JP7530836B2 - 代謝性疾患の処置において使用するためのマイクロｒｎａインヒビター - Google Patents

代謝性疾患の処置において使用するためのマイクロｒｎａインヒビター Download PDF

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JP7530836B2
JP7530836B2 JP2020569736A JP2020569736A JP7530836B2 JP 7530836 B2 JP7530836 B2 JP 7530836B2 JP 2020569736 A JP2020569736 A JP 2020569736A JP 2020569736 A JP2020569736 A JP 2020569736A JP 7530836 B2 JP7530836 B2 JP 7530836B2
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mir
inhibitor
fragment
nucleic acid
composition
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JP2021535079A (ja
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シュテファン ヘルツィヒ
マニュエル ギル ロサーノ
トビアス シャフマイヤー
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ヘルムホルツ・ツェントルム・ミュンヘン・ドイチェス・フォーシュンクスツェントルム・フュア・ゲズントハイト・ウント・ウンベルト・ゲーエムベーハー
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/13—Decoys
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/31—Combination therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

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  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
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  • Microbiology (AREA)
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  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2020569736A 2018-09-11 2019-09-10 代謝性疾患の処置において使用するためのマイクロｒｎａインヒビター Active JP7530836B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2024037853A JP2024073525A (ja) 2018-09-11 2024-03-12 代謝性疾患の処置において使用するためのマイクロｒｎａインヒビター

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
LU100927 2018-09-11
LULU100927 2018-09-11
PCT/EP2019/074056 WO2020053186A1 (en) 2018-09-11 2019-09-10 Microrna inhibitors for use in treating metabolic diseases

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JP2024037853A Division JP2024073525A (ja) 2018-09-11 2024-03-12 代謝性疾患の処置において使用するためのマイクロｒｎａインヒビター

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JP2021535079A JP2021535079A (ja) 2021-12-16
JP7530836B2 true JP7530836B2 (ja) 2024-08-08

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JP2020569736A Active JP7530836B2 (ja) 2018-09-11 2019-09-10 代謝性疾患の処置において使用するためのマイクロｒｎａインヒビター
JP2024037853A Pending JP2024073525A (ja) 2018-09-11 2024-03-12 代謝性疾患の処置において使用するためのマイクロｒｎａインヒビター

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US (1) US12584126B2 (https=)
EP (1) EP3850099B1 (https=)
JP (2) JP7530836B2 (https=)
CN (1) CN112654705B (https=)
CA (1) CA3103175A1 (https=)
DK (1) DK3850099T3 (https=)
WO (1) WO2020053186A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024073525A (ja) * 2018-09-11 2024-05-29 ヘルムホルツ・ツェントルム・ミュンヘン・ドイチェス・フォーシュンクスツェントルム・フュア・ゲズントハイト・ウント・ウンベルト・ゲーエムベーハー 代謝性疾患の処置において使用するためのマイクロｒｎａインヒビター

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111228291B (zh) * 2020-03-20 2020-10-02 军事科学院军事医学研究院环境医学与作业医学研究所 miR-541在制备抗神经元细胞缺氧损伤药物中的应用及药物

Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2015063081A2 (en) 2013-10-29 2015-05-07 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Micrornas modulating the effect of glucocorticoid signaling

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US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
CA1223831A (en) 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
US5792608A (en) 1991-12-12 1998-08-11 Gilead Sciences, Inc. Nuclease stable and binding competent oligomers and methods for their use
US5525711A (en) 1994-05-18 1996-06-11 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pteridine nucleotide analogs as fluorescent DNA probes
WO2014074874A1 (en) * 2012-11-09 2014-05-15 Regents Of The University Of Minnesota Osteosarcoma diagnostic and prognostic methods
AU2015335923B2 (en) * 2014-10-21 2021-04-29 University Of Massachusetts Recombinant AAV variants and uses thereof
CN106267207A (zh) * 2015-06-05 2017-01-04 昆山彭济凯丰生物科技有限公司 通过miR-96进行减肥、降血糖和降血脂的方法和药物及其应用
CN119033819A (zh) * 2017-11-22 2024-11-29 迈索布拉斯特国际有限公司 细胞组合物及治疗方法
US12584126B2 (en) 2018-09-11 2026-03-24 Helmholtz Zentrum Muenchen—Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt (Gmbh) microRNA inhibitors for use in treating metabolic diseases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015063081A2 (en) 2013-10-29 2015-05-07 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Micrornas modulating the effect of glucocorticoid signaling

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Cell Death & Disease，2014年，Vol.5, e.1171，p.1-10
The EMBO Journal，2015年，Vol.34，p.344-360

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024073525A (ja) * 2018-09-11 2024-05-29 ヘルムホルツ・ツェントルム・ミュンヘン・ドイチェス・フォーシュンクスツェントルム・フュア・ゲズントハイト・ウント・ウンベルト・ゲーエムベーハー 代謝性疾患の処置において使用するためのマイクロｒｎａインヒビター
US12584126B2 (en) 2018-09-11 2026-03-24 Helmholtz Zentrum Muenchen—Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt (Gmbh) microRNA inhibitors for use in treating metabolic diseases

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US12584126B2 (en) 2026-03-24
EP3850099A1 (en) 2021-07-21
CN112654705A (zh) 2021-04-13
JP2024073525A (ja) 2024-05-29
CA3103175A1 (en) 2020-03-19
JP2021535079A (ja) 2021-12-16
WO2020053186A1 (en) 2020-03-19
EP3850099B1 (en) 2025-09-03
US20210254067A1 (en) 2021-08-19
DK3850099T3 (da) 2025-10-13
CN112654705B (zh) 2024-07-02

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