JP7590952B2 - 遺伝子編集の高特異性を達成する方法 - Google Patents

遺伝子編集の高特異性を達成する方法 Download PDF

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JP7590952B2
JP7590952B2 JP2021500866A JP2021500866A JP7590952B2 JP 7590952 B2 JP7590952 B2 JP 7590952B2 JP 2021500866 A JP2021500866 A JP 2021500866A JP 2021500866 A JP2021500866 A JP 2021500866A JP 7590952 B2 JP7590952 B2 JP 7590952B2
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template
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ジウー ワン，
アンドリュー エム． チャマス，
アレクサンダー ウォード，
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アリール バイオテクノロジー アンド ファーマシューティカルズ， インコーポレイテッド
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites

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JP2021500866A 2018-07-13 2019-07-12 遺伝子編集の高特異性を達成する方法 Active JP7590952B2 (ja)

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US201862697955P 2018-07-13 2018-07-13
US62/697,955 2018-07-13
PCT/US2019/041551 WO2020014577A1 (en) 2018-07-13 2019-07-12 Methods of achieving high specificity of genome editing

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JP2021530988A JP2021530988A (ja) 2021-11-18
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US (1) US20220195403A1 (https=)
EP (1) EP3820503A4 (https=)
JP (2) JP7590952B2 (https=)
KR (1) KR20210031482A (https=)
CA (1) CA3106162A1 (https=)
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EP3204496A1 (en) 2014-10-10 2017-08-16 Editas Medicine, Inc. Compositions and methods for promoting homology directed repair
US11866726B2 (en) 2017-07-14 2024-01-09 Editas Medicine, Inc. Systems and methods for targeted integration and genome editing and detection thereof using integrated priming sites
EP3823633A4 (en) 2018-06-29 2023-05-03 Editas Medicine, Inc. SYNTHETIC LEAD MOLECULES, COMPOSITIONS AND METHODS RELATED THERETO
US12521451B2 (en) 2019-11-08 2026-01-13 Regeneron Pharmaceuticals, Inc. CRISPR and AAV strategies for x-linked juvenile retinoschisis therapy
KR20240099393A (ko) 2021-11-01 2024-06-28 톰 바이오사이언시스, 인코포레이티드 유전자 편집 기구와 핵산 카고의 동시 전달을 위한 단일 작제물 플랫폼
WO2023122764A1 (en) 2021-12-22 2023-06-29 Tome Biosciences, Inc. Co-delivery of a gene editor construct and a donor template
TW202346588A (zh) * 2022-03-04 2023-12-01 大陸商益杰立科（上海）生物科技有限公司 基因組編輯的組成物和方法
WO2023205744A1 (en) 2022-04-20 2023-10-26 Tome Biosciences, Inc. Programmable gene insertion compositions
WO2023215831A1 (en) 2022-05-04 2023-11-09 Tome Biosciences, Inc. Guide rna compositions for programmable gene insertion
WO2023225670A2 (en) 2022-05-20 2023-11-23 Tome Biosciences, Inc. Ex vivo programmable gene insertion
WO2024020587A2 (en) 2022-07-22 2024-01-25 Tome Biosciences, Inc. Pleiopluripotent stem cell programmable gene insertion
CN115312122B (zh) * 2022-10-12 2022-12-16 之江实验室 一种CRISPR-Cas酶可突变位点推荐方法和装置
WO2024138194A1 (en) 2022-12-22 2024-06-27 Tome Biosciences, Inc. Platforms, compositions, and methods for in vivo programmable gene insertion
WO2024234006A1 (en) 2023-05-11 2024-11-14 Tome Biosciences, Inc. Systems, compositions, and methods for targeting liver sinusodial endothelial cells (lsecs)
IL324634A (en) 2023-05-15 2026-01-01 Nchroma Bio Inc Compositions and methods for epigenetic regulation of hbv gene expression
WO2025050069A1 (en) 2023-09-01 2025-03-06 Tome Biosciences, Inc. Programmable gene insertion using engineered integration enzymes
EP4677108A1 (en) 2024-04-22 2026-01-14 Basecamp Research Ltd Method and compositions for detecting off-target editing
WO2025224182A2 (en) 2024-04-23 2025-10-30 Basecamp Research Ltd Single construct platform for simultaneous delivery of gene editing machinery and nucleic acid cargo

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US20160153006A1 (en) 2013-06-17 2016-06-02 The Broad Institute Inc. Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation
US20160367702A1 (en) 2013-07-11 2016-12-22 Moderna Thrapeutics, Inc. COMPOSITIONS COMPRISING SYNTHETIC POLYNUCLEOTIDES ENCODING CRISPR RELATED PROTEINS AND SYNTHETIC SGRNAs AND METHODS OF USE
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Publication number Publication date
EP3820503A1 (en) 2021-05-19
JP2021530988A (ja) 2021-11-18
TW202023605A (zh) 2020-07-01
WO2020014577A1 (en) 2020-01-16
KR20210031482A (ko) 2021-03-19
EP3820503A4 (en) 2022-07-13
JP2024164090A (ja) 2024-11-26
US20220195403A1 (en) 2022-06-23
CA3106162A1 (en) 2020-01-16

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