JP7791650B2 - Ｐｄｌ１を標的とする抗体及びそれを用いる方法 - Google Patents

Ｐｄｌ１を標的とする抗体及びそれを用いる方法

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Publication number
JP7791650B2
JP7791650B2 JP2020520150A JP2020520150A JP7791650B2 JP 7791650 B2 JP7791650 B2 JP 7791650B2 JP 2020520150 A JP2020520150 A JP 2020520150A JP 2020520150 A JP2020520150 A JP 2020520150A JP 7791650 B2 JP7791650 B2 JP 7791650B2
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JP
Japan
Prior art keywords
seq
antibody
pdl1
amino acid
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP2020520150A
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English (en)
Japanese (ja)
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JP2021501569A5 (enExample
JP2021501569A (ja
Inventor
ティー グンデ，
マシアス ブロック，
クリスチャン ヘス，
アレクサンダー シモニン，
Original Assignee
ヌマブ セラピューティックス アーゲー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Priority claimed from EP17195781.4A external-priority patent/EP3470429A1/en
Application filed by ヌマブ セラピューティックス アーゲー filed Critical ヌマブ セラピューティックス アーゲー
Publication of JP2021501569A publication Critical patent/JP2021501569A/ja
Publication of JP2021501569A5 publication Critical patent/JP2021501569A5/ja
Priority to JP2023131574A priority Critical patent/JP7649825B2/ja
Priority to JP2025035270A priority patent/JP2025102791A/ja
Application granted granted Critical
Publication of JP7791650B2 publication Critical patent/JP7791650B2/ja
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Liquid Crystal Substances (AREA)
JP2020520150A 2017-10-10 2018-10-09 Ｐｄｌ１を標的とする抗体及びそれを用いる方法 Active JP7791650B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023131574A JP7649825B2 (ja) 2017-10-10 2023-08-10 Ｐｄｌ１を標的とする抗体及びそれを用いる方法
JP2025035270A JP2025102791A (ja) 2017-10-10 2025-03-06 Ｐｄｌ１を標的とする抗体及びそれを用いる方法

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP17195781.4 2017-10-10
EP17195781.4A EP3470429A1 (en) 2017-10-10 2017-10-10 Antibodies targeting pdl1 and methods of use thereof
EP18167094 2018-04-12
EP18167094.4 2018-04-12
EP18180816.3 2018-06-29
EP18180816 2018-06-29
PCT/EP2018/077511 WO2019072869A1 (en) 2017-10-10 2018-10-09 PDL1 TARGETING ANTIBODIES AND METHODS OF USE THEREOF

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023131574A Division JP7649825B2 (ja) 2017-10-10 2023-08-10 Ｐｄｌ１を標的とする抗体及びそれを用いる方法

Publications (3)

Publication Number Publication Date
JP2021501569A JP2021501569A (ja) 2021-01-21
JP2021501569A5 JP2021501569A5 (enExample) 2021-11-11
JP7791650B2 true JP7791650B2 (ja) 2025-12-24

Family

ID=63834022

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2020520150A Active JP7791650B2 (ja) 2017-10-10 2018-10-09 Ｐｄｌ１を標的とする抗体及びそれを用いる方法
JP2023131574A Active JP7649825B2 (ja) 2017-10-10 2023-08-10 Ｐｄｌ１を標的とする抗体及びそれを用いる方法
JP2025035270A Pending JP2025102791A (ja) 2017-10-10 2025-03-06 Ｐｄｌ１を標的とする抗体及びそれを用いる方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2023131574A Active JP7649825B2 (ja) 2017-10-10 2023-08-10 Ｐｄｌ１を標的とする抗体及びそれを用いる方法
JP2025035270A Pending JP2025102791A (ja) 2017-10-10 2025-03-06 Ｐｄｌ１を標的とする抗体及びそれを用いる方法

Country Status (11)

Country Link
US (2) US12077588B2 (enExample)
EP (1) EP3694879A1 (enExample)
JP (3) JP7791650B2 (enExample)
KR (2) KR20250057935A (enExample)
CN (2) CN111225926B (enExample)
AU (2) AU2018348430B2 (enExample)
CA (1) CA3074802A1 (enExample)
IL (2) IL273578B1 (enExample)
MA (1) MA50353A (enExample)
SG (1) SG11202001654TA (enExample)
WO (1) WO2019072869A1 (enExample)

Families Citing this family (7)

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AU2018280679B2 (en) * 2017-06-05 2025-04-24 Numab Therapeutics AG Novel anti-HSA antibodies
PE20200849A1 (es) * 2017-10-10 2020-08-20 Numab Therapeutics AG Anticuerpo multiespecifico
US11208486B2 (en) * 2019-04-26 2021-12-28 I-Mab Biopharma Us Limited Human PD-L1 antibodies
EP3816185A1 (en) * 2019-11-04 2021-05-05 Numab Therapeutics AG Multispecific antibody directed against pd-l1 and a tumor-associated antigen
WO2024160721A1 (en) 2023-01-30 2024-08-08 Kymab Limited Antibodies
WO2024240690A2 (en) * 2023-05-19 2024-11-28 Numab Therapeutics AG Antibody variable domains and antibodies having decreased immunogenicity
WO2025133389A1 (en) 2023-12-22 2025-06-26 Numab Therapeutics AG Antibody binding domains having specificity for lilrb2

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013511959A (ja) 2009-11-24 2013-04-11 メディミューン リミテッド Ｂ７−ｈ１に対する標的結合剤
JP2015500207A (ja) 2011-11-28 2015-01-05 メルク パテント ゲゼルシャフト ミット ベシュレンクテ 抗ｐｄ−ｌ１抗体及びその使用
JP2017507650A (ja) 2014-01-23 2017-03-23 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Ｐｄ−ｌ１に対するヒト抗体
WO2017118321A1 (en) 2016-01-04 2017-07-13 Harbour Biomed Limited Anti-pd-l1 antibodies and uses thereof

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US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4881175A (en) 1986-09-02 1989-11-14 Genex Corporation Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
US5260203A (en) 1986-09-02 1993-11-09 Enzon, Inc. Single polypeptide chain binding molecules
US5013653A (en) 1987-03-20 1991-05-07 Creative Biomolecules, Inc. Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage
DE3853515T3 (de) 1987-05-21 2005-08-25 Micromet Ag Multifunktionelle proteine mit vorbestimmter zielsetzung.
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5258498A (en) 1987-05-21 1993-11-02 Creative Biomolecules, Inc. Polypeptide linkers for production of biosynthetic proteins
US5132405A (en) 1987-05-21 1992-07-21 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
GB9114948D0 (en) 1991-07-11 1991-08-28 Pfizer Ltd Process for preparing sertraline intermediates
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EP2380906A2 (en) 1997-06-12 2011-10-26 Novartis International Pharmaceutical Ltd. Artificial antibody polypeptides
DE19819846B4 (de) 1998-05-05 2016-11-24 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Multivalente Antikörper-Konstrukte
BR0316880A (pt) * 2002-12-23 2005-10-25 Wyeth Corp Anticorpos contra pd-1 e usos dos mesmos
US10077312B2 (en) * 2013-05-10 2018-09-18 Numab Therapeutics AG CD3 and IL-23 receptor binding bispecific constructs and their use in the treatment of various diseases
IL293435A (en) 2015-06-15 2022-07-01 Numab Therapeutics AG Heterodimeric multispecific antibody format
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Publication number Priority date Publication date Assignee Title
JP2013511959A (ja) 2009-11-24 2013-04-11 メディミューン リミテッド Ｂ７−ｈ１に対する標的結合剤
JP2015500207A (ja) 2011-11-28 2015-01-05 メルク パテント ゲゼルシャフト ミット ベシュレンクテ 抗ｐｄ−ｌ１抗体及びその使用
JP2017507650A (ja) 2014-01-23 2017-03-23 リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Ｐｄ−ｌ１に対するヒト抗体
WO2017118321A1 (en) 2016-01-04 2017-07-13 Harbour Biomed Limited Anti-pd-l1 antibodies and uses thereof

Also Published As

Publication number Publication date
CA3074802A1 (en) 2019-04-18
US12077588B2 (en) 2024-09-03
CN111225926A (zh) 2020-06-02
JP2023166403A (ja) 2023-11-21
CN120248120A (zh) 2025-07-04
US20250066482A1 (en) 2025-02-27
AU2025271488A1 (en) 2026-01-08
KR20200063147A (ko) 2020-06-04
AU2018348430B2 (en) 2025-09-04
EP3694879A1 (en) 2020-08-19
IL273578A (en) 2020-05-31
WO2019072869A1 (en) 2019-04-18
KR20250057935A (ko) 2025-04-29
JP2025102791A (ja) 2025-07-08
IL273578B1 (en) 2025-11-01
JP2021501569A (ja) 2021-01-21
IL323510A (en) 2025-11-01
SG11202001654TA (en) 2020-03-30
JP7649825B2 (ja) 2025-03-21
CN111225926B (zh) 2025-03-14
MA50353A (fr) 2020-08-19
US20200283528A1 (en) 2020-09-10
AU2018348430A1 (en) 2020-03-12

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