JP7590962B2 - 皮質興奮性ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物 - Google Patents

皮質興奮性ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物 Download PDF

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JP7590962B2
JP7590962B2 JP2021523074A JP2021523074A JP7590962B2 JP 7590962 B2 JP7590962 B2 JP 7590962B2 JP 2021523074 A JP2021523074 A JP 2021523074A JP 2021523074 A JP2021523074 A JP 2021523074A JP 7590962 B2 JP7590962 B2 JP 7590962B2
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グレイバック，ルーカス・ティー
タシッチ，ボシリカ
デイグル，ターニャ
ティン，ジョナサン
ゼン，ホンクイ
カルムバック，ブライアン・エドワード
ミッチ，ジョン・ケイ
ヘス，エリック
レイン，エドワード・セバスチャン
リーバイ，ボアズ・ピー
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    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

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JP2021523074A 2018-11-05 2019-11-05 皮質興奮性ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物 Active JP7590962B2 (ja)

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JP2024198841A JP7774695B2 (ja) 2018-11-05 2024-11-14 皮質興奮性ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物
JP2025175276A JP2026021360A (ja) 2018-11-05 2025-10-17 皮質興奮性ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201862755988P 2018-11-05 2018-11-05
US62/755,988 2018-11-05
US201962806600P 2019-02-15 2019-02-15
US201962806684P 2019-02-15 2019-02-15
US62/806,600 2019-02-15
US62/806,684 2019-02-15
US201962872021P 2019-07-09 2019-07-09
US62/872,021 2019-07-09
PCT/US2019/059927 WO2020097121A1 (en) 2018-11-05 2019-11-05 Artificial expression constructs for selectively modulating gene expression in excitatory cortical neurons

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JP2022513426A JP2022513426A (ja) 2022-02-08
JPWO2020097121A5 JPWO2020097121A5 (https=) 2022-11-10
JP2022513426A5 JP2022513426A5 (https=) 2022-11-10
JP7590962B2 true JP7590962B2 (ja) 2024-11-27

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JP2021523074A Active JP7590962B2 (ja) 2018-11-05 2019-11-05 皮質興奮性ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物
JP2024198841A Active JP7774695B2 (ja) 2018-11-05 2024-11-14 皮質興奮性ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物
JP2025175276A Pending JP2026021360A (ja) 2018-11-05 2025-10-17 皮質興奮性ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物

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JP2025175276A Pending JP2026021360A (ja) 2018-11-05 2025-10-17 皮質興奮性ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物

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US (2) US20210395780A1 (https=)
EP (1) EP3877529A4 (https=)
JP (3) JP7590962B2 (https=)
AU (2) AU2019375975B2 (https=)
CA (1) CA3118689A1 (https=)
WO (1) WO2020097121A1 (https=)

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EP3923995A4 (en) * 2019-02-15 2023-05-17 Allen Institute ARTIFICIAL EXPRESSION RECOMBINANTS FOR THE SELECTIVE MODULATION OF GENE EXPRESSION IN SELECTED NEURON CELL POPULATIONS
JP7624728B2 (ja) 2019-02-25 2025-01-31 ユニバーシティ オブ マサチューセッツ Ｄｎａ結合ドメイントランスアクチベーター及びその使用
EP4162041A4 (en) * 2020-06-04 2024-10-16 Allen Institute ARTIFICIAL EXPRESSION CONSTRUCTS TO SELECTIVELY MODULATE GENE EXPRESSION IN INHIBITORY NEOCORTICAL NEURONS
WO2022020706A1 (en) * 2020-07-24 2022-01-27 University Of Massachusetts Dna-binding domain transactivators and uses thereof
WO2022036255A1 (en) * 2020-08-14 2022-02-17 Allen Institute Artificial expression constructs for modulating gene expression in striatal neurons
GB202013940D0 (en) 2020-09-04 2020-10-21 Synpromics Ltd Regulatory nucleic acid sequences
EP4244366A4 (en) * 2020-11-10 2024-12-25 Allen Institute Artificial expression constructs for modulating gene expression in chandelier cells
WO2022155358A1 (en) * 2021-01-13 2022-07-21 Duke University Compositions for and methods of improving fluid flux in the brain
US20240182923A1 (en) * 2021-03-30 2024-06-06 Allen Institute Artificial expression constructs for modulating gene expression in claustrum neurons
US20240254514A1 (en) * 2021-05-21 2024-08-01 Allen Institute Artificial expression constructs for modulating gene expression in neurons within the thalamus
CN113736734B (zh) * 2021-09-23 2022-10-25 中山大学中山眼科中心 一种用于灵长类动物神经元分离的试剂盒及方法
WO2023108021A1 (en) * 2021-12-07 2023-06-15 Allen Institute Artificial expression constructs for modulating gene expression in neocortical layer 4 or layer 5 intratelencephalic neurons
US20250163458A1 (en) * 2022-02-24 2025-05-22 Allen Institute Artificial expression constructs for modulating gene expression in dopaminergic neurons
CN114752624B (zh) * 2022-04-08 2025-04-15 中国海洋大学 一种侏儒蛤卵子的电穿孔方法
WO2024011224A2 (en) * 2022-07-08 2024-01-11 The Trustees Of Columbia University In The City Of New York Regulatory element for cell type specific expression of genes in spinal motor neurons
WO2024238448A2 (en) * 2023-05-12 2024-11-21 Temple University - Of The Commonwealth System Of Higher Education Chimeric capsid recombinant adeno-associated virus with bbb penetration and microglia targeting (aav-bm)
CN117346715B (zh) * 2023-12-04 2024-03-08 成都深瑞同华科技有限公司 一种配电网架空线路弧垂测定方法、系统及存储介质

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JP2026021360A (ja) 2026-02-10
AU2025242185A1 (en) 2025-10-30
WO2020097121A1 (en) 2020-05-14
JP2025024092A (ja) 2025-02-19
US20250236886A1 (en) 2025-07-24
US20210395780A1 (en) 2021-12-23
AU2019375975B2 (en) 2025-07-10
EP3877529A4 (en) 2023-01-25
AU2019375975A1 (en) 2021-06-17
CA3118689A1 (en) 2020-05-14
EP3877529A1 (en) 2021-09-15
JP7774695B2 (ja) 2025-11-21
JP2022513426A (ja) 2022-02-08

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