JP7737996B2 - Ｈｅｒ２に対するキメラ抗原受容体およびその使用方法 - Google Patents

Ｈｅｒ２に対するキメラ抗原受容体およびその使用方法

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JP7737996B2
JP7737996B2 JP2022545126A JP2022545126A JP7737996B2 JP 7737996 B2 JP7737996 B2 JP 7737996B2 JP 2022545126 A JP2022545126 A JP 2022545126A JP 2022545126 A JP2022545126 A JP 2022545126A JP 7737996 B2 JP7737996 B2 JP 7737996B2
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car
domain
cell
seq
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JP2023513458A (ja
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イアン フロスト グレゴリー
ジョセフ オヌファー，ジュニア ジェイムズ
クンドゥ アニルバン
エム ショート ジェイ
フレイ ゲルハルト
ウェン チャン フワイ
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エクスマ バイオテック コーポレイション
バイオアトラ，インコーポレイティド
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K39/0005—Vertebrate antigens
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    • A61K39/001103—Receptors for growth factors
    • A61K39/001106—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • C07K2319/00—Fusion polypeptide
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JP2022545126A 2020-01-23 2021-01-23 Ｈｅｒ２に対するキメラ抗原受容体およびその使用方法 Active JP7737996B2 (ja)

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US202062964947P 2020-01-23 2020-01-23
US62/964,947 2020-01-23
PCT/US2021/070073 WO2021151119A1 (en) 2020-01-23 2021-01-23 Chimeric antigen receptors to her2 and methods of use thereof

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JP2023513458A JP2023513458A (ja) 2023-03-31
JP2023513458A5 JP2023513458A5 (https=) 2024-01-31
JP7737996B2 true JP7737996B2 (ja) 2025-09-11

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US (1) US20230072955A1 (https=)
EP (1) EP4087867A4 (https=)
JP (1) JP7737996B2 (https=)
KR (1) KR20220153578A (https=)
CN (1) CN115485293A (https=)
AU (1) AU2021210446A1 (https=)
BR (1) BR112022014568A2 (https=)
CA (1) CA3168813A1 (https=)
IL (1) IL294877A (https=)
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US20250222029A1 (en) 2022-04-08 2025-07-10 Fate Therapeutics, Inc. Chimeric antigen receptor for tumor targeting
US20250228943A1 (en) 2022-04-08 2025-07-17 Fate Therapeutics, Inc. Cells having solid tumor targeting backbone and use thereof

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WO2018136570A1 (en) 2017-01-18 2018-07-26 F1 Oncology, Inc. Chimeric antigen receptors against axl or ror2 and methods of use thereof
JP2019500894A (ja) 2015-11-04 2019-01-17 ジェイ． プライスマン，ソール Ｈｅｒ２を標的とするキメラ抗原受容体
US20190194349A1 (en) 2010-12-06 2019-06-27 National Research Council Of Canada Antibodies selective for cells presenting erbb2 at high density

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CA2861003C (en) * 2012-01-13 2023-03-28 Julius-Maximilians-Universitat Wurzburg Dual antigen-induced bipartite functional complementation
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