JP7539897B2 - ヒトｃｄ１３７に結合する抗体の製剤およびその使用 - Google Patents

ヒトｃｄ１３７に結合する抗体の製剤およびその使用 Download PDF

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JP7539897B2
JP7539897B2 JP2021541095A JP2021541095A JP7539897B2 JP 7539897 B2 JP7539897 B2 JP 7539897B2 JP 2021541095 A JP2021541095 A JP 2021541095A JP 2021541095 A JP2021541095 A JP 2021541095A JP 7539897 B2 JP7539897 B2 JP 7539897B2
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antibody
seq
nos
formulation
amino acid
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JP2022518441A (ja
JP2022518441A5 (OSRAM
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ザービス－パパストイトシス、グリゴリオス
ワン、シェンジェ
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コンパス セラピューティクス リミテッド ライアビリティ カンパニー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2021541095A 2019-01-16 2020-01-16 ヒトｃｄ１３７に結合する抗体の製剤およびその使用 Active JP7539897B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962793342P 2019-01-16 2019-01-16
US62/793,342 2019-01-16
US202062960501P 2020-01-13 2020-01-13
US62/960,501 2020-01-13
PCT/US2020/013916 WO2020150496A1 (en) 2019-01-16 2020-01-16 Formulations of antibodies that bind human cd137 and uses thereof

Publications (3)

Publication Number Publication Date
JP2022518441A JP2022518441A (ja) 2022-03-15
JP2022518441A5 JP2022518441A5 (OSRAM) 2023-01-20
JP7539897B2 true JP7539897B2 (ja) 2024-08-26

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JP2021541095A Active JP7539897B2 (ja) 2019-01-16 2020-01-16 ヒトｃｄ１３７に結合する抗体の製剤およびその使用

Country Status (12)

Country Link
US (1) US20220111047A1 (OSRAM)
EP (1) EP3911679A1 (OSRAM)
JP (1) JP7539897B2 (OSRAM)
KR (1) KR20210131312A (OSRAM)
CN (1) CN113474371B (OSRAM)
AU (1) AU2020208397A1 (OSRAM)
BR (1) BR112021013571A2 (OSRAM)
CA (1) CA3127072A1 (OSRAM)
IL (1) IL284208A (OSRAM)
MX (1) MX2021008453A (OSRAM)
SG (1) SG11202107538VA (OSRAM)
WO (1) WO2020150496A1 (OSRAM)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024508746A (ja) * 2021-02-17 2024-02-28 アプティーボ リサーチ アンド デベロップメント エルエルシー ４－１ｂｂおよびｏｘ４０結合タンパク質を含む組成物および使用方法
CN118090983B (zh) * 2024-04-26 2024-09-06 山东齐都药业有限公司 布比卡因/美洛昔康复方凝胶中活性物质的检测方法

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Also Published As

Publication number Publication date
SG11202107538VA (en) 2021-08-30
CA3127072A1 (en) 2020-07-23
EP3911679A1 (en) 2021-11-24
JP2022518441A (ja) 2022-03-15
US20220111047A1 (en) 2022-04-14
WO2020150496A1 (en) 2020-07-23
CN113474371B (zh) 2025-07-29
KR20210131312A (ko) 2021-11-02
CN113474371A (zh) 2021-10-01
IL284208A (en) 2021-08-31
BR112021013571A2 (pt) 2021-09-21
AU2020208397A1 (en) 2021-08-12
MX2021008453A (es) 2021-08-19

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