JP7785696B2 - 操作されたｔ細胞受容体および使用の方法 - Google Patents

操作されたｔ細胞受容体および使用の方法

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Publication number
JP7785696B2
JP7785696B2 JP2022570271A JP2022570271A JP7785696B2 JP 7785696 B2 JP7785696 B2 JP 7785696B2 JP 2022570271 A JP2022570271 A JP 2022570271A JP 2022570271 A JP2022570271 A JP 2022570271A JP 7785696 B2 JP7785696 B2 JP 7785696B2
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Japan
Prior art keywords
tcr
seq
amino acid
polypeptide
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP2022570271A
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English (en)
Japanese (ja)
Other versions
JP2023528255A5 (https=
JP2023528255A (ja
JPWO2021236548A5 (https=
Inventor
キャシアン イー
ケ パン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
University of Texas System
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Filing date
Publication date
Application filed by University of Texas System filed Critical University of Texas System
Publication of JP2023528255A publication Critical patent/JP2023528255A/ja
Publication of JP2023528255A5 publication Critical patent/JP2023528255A5/ja
Publication of JPWO2021236548A5 publication Critical patent/JPWO2021236548A5/ja
Application granted granted Critical
Publication of JP7785696B2 publication Critical patent/JP7785696B2/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K40/4268—MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2022570271A 2020-05-18 2021-05-17 操作されたｔ細胞受容体および使用の方法 Active JP7785696B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063026445P 2020-05-18 2020-05-18
US63/026,445 2020-05-18
PCT/US2021/032818 WO2021236548A1 (en) 2020-05-18 2021-05-17 Engineered t cell receptors and methods of use

Publications (4)

Publication Number Publication Date
JP2023528255A JP2023528255A (ja) 2023-07-04
JP2023528255A5 JP2023528255A5 (https=) 2024-05-28
JPWO2021236548A5 JPWO2021236548A5 (https=) 2024-05-28
JP7785696B2 true JP7785696B2 (ja) 2025-12-15

Family

ID=78708026

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022570271A Active JP7785696B2 (ja) 2020-05-18 2021-05-17 操作されたｔ細胞受容体および使用の方法

Country Status (8)

Country Link
US (1) US20230190812A1 (https=)
EP (1) EP4153618A4 (https=)
JP (1) JP7785696B2 (https=)
CN (1) CN116322715A (https=)
AU (1) AU2021276264A1 (https=)
CA (1) CA3183663A1 (https=)
TW (1) TWI907427B (https=)
WO (1) WO2021236548A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3236237A1 (en) * 2021-10-25 2023-05-04 Board Of Regents, The University Of Texas System Peptides and engineered t cell receptors targeting mage-a4 antigen and methods of use
CN114149978B (zh) * 2022-02-09 2022-04-26 深圳博雅感知药业有限公司 制备car-t细胞的方法
CN116836261A (zh) * 2022-03-24 2023-10-03 香雪生命科学技术（广东）有限公司 一种识别mage-a4抗原的高亲和力tcr及其序列和应用
JP2026505826A (ja) 2023-02-03 2026-02-18 ゼルナ・イミュノセラピー・アーエス 抗ｍａｇｅ－ａ４ ｔ細胞受容体
CN120924527B (zh) * 2025-10-16 2026-02-06 内蒙古科为博生物科技有限公司 一种内切葡聚糖酶突变体eg06、其编码基因及其产品与应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013002086A1 (ja) 2011-06-28 2013-01-03 株式会社癌免疫研究所 ペプチド癌抗原特異的ｔ細胞のレセプター遺伝子
JP2018531044A (ja) 2015-09-29 2018-10-25 アイレパートリー インコーポレイテッド 免疫レパートリーの正常性の評価方法およびその使用
WO2019036688A1 (en) 2017-08-18 2019-02-21 Gritstone Oncology, Inc. ANTIGEN BINDING PROTEINS TARGETING SHARED ANTIGENS
WO2019133853A1 (en) 2017-12-28 2019-07-04 Gritstone Oncology, Inc. Antigen-binding proteins targeting shared antigens

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3173480A3 (en) * 2007-03-05 2017-08-16 International Institute of Cancer Immunology, Inc. Cancer antigen-specific t-cell receptor gene, peptide encoded by the gene, and use of them
CN102272153B (zh) * 2008-11-24 2015-04-15 德国慕尼黑亥姆霍兹研究中心健康和环境有限公司 高亲和力t细胞受体及其应用
GB0911566D0 (en) * 2009-07-03 2009-08-12 Immunocore Ltd T cell receptors
CN106103711A (zh) * 2013-11-21 2016-11-09 组库创世纪株式会社 T细胞受体和b细胞受体库分析系统及其在治疗和诊断中的应用
PL3440105T3 (pl) * 2016-04-08 2022-08-29 Immunocore Limited Receptory komórek t
EP3731861A1 (en) * 2017-12-29 2020-11-04 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft T cell receptors for tumor specific proteasome splice variants and uses thereof
EP3749753B1 (en) * 2018-02-09 2025-04-02 Immatics US, Inc. Methods for manufacturing t cells
DE102018108612A1 (de) * 2018-03-21 2019-09-26 Immatics US, Inc. Verfahren zur erhöhung der persistenz von adoptiv infundierten t-zellen
EP3962939A4 (en) * 2019-05-03 2023-05-17 Gigamune, Inc. MODIFIED CELLS EXPRESSING ANTITUMOR T-LYMPHOCYTE RECEPTORS AND METHODS OF USING THEM

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013002086A1 (ja) 2011-06-28 2013-01-03 株式会社癌免疫研究所 ペプチド癌抗原特異的ｔ細胞のレセプター遺伝子
JP2018531044A (ja) 2015-09-29 2018-10-25 アイレパートリー インコーポレイテッド 免疫レパートリーの正常性の評価方法およびその使用
WO2019036688A1 (en) 2017-08-18 2019-02-21 Gritstone Oncology, Inc. ANTIGEN BINDING PROTEINS TARGETING SHARED ANTIGENS
WO2019133853A1 (en) 2017-12-28 2019-07-04 Gritstone Oncology, Inc. Antigen-binding proteins targeting shared antigens

Also Published As

Publication number Publication date
EP4153618A1 (en) 2023-03-29
AU2021276264A1 (en) 2022-12-22
EP4153618A4 (en) 2024-06-26
TW202146438A (zh) 2021-12-16
JP2023528255A (ja) 2023-07-04
WO2021236548A1 (en) 2021-11-25
CN116322715A (zh) 2023-06-23
TWI907427B (zh) 2025-12-11
US20230190812A1 (en) 2023-06-22
CA3183663A1 (en) 2021-11-25

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