JP7766691B2 - Ｎａｄ（ｐ）依存性酵素ベースのセンサのためのｎａｄ（ｐ）デポー - Google Patents

Ｎａｄ（ｐ）依存性酵素ベースのセンサのためのｎａｄ（ｐ）デポー

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Publication number
JP7766691B2
JP7766691B2 JP2023536195A JP2023536195A JP7766691B2 JP 7766691 B2 JP7766691 B2 JP 7766691B2 JP 2023536195 A JP2023536195 A JP 2023536195A JP 2023536195 A JP2023536195 A JP 2023536195A JP 7766691 B2 JP7766691 B2 JP 7766691B2
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Japan
Prior art keywords
sensor
analyte
nad
certain embodiments
active region
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JP2023536195A
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English (en)
Japanese (ja)
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JP2023554367A (ja
Inventor
オーヤン、ティエンメイ
フォックス、ケイド
リウ、ゼンホァ
オージャ、スティーブン
ジェイ． フェルドマン、ベンジャミン
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Abbott Diabetes Care Inc
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Abbott Diabetes Care Inc
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Priority to JP2025181536A priority Critical patent/JP2026016616A/ja
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Publication of JP7766691B2 publication Critical patent/JP7766691B2/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/002—Electrode membranes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0015—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
    • A61B5/0022—Monitoring a patient using a global network, e.g. telephone networks, internet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
    • A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/683—Means for maintaining contact with the body
    • A61B5/6832—Means for maintaining contact with the body using adhesives
    • A61B5/6833—Adhesive patches
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/008—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions for determining co-enzymes or co-factors, e.g. NAD, ATP
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/0103—3-Hydroxybutyrate dehydrogenase (1.1.1.30)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y112/00—Oxidoreductases acting on hydrogen as donor (1.12)
    • C12Y112/01—Oxidoreductases acting on hydrogen as donor (1.12) with NAD+ or NADP+ as acceptor (1.12.1)
    • C12Y112/01002—Hydrogen dehydrogenase (1.12.1.2)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Emergency Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2023536195A 2020-12-15 2021-12-15 Ｎａｄ（ｐ）依存性酵素ベースのセンサのためのｎａｄ（ｐ）デポー Active JP7766691B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025181536A JP2026016616A (ja) 2020-12-15 2025-10-28 Ｎａｄ（ｐ）依存性酵素ベースのセンサのためのｎａｄ（ｐ）デポー

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063125846P 2020-12-15 2020-12-15
US63/125,846 2020-12-15
PCT/US2021/063600 WO2022132963A1 (en) 2020-12-15 2021-12-15 Nad(p) depot for nad(p)-dependent enzyme-based sensors

Related Child Applications (1)

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JP2025181536A Division JP2026016616A (ja) 2020-12-15 2025-10-28 Ｎａｄ（ｐ）依存性酵素ベースのセンサのためのｎａｄ（ｐ）デポー

Publications (2)

Publication Number Publication Date
JP2023554367A JP2023554367A (ja) 2023-12-27
JP7766691B2 true JP7766691B2 (ja) 2025-11-10

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Family Applications (2)

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JP2023536195A Active JP7766691B2 (ja) 2020-12-15 2021-12-15 Ｎａｄ（ｐ）依存性酵素ベースのセンサのためのｎａｄ（ｐ）デポー
JP2025181536A Pending JP2026016616A (ja) 2020-12-15 2025-10-28 Ｎａｄ（ｐ）依存性酵素ベースのセンサのためのｎａｄ（ｐ）デポー

Family Applications After (1)

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JP2025181536A Pending JP2026016616A (ja) 2020-12-15 2025-10-28 Ｎａｄ（ｐ）依存性酵素ベースのセンサのためのｎａｄ（ｐ）デポー

Country Status (7)

Country Link
US (2) US12404535B2 (https=)
EP (2) EP4262557B1 (https=)
JP (2) JP7766691B2 (https=)
CN (1) CN116648191B (https=)
AU (2) AU2021400588B2 (https=)
CA (1) CA3200244A1 (https=)
WO (1) WO2022132963A1 (https=)

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CN121843651A (zh) 2023-09-22 2026-04-10 雅培糖尿病护理公司 葡萄糖-酮传感器的决策支持
AU2024357038A1 (en) * 2023-10-04 2026-04-09 Abbott Diabetes Care Inc. Stabilization of nad(p)-dependent sensor with negatively charged membrane
WO2025224173A1 (en) 2024-04-23 2025-10-30 Directsens Gmbh Enzymatic assessment of glucose metabolic disorders
WO2025245355A1 (en) 2024-05-24 2025-11-27 Abbott Diabetes Care Inc. Dispensed area and drop solid content tunability
CN119224087A (zh) * 2024-09-30 2024-12-31 深圳津合生物有限公司 一种用于葡萄糖检测的酶电极、传感器及其应用

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JP5395665B2 (ja) 2006-09-22 2014-01-22 バイエル・ヘルスケア・エルエルシー 改善された安定性およびヘマトクリット性能（ｐｅｒｆｏｒｍａｎｃｅ）を有するバイオセンサー系
US20190024130A1 (en) 2016-03-04 2019-01-24 Abbott Diabetes Care Inc. NAD(P)- Dependent Responsive Enzymes, Electrodes And Sensors, And Methods For Making And Using The Same
WO2020159956A1 (en) 2019-01-28 2020-08-06 Abbott Diabetes Care Inc. Analyte sensors and sensing methods featuring dual detection of glucose and ketones

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JP5395665B2 (ja) 2006-09-22 2014-01-22 バイエル・ヘルスケア・エルエルシー 改善された安定性およびヘマトクリット性能（ｐｅｒｆｏｒｍａｎｃｅ）を有するバイオセンサー系
JP2012502689A (ja) 2008-09-15 2012-02-02 アボット ダイアベティス ケア インコーポレイテッド 検体センサに用いる陽イオンポリマー系ワイアード酵素組成物
US20190024130A1 (en) 2016-03-04 2019-01-24 Abbott Diabetes Care Inc. NAD(P)- Dependent Responsive Enzymes, Electrodes And Sensors, And Methods For Making And Using The Same
WO2020159956A1 (en) 2019-01-28 2020-08-06 Abbott Diabetes Care Inc. Analyte sensors and sensing methods featuring dual detection of glucose and ketones

Also Published As

Publication number Publication date
JP2026016616A (ja) 2026-02-03
EP4262557A1 (en) 2023-10-25
AU2021400588A1 (en) 2023-06-22
US12404535B2 (en) 2025-09-02
WO2022132963A1 (en) 2022-06-23
US20220186277A1 (en) 2022-06-16
AU2021400588B2 (en) 2025-04-10
CN116648191B (zh) 2026-04-10
AU2025205202A1 (en) 2025-07-24
US20240279708A1 (en) 2024-08-22
CN116648191A (zh) 2023-08-25
CA3200244A1 (en) 2022-06-23
EP4262557B1 (en) 2026-01-21
EP4714348A1 (en) 2026-03-25
JP2023554367A (ja) 2023-12-27

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