JP7658902B2 - Ｐｄ－ｌ１に特異的な二環式ペプチドリガンド - Google Patents
Ｐｄ－ｌ１に特異的な二環式ペプチドリガンド Download PDFInfo
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- JP7658902B2 JP7658902B2 JP2021536064A JP2021536064A JP7658902B2 JP 7658902 B2 JP7658902 B2 JP 7658902B2 JP 2021536064 A JP2021536064 A JP 2021536064A JP 2021536064 A JP2021536064 A JP 2021536064A JP 7658902 B2 JP7658902 B2 JP 7658902B2
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Classifications
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- C07K7/04—Linear peptides containing only normal peptide links
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0056—Peptides, proteins, polyamino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70532—B7 molecules, e.g. CD80, CD86
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
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- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
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| GB1820969.2 | 2018-12-21 | ||
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| GB1904622.6 | 2019-04-02 | ||
| GBGB1904622.6A GB201904622D0 (en) | 2019-04-02 | 2019-04-02 | Bicyclic peptide ligands specific for pd-l1 |
| PCT/GB2019/053680 WO2020128527A1 (en) | 2018-12-21 | 2019-12-23 | Bicyclic peptide ligands specific for pd-l1 |
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| JP2022514687A JP2022514687A (ja) | 2022-02-14 |
| JPWO2020128527A5 JPWO2020128527A5 (enExample) | 2022-12-28 |
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| EP (1) | EP3897850A1 (enExample) |
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| SI3215518T1 (sl) | 2014-10-29 | 2021-08-31 | Bicyclerd Limited | Biciklični peptidni ligandi, značilni za MT1-MMP |
| CN111183147B (zh) | 2017-08-04 | 2024-07-05 | 拜斯科技术开发有限公司 | Cd137特异性的双环肽配体 |
| WO2019162682A1 (en) | 2018-02-23 | 2019-08-29 | Bicycletx Limited | Multimeric bicyclic peptide ligands |
| US11180531B2 (en) | 2018-06-22 | 2021-11-23 | Bicycletx Limited | Bicyclic peptide ligands specific for Nectin-4 |
| GB201820325D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for psma |
| GB201820288D0 (en) | 2018-12-13 | 2019-01-30 | Bicycle Tx Ltd | Bicycle peptide ligaands specific for MT1-MMP |
| GB201820295D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for MT1-MMP |
| WO2020128526A1 (en) | 2018-12-21 | 2020-06-25 | Bicycletx Limited | Bicyclic peptide ligands specific for pd-l1 |
| TWI862640B (zh) | 2019-07-30 | 2024-11-21 | 英商拜西可泰克斯有限公司 | 異質雙環肽複合物 |
| AU2022206577A1 (en) | 2021-01-08 | 2023-08-24 | Bicycletx Limited | Heterotandem bicyclic peptide complexes |
| US20250186539A2 (en) | 2021-01-11 | 2025-06-12 | Bicycletx Limited | Methods for treating cancer |
| WO2024261490A1 (en) | 2023-06-23 | 2024-12-26 | Bicycletx Limited | Bicyclic peptide ligands specific for nk cells |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017191460A1 (en) | 2016-05-04 | 2017-11-09 | Bicycle Therapeutics Limited | Bicyclic peptide-toxin conjugates specific for mt1-mmp |
| WO2018133873A1 (zh) | 2017-01-23 | 2018-07-26 | 苏州康宁杰瑞生物科技有限公司 | Pd-l1结合多肽或化合物 |
| WO2018210927A2 (en) | 2017-05-16 | 2018-11-22 | Fastbase Solutions Ltd | Kits, methods and their uses for detecting cell-cell interactions in a sample kits |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040142325A1 (en) * | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
| EP1452868A2 (en) | 2003-02-27 | 2004-09-01 | Pepscan Systems B.V. | Method for selecting a candidate drug compound |
| PL1844337T3 (pl) | 2005-01-24 | 2013-12-31 | Pepscan Systems Bv | Związki wiążące, związki immunogenne i peptydomimetyki |
| ES2509959T5 (en) | 2008-02-05 | 2024-12-19 | Bicyclerd Ltd | Methods and compositions |
| SI3215518T1 (sl) * | 2014-10-29 | 2021-08-31 | Bicyclerd Limited | Biciklični peptidni ligandi, značilni za MT1-MMP |
| KR20200139236A (ko) * | 2018-04-04 | 2020-12-11 | 바이사이클티엑스 리미티드 | 헤테로탠덤 비사이클릭 펩티드 복합체 |
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- 2019-12-23 CN CN201980083299.2A patent/CN113260420A/zh active Pending
- 2019-12-23 JP JP2021536064A patent/JP7658902B2/ja active Active
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017191460A1 (en) | 2016-05-04 | 2017-11-09 | Bicycle Therapeutics Limited | Bicyclic peptide-toxin conjugates specific for mt1-mmp |
| WO2018133873A1 (zh) | 2017-01-23 | 2018-07-26 | 苏州康宁杰瑞生物科技有限公司 | Pd-l1结合多肽或化合物 |
| WO2018210927A2 (en) | 2017-05-16 | 2018-11-22 | Fastbase Solutions Ltd | Kits, methods and their uses for detecting cell-cell interactions in a sample kits |
Non-Patent Citations (1)
| Title |
|---|
| Angew. Chem. Int. Ed.，2014年，53，1602-1606 |
Also Published As
| Publication number | Publication date |
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| JP2022514687A (ja) | 2022-02-14 |
| US20220088207A1 (en) | 2022-03-24 |
| WO2020128527A1 (en) | 2020-06-25 |
| EP3897850A1 (en) | 2021-10-27 |
| CN113260420A (zh) | 2021-08-13 |
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