JP7751357B2 - 合成タンパク質およびその治療学的用途 - Google Patents

合成タンパク質およびその治療学的用途

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Publication number
JP7751357B2
JP7751357B2 JP2020502422A JP2020502422A JP7751357B2 JP 7751357 B2 JP7751357 B2 JP 7751357B2 JP 2020502422 A JP2020502422 A JP 2020502422A JP 2020502422 A JP2020502422 A JP 2020502422A JP 7751357 B2 JP7751357 B2 JP 7751357B2
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JP
Japan
Prior art keywords
synthetic
protein
linker
synthetic protein
growth factor
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP2020502422A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020527579A (ja
JP2020527579A5 (https=
Inventor
ドント，エリック
チャールトン，キース・アラン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
In3bio Ltd
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In3bio Ltd
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Publication of JP2020527579A publication Critical patent/JP2020527579A/ja
Publication of JP2020527579A5 publication Critical patent/JP2020527579A5/ja
Application granted granted Critical
Publication of JP7751357B2 publication Critical patent/JP7751357B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1883—Neuregulins, e.g.. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/00113—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/00113—Growth factors
    • A61K39/001131—Epidermal growth factor [EGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/00113—Growth factors
    • A61K39/001134—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
    • A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
JP2020502422A 2017-07-18 2018-07-18 合成タンパク質およびその治療学的用途 Active JP7751357B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762533901P 2017-07-18 2017-07-18
US62/533,901 2017-07-18
PCT/IB2018/000898 WO2019016597A2 (en) 2017-07-18 2018-07-18 SYNTHETIC PROTEINS AND THEIR THERAPEUTIC USES

Publications (3)

Publication Number Publication Date
JP2020527579A JP2020527579A (ja) 2020-09-10
JP2020527579A5 JP2020527579A5 (https=) 2021-08-26
JP7751357B2 true JP7751357B2 (ja) 2025-10-08

Family

ID=63857968

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020502422A Active JP7751357B2 (ja) 2017-07-18 2018-07-18 合成タンパク質およびその治療学的用途

Country Status (12)

Country Link
US (1) US12134662B2 (https=)
EP (1) EP3655025A2 (https=)
JP (1) JP7751357B2 (https=)
KR (1) KR102903351B1 (https=)
CN (1) CN111246878A (https=)
AU (1) AU2018304957B2 (https=)
BR (1) BR112020001045A2 (https=)
CA (1) CA3070034A1 (https=)
IL (2) IL300235A (https=)
MX (1) MX2020000636A (https=)
RU (1) RU2020106669A (https=)
WO (1) WO2019016597A2 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112996534B (zh) 2018-08-07 2025-11-18 因斯瑞拜奥有限公司 结合间变性淋巴瘤激酶抑制剂进行egf/egfr通路抑制的方法和组合物
AU2020301638A1 (en) * 2019-06-25 2022-02-17 In3Bio Ltd. Stabilized chimeric synthetic proteins and therapeutic uses thereof
CN115379851A (zh) * 2019-11-07 2022-11-22 因斯瑞拜奥有限公司 使用生长因子抗体与非酪氨酸靶向激酶抑制剂的组合的方法和组合物
MX2024005177A (es) 2021-10-28 2024-08-27 In3Bio Ltd Métodos de uso de anticuerpos anti-fce para aumentar la actividad de los inhibidores de braf y kras.
USD1055117S1 (en) 2022-12-29 2024-12-24 Samsung Electronics Co., Ltd. Refrigerator

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080249008A1 (en) 2006-03-20 2008-10-09 Cochran Jennifer R Mutant epidermal growth factor polypeptides, nucleic acids, and uses therefor
JP2014534258A (ja) 2011-11-23 2014-12-18 バイオベン・3・リミテッドBioven 3 Limited 組換えタンパク質及びそれらの治療的用途
JP2016517402A (ja) 2013-03-15 2016-06-16 バイオベン・3・リミテッドBioven 3 Limited 自己組織化合成タンパク質（Ｓｅｌｆ−ＡｓｓｅｍｂｌｉｎｇＳｙｎｔｈｅｔｉｃＰｒｏｔｅｉｎｓ）

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US3238190A (en) 1963-10-23 1966-03-01 Madaus & Co K G Fa Dr Aescin recovery
SE8205892D0 (sv) 1982-10-18 1982-10-18 Bror Morein Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin
CA1331443C (en) 1987-05-29 1994-08-16 Charlotte A. Kensil Saponin adjuvant
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
CA2261433A1 (en) 1993-12-09 1995-06-10 Belinda Sanchez Ramirez Composition comprising autologous epidermal growth factor
GB9326253D0 (en) 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
AUPM873294A0 (en) 1994-10-12 1994-11-03 Csl Limited Saponin preparations and use thereof in iscoms
UA56132C2 (uk) 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
JPH10147952A (ja) 1996-11-18 1998-06-02 Komatsu Ltd ブルドーザのドージング装置
US6645495B1 (en) 1997-08-29 2003-11-11 Antigenics, Inc. Compositions of saponin adjuvants and excipients
DE60014076T2 (de) 1999-04-19 2005-10-13 Glaxosmithkline Biologicals S.A. Adjuvans-zusammensetzung, enthaltend saponin und ein immunstimulatorisches oligonukleotid
CU22999A1 (es) 2001-12-04 2004-10-12 Centro Inmunologia Molecular Método de tratamiento de enfermedades malignas e infecciosas crónicas
JP3855886B2 (ja) 2002-08-29 2006-12-13 トヨタ自動車株式会社 路面状態変化推定装置およびこれを搭載する自動車
JP4623625B2 (ja) * 2003-07-24 2011-02-02 株式会社AMBiS ヘテロ型５量体組換えワクチン
US12595297B2 (en) * 2015-05-12 2026-04-07 In3Bio Ltd. Methods and compositions for inhibition of EGF/EGFR pathway in combination with tyrosine kinase inhibitors
FI3345613T3 (fi) * 2015-09-01 2023-07-28 Il Dong Pharma Koostumus käytettäväksi syövän tai angiogeneesiin liittyvän sairauden hoidossa käsittäen tuumoriin penetroituvan peptidin ja VEGF-estäjän fuusioproteiinin

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080249008A1 (en) 2006-03-20 2008-10-09 Cochran Jennifer R Mutant epidermal growth factor polypeptides, nucleic acids, and uses therefor
JP2014534258A (ja) 2011-11-23 2014-12-18 バイオベン・3・リミテッドBioven 3 Limited 組換えタンパク質及びそれらの治療的用途
JP2016517402A (ja) 2013-03-15 2016-06-16 バイオベン・3・リミテッドBioven 3 Limited 自己組織化合成タンパク質（Ｓｅｌｆ−ＡｓｓｅｍｂｌｉｎｇＳｙｎｔｈｅｔｉｃＰｒｏｔｅｉｎｓ）

Non-Patent Citations (1)

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Title
van de Poll ML et al, Non-linear antigenic regions in epidermal growth factor (EGF) and transforming growth factor α (TGFα) studied by EGF-TGFα chimaeras, Biochemical Journal, 2000, Vol.349, No.1, pp.267-274

Also Published As

Publication number Publication date
EP3655025A2 (en) 2020-05-27
WO2019016597A2 (en) 2019-01-24
AU2018304957A1 (en) 2020-02-13
JP2020527579A (ja) 2020-09-10
IL300235A (en) 2023-03-01
WO2019016597A3 (en) 2019-04-18
RU2020106669A (ru) 2021-08-18
IL272050B2 (en) 2023-07-01
RU2020106669A3 (https=) 2022-04-07
AU2018304957B2 (en) 2025-05-15
KR20200029010A (ko) 2020-03-17
KR102903351B1 (ko) 2025-12-24
IL272050B1 (en) 2023-03-01
US12134662B2 (en) 2024-11-05
BR112020001045A2 (pt) 2020-09-08
CN111246878A (zh) 2020-06-05
US20210009716A1 (en) 2021-01-14
IL272050A (en) 2020-03-31
MX2020000636A (es) 2020-08-20
CA3070034A1 (en) 2019-01-24

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