JP7675502B2 - アルツハイマー病の治療用組成物および治療方法 - Google Patents
アルツハイマー病の治療用組成物および治療方法 Download PDFInfo
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- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- C12N9/0004—Oxidoreductases (1.)
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- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/99—Miscellaneous (1.14.99)
- C12Y114/99038—Cholesterol 25-hydroxylase (1.14.99.38)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022143550A JP2022174207A (ja) | 2017-05-16 | 2022-09-09 | アルツハイマー病の治療用組成物および治療方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762506782P | 2017-05-16 | 2017-05-16 | |
| US62/506,782 | 2017-05-16 | ||
| PCT/US2018/031901 WO2018213081A1 (en) | 2017-05-16 | 2018-05-09 | Compositions and methods for treating alzheimer's disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022143550A Division JP2022174207A (ja) | 2017-05-16 | 2022-09-09 | アルツハイマー病の治療用組成物および治療方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020520931A JP2020520931A (ja) | 2020-07-16 |
| JP7675502B2 true JP7675502B2 (ja) | 2025-05-13 |
Family
ID=64274628
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019563786A Active JP7675502B2 (ja) | 2017-05-16 | 2018-05-09 | アルツハイマー病の治療用組成物および治療方法 |
| JP2022143550A Pending JP2022174207A (ja) | 2017-05-16 | 2022-09-09 | アルツハイマー病の治療用組成物および治療方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022143550A Pending JP2022174207A (ja) | 2017-05-16 | 2022-09-09 | アルツハイマー病の治療用組成物および治療方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11873321B2 (https=) |
| EP (1) | EP3628008A4 (https=) |
| JP (2) | JP7675502B2 (https=) |
| KR (1) | KR20200010311A (https=) |
| CN (2) | CN111132694B (https=) |
| AU (1) | AU2018270906B2 (https=) |
| CA (1) | CA3063217A1 (https=) |
| TW (1) | TW201900216A (https=) |
| WO (1) | WO2018213081A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200010311A (ko) * | 2017-05-16 | 2020-01-30 | 제네로스 바이오파마 리미티드 | 알츠하이머병의 치료를 위한 조성물 및 방법 |
| CN111500694B (zh) * | 2019-01-31 | 2023-02-24 | 中国科学院脑科学与智能技术卓越创新中心 | Baz2b基因作为靶点在缓解衰老中的应用 |
| JP2023521646A (ja) * | 2020-03-31 | 2023-05-25 | ウィルフレッド ジェフリーズ | アルツハイマー病の治療方法 |
| CA3259413A1 (en) * | 2022-06-13 | 2023-12-21 | The University Of Queensland | USES OF JAK INHIBITORS IN THE MANAGEMENT OF DEPRESSION AND CENTRAL NERVOUS SYSTEM (CNS) DISEASES ASSOCIATED WITH INFLAMMATION |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7285526B2 (en) * | 1995-07-14 | 2007-10-23 | Meiogen Biotechnology Corporation | Interferon antagonists useful for the treatment of interferon related diseases |
| US20020188012A1 (en) * | 1998-01-28 | 2002-12-12 | Bisgaier Charles Larry | Method for treating Alzheimer's disease |
| US20060275294A1 (en) | 2002-08-22 | 2006-12-07 | Omoigui Osemwota S | Method of prevention and treatment of aging, age-related disorders and/or age-related manifestations including atherosclerosis, peripheral vascular disease, coronary artery disease, osteoporosis, arthritis, type 2 diabetes, dementia, alzheimers disease and cancer |
| US8771700B2 (en) * | 2006-08-23 | 2014-07-08 | Rutgers, The State University Of New Jersey | Interferon antagonists, antibodies thereto and associated methods of use |
| US9272029B2 (en) * | 2009-03-26 | 2016-03-01 | Ibc Pharmaceuticals, Inc. | Interferon lambada-antibody complexes |
| US9987224B2 (en) * | 2011-02-04 | 2018-06-05 | Joseph E. Kovarik | Method and system for preventing migraine headaches, cluster headaches and dizziness |
| EP3140403A4 (en) * | 2014-05-09 | 2017-12-20 | Université Laval | Prevention and treatment of alzheimer's disease by genome editing using the crispr/cas system |
| ES2731437T3 (es) * | 2014-11-21 | 2019-11-15 | Regeneron Pharma | Métodos y composiciones para la modificación genética dirigida mediante el uso de pares de ARN guías |
| KR20200010311A (ko) * | 2017-05-16 | 2020-01-30 | 제네로스 바이오파마 리미티드 | 알츠하이머병의 치료를 위한 조성물 및 방법 |
-
2018
- 2018-05-09 KR KR1020197036561A patent/KR20200010311A/ko not_active Ceased
- 2018-05-09 AU AU2018270906A patent/AU2018270906B2/en active Active
- 2018-05-09 WO PCT/US2018/031901 patent/WO2018213081A1/en not_active Ceased
- 2018-05-09 JP JP2019563786A patent/JP7675502B2/ja active Active
- 2018-05-09 CN CN201880045403.4A patent/CN111132694B/zh active Active
- 2018-05-09 US US16/613,264 patent/US11873321B2/en active Active
- 2018-05-09 CA CA3063217A patent/CA3063217A1/en active Pending
- 2018-05-09 EP EP18802949.0A patent/EP3628008A4/en active Pending
- 2018-05-09 CN CN202411664773.XA patent/CN119488598A/zh active Pending
- 2018-05-16 TW TW107116606A patent/TW201900216A/zh unknown
-
2022
- 2022-09-09 JP JP2022143550A patent/JP2022174207A/ja active Pending
Non-Patent Citations (17)
| Title |
|---|
| Balschun, D. et al., Interleukin-6: a cytokine to forget, The FASEB Journal, 2004, 発行日, Vol.18, No.14, p.1788-1790 |
| Browne, T. C. et al., IFN-γ Production by amyloid β-specific Th1 cells promotes microglial activation and increases plaq, The Journal of Immunology, 2013, 発行日, Vol.190, No.5, p.2241-2251 |
| Devaux, P. et al., The measles virus phosphoprotein interacts with the linker domain of STAT1, Virology, 2013, 発行日, Vol.444, No.1-2, p.250-256 |
| Elcioglu, H. K. et al., Tocilizumab's effect on cognitive deficits induced by intracerebroventricular administration of stre, Molecular and Cellular Biochemistry, 2016, 発行日, Vol.420, No.1-2, p.21-28 |
| Fassbender, K. et al., Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta, Proceedings of the National Academy of Sciences of the United States of America, 2001, 発行日, Vol.98, No.10, p.5856-5861 |
| Hsu, W. L. et al., STAT1 negatively regulates spatial memory formation and mediates the memory-impairing effect of Aβ, Neuropsychopharmacology, 2014, 発行日, Vol.39, No.3, p.746-758 |
| Jin, P. et al., Anti-inflammatory and anti-amyloidogenic effects of a small molecule, 2,4-bis(p-hydroxyphenyl)-2-but, Journal of Neuroinflammation, 2013, 発行日, 10:2 |
| Matsumiya, T., Imaizumi, T., How are STAT1 and cholesterol metabolism associated in antiviral responses?, JAK-STAT, 2013, Vol.2,No.3, e24189, doi: 10.4161/jkst.24189 |
| Murlidharan, G. et al., CNS-restricted Transduction and CRISPR/Cas9-mediated Gene Deletion with an Engineered AAV Vector, Molecular Therapy. Nucleic Acids, 2016, 発行日, Vol.5, No.7, e338 |
| Papassotiropoulos, A. et al., Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's disea, Neurodegenerative Diseases, 2005, 発行日, Vol.2, No.5, p.233-241 |
| Park, W. et al., New perspectives of curcumin in cancer prevention, Cancer Prevention Research, 2013, 発行日, Vol.6, No.5, p.387-400 |
| Peng, L. et al., Molecular basis for antagonistic activity of anifrolumab, an anti-interferon-α receptor 1 antibody, mAbs, 2015, 発行日, Vol.7, No.2, p.428-439 |
| Taylor, J. M. et al., Type-1 interferon signaling mediates neuro-inflammatory events in models of Alzheimer's disease, Neurobiology of Aging, 2014, 発行日, Vol.35, No.5, p.1012-1023 |
| Wu, Y. Y. et al., Alterations of the Neuroinflammatory Markers IL-6 and TRAIL in Alzheimer's Disease, Dementia and Geriatric Cognitive Disorders Extra, 2015, 発行日, Vol.5, No.3, p.424-434 |
| Zhang, Y. Y. et al., Atorvastatin attenuates the production of IL-1β, IL-6, and TNF-α in the hippocampus of an amyloid, Clinical Interventions in Aging, 2013, 発行日, Vol.8, p.103-110 |
| 天野 宏一, 臨床リウマチ医のための基礎講座 JAKとリウマチ性疾患, 臨床リウマチ, 2014, 発行日, 第26巻, 第4号, p.330-332 |
| 小野 賢二郎, 山田 正仁, Aβ凝集機序とその制御(解説), 医学のあゆみ, 2009, 発行日, 第229巻, 第5号, p.405-408 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3628008A4 (en) | 2021-04-28 |
| KR20200010311A (ko) | 2020-01-30 |
| CN119488598A (zh) | 2025-02-21 |
| JP2022174207A (ja) | 2022-11-22 |
| AU2018270906B2 (en) | 2024-02-29 |
| TW201900216A (zh) | 2019-01-01 |
| CN111132694A (zh) | 2020-05-08 |
| AU2018270906A1 (en) | 2019-12-19 |
| EP3628008A1 (en) | 2020-04-01 |
| US11873321B2 (en) | 2024-01-16 |
| CA3063217A1 (en) | 2018-11-22 |
| US20200199239A1 (en) | 2020-06-25 |
| CN111132694B (zh) | 2024-12-03 |
| WO2018213081A1 (en) | 2018-11-22 |
| JP2020520931A (ja) | 2020-07-16 |
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