JP7724866B2 - 抗体薬物複合体およびその用途 - Google Patents

抗体薬物複合体およびその用途

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Publication number
JP7724866B2
JP7724866B2 JP2023547736A JP2023547736A JP7724866B2 JP 7724866 B2 JP7724866 B2 JP 7724866B2 JP 2023547736 A JP2023547736 A JP 2023547736A JP 2023547736 A JP2023547736 A JP 2023547736A JP 7724866 B2 JP7724866 B2 JP 7724866B2
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JP
Japan
Prior art keywords
seq
antibody
claudin
variable region
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2023547736A
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English (en)
Japanese (ja)
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JP2024530368A (ja
JP2024530368A5 (enExample
Inventor
朝 紅 胡
虎 李
博 陳
剛 徐
瑩 王
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Miracogen Inc
Keymed Biosciences (Chengdu) Co Ltd
Original Assignee
Shanghai Miracogen Inc
Keymed Biosciences (Chengdu) Co Ltd
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Application filed by Shanghai Miracogen Inc, Keymed Biosciences (Chengdu) Co Ltd filed Critical Shanghai Miracogen Inc
Publication of JP2024530368A publication Critical patent/JP2024530368A/ja
Publication of JP2024530368A5 publication Critical patent/JP2024530368A5/ja
Priority to JP2025130431A priority Critical patent/JP2025183203A/ja
Application granted granted Critical
Publication of JP7724866B2 publication Critical patent/JP7724866B2/ja
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
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    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2023547736A 2020-10-15 2021-10-19 抗体薬物複合体およびその用途 Active JP7724866B2 (ja)

Priority Applications (1)

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JP2025130431A JP2025183203A (ja) 2020-10-15 2025-08-05 抗体薬物複合体およびその用途

Applications Claiming Priority (2)

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