JP7777872B2 - 細胞ベースの治療を脳にホーミング、ブロック及び送達するための脳特異的抗原の使用 - Google Patents

細胞ベースの治療を脳にホーミング、ブロック及び送達するための脳特異的抗原の使用

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Publication number
JP7777872B2
JP7777872B2 JP2022545967A JP2022545967A JP7777872B2 JP 7777872 B2 JP7777872 B2 JP 7777872B2 JP 2022545967 A JP2022545967 A JP 2022545967A JP 2022545967 A JP2022545967 A JP 2022545967A JP 7777872 B2 JP7777872 B2 JP 7777872B2
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cells
antigen
cell
binding
car
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JP2023515322A5 (https=
JP2023515322A (ja
Inventor
エー． リム，ウェンデル
シミック，ミロス
秀穂 岡田
エイチ． チョー，ジョセフ
ビー． ウォッチメーカー，パヤル
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University of California San Diego UCSD
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University of California San Diego UCSD
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4203—Receptors for growth factors
    • A61K40/4204—Epidermal growth factor receptors [EGFR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4214—Receptors for cytokines
    • A61K40/4217—Receptors for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/422—Ephrin Receptors [Eph]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4254—Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
    • A61K2239/22—Intracellular domain
    • A—HUMAN NECESSITIES
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/27—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by targeting or presenting multiple antigens
    • A61K2239/29—Multispecific CARs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/47—Brain; Nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Microbiology (AREA)
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  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Developmental Biology & Embryology (AREA)
JP2022545967A 2020-02-24 2020-11-06 細胞ベースの治療を脳にホーミング、ブロック及び送達するための脳特異的抗原の使用 Active JP7777872B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025190141A JP2026041745A (ja) 2020-02-24 2025-11-11 細胞ベースの治療を脳にホーミング、ブロック及び送達するための脳特異的抗原の使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062980885P 2020-02-24 2020-02-24
US62/980,885 2020-02-24
PCT/US2020/059368 WO2021173193A1 (en) 2020-02-24 2020-11-06 Use of brain-specific antigens to home, block and deliver cell-based treatments to the brain

Related Child Applications (1)

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JP2025190141A Division JP2026041745A (ja) 2020-02-24 2025-11-11 細胞ベースの治療を脳にホーミング、ブロック及び送達するための脳特異的抗原の使用

Publications (3)

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JP2023515322A JP2023515322A (ja) 2023-04-13
JP2023515322A5 JP2023515322A5 (https=) 2023-11-10
JP7777872B2 true JP7777872B2 (ja) 2025-12-01

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JP2022545967A Active JP7777872B2 (ja) 2020-02-24 2020-11-06 細胞ベースの治療を脳にホーミング、ブロック及び送達するための脳特異的抗原の使用
JP2025190141A Pending JP2026041745A (ja) 2020-02-24 2025-11-11 細胞ベースの治療を脳にホーミング、ブロック及び送達するための脳特異的抗原の使用

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US (1) US20230055337A1 (https=)
EP (1) EP4110354A4 (https=)
JP (2) JP7777872B2 (https=)
CN (1) CN115151268A (https=)
AU (1) AU2020431140A1 (https=)
CA (1) CA3170412A1 (https=)
WO (1) WO2021173193A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024121414A1 (en) * 2022-12-08 2024-06-13 Université De Genève Chimeric antigen receptor
WO2025054259A1 (en) * 2023-09-08 2025-03-13 The Regents Of The University Of California Guiding development using self-assembling cells
CN119306836B (zh) * 2024-10-14 2025-07-11 中国人民解放军陆军军医大学第一附属医院 抗ptprz1嵌合抗原受体巨噬细胞在肺癌治疗中的应用
CN119286939B (zh) * 2024-11-15 2025-05-02 广东君厚生物医药有限公司 PSR.Syn.CD19.BCMA CAR-T细胞的制备方法及其细胞和应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010534464A (ja) 2007-07-27 2010-11-11 イマティクス バイオテクノロジーズ ゲーエムベーハー 神経細胞性脳腫瘍に対する新規免疫療法
JP2016047825A (ja) 2008-10-01 2016-04-07 イマティクス バイオテクノロジーズ ゲーエムベーハー 神経細胞性脳腫瘍など数種の腫瘍に対する新規免疫療法
JP2018506293A (ja) 2015-02-24 2018-03-08 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 結合誘発型転写スイッチ及びその使用方法
WO2018123979A1 (ja) 2016-12-26 2018-07-05 協和発酵キリン株式会社 ミエリンオリゴデンドロサイト糖タンパク質に結合する抗体
US20190134093A1 (en) 2016-05-06 2019-05-09 The Regents Of The University Of California Systems and methods for targeting cancer cells
US20200032351A1 (en) 2014-03-21 2020-01-30 The Translational Genomics Research Institute Compositions, methods and kits for characterizing and screening for small cell ovarian carcinoma

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CN103491978A (zh) * 2010-10-25 2014-01-01 明尼苏达大学评议会 用于治疗成胶质细胞瘤的治疗组合物
WO2019068007A1 (en) * 2017-09-28 2019-04-04 Immpact-Bio Ltd. UNIVERSAL PLATFORM FOR PREPARING AN INHIBITORY CHIMERIC ANTIGEN RECEPTOR (ICAR)
CA3095757A1 (en) * 2018-04-06 2019-10-10 The Regents Of The University Of California Methods of treating glioblastomas

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010534464A (ja) 2007-07-27 2010-11-11 イマティクス バイオテクノロジーズ ゲーエムベーハー 神経細胞性脳腫瘍に対する新規免疫療法
JP2016047825A (ja) 2008-10-01 2016-04-07 イマティクス バイオテクノロジーズ ゲーエムベーハー 神経細胞性脳腫瘍など数種の腫瘍に対する新規免疫療法
US20200032351A1 (en) 2014-03-21 2020-01-30 The Translational Genomics Research Institute Compositions, methods and kits for characterizing and screening for small cell ovarian carcinoma
JP2018506293A (ja) 2015-02-24 2018-03-08 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 結合誘発型転写スイッチ及びその使用方法
US20190134093A1 (en) 2016-05-06 2019-05-09 The Regents Of The University Of California Systems and methods for targeting cancer cells
WO2018123979A1 (ja) 2016-12-26 2018-07-05 協和発酵キリン株式会社 ミエリンオリゴデンドロサイト糖タンパク質に結合する抗体

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Publication number Publication date
US20230055337A1 (en) 2023-02-23
CN115151268A (zh) 2022-10-04
EP4110354A4 (en) 2024-11-13
AU2020431140A1 (en) 2022-08-18
EP4110354A1 (en) 2023-01-04
CA3170412A1 (en) 2021-09-02
WO2021173193A1 (en) 2021-09-02
JP2026041745A (ja) 2026-03-10
JP2023515322A (ja) 2023-04-13

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