JP7709379B2 - イミプリドン様薬剤に対する薬物反応のバイオマーカとしてのカゼイン分解プロテアーゼｐの機能の使用 - Google Patents

イミプリドン様薬剤に対する薬物反応のバイオマーカとしてのカゼイン分解プロテアーゼｐの機能の使用

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Publication number
JP7709379B2
JP7709379B2 JP2021550133A JP2021550133A JP7709379B2 JP 7709379 B2 JP7709379 B2 JP 7709379B2 JP 2021550133 A JP2021550133 A JP 2021550133A JP 2021550133 A JP2021550133 A JP 2021550133A JP 7709379 B2 JP7709379 B2 JP 7709379B2
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JP2022521797A5 (enExample
JP2022521797A (ja
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イワノヴィッチ，エドウィン
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Madera Therapeutics LLC
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Madera Therapeutics LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2021550133A 2019-02-27 2020-02-26 イミプリドン様薬剤に対する薬物反応のバイオマーカとしてのカゼイン分解プロテアーゼｐの機能の使用 Active JP7709379B2 (ja)

Applications Claiming Priority (19)

Application Number Priority Date Filing Date Title
US201962811432P 2019-02-27 2019-02-27
US62/811,432 2019-02-27
US201962819204P 2019-03-15 2019-03-15
US62/819,204 2019-03-15
US201962825667P 2019-03-28 2019-03-28
US62/825,667 2019-03-28
US201962840254P 2019-04-29 2019-04-29
US62/840,254 2019-04-29
US201962871694P 2019-07-08 2019-07-08
US62/871,694 2019-07-08
US201962885055P 2019-08-09 2019-08-09
US62/885,055 2019-08-09
US201962901142P 2019-09-16 2019-09-16
US62/901,142 2019-09-16
US201962931043P 2019-11-05 2019-11-05
US62/931,043 2019-11-05
US202062975088P 2020-02-11 2020-02-11
US62/975,088 2020-02-11
PCT/US2020/019944 WO2020176654A1 (en) 2019-02-27 2020-02-26 Use of caseinolytic protease p function as a biomarker of drug response to imipridone-like agents

Publications (3)

Publication Number Publication Date
JP2022521797A JP2022521797A (ja) 2022-04-12
JP2022521797A5 JP2022521797A5 (enExample) 2023-02-17
JP7709379B2 true JP7709379B2 (ja) 2025-07-16

Family

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Family Applications (1)

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JP2021550133A Active JP7709379B2 (ja) 2019-02-27 2020-02-26 イミプリドン様薬剤に対する薬物反応のバイオマーカとしてのカゼイン分解プロテアーゼｐの機能の使用

Country Status (7)

Country Link
US (1) US12459945B2 (enExample)
EP (1) EP3930714A4 (enExample)
JP (1) JP7709379B2 (enExample)
CN (2) CN113795251B (enExample)
AU (2) AU2020228047B2 (enExample)
CA (1) CA3131740A1 (enExample)
WO (1) WO2020176654A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230339947A1 (en) * 2019-02-27 2023-10-26 Madera Therapeutics, LLC Use of caseinolytic protease p function as a biomarker of drug response to imipridone-like agents
CN117580578A (zh) * 2021-05-13 2024-02-20 奇默里克斯公司 用于复发性原发性cns肿瘤的方法及用途
CN115611896A (zh) * 2021-07-16 2023-01-17 中国药科大学 含四氢萘啶酮或四氢吡啶并嘧啶酮骨架的化合物及其制备方法与制药用途
CN119997956A (zh) * 2022-08-05 2025-05-13 奇默里克斯公司 药物组合物及其用于治疗胶质瘤的用途
CN118724903A (zh) * 2023-03-31 2024-10-01 苏州安赛隆医药科技有限公司 并环结构化合物、其制备方法及其用途以及药物组合物及其用途
CN119039287A (zh) * 2023-05-29 2024-11-29 中国药科大学 一类四氢吡啶并嘧啶酮衍生物及其制备方法与应用
EP4488279A1 (en) * 2023-07-03 2025-01-08 Centro Atlantico del Medicamento S.A (Ceamed, S.A) Substituted hexahydro-2h-pyrazino[1,2-a]pyrazin-1(6h)-one derivatives as activators of human caseinolytic protease p (hsclpp)
CN121816351A (zh) * 2023-07-10 2026-04-07 苏州安赛隆医药科技有限公司 人源酪蛋白水解蛋白酶p激动剂及其用途
CN119306718A (zh) * 2023-07-11 2025-01-14 中科中山药物创新研究院 一种咪唑并吡啶并嘧啶酮类化合物及其制备方法和应用

Citations (2)

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JP2010524941A (ja) 2007-04-20 2010-07-22 シェーリング コーポレイション ピリミジノン誘導体およびそれらの使用方法
JP2022520997A (ja) 2019-02-22 2022-04-04 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム イミプリドンを使用する方法

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US5525464A (en) 1987-04-01 1996-06-11 Hyseq, Inc. Method of sequencing by hybridization of oligonucleotide probes
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
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US20230339947A1 (en) * 2019-02-27 2023-10-26 Madera Therapeutics, LLC Use of caseinolytic protease p function as a biomarker of drug response to imipridone-like agents

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JP2010524941A (ja) 2007-04-20 2010-07-22 シェーリング コーポレイション ピリミジノン誘導体およびそれらの使用方法
JP2022520997A (ja) 2019-02-22 2022-04-04 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム イミプリドンを使用する方法

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Also Published As

Publication number Publication date
US20220089596A1 (en) 2022-03-24
AU2020228047A1 (en) 2021-09-30
CN121758447A (zh) 2026-03-31
EP3930714A1 (en) 2022-01-05
CN113795251A (zh) 2021-12-14
WO2020176654A8 (en) 2020-10-08
EP3930714A4 (en) 2022-10-26
WO2020176654A1 (en) 2020-09-03
AU2026201069A1 (en) 2026-03-12
US12459945B2 (en) 2025-11-04
CN113795251B (zh) 2026-01-13
AU2020228047B2 (en) 2025-11-20
CA3131740A1 (en) 2020-09-03
JP2022521797A (ja) 2022-04-12

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