JP7661319B2 - 軟骨形成ヒト間葉系幹細胞（ｍｓｃ）シート - Google Patents

軟骨形成ヒト間葉系幹細胞（ｍｓｃ）シート Download PDF

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JP7661319B2
JP7661319B2 JP2022520865A JP2022520865A JP7661319B2 JP 7661319 B2 JP7661319 B2 JP 7661319B2 JP 2022520865 A JP2022520865 A JP 2022520865A JP 2022520865 A JP2022520865 A JP 2022520865A JP 7661319 B2 JP7661319 B2 JP 7661319B2
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chondrogenic
cell
cell sheet
sheets
cartilage
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JP2022550911A5 (cg-RX-API-DMAC7.html
JP2022550911A (ja
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光夫 岡野
キム，キュンソク
ソープ，ハリー
ダブリュ． グレイガー，デイビッド
マーク，トラヴィス
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UNIVERSITY OF UTHA RESEARCHFOUNDATION
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3612—Cartilage, synovial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633—Extracellular matrix [ECM]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/3654—Cartilage, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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    • C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
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JP2022520865A 2019-10-07 2020-10-07 軟骨形成ヒト間葉系幹細胞（ｍｓｃ）シート Active JP7661319B2 (ja)

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US201962911441P 2019-10-07 2019-10-07
US62/911,441 2019-10-07
PCT/US2020/054477 WO2021071875A1 (en) 2019-10-07 2020-10-07 Chondrogenic human mesenchymal stem cell (msc) sheets

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CN115197904B (zh) * 2022-06-22 2024-09-03 广东省科学院生物与医学工程研究所 一种骨修复材料体外评价模型

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007528706A (ja) 2003-06-27 2007-10-18 エチコン、インコーポレイテッド 分娩後由来細胞を用いた軟骨と骨の修復と再生
JP2007528756A (ja) 2003-08-01 2007-10-18 憲正 中村 スキャフォールドフリー自己組織性三次元人工組織（Ｓｃａｆｆｏｌｄ−ｆｒｅｅＳｅｌｆ−Ｏｒｇａｎｉｚｅｄ３Ｄｓｙｎｔｈｅｔｉｃｔｉｓｓｕｅ）
JP2016140308A (ja) 2015-02-02 2016-08-08 高木　睦 間葉系幹細胞を用いた軟骨様シート作成方法
WO2018067175A1 (en) 2016-10-07 2018-04-12 Cytori Therapetics, Inc. Regenerative cell therapy for musculoskeletal disorders

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007528706A (ja) 2003-06-27 2007-10-18 エチコン、インコーポレイテッド 分娩後由来細胞を用いた軟骨と骨の修復と再生
JP2007528756A (ja) 2003-08-01 2007-10-18 憲正 中村 スキャフォールドフリー自己組織性三次元人工組織（Ｓｃａｆｆｏｌｄ−ｆｒｅｅＳｅｌｆ−Ｏｒｇａｎｉｚｅｄ３Ｄｓｙｎｔｈｅｔｉｃｔｉｓｓｕｅ）
JP2016140308A (ja) 2015-02-02 2016-08-08 高木　睦 間葉系幹細胞を用いた軟骨様シート作成方法
WO2018067175A1 (en) 2016-10-07 2018-04-12 Cytori Therapetics, Inc. Regenerative cell therapy for musculoskeletal disorders

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ITOKAZU, M. et al.，Transplantation of Scaffold-Free Cartilage-Like Cell-Sheets Made from Human Bone Marrow Mesenchymal Stem Cells for Cartilage Repair: A Preclinical Study，Cartilage，米国，SAGE Publications，2016年10月，7 (4)，361-372
SATO, Y. et al，Xeno-free and shrinkage-free preparation of scaffold-free cartilage-like disc-shaped cell sheet using human bone marrow mesenchymal stem cells，J Biosci Bioeng，NL，Elsevier，2013年12月，116 (6)，734-739
SEKINE, W. et al.，Chondrocyte Differentiation of Human Endometrial Gland-Derived MSCs in Layered Cell Sheets，Scientific World Journal，米国，Hindawi Publishing Corporation，2013年11月18日，2013 (359109)，1-7

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US20240052313A1 (en) 2024-02-15
EP4041260A1 (en) 2022-08-17
KR20220080145A (ko) 2022-06-14
WO2021071875A1 (en) 2021-04-15
EP4041260A4 (en) 2023-11-01
JP2022550911A (ja) 2022-12-05

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