JP7702878B2 - Ｃａｓ９／ｒｎｐおよびａａｖウイルスの組み合わせを使用したがん免疫療法のための、キメラ抗原受容体（ｃａｒ）－初代ｎｋ細胞の生成 - Google Patents

Ｃａｓ９／ｒｎｐおよびａａｖウイルスの組み合わせを使用したがん免疫療法のための、キメラ抗原受容体（ｃａｒ）－初代ｎｋ細胞の生成 Download PDF

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JP7702878B2
JP7702878B2 JP2021557392A JP2021557392A JP7702878B2 JP 7702878 B2 JP7702878 B2 JP 7702878B2 JP 2021557392 A JP2021557392 A JP 2021557392A JP 2021557392 A JP2021557392 A JP 2021557392A JP 7702878 B2 JP7702878 B2 JP 7702878B2
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cells
cell
transgene
aav
cas9
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リー，ディーン，アンソニー
マイヤー，キャスリン，クリスティン
カラロウディ，メイサム，ナエイミ
リキーテ，シビ
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Nationwide Childrens Hospital Inc
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • A—HUMAN NECESSITIES
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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JP2021557392A 2019-03-27 2020-03-27 Ｃａｓ９／ｒｎｐおよびａａｖウイルスの組み合わせを使用したがん免疫療法のための、キメラ抗原受容体（ｃａｒ）－初代ｎｋ細胞の生成 Active JP7702878B2 (ja)

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JP2025106768A JP2025160172A (ja) 2019-03-27 2025-06-24 Ｃａｓ９／ｒｎｐおよびａａｖウイルスの組み合わせを使用したがん免疫療法のための、キメラ抗原受容体（ｃａｒ）－初代ｎｋ細胞の生成

Applications Claiming Priority (3)

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US201962825007P 2019-03-27 2019-03-27
US62/825,007 2019-03-27
PCT/US2020/025454 WO2020198675A1 (en) 2019-03-27 2020-03-27 Generation of chimeric antigen receptor (car)-primary nk cells for cancer immunotherapy using a combination of cas9/rnp and aav viruses

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JP2025106768A Division JP2025160172A (ja) 2019-03-27 2025-06-24 Ｃａｓ９／ｒｎｐおよびａａｖウイルスの組み合わせを使用したがん免疫療法のための、キメラ抗原受容体（ｃａｒ）－初代ｎｋ細胞の生成

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JP2022527709A JP2022527709A (ja) 2022-06-03
JP2022527709A5 JP2022527709A5 (https=) 2023-03-31
JP7702878B2 true JP7702878B2 (ja) 2025-07-04

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JP2021557392A Active JP7702878B2 (ja) 2019-03-27 2020-03-27 Ｃａｓ９／ｒｎｐおよびａａｖウイルスの組み合わせを使用したがん免疫療法のための、キメラ抗原受容体（ｃａｒ）－初代ｎｋ細胞の生成
JP2025106768A Pending JP2025160172A (ja) 2019-03-27 2025-06-24 Ｃａｓ９／ｒｎｐおよびａａｖウイルスの組み合わせを使用したがん免疫療法のための、キメラ抗原受容体（ｃａｒ）－初代ｎｋ細胞の生成

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US (1) US20220177917A1 (https=)
EP (1) EP3946432A4 (https=)
JP (2) JP7702878B2 (https=)
KR (1) KR20220017887A (https=)
CN (1) CN113891727A (https=)
AU (1) AU2020248097A1 (https=)
BR (1) BR112021019180A2 (https=)
CA (1) CA3135198A1 (https=)
CO (1) CO2021014353A2 (https=)
IL (1) IL286701A (https=)
MX (1) MX2021011782A (https=)
PH (1) PH12021552383A1 (https=)
SG (1) SG11202110613SA (https=)
WO (1) WO2020198675A1 (https=)

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US12473336B2 (en) 2018-02-21 2025-11-18 Board Of Regents, The University Of Texas System Methods for activation and expansion of natural killer cells and uses thereof
MX2023004811A (es) * 2020-10-26 2023-06-29 Res Institute At Nationwide Children´S Hospital Células nk del receptor de antígeno quimérico (car) y usos de las mismas.
WO2022236174A1 (en) * 2021-05-07 2022-11-10 Washington University In situ car-t therapies, vectors and methods therefor
US20240254445A1 (en) * 2021-06-01 2024-08-01 Vaxcell-Bio Composition containing feeder cell for proliferating natural killer cell

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WO2018081470A1 (en) 2016-10-27 2018-05-03 Intima Bioscience, Inc. Viral methods of making genetically modified cells
WO2019005957A1 (en) 2017-06-30 2019-01-03 Precision Biosciences, Inc. GENETICALLY MODIFIED T CELLS COMPRISING A MODIFIED INTRON IN THE ALPHA T CELL RECEPTOR GENE

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JP7103750B2 (ja) * 2013-12-12 2022-07-20 ザ・ブロード・インスティテュート・インコーポレイテッド ゲノム編集のためのＣＲＩＳＰＲ－Ｃａｓ系及び組成物の送達、使用及び治療適用
SG10201913782UA (en) * 2014-07-21 2020-03-30 Novartis Ag Treatment of cancer using a cll-1 chimeric antigen receptor
AU2015330699B2 (en) * 2014-10-10 2021-12-02 Editas Medicine, Inc. Compositions and methods for promoting homology directed repair
BR112017024514A2 (pt) * 2015-05-16 2018-07-24 Genzyme Corporation edição genética de mutações intrônicas profundas
CN108026526B (zh) * 2015-06-09 2023-05-12 爱迪塔斯医药公司 用于改善移植的crispr/cas相关方法和组合物
CN109715801B (zh) * 2015-12-01 2022-11-01 克里斯普治疗股份公司 用于治疗α1抗胰蛋白酶缺乏的材料和方法
US11655275B2 (en) * 2017-05-03 2023-05-23 Sangamo Therapeutics, Inc. Methods and compositions for modification of a cystic fibrosis transmembrane conductance regulator (CFTR) gene

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018081470A1 (en) 2016-10-27 2018-05-03 Intima Bioscience, Inc. Viral methods of making genetically modified cells
WO2019005957A1 (en) 2017-06-30 2019-01-03 Precision Biosciences, Inc. GENETICALLY MODIFIED T CELLS COMPRISING A MODIFIED INTRON IN THE ALPHA T CELL RECEPTOR GENE

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JP2025160172A (ja) 2025-10-22
IL286701A (en) 2021-10-31
KR20220017887A (ko) 2022-02-14
AU2020248097A1 (en) 2021-11-18
MX2021011782A (es) 2021-12-10
EP3946432A1 (en) 2022-02-09
CO2021014353A2 (es) 2022-01-17
US20220177917A1 (en) 2022-06-09
CN113891727A (zh) 2022-01-04
PH12021552383A1 (en) 2022-06-13
JP2022527709A (ja) 2022-06-03
BR112021019180A2 (pt) 2022-03-03
WO2020198675A1 (en) 2020-10-01
EP3946432A4 (en) 2023-04-05
SG11202110613SA (en) 2021-10-28
CA3135198A1 (en) 2020-10-01

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