JP7579284B2 - セマフォリン４ｄ遮断（ｓｅｍａ４ｄ）とｄｃ１療法との併用療法 - Google Patents

セマフォリン４ｄ遮断（ｓｅｍａ４ｄ）とｄｃ１療法との併用療法 Download PDF

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JP7579284B2
JP7579284B2 JP2021576300A JP2021576300A JP7579284B2 JP 7579284 B2 JP7579284 B2 JP 7579284B2 JP 2021576300 A JP2021576300 A JP 2021576300A JP 2021576300 A JP2021576300 A JP 2021576300A JP 7579284 B2 JP7579284 B2 JP 7579284B2
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cancer
her2
sema4d
antibody
combination
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JP2022537453A (ja
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ブライアン チェルニエッキ
クリティカ コドゥムディ
エリザベス エヴァンス
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バクシネックス インコーポレーティッド
エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド
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    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24—Antigen-presenting cells [APC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4203—Receptors for growth factors
    • A61K40/4205—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ ErbB4
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/49—Breast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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JP2021576300A 2019-06-21 2020-06-19 セマフォリン４ｄ遮断（ｓｅｍａ４ｄ）とｄｃ１療法との併用療法 Active JP7579284B2 (ja)

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US201962865027P 2019-06-21 2019-06-21
US62/865,027 2019-06-21
PCT/US2020/038719 WO2020257640A1 (en) 2019-06-21 2020-06-19 Combination therapy with semaphorin-4d blockade (sema4d) and dc1 therapy

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JP2022537453A JP2022537453A (ja) 2022-08-25
JP2022537453A5 JP2022537453A5 (https=) 2023-05-30
JP7579284B2 true JP7579284B2 (ja) 2024-11-07

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US (2) US11660330B2 (https=)
EP (1) EP3986446A1 (https=)
JP (1) JP7579284B2 (https=)
KR (1) KR20220044490A (https=)
CN (1) CN114364399A (https=)
AU (1) AU2020297592A1 (https=)
BR (1) BR112021025795A2 (https=)
IL (1) IL288779B2 (https=)
MX (1) MX2021015970A (https=)
WO (1) WO2020257640A1 (https=)

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US20230390345A1 (en) * 2020-08-21 2023-12-07 H. Lee Moffitt Cancer Center And Research Institute, Inc. Combination therapy comprising her-2-dc1 vaccine, a probiotic, and semaphorin
WO2024159101A1 (en) * 2023-01-26 2024-08-02 H. Lee Moffitt Cancer Center And Research Institute, Inc. Methods for identifying disseminated cancer cells in breast cancer patients
WO2024159105A1 (en) * 2023-01-26 2024-08-02 H. Lee Moffitt Cancer Center And Research Institute, Inc. Methods of treating cancer comprising administration of intratumoral dcs in combination with systemic igg monoclonal antibody

Citations (2)

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JP2016528195A (ja) 2013-06-25 2016-09-15 バクシネックス インコーポレーティッド 腫瘍成長および転移を阻害するための免疫調節療法との組み合わせでのセマフォリン−４ｄ阻害分子の使用
JP2018515421A (ja) 2015-05-22 2018-06-14 ブライアン ジェイ ツェルニキＣＺＥＲＮＩＥＣＫＩ， Ｂｒｉａｎ， Ｊ． 複数用量注射準備済樹状細胞ワクチンの製造

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DE69120146T2 (de) 1990-01-12 1996-12-12 Cell Genesys Inc Erzeugung xenogener antikörper
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JP2016528195A (ja) 2013-06-25 2016-09-15 バクシネックス インコーポレーティッド 腫瘍成長および転移を阻害するための免疫調節療法との組み合わせでのセマフォリン−４ｄ阻害分子の使用
JP2018515421A (ja) 2015-05-22 2018-06-14 ブライアン ジェイ ツェルニキＣＺＥＲＮＩＥＣＫＩ， Ｂｒｉａｎ， Ｊ． 複数用量注射準備済樹状細胞ワクチンの製造

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Also Published As

Publication number Publication date
WO2020257640A1 (en) 2020-12-24
MX2021015970A (es) 2022-04-06
KR20220044490A (ko) 2022-04-08
EP3986446A1 (en) 2022-04-27
AU2020297592A1 (en) 2022-01-06
IL288779B2 (en) 2025-11-01
US20240050544A1 (en) 2024-02-15
IL288779A (en) 2022-02-01
CA3142777A1 (en) 2020-12-24
US11660330B2 (en) 2023-05-30
BR112021025795A2 (pt) 2022-02-01
JP2022537453A (ja) 2022-08-25
US20200397881A1 (en) 2020-12-24
CN114364399A (zh) 2022-04-15
IL288779B1 (en) 2025-07-01
US12201719B2 (en) 2025-01-21

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