JP7473706B2 - 制御された濃度で送達を行うための気化システム - Google Patents
制御された濃度で送達を行うための気化システム Download PDFInfo
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- 238000009834 vaporization Methods 0.000 title description 3
- 230000008016 vaporization Effects 0.000 title description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 99
- 239000000203 mixture Substances 0.000 claims description 10
- QQZWEECEMNQSTG-UHFFFAOYSA-N Ethyl nitrite Chemical compound CCON=O QQZWEECEMNQSTG-UHFFFAOYSA-N 0.000 claims description 8
- JQJPBYFTQAANLE-UHFFFAOYSA-N Butyl nitrite Chemical compound CCCCON=O JQJPBYFTQAANLE-UHFFFAOYSA-N 0.000 claims description 3
- 229960003116 amyl nitrite Drugs 0.000 claims description 3
- APNSGVMLAYLYCT-UHFFFAOYSA-N isobutyl nitrite Chemical compound CC(C)CON=O APNSGVMLAYLYCT-UHFFFAOYSA-N 0.000 claims description 3
- CSDTZUBPSYWZDX-UHFFFAOYSA-N n-pentyl nitrite Chemical compound CCCCCON=O CSDTZUBPSYWZDX-UHFFFAOYSA-N 0.000 claims description 3
- IOGXOCVLYRDXLW-UHFFFAOYSA-N tert-butyl nitrite Chemical compound CC(C)(C)ON=O IOGXOCVLYRDXLW-UHFFFAOYSA-N 0.000 claims description 3
- 239000012414 tert-butyl nitrite Substances 0.000 claims description 3
- 238000012544 monitoring process Methods 0.000 claims description 2
- 230000004044 response Effects 0.000 claims description 2
- 239000012071 phase Substances 0.000 claims 9
- 239000007791 liquid phase Substances 0.000 claims 3
- 239000012808 vapor phase Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 description 17
- 238000000034 method Methods 0.000 description 16
- 230000001276 controlling effect Effects 0.000 description 6
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- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 description 2
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 2
- 229910000831 Steel Inorganic materials 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 230000009977 dual effect Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000010348 incorporation Methods 0.000 description 2
- 229910052744 lithium Inorganic materials 0.000 description 2
- 229920000515 polycarbonate Polymers 0.000 description 2
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- 229910052751 metal Inorganic materials 0.000 description 1
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- A61M16/122—Preparation of respiratory gases or vapours by mixing different gases with dilution
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Description
本出願は、2017年6月8日に出願された米国仮出願第62/516,973号の、米国特許法第119条(e)に基づく利益及び優先権を主張し、この出願の内容の全体が参照により本明細書に組み込まれる。
本発明は、米国国防高等研究計画局が認可した連邦助成金第N66001-10-C-2015号に基づく政府支援を受けて成された。政府は当該発明において一定の権利を有する。
Claims (13)
- 患者によって持ち運びされるかまたは着用されるように構成された外部ケーシングを含み、
液相のニトロシル化剤を保存する貯蔵部及び気相の前記ニトロシル化剤を保存するデッドスペース部を含むリザーバと、
前記リザーバに動作可能に接続され、前記気相のニトロシル化剤を前記リザーバ外部に流させるように構成された流量制御部と、
前記リザーバ内の第一の温度及び前記流量制御部内の第二の温度を制御するように構成された温度コントローラと、
前記流量制御部から前記気相のニトロシル化剤を放出するために構成された弁、及び
空気と前記気相のニトロシル化剤を混合させ、前記空気と前記気相のニトロシル化剤との混合物を前記患者へと流出させるためのポンプと、を備え、
前記気相のニトロシル化剤に変化する前記液相のニトロシル化剤の量は、前記第一の温度に基づくものであり、前記流量制御部が前記リザーバよりもより近接して前記温度コントローラに取り付けられている、歩行用デバイス。 - 前記弁は前記患者の吸気を感知すると開に切り替えられる、請求項1に記載の歩行用デバイス。
- 前記流量制御部は気体膨張チャンバを備える、請求項1に記載の歩行用デバイス。
- 前記リザーバ内の前記気相のニトロシル化剤の前記蒸気圧を監視するための圧力計、及び
前記リザーバから前記気体膨張チャンバへの前記気相のニトロシル化剤の流れを制御するように構成された圧力調整器をさらに備える、請求項3に記載の歩行用デバイス。 - 前記空気と混合された前記ニトロシル化剤を送達するための患者送達要素をさらに備え、前記患者送達要素は管及び鼻カニューレを含む、請求項1に記載の歩行用デバイス。
- 前記リザーバは20mLの容量であり、前記貯蔵部は10mLの前記液相のニトロシル化剤を貯蔵するように構成されている、請求項1に記載の歩行用デバイス。
- 前記ニトロシル化剤は亜硝酸エチル、亜硝酸アミル、亜硝酸ブチル、亜硝酸イソブチル、または亜硝酸tert-ブチルのうち少なくとも1つである、請求項1に記載の歩行用デバイス。
- 前記リザーバは交換可能であり、前記歩行用デバイスは前記交換可能なリザーバと前記流量制御部との間に遮断バルブをさらに備える、請求項1に記載の歩行用デバイス。
- 前記患者に送達される前記ニトロシル化剤の量を監視または制御するように構成された少なくとも1つのセンサ、及び
前記温度コントローラ、前記弁、前記ポンプ、及び前記少なくとも1つのセンサの温度を監視または調整するように構成された、プロセッサを含むコントローラ、をさらに備える、請求項1に記載の歩行用デバイス。 - 前記患者にシステムメッセージを通知するように構成されたバイブレータと、
前記患者からの入力を受けつける少なくとも1つの入力ボタンと、
前記システムメッセージを表示するディスプレイと、をさらに備える、請求項9に記載の歩行用デバイス。 - 前記歩行用デバイスは約175cm3または250グラム未満の物理的容積を有する、請求項1に記載の歩行用デバイス。
- 前記歩行用デバイスは前記患者の吸気に反応して前記気相のニトロシル化剤を前記空気の混合物を前記患者に送達するように構成されている、請求項1に記載の歩行用デバイス。
- 前記温度コントローラは、前記リザーバ内の第一の温度を制御して、前記気相のニトロシル化剤の圧力を制御する、請求項1に記載の歩行用デバイス。
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762516973P | 2017-06-08 | 2017-06-08 | |
US62/516,973 | 2017-06-08 | ||
JP2019567711A JP7263261B2 (ja) | 2017-06-08 | 2018-06-07 | 制御された濃度で送達を行うための気化システム |
PCT/US2018/036412 WO2018226928A1 (en) | 2017-06-08 | 2018-06-07 | Vaporization system for delivery in a controlled concentration |
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JP2019567711A Division JP7263261B2 (ja) | 2017-06-08 | 2018-06-07 | 制御された濃度で送達を行うための気化システム |
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JP2023085537A JP2023085537A (ja) | 2023-06-20 |
JP7473706B2 true JP7473706B2 (ja) | 2024-04-23 |
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JP2023064533A Active JP7473706B2 (ja) | 2017-06-08 | 2023-04-12 | 制御された濃度で送達を行うための気化システム |
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Country | Link |
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US (2) | US11577042B2 (ja) |
EP (2) | EP3634554B1 (ja) |
JP (2) | JP7263261B2 (ja) |
CN (2) | CN111194230B (ja) |
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008118360A1 (en) | 2007-03-23 | 2008-10-02 | Geno Llc | Conversion of nitrogen dioxide (no2) to nitric oxide (no) |
WO2011063335A1 (en) | 2009-11-20 | 2011-05-26 | Geno Llc | Nitric oxide delivery system |
WO2011094684A1 (en) | 2010-02-01 | 2011-08-04 | Geno Llc | Nitric oxide delivery system |
JP2014506872A (ja) | 2010-12-03 | 2014-03-20 | ゲノ エルエルシー | 一酸化窒素治療 |
US20160121071A1 (en) | 2014-10-30 | 2016-05-05 | Nu-Med Plus | Controlled delivery of medical gases using diffusion membranes |
JP2020523100A (ja) | 2017-06-08 | 2020-08-06 | ケース ウエスタン リザーブ ユニバーシティ | 制御された濃度で送達を行うための気化システム |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH025800Y2 (ja) * | 1985-01-14 | 1990-02-13 | ||
US5607000A (en) | 1994-10-31 | 1997-03-04 | Motorola, Inc. | Hazardous material liquid dispensing system and method |
US20050107767A1 (en) * | 1998-05-19 | 2005-05-19 | Ott Douglas E. | Method and apparatus for delivering an agent to the abdomen |
US6758214B2 (en) * | 2000-01-28 | 2004-07-06 | Cyterra Corporation | Simple nitric oxide generator for ambulatory and/or bedside inhaled no treatment |
ES2474600T3 (es) * | 2001-07-31 | 2014-07-09 | Philip Morris Products S.A. | Método y aparato para generar un material volatilizado |
US20040225275A1 (en) * | 2001-08-02 | 2004-11-11 | Reynolds James Dixon | Fetal physiology during maternal surgery or diagnosis |
US6676855B2 (en) * | 2001-08-02 | 2004-01-13 | Duke University | Use of a blood-flow decrease preventing agent in conjunction with insufflating gas |
US7438072B2 (en) * | 2005-03-02 | 2008-10-21 | Izuchukwu John I | Portable field anesthesia machine and control therefore |
WO2006113540A2 (en) * | 2005-04-14 | 2006-10-26 | Duke University | Use of ntrosylated hemoglobin |
WO2007103534A2 (en) * | 2006-03-07 | 2007-09-13 | Nitrox, Llc | Ethyl nitrite as a gastrointestinal smooth muscle relaxant and diagnostic and therapeutic uses thereof |
US20110003012A1 (en) * | 2007-09-10 | 2011-01-06 | Duke University | Treating patients with subarachnoid hemorrhage |
US8052127B2 (en) * | 2007-10-19 | 2011-11-08 | Philip Morris Usa Inc. | Respiratory humidification system |
WO2009105711A1 (en) * | 2008-02-21 | 2009-08-27 | Decision Biomarkers, Inc. | Assays based on liquid flow over arrays |
CN103429293B (zh) * | 2011-03-14 | 2016-02-24 | 皇家飞利浦有限公司 | 具有进液保护的加湿器 |
US9072859B2 (en) * | 2011-05-31 | 2015-07-07 | Naoyuki Ishikita | Anesthetic inhalation aid device and attachment used for the same |
JP5856287B2 (ja) * | 2012-03-27 | 2016-02-09 | 帝人ファーマ株式会社 | 消音器およびそれを備えた酸素濃縮装置 |
EP2830693A4 (en) * | 2012-03-29 | 2015-11-25 | Joseph Fisher | NARCOSEGAS DELIVERY SYSTEM |
WO2014059405A1 (en) * | 2012-10-12 | 2014-04-17 | Inova Labs, Inc. | Method and systems for the delivery of oxygen enriched gas |
US10668243B2 (en) * | 2014-07-09 | 2020-06-02 | General Electric Company | Anesthesia compliant volume system and method |
GB201414820D0 (en) * | 2014-08-20 | 2014-10-01 | Brown Sebastian M | Improvements to anaesthetic recycling methods and systems |
US10300226B2 (en) * | 2015-06-15 | 2019-05-28 | Binyomin COHEN | Rescue inhaler |
US10773045B2 (en) * | 2016-09-30 | 2020-09-15 | Kirura Holding B.V. | Anesthesia delivery and ventilation system |
-
2018
- 2018-06-07 CN CN201880047660.1A patent/CN111194230B/zh active Active
- 2018-06-07 EP EP18734722.4A patent/EP3634554B1/en active Active
- 2018-06-07 WO PCT/US2018/036412 patent/WO2018226928A1/en unknown
- 2018-06-07 CN CN202310333306.8A patent/CN116236665A/zh active Pending
- 2018-06-07 JP JP2019567711A patent/JP7263261B2/ja active Active
- 2018-06-07 EP EP23197388.4A patent/EP4285977A3/en active Pending
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-
2023
- 2023-02-06 US US18/105,921 patent/US20230191069A1/en active Pending
- 2023-04-12 JP JP2023064533A patent/JP7473706B2/ja active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008118360A1 (en) | 2007-03-23 | 2008-10-02 | Geno Llc | Conversion of nitrogen dioxide (no2) to nitric oxide (no) |
WO2011063335A1 (en) | 2009-11-20 | 2011-05-26 | Geno Llc | Nitric oxide delivery system |
WO2011094684A1 (en) | 2010-02-01 | 2011-08-04 | Geno Llc | Nitric oxide delivery system |
JP2014506872A (ja) | 2010-12-03 | 2014-03-20 | ゲノ エルエルシー | 一酸化窒素治療 |
US20160121071A1 (en) | 2014-10-30 | 2016-05-05 | Nu-Med Plus | Controlled delivery of medical gases using diffusion membranes |
JP2020523100A (ja) | 2017-06-08 | 2020-08-06 | ケース ウエスタン リザーブ ユニバーシティ | 制御された濃度で送達を行うための気化システム |
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JP2020523100A (ja) | 2020-08-06 |
CN111194230B (zh) | 2023-04-21 |
JP2023085537A (ja) | 2023-06-20 |
WO2018226928A1 (en) | 2018-12-13 |
US20200114110A1 (en) | 2020-04-16 |
EP3634554A1 (en) | 2020-04-15 |
JP7263261B2 (ja) | 2023-04-24 |
EP4285977A3 (en) | 2024-02-14 |
US20230191069A1 (en) | 2023-06-22 |
CN111194230A (zh) | 2020-05-22 |
US11577042B2 (en) | 2023-02-14 |
EP4285977A2 (en) | 2023-12-06 |
EP3634554B1 (en) | 2023-11-08 |
CN116236665A (zh) | 2023-06-09 |
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