JP7747670B2 - 表面提示ペプチドを予測するための機械学習技術 - Google Patents

表面提示ペプチドを予測するための機械学習技術

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JP7747670B2
JP7747670B2 JP2022577543A JP2022577543A JP7747670B2 JP 7747670 B2 JP7747670 B2 JP 7747670B2 JP 2022577543 A JP2022577543 A JP 2022577543A JP 2022577543 A JP2022577543 A JP 2022577543A JP 7747670 B2 JP7747670 B2 JP 7747670B2
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peptide
peptides
machine learning
data
learning model
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JP2023530719A (ja
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ウィルバー アボット ザ サード チャールズ
マイケル ボイル ショーン
マーティー パイク レイチェル
レビー エリック
メラチェルービュー ダッタトレヤ
マクロリー リーナ
チェン リチャード
パワー ロバート
バルサ ガーボル
ハリス ジェイソン
ミラーニ パメラ
タンドン プラティーク
マクニット ポール
モラ マッシモ
デサイ セジャル
サルディバー ジュアン－セバスチャン
クラーク マイケル
ホーデンシルド クリスチャン
ウエスト ジョン
フィリップス ニック
ブイ．チャン シモ
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パーソナリス，インコーポレイティド
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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N20/00—Machine learning
    • G06N20/20—Ensemble learning
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medical Informatics (AREA)
  • Theoretical Computer Science (AREA)
  • Data Mining & Analysis (AREA)
  • Software Systems (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Evolutionary Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Evolutionary Computation (AREA)
  • Molecular Biology (AREA)
  • Bioethics (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Computing Systems (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Mathematical Physics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2022577543A 2020-06-18 2021-06-17 表面提示ペプチドを予測するための機械学習技術 Active JP7747670B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024143327A JP7819262B2 (ja) 2020-06-18 2024-08-23 表面提示ペプチドを予測するための機械学習技術

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063040943P 2020-06-18 2020-06-18
US63/040,943 2020-06-18
US202063111007P 2020-11-07 2020-11-07
US63/111,007 2020-11-07
PCT/US2021/037902 WO2021257879A1 (en) 2020-06-18 2021-06-17 Machine-learning techniques for predicting surface-presenting peptides

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JP2023530719A JP2023530719A (ja) 2023-07-19
JP7747670B2 true JP7747670B2 (ja) 2025-10-01

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US (1) US20230115039A1 (https=)
EP (1) EP4168569A4 (https=)
JP (2) JP7747670B2 (https=)
WO (1) WO2021257879A1 (https=)

Families Citing this family (5)

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KR102517004B1 (ko) * 2022-01-24 2023-04-03 주식회사 네오젠티씨 면역펩티돔을 분석하기 위한 방법 및 장치
KR102507110B1 (ko) * 2022-02-15 2023-03-07 주식회사 네오젠티씨 주조직 적합성 복합체의 타입들을 분석하기 위한 방법 및 장치
US20230377682A1 (en) * 2022-05-20 2023-11-23 Nec Laboratories America, Inc. Peptide binding motif generation
WO2025036943A1 (en) * 2023-08-14 2025-02-20 Immatics Biotechnologies Gmbh Method of determining mhc-presented peptides
WO2025125536A1 (en) * 2023-12-13 2025-06-19 Immatics Biotechnologies Gmbh Absolute copy number prediction of mhc-presented peptides by relative quantitative measurement

Citations (2)

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WO2018195357A1 (en) 2017-04-19 2018-10-25 Gritstone Oncology, Inc. Neoantigen identification, manufacture, and use
US20190346442A1 (en) 2016-04-18 2019-11-14 The Broad Institute, Inc. Improved hla epitope prediction

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US7283982B2 (en) * 2003-12-05 2007-10-16 International Business Machines Corporation Method and structure for transform regression
US10892035B2 (en) * 2014-10-10 2021-01-12 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2018148671A1 (en) * 2017-02-12 2018-08-16 Neon Therapeutics, Inc. Hla-based methods and compositions and uses thereof
CN119851752A (zh) * 2018-02-27 2025-04-18 磨石生物公司 利用泛等位基因模型进行的新抗原鉴别
EP3796930A4 (en) * 2018-05-23 2022-05-04 Gritstone bio, Inc. IMMUNE CHECKPOINT INHIBITOR KO-EXPRESSION VECTORS
AU2019404547B2 (en) * 2018-12-21 2025-01-30 Biontech Us Inc. Method and systems for prediction of HLA class II-specific epitopes and characterization of CD4+ T cells

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
US20190346442A1 (en) 2016-04-18 2019-11-14 The Broad Institute, Inc. Improved hla epitope prediction
WO2018195357A1 (en) 2017-04-19 2018-10-25 Gritstone Oncology, Inc. Neoantigen identification, manufacture, and use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Rachel Marty Pyke，ほか１３名，"Precision neoantigen discovery using large-scale immunopeptidomes and composite modeling of MHC peptide presentation"，［online］，米国，bioRxiv，2021年06月07日，［令和５年１０月３日検索］，インターネット，＜URL：https://www.biorxiv.org/content/10.1101/2021.04.30.442203v2＞

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JP2023530719A (ja) 2023-07-19
JP2024178175A (ja) 2024-12-24
EP4168569A4 (en) 2024-08-07
WO2021257879A1 (en) 2021-12-23
US20230115039A1 (en) 2023-04-13
JP7819262B2 (ja) 2026-02-24
EP4168569A1 (en) 2023-04-26

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