JP7669396B2 - 骨髄増殖性腫瘍の治療のための、ルキソリチニブとｉｎｃｂ０５７６４３との組合わせ - Google Patents

骨髄増殖性腫瘍の治療のための、ルキソリチニブとｉｎｃｂ０５７６４３との組合わせ Download PDF

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JP7669396B2
JP7669396B2 JP2022574520A JP2022574520A JP7669396B2 JP 7669396 B2 JP7669396 B2 JP 7669396B2 JP 2022574520 A JP2022574520 A JP 2022574520A JP 2022574520 A JP2022574520 A JP 2022574520A JP 7669396 B2 JP7669396 B2 JP 7669396B2
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acceptable salt
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pyrrolo
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JP2023529365A (ja
JP2023529365A5 (https=
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シュトゥブス，マシュー
シー リウ，フィリップ
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Incyte Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2022574520A 2020-06-03 2020-09-14 骨髄増殖性腫瘍の治療のための、ルキソリチニブとｉｎｃｂ０５７６４３との組合わせ Active JP7669396B2 (ja)

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JP2025067272A JP2025111539A (ja) 2020-06-03 2025-04-16 骨髄増殖性腫瘍の治療のための、ルキソリチニブとｉｎｃｂ０５７６４３との組合わせ

Applications Claiming Priority (3)

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US202063034214P 2020-06-03 2020-06-03
US63/034,214 2020-06-03
PCT/US2020/050753 WO2021247064A1 (en) 2020-06-03 2020-09-14 Combination of ruxolitinib with incb057643 for treatment of myeloproliferative neoplasms

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JP2025067272A Division JP2025111539A (ja) 2020-06-03 2025-04-16 骨髄増殖性腫瘍の治療のための、ルキソリチニブとｉｎｃｂ０５７６４３との組合わせ

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JP2023529365A JP2023529365A (ja) 2023-07-10
JP2023529365A5 JP2023529365A5 (https=) 2023-09-22
JP7669396B2 true JP7669396B2 (ja) 2025-04-28

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JP2022574520A Active JP7669396B2 (ja) 2020-06-03 2020-09-14 骨髄増殖性腫瘍の治療のための、ルキソリチニブとｉｎｃｂ０５７６４３との組合わせ
JP2025067272A Pending JP2025111539A (ja) 2020-06-03 2025-04-16 骨髄増殖性腫瘍の治療のための、ルキソリチニブとｉｎｃｂ０５７６４３との組合わせ

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KR (1) KR20230031242A (https=)
CN (1) CN115835868A (https=)
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CL (1) CL2022003409A1 (https=)
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Families Citing this family (3)

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MX2023009858A (es) * 2021-02-25 2023-09-12 Impact Biomedicines Inc Uso de inhibidores de proteina de bromodominio y motivo extraterminal (bet) solo o en combinacion con fedratinib o ruxolitinib como tratamiento para una malignidad hematologica tal como la mielofibrosis.
WO2024039883A2 (en) * 2022-08-19 2024-02-22 Translational Drug Development Llc Compositions and methods to treat myeloproliferative disorders and myeloproliferative neoplasms
AU2024306742A1 (en) * 2023-06-28 2025-12-04 Active Biotech Ab Quinoline carboxamides for use in the treatment of mpn

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019524660A (ja) 2016-06-20 2019-09-05 インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ Ｂｅｔ阻害剤の結晶固体形態

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KR100786927B1 (ko) 2000-06-28 2007-12-17 스미스클라인비이참피이엘시이 습식 분쇄방법
SG10202003901UA (en) 2005-12-13 2020-05-28 Incyte Holdings Corp Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors
KR20150036210A (ko) 2007-06-13 2015-04-07 인사이트 코포레이션 야누스 키나제 억제제（Ｒ）―３―（４―（７Ｈ―피롤로［２，３－ｄ］피리미딘―4―일）―1Ｈ―피라졸―1―일）―３―사이클로펜틸프로판니트릴의 염
PL3134403T3 (pl) * 2014-04-23 2020-07-13 Incyte Corporation 1H-pirolo[2,3-c]pirydyn-7(6H)-ony i pirazolo[3,4-c]pirydyn-7(6H)-ony jako inhibitory białek BET

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019524660A (ja) 2016-06-20 2019-09-05 インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ Ｂｅｔ阻害剤の結晶固体形態

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FALCHOOK G et al.，Clinical Cancer Research，2020年03月，Vol. 26，No. 6，pp.1247-1257.

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IL298200A (en) 2023-01-01
LT4161528T (lt) 2026-02-10
SI4161528T1 (sl) 2026-01-30
EP4691563A2 (en) 2026-02-11
JP2023529365A (ja) 2023-07-10
PH12022553276A1 (en) 2024-02-19
EP4161528A1 (en) 2023-04-12
CN115835868A (zh) 2023-03-21
FI4161528T3 (fi) 2025-12-12
MX2022015220A (es) 2023-03-08
WO2021247064A1 (en) 2021-12-09
RS67440B1 (sr) 2025-12-31
DK4161528T3 (da) 2025-11-24
HRP20251457T1 (hr) 2026-01-02
PT4161528T (pt) 2026-01-23
SMT202600021T1 (it) 2026-03-09
CL2022003409A1 (es) 2023-05-26
ES3058891T3 (en) 2026-03-13
AU2020451061A1 (en) 2022-12-15
CA3184633A1 (en) 2021-12-09
EP4691563A3 (en) 2026-04-01
KR20230031242A (ko) 2023-03-07
JP2025111539A (ja) 2025-07-30
MD4161528T2 (ro) 2026-03-31
PL4161528T3 (pl) 2026-03-16
MA59868B1 (fr) 2025-11-28
EP4161528B1 (en) 2025-11-05

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