AU2019269881B2 - Disintegrating oral tablet suitable for active pharmaceutical ingredients - Google Patents

Disintegrating oral tablet suitable for active pharmaceutical ingredients Download PDF

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Publication number
AU2019269881B2
AU2019269881B2 AU2019269881A AU2019269881A AU2019269881B2 AU 2019269881 B2 AU2019269881 B2 AU 2019269881B2 AU 2019269881 A AU2019269881 A AU 2019269881A AU 2019269881 A AU2019269881 A AU 2019269881A AU 2019269881 B2 AU2019269881 B2 AU 2019269881B2
Authority
AU
Australia
Prior art keywords
tablet
particles
sugar alcohol
flavor
population
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2019269881A
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English (en)
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AU2019269881A1 (en
Inventor
Helle Wittorff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fertin Pharma AS
Original Assignee
Fertin Pharma AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fertin Pharma AS filed Critical Fertin Pharma AS
Publication of AU2019269881A1 publication Critical patent/AU2019269881A1/en
Application granted granted Critical
Publication of AU2019269881B2 publication Critical patent/AU2019269881B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0204—Specific forms not provided for by any of groups A61K8/0208 - A61K8/14
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/733—Alginic acid; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Nutrition Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2019269881A 2018-05-17 2019-05-15 Disintegrating oral tablet suitable for active pharmaceutical ingredients Active AU2019269881B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15/982,556 2018-05-17
US15/982,556 US11058633B2 (en) 2018-05-17 2018-05-17 Disintegrating oral tablet suitable for active pharmaceutical ingredients
PCT/DK2019/050154 WO2019219144A1 (en) 2018-05-17 2019-05-15 Disintegrating oral tablet suitable for active pharmaceutical ingredients

Publications (2)

Publication Number Publication Date
AU2019269881A1 AU2019269881A1 (en) 2020-10-22
AU2019269881B2 true AU2019269881B2 (en) 2022-08-04

Family

ID=66793733

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2019269881A Active AU2019269881B2 (en) 2018-05-17 2019-05-15 Disintegrating oral tablet suitable for active pharmaceutical ingredients

Country Status (7)

Country Link
US (3) US11058633B2 (https=)
EP (1) EP3793531A1 (https=)
JP (1) JP7475286B2 (https=)
CN (1) CN112118833B (https=)
AU (1) AU2019269881B2 (https=)
CA (1) CA3096339C (https=)
WO (1) WO2019219144A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11096896B2 (en) 2018-05-17 2021-08-24 Fertin Pharma A/S Tablet dosage form for buccal absorption of active ingredients
US20210106516A1 (en) * 2019-10-11 2021-04-15 Fertin Pharma A/S Ion-Exchange Composition With Water-Soluble Mucoadhesive Polymers
EP4072516A1 (en) 2019-12-09 2022-10-19 Nicoventures Trading Limited Oral product comprising a cannabinoid
MX2022006979A (es) * 2019-12-09 2022-08-25 Nicoventures Trading Ltd Productos orales con liberacion controlada.
EP4146166A1 (en) * 2020-05-08 2023-03-15 Fertin Pharma A/S Mouthwash for oral care benefits
AU2021364255B2 (en) * 2020-10-23 2025-02-13 Hk Inno.N Corporation Orally disintegrating tablet comprising benzimidazole derivative compound and preparation method thereof
CN113041228A (zh) * 2021-03-30 2021-06-29 新乡市常乐制药有限责任公司 一种他达拉非片剂混合物及其制备方法
US11786473B2 (en) 2021-12-14 2023-10-17 Fertin Pharma A/S Nicotine tablet
US12295412B2 (en) 2022-01-28 2025-05-13 Altria Client Services Llc Oral pouch product
DK182278B1 (en) * 2023-07-07 2026-02-04 Fertin Pharma As Dissolvable orally adhering tablet
DK182273B1 (en) * 2023-07-07 2026-01-30 Fertin Pharma As Dissolvable orally adhering nicotine tablet
WO2024186829A2 (en) * 2023-03-07 2024-09-12 Bayer Healthcare Llc Orally disintegrating tablet and methods of making thereof
AU2024296756A1 (en) * 2023-07-07 2026-01-22 Fertin Pharma A/S Dissolvable orally adhering nicotine tablet

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3639169A (en) * 1969-04-29 1972-02-01 Sucrest Corp Direct compression vehicles and method therefor
GB1526020A (en) * 1975-12-24 1978-09-27 Life Savers Inc Confectionary tablets
EP0329977A2 (en) * 1988-02-25 1989-08-30 Xyrofin Oy A xylitol-based binding and diluting agent and a process for the production thereof
US5204115A (en) * 1990-12-12 1993-04-20 Suomen Xyrofin Oy Directly compressible xylitol and method
US5385749A (en) * 1990-12-14 1995-01-31 Roquette Freres Directly compressible pulverulent composition and a process for obtaining the same
WO1999032092A1 (en) * 1997-12-19 1999-07-01 Smithkline Beecham Corporation Process for manufacturing bite-dispersion tablets
US20090311320A1 (en) * 2006-08-04 2009-12-17 Ethypharm Multilayer orally disintegrating tablet
WO2018091048A1 (en) * 2016-11-18 2018-05-24 Fertin Pharma A/S Oral delivery vehicle

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4627977A (en) 1985-09-13 1986-12-09 Colgate-Palmolive Company Anticalculus oral composition
US4820506A (en) 1987-05-01 1989-04-11 Research Foundation, State University Of New York Salivary stimulant
US4997654A (en) 1989-08-14 1991-03-05 Warner-Lambert Company Method for increasing salivation for xerostomia patients
GB9100009D0 (en) 1991-01-02 1991-02-20 Cerestar Holding Bv Erythritol compositions
US5576014A (en) 1994-01-31 1996-11-19 Yamanouchi Pharmaceutical Co., Ltd Intrabuccally dissolving compressed moldings and production process thereof
TW469135B (en) 1995-10-03 2001-12-21 Chugai Pharmaceutical Co Ltd Chewable tablet
PT922464E (pt) * 1996-07-12 2005-07-29 Daiichi Seiyaku Co Materiais moldados por compressao rapidamente desintegraveis e processo para a sua producao
US6024981A (en) 1997-04-16 2000-02-15 Cima Labs Inc. Rapidly dissolving robust dosage form
GB9716432D0 (en) 1997-08-05 1997-10-08 Cerestar Holding Bv Tableting of erythritol
US5874068A (en) 1997-12-08 1999-02-23 Warner-Lambert Company Stabilized antiplaque and antigingivitis oral compositions containing N.sup.α -alkyl-L-arginine alkyl ester salts
WO2000025598A1 (en) 1998-11-03 2000-05-11 Dandy A/S Sucrose fatty acid esters for use as increased release of active ingredients
FR2785538B1 (fr) 1998-11-06 2004-04-09 Prographarm Laboratoires Comprime a delitement rapide perfectionne
JP2004520389A (ja) 2001-02-08 2004-07-08 ファルマシア・コーポレーション 性的不全の治療のための早期効果発現薬剤
JPWO2002069934A1 (ja) 2001-03-06 2004-07-02 協和醗酵工業株式会社 口腔内速崩壊性製剤
SE0102197D0 (sv) 2001-06-20 2001-06-20 Pharmacia Ab New product and use and manufacture thereof
WO2003080023A2 (en) 2002-03-20 2003-10-02 Elan Pharma International Limited Fast dissolving dosage forms having reduced friability
EP1589826B1 (en) * 2003-02-04 2009-04-15 Gumlink A/S Compressed chewing gum tablet
CN100374035C (zh) 2003-02-04 2008-03-12 古木林科有限公司 压缩口香糖片
US7223072B2 (en) 2004-01-27 2007-05-29 Honeywell International, Inc. Gas turbine engine including airfoils having an improved airfoil film cooling configuration and method therefor
WO2005102066A2 (en) 2004-04-20 2005-11-03 Wm. Wrigley Jr. Company Breath freshening confectionery products and methods of making and using same
WO2006063189A2 (en) 2004-12-10 2006-06-15 Novartis Ag Multi-layered chewing gum tablet with quick disintegration layer
US8435542B2 (en) 2005-03-03 2013-05-07 Takasago International Corp. (Usa) Synergistic salivation agents
CN1327865C (zh) 2005-06-03 2007-07-25 贵州威门药业股份有限公司 治疗咳喘的中药制剂及其制备方法
US20070009595A1 (en) 2005-06-28 2007-01-11 Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo Sugar alcohol composition for tableting
JP2009521523A (ja) * 2005-12-27 2009-06-04 ジュビラント・オルガノシス・リミテッド 口中溶解性医薬組成物およびその製造方法
WO2009007768A1 (en) 2007-07-06 2009-01-15 Gumlink A/S Compressed tablet comprising polyol
CN103691530A (zh) 2007-07-27 2014-04-02 卡吉尔公司 多元醇的微粉化
DK2229157T3 (en) * 2007-12-20 2016-12-05 Fertin Pharma As Compressed chewing gum tablet
WO2009080023A1 (en) 2007-12-20 2009-07-02 Fertin Pharma A/S Compressed chewing gum comprising peptide
WO2009080032A1 (en) * 2007-12-20 2009-07-02 Fertin Pharma A/S Compressed chewing gum comprising a systemically active small peptide
ES2377869T3 (es) 2008-09-04 2012-04-02 Cargill, Incorporated Fabricación de comprimidos de eritritol
MX2011009053A (es) 2009-03-09 2012-04-02 Spi Pharma Inc Excipientes de compresion directa con alta capacidad de compactacion y durables y sistemas de excipiente.
US9591852B2 (en) 2009-11-23 2017-03-14 Mcneil-Ppc, Inc. Biofilm disruptive compositions
US8658139B1 (en) 2010-02-27 2014-02-25 Squigle, Inc. Prevention and treatment of oral diseases
CN107252419A (zh) 2010-12-22 2017-10-17 巴斯夫欧洲公司 快速崩解的固体包衣剂型
US20120276199A1 (en) * 2011-04-01 2012-11-01 Dr. Reddy's Laboratories Limited Taste masked pharmaceutical formulations
EP2793849A1 (en) 2011-12-22 2014-10-29 Fertin Pharma A/S Method of releasing nicotine from chewing gum
JP6040218B2 (ja) 2012-02-23 2016-12-07 フロイント産業株式会社 口腔内崩壊錠用直打賦形剤及びその製造方法、並びに口腔内崩壊錠
WO2013171164A1 (en) 2012-05-14 2013-11-21 EJP Pharmaceutical ApS Compositions and formulations for the treatment of halitosis
AU2014266070A1 (en) 2013-05-17 2015-12-10 Alequident Limited Oral healthcare product
US10357054B2 (en) 2013-10-16 2019-07-23 R.J. Reynolds Tobacco Company Smokeless tobacco pastille
WO2016061486A1 (en) 2014-10-16 2016-04-21 Cargill, Incorporated Process for preparing a directly compressible erythritol & uses thereof
BR112017009601B8 (pt) 2014-11-11 2022-07-26 Johnson & Johnson Consumer Inc Derivados de aminoácidos e composição que os compreende
CN110087634A (zh) 2016-11-18 2019-08-02 费丁制药联合股份有限公司 提供口腔护理有益效果的方法
US11351103B2 (en) 2016-11-18 2022-06-07 Johnson & Johnson Consumer Inc. Method of providing oral care benefits
US10543205B2 (en) 2016-11-18 2020-01-28 Fertin Pharma A/S Oral delivery vehicle containing nicotine
US10632076B2 (en) 2016-11-18 2020-04-28 Fertin Pharma A/S Tablet comprising separate binder and erythritol
US11058641B2 (en) * 2018-05-17 2021-07-13 Fertin Pharma A/S Oral tablet for taste masking of active ingredients

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3639169A (en) * 1969-04-29 1972-02-01 Sucrest Corp Direct compression vehicles and method therefor
GB1526020A (en) * 1975-12-24 1978-09-27 Life Savers Inc Confectionary tablets
EP0329977A2 (en) * 1988-02-25 1989-08-30 Xyrofin Oy A xylitol-based binding and diluting agent and a process for the production thereof
US5204115A (en) * 1990-12-12 1993-04-20 Suomen Xyrofin Oy Directly compressible xylitol and method
US5385749A (en) * 1990-12-14 1995-01-31 Roquette Freres Directly compressible pulverulent composition and a process for obtaining the same
WO1999032092A1 (en) * 1997-12-19 1999-07-01 Smithkline Beecham Corporation Process for manufacturing bite-dispersion tablets
US20090311320A1 (en) * 2006-08-04 2009-12-17 Ethypharm Multilayer orally disintegrating tablet
WO2018091048A1 (en) * 2016-11-18 2018-05-24 Fertin Pharma A/S Oral delivery vehicle

Also Published As

Publication number Publication date
CA3096339A1 (en) 2019-11-21
US12102714B2 (en) 2024-10-01
CN112118833B (zh) 2023-03-03
CN112118833A (zh) 2020-12-22
US20210290530A1 (en) 2021-09-23
AU2019269881A1 (en) 2020-10-22
US20210106534A1 (en) 2021-04-15
US11058633B2 (en) 2021-07-13
JP2021524444A (ja) 2021-09-13
JP7475286B2 (ja) 2024-04-26
WO2019219144A1 (en) 2019-11-21
US20190350847A1 (en) 2019-11-21
CA3096339C (en) 2023-08-29
EP3793531A1 (en) 2021-03-24

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Legal Events

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FGA Letters patent sealed or granted (standard patent)