JP7683882B2 - ストレスに対するセロトニン４受容体アゴニストの予防的有効性 - Google Patents

ストレスに対するセロトニン４受容体アゴニストの予防的有効性 Download PDF

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JP7683882B2
JP7683882B2 JP2021560628A JP2021560628A JP7683882B2 JP 7683882 B2 JP7683882 B2 JP 7683882B2 JP 2021560628 A JP2021560628 A JP 2021560628A JP 2021560628 A JP2021560628 A JP 2021560628A JP 7683882 B2 JP7683882 B2 JP 7683882B2
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JP2022527865A5 (https=
JP2022527865A (ja
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デニー，クリスティン，エー．
ガーディアー，アラン，エム．
デイビッド，デニス，ジェイ．
メンデス－デイビッド，インディラ
フェイ，シャーリーン
チェン，ブリアナ，ケイ．
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Columbia University in the City of New York
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Columbia University in the City of New York
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2021560628A 2019-04-09 2020-04-08 ストレスに対するセロトニン４受容体アゴニストの予防的有効性 Active JP7683882B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962831517P 2019-04-09 2019-04-09
US62/831,517 2019-04-09
US201962857075P 2019-06-04 2019-06-04
US62/857,075 2019-06-04
US201962910859P 2019-10-04 2019-10-04
US62/910,859 2019-10-04
PCT/US2020/027321 WO2020210393A1 (en) 2019-04-09 2020-04-08 Prophylactic efficacy of serotonin 4 receptor agonists against stress

Publications (3)

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JP2022527865A JP2022527865A (ja) 2022-06-06
JP2022527865A5 JP2022527865A5 (https=) 2023-04-13
JP7683882B2 true JP7683882B2 (ja) 2025-05-27

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JP2021560628A Active JP7683882B2 (ja) 2019-04-09 2020-04-08 ストレスに対するセロトニン４受容体アゴニストの予防的有効性

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Country Link
US (1) US20220031684A1 (https=)
EP (1) EP3952852A4 (https=)
JP (1) JP7683882B2 (https=)
CN (1) CN113924087A (https=)
AU (1) AU2020271839B2 (https=)
CA (1) CA3136328A1 (https=)
MX (1) MX2021012394A (https=)
WO (1) WO2020210393A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7821116B2 (ja) * 2020-04-07 2026-02-26 ザ トラスティーズ オブ コロンビア ユニバーシティー イン ザ シティー オブ ニューヨーク ストレス誘導性恐怖、うつ様行動および不安様行動の予防のための組成物および方法
EP4577305A2 (en) * 2022-08-25 2025-07-02 1/1The Trustees Of Columbia University In The City Of New York Compositions and methods for the treatment of alzheimer's disease and other neurogenerative disease
CN118105081B (zh) * 2024-03-04 2025-02-11 天津大学 一种情绪状态与神经电生理状态调节装置、验证系统及方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090170899A1 (en) 2004-09-14 2009-07-02 Guy Debonnel Stimulators of 5-HT4 receptors and uses thereof
US20180325844A1 (en) 2015-11-17 2018-11-15 The Trusttees of Columbia University in the City of New York Pharmacological prophylactics against stress-induced affective disorders and their associated symptoms

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2846559B1 (fr) * 2002-10-31 2007-06-15 Centre Nat Rech Scient Composition pharmaceutique pour la preparation d'un medicament destine a traiter et/ou a prevenir une pathologie liee a une conduite obsessionnelle
EP2640398A4 (en) 2010-11-18 2014-05-14 White Mountain Pharma Inc METHOD FOR TREATING CHRONIC OR BZW. NON-RELIABLE PAIN AND / OR INCREASE OF PATIENT PAIN THRESHOLD AND PHARMACEUTICAL COMPOSITION FOR USE THEREOF

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090170899A1 (en) 2004-09-14 2009-07-02 Guy Debonnel Stimulators of 5-HT4 receptors and uses thereof
US20180325844A1 (en) 2015-11-17 2018-11-15 The Trusttees of Columbia University in the City of New York Pharmacological prophylactics against stress-induced affective disorders and their associated symptoms

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Guillaume Lucas et al.，Serotonin4 (5-HT4) Receptor Agonists Are Putative Antidepressants with a Rapid Onset of Action，Neuron，2007年，Vol.55, No.5，Pages 712-725
Jaclyn N. Highland et al.，Group II metabotropic glutamate receptor blockade promotes stress resilience in mice，Neuropsychopharmacology，2019年04月02日，Vol.44, No.10，Pages 1788-1796

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CA3136328A1 (en) 2020-10-15
AU2020271839B2 (en) 2025-04-24
US20220031684A1 (en) 2022-02-03
EP3952852A1 (en) 2022-02-16
MX2021012394A (es) 2022-01-19
CN113924087A (zh) 2022-01-11
WO2020210393A1 (en) 2020-10-15
EP3952852A4 (en) 2023-01-04
JP2022527865A (ja) 2022-06-06
AU2020271839A1 (en) 2021-11-04

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