JP7585214B2 - Ｂ型肝炎ウイルス感染のためのＲＮＡｉ薬 - Google Patents

Ｂ型肝炎ウイルス感染のためのＲＮＡｉ薬 Download PDF

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JP7585214B2
JP7585214B2 JP2021546213A JP2021546213A JP7585214B2 JP 7585214 B2 JP7585214 B2 JP 7585214B2 JP 2021546213 A JP2021546213 A JP 2021546213A JP 2021546213 A JP2021546213 A JP 2021546213A JP 7585214 B2 JP7585214 B2 JP 7585214B2
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administered
seq
sequence
hbv
dose
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JP2022521155A (ja
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ディー． ギブン，ブルース
シー． ハミルトン，ジェイムス
シュルエップ，トーマス
グローリア ボーモント，マリア
レンズ，オリバー
コーネリス マリエ カルメイジャー，ロナルド
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GlaxoSmithKline Intellectual Property No 3 Ltd
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2021546213A 2019-02-07 2020-02-07 Ｂ型肝炎ウイルス感染のためのＲＮＡｉ薬 Active JP7585214B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024122919A JP7763907B2 (ja) 2019-02-07 2024-07-30 Ｂ型肝炎ウイルス感染のためのＲＮＡｉ薬

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962802614P 2019-02-07 2019-02-07
US62/802,614 2019-02-07
US201962853659P 2019-05-28 2019-05-28
US62/853,659 2019-05-28
US201962932315P 2019-11-07 2019-11-07
US62/932,315 2019-11-07
PCT/US2020/017264 WO2020163747A1 (en) 2019-02-07 2020-02-07 Rnai agents for hepatitis b virus infection

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JP2024122919A Division JP7763907B2 (ja) 2019-02-07 2024-07-30 Ｂ型肝炎ウイルス感染のためのＲＮＡｉ薬

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JP2022521155A JP2022521155A (ja) 2022-04-06
JP7585214B2 true JP7585214B2 (ja) 2024-11-18

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JP2024122919A Active JP7763907B2 (ja) 2019-02-07 2024-07-30 Ｂ型肝炎ウイルス感染のためのＲＮＡｉ薬

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US (1) US20210395745A1 (https=)
EP (2) EP4707394A3 (https=)
JP (2) JP7585214B2 (https=)
KR (1) KR20210130736A (https=)
CN (1) CN113507920A (https=)
AU (1) AU2020219355A1 (https=)
BR (1) BR112021015361A2 (https=)
CA (1) CA3129261A1 (https=)
IL (1) IL285257A (https=)
JO (1) JOP20210208A1 (https=)
MX (1) MX2021009495A (https=)
PH (1) PH12021551866A1 (https=)
SG (1) SG11202108395SA (https=)
TW (1) TWI872048B (https=)
WO (1) WO2020163747A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024153797A (ja) * 2019-02-07 2024-10-29 アローヘッド ファーマシューティカルズ インコーポレイテッド Ｂ型肝炎ウイルス感染のためのＲＮＡｉ薬

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180038465A (ko) 2015-08-07 2018-04-16 애로우헤드 파마슈티컬스 인코포레이티드 Ｂ형 간염 바이러스 감염에 대한 ｒｎａｉ 치료법
JOP20190015A1 (ar) 2016-08-04 2019-02-04 Arrowhead Pharmaceuticals Inc عوامل (ار ان ايه آي) لعدوى فيروس الالتهاب الكبدي الوبائي ب
EA202091513A1 (ru) 2017-12-19 2020-09-09 Янссен Сайенсиз Айрлэнд Анлимитед Компани Вакцины против вируса гепатита b (hbv) и их применение
US20210403908A1 (en) * 2020-06-22 2021-12-30 Janssen Pharmaceuticals, Inc. Compositions and methods for treatment of hepatitis d virus infection
WO2022078479A1 (en) * 2020-10-16 2022-04-21 Janssen Pharmaceuticals, Inc. Combination therapy for treating hepatitis b virus infection
TW202245809A (zh) * 2020-12-18 2022-12-01 美商詹森藥物公司 用於治療b型肝炎病毒感染之組合療法
US20240124879A1 (en) * 2020-12-18 2024-04-18 Olix Pharmaceuticals, Inc. Rnai agent for inhibiting hbv expression and use thereof
WO2022152869A1 (en) * 2021-01-15 2022-07-21 Janssen Sciences Ireland Unlimited Company Use of oligonucleotides for individuals with hepatic impairment
EP4367241A1 (en) * 2021-07-09 2024-05-15 GlaxoSmithKline Intellectual Property (No.3) Limited Use of oligonucleotides for individuals with renal impairment
JP2024541559A (ja) * 2021-11-29 2024-11-08 シャンハイ アルゴ バイオファーマシューティカル カンパニー，リミテッド Ｂ型肝炎ウイルス（ｈｂｖ）タンパク質の発現を阻害するための組成物および方法
WO2025199466A1 (en) 2024-03-22 2025-09-25 Purdue Research Foundation Liver-specific asialoglycoprotein receptor targeting ligands, conjugates comprising same, and related compositions and methods of use
CA3279332A1 (en) * 2024-07-08 2026-03-01 Hangzhou Tianlong Pharmaceutical Co., Ltd. DOUBLE-STRANDED RNAi AGENTS FOR TARGETING AND REGULATING HBV GENE EXPRESSION, AND A USE THEREOF

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
NL9201440A (nl) 1992-08-11 1994-03-01 Univ Leiden Triantennaire clusterglycosiden, hun bereiding en toepassing.
DE60040274D1 (de) 1999-03-10 2008-10-30 Phogen Ltd Verabreichung von nukleinsäuren und proteinen an zellen
US8137695B2 (en) 2006-08-18 2012-03-20 Arrowhead Madison Inc. Polyconjugates for in vivo delivery of polynucleotides
DK2539451T3 (da) 2010-02-24 2016-04-04 Arrowhead Res Corp Sammensætninger til målrettet tilførsel af siRNA
US8501930B2 (en) 2010-12-17 2013-08-06 Arrowhead Madison Inc. Peptide-based in vivo siRNA delivery system
HRP20181564T1 (hr) 2011-06-30 2018-11-30 Arrowhead Pharmaceuticals, Inc. Pripravci i postupci za inhibiciju ekspresije gena virusa hepatitisa b
WO2013032829A1 (en) 2011-08-26 2013-03-07 Arrowhead Research Corporation Poly(vinyl ester) polymers for in vivo nucleic acid delivery
JP2015515530A (ja) 2012-04-18 2015-05-28 アローヘッド リサーチ コーポレイション インビボ核酸送達のためのポリ（アクリラート）ポリマー
KR20180038465A (ko) * 2015-08-07 2018-04-16 애로우헤드 파마슈티컬스 인코포레이티드 Ｂ형 간염 바이러스 감염에 대한 ｒｎａｉ 치료법
JOP20190015A1 (ar) * 2016-08-04 2019-02-04 Arrowhead Pharmaceuticals Inc عوامل (ار ان ايه آي) لعدوى فيروس الالتهاب الكبدي الوبائي ب
SG11202108395SA (en) * 2019-02-07 2021-08-30 Arrowhead Pharmaceuticals Inc Rnai agents for hepatitis b virus infection

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Conference Reports for NATAP，The Liver Meeting,San Francisco，2018年11月，https://natap.org/2018/AASLD/AASLD_249.htm

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024153797A (ja) * 2019-02-07 2024-10-29 アローヘッド ファーマシューティカルズ インコーポレイテッド Ｂ型肝炎ウイルス感染のためのＲＮＡｉ薬
JP7763907B2 (ja) 2019-02-07 2025-11-04 アローヘッド ファーマシューティカルズ インコーポレイテッド Ｂ型肝炎ウイルス感染のためのＲＮＡｉ薬

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