JP7730811B2 - ５－ヒドロキシトリプタミン受容体７の調節因子としての新規官能化ラクタムおよびその使用方法 - Google Patents

５－ヒドロキシトリプタミン受容体７の調節因子としての新規官能化ラクタムおよびその使用方法

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Publication number
JP7730811B2
JP7730811B2 JP2022527717A JP2022527717A JP7730811B2 JP 7730811 B2 JP7730811 B2 JP 7730811B2 JP 2022527717 A JP2022527717 A JP 2022527717A JP 2022527717 A JP2022527717 A JP 2022527717A JP 7730811 B2 JP7730811 B2 JP 7730811B2
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cycloalkyl
general formula
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JP2023501577A5 (https=
JP2023501577A (ja
Inventor
ダニエル ジェイ． キャニー，
ベンジャミン イー． ブラス，
ケビン エム． ブラットナー，
ダグラス エー． ピピン，
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Temple Univ School of Medicine
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Temple Univ School of Medicine
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Priority to JP2025135739A priority Critical patent/JP2025161894A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2022527717A 2019-11-13 2020-11-12 ５－ヒドロキシトリプタミン受容体７の調節因子としての新規官能化ラクタムおよびその使用方法 Active JP7730811B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025135739A JP2025161894A (ja) 2019-11-13 2025-08-18 ５－ヒドロキシトリプタミン受容体７の調節因子としての新規官能化ラクタムおよびその使用方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962934997P 2019-11-13 2019-11-13
US62/934,997 2019-11-13
PCT/US2020/060270 WO2021097116A1 (en) 2019-11-13 2020-11-12 Novel functionalized lactams as modulators of the 5-hydroxytryptamine receptor 7 and their method of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025135739A Division JP2025161894A (ja) 2019-11-13 2025-08-18 ５－ヒドロキシトリプタミン受容体７の調節因子としての新規官能化ラクタムおよびその使用方法

Publications (3)

Publication Number Publication Date
JP2023501577A JP2023501577A (ja) 2023-01-18
JP2023501577A5 JP2023501577A5 (https=) 2023-11-20
JP7730811B2 true JP7730811B2 (ja) 2025-08-28

Family

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Family Applications (2)

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JP2022527717A Active JP7730811B2 (ja) 2019-11-13 2020-11-12 ５－ヒドロキシトリプタミン受容体７の調節因子としての新規官能化ラクタムおよびその使用方法
JP2025135739A Pending JP2025161894A (ja) 2019-11-13 2025-08-18 ５－ヒドロキシトリプタミン受容体７の調節因子としての新規官能化ラクタムおよびその使用方法

Family Applications After (1)

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JP2025135739A Pending JP2025161894A (ja) 2019-11-13 2025-08-18 ５－ヒドロキシトリプタミン受容体７の調節因子としての新規官能化ラクタムおよびその使用方法

Country Status (12)

Country Link
US (1) US20230002383A1 (https=)
EP (1) EP4058455A1 (https=)
JP (2) JP7730811B2 (https=)
KR (1) KR20220113702A (https=)
CN (1) CN115003675A (https=)
AU (1) AU2020381460A1 (https=)
BR (1) BR112022009374A2 (https=)
CA (1) CA3160801A1 (https=)
IL (1) IL292811A (https=)
MX (1) MX2022005820A (https=)
TW (1) TWI905129B (https=)
WO (1) WO2021097116A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA49019A (fr) 2017-03-21 2020-02-05 Univ Temple Nouveaux modulateurs du récepteur sigma 2 et leur procédé d'utilisation
EA202092328A1 (ru) 2018-05-11 2021-04-08 Темпл Юниверсити-Оф Зэ Коммонвелс Систем Оф Хаер Эдьюкейшн Новые функционализированные лактамы в качестве модуляторов 5-гидрокситриптаминового рецептора 7 и способ их применения

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014164756A1 (en) 2013-03-11 2014-10-09 Temple University Of The Commonwealth System Of Higher Education Novel 5-hydroxytryptamine receptor 7 activity modulators and their method of use
WO2016040554A1 (en) 2014-09-10 2016-03-17 Temple University-Of The Commonwealth System Of Higher Education Novel 5-hydroxytryptamine receptor 7 activity modulators and their method of use
WO2018093818A1 (en) 2016-11-15 2018-05-24 Temple University-Of The Commonwealth System Of Higher Education Novel modulators of the 5-hydroxytryptamine receptor 7 and their method of use
WO2018175190A1 (en) 2017-03-21 2018-09-27 Temple University-Of The Commonwealth System Of Higher Education 5-hydroxytryptamine receptor 7 modulators and their use as therapeutic agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201002563D0 (en) * 2010-02-15 2010-03-31 Cambridge Entpr Ltd Compounds
WO2019094856A1 (en) * 2017-11-13 2019-05-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Atypical inhibitors of monoamine transporters; method of making; and use thereof
EA202092328A1 (ru) * 2018-05-11 2021-04-08 Темпл Юниверсити-Оф Зэ Коммонвелс Систем Оф Хаер Эдьюкейшн Новые функционализированные лактамы в качестве модуляторов 5-гидрокситриптаминового рецептора 7 и способ их применения

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014164756A1 (en) 2013-03-11 2014-10-09 Temple University Of The Commonwealth System Of Higher Education Novel 5-hydroxytryptamine receptor 7 activity modulators and their method of use
WO2016040554A1 (en) 2014-09-10 2016-03-17 Temple University-Of The Commonwealth System Of Higher Education Novel 5-hydroxytryptamine receptor 7 activity modulators and their method of use
WO2018093818A1 (en) 2016-11-15 2018-05-24 Temple University-Of The Commonwealth System Of Higher Education Novel modulators of the 5-hydroxytryptamine receptor 7 and their method of use
WO2018175190A1 (en) 2017-03-21 2018-09-27 Temple University-Of The Commonwealth System Of Higher Education 5-hydroxytryptamine receptor 7 modulators and their use as therapeutic agents

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Bioorganic & Medicinal Chemistry Letters，2002年，Vol. 12，No. 23，pp. 3431-3433
STN REGISTRY File，RN: 2326123-00-4, [online], Entered STN: 07 Jun. 2019, [retrieved on 4 Oct. 2024]
STN REGISTRY File，RN: 2327077-40-5, [online], Entered STN: 09 Jun. 2019, [retrieved on 4 Oct. 2024]
野崎 正勝 他，創薬化学，第1版，日本，化学同人，1995年，pp. 98-99

Also Published As

Publication number Publication date
WO2021097116A1 (en) 2021-05-20
CA3160801A1 (en) 2021-05-20
TWI905129B (zh) 2025-11-21
AU2020381460A1 (en) 2022-06-09
IL292811A (en) 2022-07-01
CN115003675A (zh) 2022-09-02
US20230002383A1 (en) 2023-01-05
JP2023501577A (ja) 2023-01-18
MX2022005820A (es) 2022-08-16
EP4058455A1 (en) 2022-09-21
JP2025161894A (ja) 2025-10-24
BR112022009374A2 (pt) 2022-08-09
KR20220113702A (ko) 2022-08-16
TW202132301A (zh) 2021-09-01

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