JP7743080B2 - 一酸化窒素放出抗菌化合物、製剤、およびそれらに関連する方法 - Google Patents

一酸化窒素放出抗菌化合物、製剤、およびそれらに関連する方法

Info

Publication number
JP7743080B2
JP7743080B2 JP2022547051A JP2022547051A JP7743080B2 JP 7743080 B2 JP7743080 B2 JP 7743080B2 JP 2022547051 A JP2022547051 A JP 2022547051A JP 2022547051 A JP2022547051 A JP 2022547051A JP 7743080 B2 JP7743080 B2 JP 7743080B2
Authority
JP
Japan
Prior art keywords
compound
alkyl
group
composition
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2022547051A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023513106A5 (https=
JP2023513106A (ja
Inventor
フォーク，ドリュー
ジェラルド アンダーソン，ライアン
ケリー シモンズ，ジョン
ジャスミン ロサレス アホネン，モナ
アンソアード マクドナルド，レベッカ
Original Assignee
ノウ・バイオ・エルエルシー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ノウ・バイオ・エルエルシー filed Critical ノウ・バイオ・エルエルシー
Publication of JP2023513106A publication Critical patent/JP2023513106A/ja
Publication of JP2023513106A5 publication Critical patent/JP2023513106A5/ja
Application granted granted Critical
Publication of JP7743080B2 publication Critical patent/JP7743080B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/12—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N51/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds having the sequences of atoms O—N—S, X—O—S, N—N—S, O—N—N or O-halogen, regardless of the number of bonds each atom has and with no atom of these sequences forming part of a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/06—Aluminium; Calcium; Magnesium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/02—Ammonia; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Dentistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
JP2022547051A 2020-02-07 2021-02-05 一酸化窒素放出抗菌化合物、製剤、およびそれらに関連する方法 Active JP7743080B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062971624P 2020-02-07 2020-02-07
US62/971,624 2020-02-07
PCT/US2021/016854 WO2021158941A1 (en) 2020-02-07 2021-02-05 Nitric oxide-releasing antibacterial compounds, formulations, and methods pertaining thereto

Publications (3)

Publication Number Publication Date
JP2023513106A JP2023513106A (ja) 2023-03-30
JP2023513106A5 JP2023513106A5 (https=) 2024-02-13
JP7743080B2 true JP7743080B2 (ja) 2025-09-24

Family

ID=77199389

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022547051A Active JP7743080B2 (ja) 2020-02-07 2021-02-05 一酸化窒素放出抗菌化合物、製剤、およびそれらに関連する方法

Country Status (4)

Country Link
US (4) US20230108186A1 (https=)
EP (1) EP4093205A4 (https=)
JP (1) JP7743080B2 (https=)
WO (3) WO2021158941A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230108186A1 (en) * 2020-02-07 2023-04-06 Know Bio, Llc Nitric oxide-releasing antibacterial compounds, formulations, and methods pertaining thereto
WO2023211932A1 (en) * 2022-04-28 2023-11-02 Know Bio, Llc Buffering agent-containing compositions and methods of using same
AU2023275534A1 (en) * 2022-05-23 2024-12-05 Inhalon Biopharma, Inc. Compositions and methods for inhalable therapeutics
CN119789870A (zh) * 2022-06-08 2025-04-08 诺欧生物有限责任公司 含有一氧化氮释放化合物的多组分药物组合物和试剂盒及其使用方法
AU2023384992B2 (en) * 2022-11-26 2025-07-17 Sterile State, Inc. Thiol-containing alcohols for generating nitric oxide and methods of forming the same
EP4676492A2 (en) * 2023-03-07 2026-01-14 KNOW Bio, LLC High purity nitric oxide releasing compounds and methods of preparing same
US20250339449A1 (en) * 2024-05-02 2025-11-06 Know Bio, Llc Inhalation formulations containing nitric oxide releasing compounds and methods of using same

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001509481A (ja) 1997-07-11 2001-07-24 ザ ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン 一酸化窒素はライノウイルス感染症を抑制する
JP2001527072A (ja) 1997-12-23 2001-12-25 ニユコメド・イメージング・アクシエセルカペト 一酸化窒素を放出するキレート化剤およびその治療上の使用
JP2017520594A (ja) 2014-07-11 2017-07-27 ノヴァン，インコーポレイテッド 局所用抗ウイルス薬組成物及びこれを使用する方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5910316A (en) 1992-08-24 1999-06-08 The United States Of America, As Represented By The Department Of Health And Human Services Use of nitric oxide-releasing agents to treat impotency
US6203822B1 (en) * 1996-09-03 2001-03-20 University Of Iowa Research Foundation Gallium-containing compounds for the treatment of infections caused by intracellular pathogens and pathogens causing chronic pulmonary infection
US20020182162A1 (en) * 2002-08-07 2002-12-05 Mohsen Shahinpoor Nitric oxide (NO) donor+cGMP-PDE5 inhibitor as a topical drug for enhanced hair growth
US7569559B2 (en) * 2004-02-09 2009-08-04 Noxilizer, Inc. Nitric oxide-releasing molecules
EP1858525A2 (en) * 2005-02-16 2007-11-28 Nitromed, Inc. Organic nitric oxide donor salts of antimicrobial compounds, compositions and methods of use
WO2006125123A2 (en) * 2005-05-19 2006-11-23 University Of Cincinnati Methods for treating bacterial respiratory tract infections in an individual using acidified nitrite
EP1888510A4 (en) * 2005-05-27 2013-01-16 Univ North Carolina NITROGEN OXIDE-RELATED PARTICLES FOR NITROGEN OXIDE THERAPEUTICS AND BIOMEDICAL APPLICATIONS
AU2006309212B2 (en) * 2005-10-31 2011-09-15 Government Of The United States Of America, Represented By The Secretary Department Of Health And Human Services Polysaccharide-derived nitric oxide-releasing carbon-bound diazeniumdiolates
US8236341B2 (en) * 2009-04-02 2012-08-07 Medtronic Vascular, Inc. Poly(tetrafluoroethylene) polymer with nitric oxide donating surface
US11072668B2 (en) * 2017-01-03 2021-07-27 The University Of North Carolina At Chapel Hill Nitric oxide-releasing alginates as biodegradable antibacterial scaffolds and methods pertaining thereto
WO2019173539A1 (en) * 2018-03-06 2019-09-12 The University Of North Carolina At Chapel Hill Nitric oxide-releasing cyclodextrins as biodegradable antibacterial scaffolds and methods pertaining thereto
US20230108186A1 (en) * 2020-02-07 2023-04-06 Know Bio, Llc Nitric oxide-releasing antibacterial compounds, formulations, and methods pertaining thereto

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001509481A (ja) 1997-07-11 2001-07-24 ザ ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン 一酸化窒素はライノウイルス感染症を抑制する
JP2001527072A (ja) 1997-12-23 2001-12-25 ニユコメド・イメージング・アクシエセルカペト 一酸化窒素を放出するキレート化剤およびその治療上の使用
JP2017520594A (ja) 2014-07-11 2017-07-27 ノヴァン，インコーポレイテッド 局所用抗ウイルス薬組成物及びこれを使用する方法

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
Ernst V. Arnold et al.，A Nitric Oxide-Releasing Polydiazeniumdiolate Derived from Acetonitrile，Organic Letters，2002年，4，1323-1325，DOI:10.1021/ol025624j
Hyejoong Jeong et al.，Nanocrystals Continuously Releasing Nitric Oxide: Promoting Cell Migration and Increasing Cell Survival against Oxidative Stress，Chem. Mater.，2000年，32，9787-9797，DOI:10.1021/acs.chemmater.0c03800
Hyejoong Jeong et al.，Sustained Nitric Oxide-Providing Small Molecule and Precise Release Behavior Study for Glaucoma Treatment，Mol. Pharmaceutics，2000年01月08日，17，656-665，DOI:10.1021/acs.molpharmaceut.9b01137
Lei Yang et al.，Nitric Oxide-Releasing Macromolecular Scaffolds for Antibacterial Applications，Adv. Healthcare Mater.，2018年，7，1800155, 1-18，DOI:10.1002/adhm.201800155
Mohammad Samiul Alam et al.，Role of Nitric Oxide in Host Defense in Murine Salmonellosis as a Function of Its Antibacterial and Antiapoptotic Activities，INFECTION AND IMMUNITY，70，2002年，3130-3142，DOI:10.1128/iai.70.6.3130-3142.2002
Satoshi Noda et al.，Role of Nitric Oxide Synthase Type 2 in Acute Infection with Murine Cytomegalovirus，J. Immunol.，2001年，166，3533-3541，DOI:10.4049/jimmunol.166.5.3533
赤池孝章 他，NOによる細胞内感染防御の新しい展開，Jpn. J. Leprosy，2009年，78，41-47，DOI:10.5025/hansen.78.41

Also Published As

Publication number Publication date
US20230337678A1 (en) 2023-10-26
US20220152063A1 (en) 2022-05-19
US20220160736A1 (en) 2022-05-26
EP4093205A1 (en) 2022-11-30
US12390479B2 (en) 2025-08-19
WO2021158941A1 (en) 2021-08-12
JP2023513106A (ja) 2023-03-30
US11813270B2 (en) 2023-11-14
WO2021158930A1 (en) 2021-08-12
US20230108186A1 (en) 2023-04-06
EP4093205A4 (en) 2024-02-21
WO2021158954A1 (en) 2021-08-12

Similar Documents

Publication Publication Date Title
JP7743080B2 (ja) 一酸化窒素放出抗菌化合物、製剤、およびそれらに関連する方法
JP7686578B2 (ja) 窒素酸化物を生成するための方法および組成物、ならびに気道を介して窒素酸化物を送達するためのそれらの使用
US20250241919A1 (en) Combination of active agents for the treatment of Progressive Fibrosing Interstitial Lung Diseases (PF-ILD)
US12274830B2 (en) Nitric oxide inhalation therapy for infants with bronchiolitis
CN114206325A (zh) 用于生成一氧化氮的方法和组合物及其用途
US20230174679A1 (en) Nitric oxide-releasing antibacterial polymers and scaffolds fabricated therefrom and methods pertaining thereto
JP2023526584A (ja) Ｓａｒｓ－ｃｏｖ及びｓａｒｓ－ｃｏｖ－２の治療に使用するための一酸化窒素または一酸化窒素放出組成物
US20230129866A1 (en) Methods of treating respiratory disease with deupirfenidone
CN115768413A (zh) 用于治疗及抗击结核病的方法和组合物
EP2956153A1 (en) Treatment of evolving bacterial resistance diseases including klebsiella pneumoniae with liposomally formulated glutathione
US20240261243A1 (en) Nitric oxide donors, compositions, and methods of use
JP2022537792A (ja) 感染を処置するための組成物および相乗的方法
EP3843785A1 (en) Compositions with synergistic permeation enhancers for drug delivery
JP2020502096A (ja) 抗バクテリア剤（ａｎｔｉｂａｃｔｅｒｉａｌ ａｇｅｎｔ）として使用するためのｎ−アセチルシステイン
EA043054B1 (ru) N-ацетилцистеин для применения в качестве антибактериального агента

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240202

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20240202

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20241218

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20250114

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20250414

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20250805

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20250903

R150 Certificate of patent or registration of utility model

Ref document number: 7743080

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150