) * 2021-01-07 2022-07-14 Innovative Cellular Therapeutics Holdings, Ltd. Car cells and polyspecific binding molecules for treating solid tumor
WO2022192286A1 (en) * 2021-03-09 2022-09-15 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins and rna interference
WO2022232277A1 (en) * 2021-04-27 2022-11-03 TCR2 Therapeutics Inc. COMPOSITIONS AND METHODS FOR TCR REPROGRAMMING USING FUSION PROTEINS AND TGFβR SWITCH

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014504148A (ja) 2010-10-27 2014-02-20 ベイラー カレッジ オブ メディスン Ｔ細胞をｃｄ７０陽性悪性腫瘍に仕向けるためのキメラなｃｄ２７受容体
JP2018515123A (ja) 2015-05-18 2018-06-14 ティーシーアール２ セラピューティクス インク． 融合タンパク質を用いたｔｃｒの再プログラミングのための組成物及び方法
JP2019536452A (ja) 2016-11-22 2019-12-19 ティーシーアール２ セラピューティクス インク． 融合タンパク質を用いたｔｃｒの再プログラミングのための組成物及び方法
WO2018152181A1 (en) 2017-02-14 2018-08-23 Kite Pharma, Inc. Cd70 binding molecules and methods of use thereof
WO2020060593A1 (en) 2018-09-21 2020-03-26 Harpoon Therapeutics, Inc. Conditionally active receptors

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EP4146233A2 (en) 2023-03-15
IL297916A (en) 2023-01-01
BR112022022353A2 (pt) 2023-03-14
CN115989033B (zh) 2026-03-10
EP4146233A4 (en) 2024-05-22
AU2021268953A1 (en) 2022-12-08
WO2021226289A2 (en) 2021-11-11
US20240252641A1 (en) 2024-08-01
MX2022013956A (es) 2023-02-09
WO2021226289A3 (en) 2021-12-09
JP2023524811A (ja) 2023-06-13
CA3177488A1 (en) 2021-11-11
KR20230020421A (ko) 2023-02-10

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