JP7475286B2 - 医薬品活性成分に適した崩壊性経口錠剤 - Google Patents

医薬品活性成分に適した崩壊性経口錠剤 Download PDF

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JP7475286B2
JP7475286B2 JP2020564460A JP2020564460A JP7475286B2 JP 7475286 B2 JP7475286 B2 JP 7475286B2 JP 2020564460 A JP2020564460 A JP 2020564460A JP 2020564460 A JP2020564460 A JP 2020564460A JP 7475286 B2 JP7475286 B2 JP 7475286B2
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tablet
particles
sugar alcohol
oral tablet
chewable oral
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Japanese (ja)
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JP2021524444A5 (https=
JP2021524444A (ja
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ヘレ・ウィトルフ
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フェルティン ファルマ アー／エス
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0204—Specific forms not provided for by any of groups A61K8/0208 - A61K8/14
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/733—Alginic acid; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Birds (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2020564460A 2018-05-17 2019-05-15 医薬品活性成分に適した崩壊性経口錠剤 Active JP7475286B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15/982,556 US11058633B2 (en) 2018-05-17 2018-05-17 Disintegrating oral tablet suitable for active pharmaceutical ingredients
US15/982,556 2018-05-17
PCT/DK2019/050154 WO2019219144A1 (en) 2018-05-17 2019-05-15 Disintegrating oral tablet suitable for active pharmaceutical ingredients

Publications (3)

Publication Number Publication Date
JP2021524444A JP2021524444A (ja) 2021-09-13
JP2021524444A5 JP2021524444A5 (https=) 2021-10-21
JP7475286B2 true JP7475286B2 (ja) 2024-04-26

Family

ID=66793733

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020564460A Active JP7475286B2 (ja) 2018-05-17 2019-05-15 医薬品活性成分に適した崩壊性経口錠剤

Country Status (7)

Country Link
US (3) US11058633B2 (https=)
EP (1) EP3793531A1 (https=)
JP (1) JP7475286B2 (https=)
CN (1) CN112118833B (https=)
AU (1) AU2019269881B2 (https=)
CA (1) CA3096339C (https=)
WO (1) WO2019219144A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11096896B2 (en) 2018-05-17 2021-08-24 Fertin Pharma A/S Tablet dosage form for buccal absorption of active ingredients
US20210106516A1 (en) * 2019-10-11 2021-04-15 Fertin Pharma A/S Ion-Exchange Composition With Water-Soluble Mucoadhesive Polymers
MX2022006979A (es) * 2019-12-09 2022-08-25 Nicoventures Trading Ltd Productos orales con liberacion controlada.
JP2023504756A (ja) 2019-12-09 2023-02-06 ニコベンチャーズ トレーディング リミテッド カンナビノイドを含む口腔用製品
DK4146164T3 (da) * 2020-05-08 2025-05-26 Fertin Pharma As Flowpack til oral afgivelse af aktive ingredienser
WO2022086238A1 (en) * 2020-10-23 2022-04-28 Hk Inno.N Corporation Orally disintegrating tablet comprising benzimidazole derivative compound and preparation method thereof
CN113041228A (zh) * 2021-03-30 2021-06-29 新乡市常乐制药有限责任公司 一种他达拉非片剂混合物及其制备方法
US11786473B2 (en) 2021-12-14 2023-10-17 Fertin Pharma A/S Nicotine tablet
US12295412B2 (en) 2022-01-28 2025-05-13 Altria Client Services Llc Oral pouch product
DK182273B1 (en) * 2023-07-07 2026-01-30 Fertin Pharma As Dissolvable orally adhering nicotine tablet
DK182278B1 (en) * 2023-07-07 2026-02-04 Fertin Pharma As Dissolvable orally adhering tablet
WO2024186829A2 (en) * 2023-03-07 2024-09-12 Bayer Healthcare Llc Orally disintegrating tablet and methods of making thereof
WO2025011727A1 (en) * 2023-07-07 2025-01-16 Fertin Pharma A/S Dissolvable orally adhering nicotine tablet

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009545561A (ja) 2006-08-04 2009-12-24 エチファーム 多層口腔内崩壊錠剤

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3639169A (en) * 1969-04-29 1972-02-01 Sucrest Corp Direct compression vehicles and method therefor
CA1080024A (en) * 1975-12-24 1980-06-24 Leonard Spooner Confection containing xylitol
US4627977A (en) 1985-09-13 1986-12-09 Colgate-Palmolive Company Anticalculus oral composition
US4820506A (en) 1987-05-01 1989-04-11 Research Foundation, State University Of New York Salivary stimulant
FI81004C (fi) * 1988-02-25 1990-09-10 Suomen Sokeri Oy Binde- och utspaedningsmedel pao basis av xylitol och foerfarande foer dess framstaellning.
US4997654A (en) 1989-08-14 1991-03-05 Warner-Lambert Company Method for increasing salivation for xerostomia patients
US5204115A (en) * 1990-12-12 1993-04-20 Suomen Xyrofin Oy Directly compressible xylitol and method
FR2670398B1 (fr) * 1990-12-14 1995-02-17 Roquette Freres Composition pulverulente directement compressible et procede d'obtention.
GB9100009D0 (en) 1991-01-02 1991-02-20 Cerestar Holding Bv Erythritol compositions
US5576014A (en) 1994-01-31 1996-11-19 Yamanouchi Pharmaceutical Co., Ltd Intrabuccally dissolving compressed moldings and production process thereof
TW469135B (en) 1995-10-03 2001-12-21 Chugai Pharmaceutical Co Ltd Chewable tablet
DE69738829D1 (de) * 1996-07-12 2008-08-21 Daiichi Seiyaku Co Schnell zerfallende, druckgeformte Materialien sowie Prozess zu deren Herstellung
US6024981A (en) 1997-04-16 2000-02-15 Cima Labs Inc. Rapidly dissolving robust dosage form
GB9716432D0 (en) 1997-08-05 1997-10-08 Cerestar Holding Bv Tableting of erythritol
US5874068A (en) 1997-12-08 1999-02-23 Warner-Lambert Company Stabilized antiplaque and antigingivitis oral compositions containing N.sup.α -alkyl-L-arginine alkyl ester salts
CA2315088A1 (en) 1997-12-19 1999-07-01 Smithkline Beecham Corporation Process for manufacturing bite-dispersion tablets
AU1031500A (en) 1998-11-03 2000-05-22 Dandy A/S Sucrose fatty acid esters for use as increased release of active ingredients
FR2785538B1 (fr) 1998-11-06 2004-04-09 Prographarm Laboratoires Comprime a delitement rapide perfectionne
EP1365740A1 (en) 2001-02-08 2003-12-03 Pharmacia Corporation Rapid-onset medicament for the treatment of sexual dysfunction
KR20030081472A (ko) 2001-03-06 2003-10-17 교와 핫꼬 고교 가부시끼가이샤 구강내 속붕괴성 제제
SE0102197D0 (sv) 2001-06-20 2001-06-20 Pharmacia Ab New product and use and manufacture thereof
WO2003080023A2 (en) 2002-03-20 2003-10-02 Elan Pharma International Limited Fast dissolving dosage forms having reduced friability
US20060147580A1 (en) 2003-02-04 2006-07-06 Vibeke Nissen Compressed chewing gum tablet
WO2004068965A1 (en) * 2003-02-04 2004-08-19 Gumlink A/S Compressed chewing gum tablet
US7223072B2 (en) 2004-01-27 2007-05-29 Honeywell International, Inc. Gas turbine engine including airfoils having an improved airfoil film cooling configuration and method therefor
PL1737302T3 (pl) 2004-04-20 2018-05-30 Wm. Wrigley Jr. Company Odświeżające oddech produkty cukiernicze oraz sposoby ich wytwarzania i stosowania
WO2006063189A2 (en) 2004-12-10 2006-06-15 Novartis Ag Multi-layered chewing gum tablet with quick disintegration layer
WO2006112961A2 (en) 2005-03-03 2006-10-26 Takasago International Corp. (Usa) Synergistic salivation components
CN1327865C (zh) 2005-06-03 2007-07-25 贵州威门药业股份有限公司 治疗咳喘的中药制剂及其制备方法
CN1891299B (zh) 2005-06-28 2012-06-27 上野制药株式会社 用于压片的糖醇组合物
BRPI0620578A2 (pt) * 2005-12-27 2011-12-06 Jubilant Organosys Ltd composição farmacêutica que dissolve na boca e processo para o preparo da mesma
WO2009007768A1 (en) 2007-07-06 2009-01-15 Gumlink A/S Compressed tablet comprising polyol
EP2264042B1 (en) 2007-07-27 2012-07-18 Cargill, Incorporated Micronization of polyols
WO2009080023A1 (en) 2007-12-20 2009-07-02 Fertin Pharma A/S Compressed chewing gum comprising peptide
EP2229157B1 (en) * 2007-12-20 2016-08-10 Fertin Pharma A/S Compressed chewing gum tablet
WO2009080032A1 (en) * 2007-12-20 2009-07-02 Fertin Pharma A/S Compressed chewing gum comprising a systemically active small peptide
WO2010025796A1 (en) 2008-09-04 2010-03-11 Cargill Incorporated Tabletting of ervthritol
US8617588B2 (en) 2009-03-09 2013-12-31 Spi Pharma, Inc. Highly compactable and durable direct compression excipients and excipient systems
US9591852B2 (en) 2009-11-23 2017-03-14 Mcneil-Ppc, Inc. Biofilm disruptive compositions
US8658139B1 (en) 2010-02-27 2014-02-25 Squigle, Inc. Prevention and treatment of oral diseases
CN107252419A (zh) 2010-12-22 2017-10-17 巴斯夫欧洲公司 快速崩解的固体包衣剂型
US20120276199A1 (en) * 2011-04-01 2012-11-01 Dr. Reddy's Laboratories Limited Taste masked pharmaceutical formulations
WO2013091631A1 (en) 2011-12-22 2013-06-27 Fertin Pharma A/S Method of releasing nicotine from chewing gum
JP6040218B2 (ja) 2012-02-23 2016-12-07 フロイント産業株式会社 口腔内崩壊錠用直打賦形剤及びその製造方法、並びに口腔内崩壊錠
WO2013171164A1 (en) 2012-05-14 2013-11-21 EJP Pharmaceutical ApS Compositions and formulations for the treatment of halitosis
US20160120793A1 (en) 2013-05-17 2016-05-05 Alequident Limited Oral Healthcare Product
US10357054B2 (en) 2013-10-16 2019-07-23 R.J. Reynolds Tobacco Company Smokeless tobacco pastille
EP3206671B1 (en) 2014-10-16 2024-06-12 Cargill, Incorporated Process for preparing a directly compressible erythritol and uses thereof
US9975847B2 (en) 2014-11-11 2018-05-22 Johnson & Johnson Consumer Inc. Amino acid derivatives and their uses
RU2736072C1 (ru) 2016-11-18 2020-11-11 Фертин Фарма А/С Таблетка, содержащая отдельное связывающее вещество и эритрит
US10543205B2 (en) 2016-11-18 2020-01-28 Fertin Pharma A/S Oral delivery vehicle containing nicotine
US11351103B2 (en) 2016-11-18 2022-06-07 Johnson & Johnson Consumer Inc. Method of providing oral care benefits
ES2870142T3 (es) 2016-11-18 2021-10-26 Fertin Pharma As Vehículo de administración oral
US10632076B2 (en) 2016-11-18 2020-04-28 Fertin Pharma A/S Tablet comprising separate binder and erythritol
US11058641B2 (en) * 2018-05-17 2021-07-13 Fertin Pharma A/S Oral tablet for taste masking of active ingredients

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009545561A (ja) 2006-08-04 2009-12-24 エチファーム 多層口腔内崩壊錠剤

Also Published As

Publication number Publication date
US20210106534A1 (en) 2021-04-15
US11058633B2 (en) 2021-07-13
AU2019269881B2 (en) 2022-08-04
US12102714B2 (en) 2024-10-01
US20190350847A1 (en) 2019-11-21
EP3793531A1 (en) 2021-03-24
CA3096339C (en) 2023-08-29
CN112118833A (zh) 2020-12-22
JP2021524444A (ja) 2021-09-13
WO2019219144A1 (en) 2019-11-21
AU2019269881A1 (en) 2020-10-22
US20210290530A1 (en) 2021-09-23
CN112118833B (zh) 2023-03-03
CA3096339A1 (en) 2019-11-21

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