JP7470105B2 - 非マイクロサテライト高不安定性／ミスマッチ修復の良好な結腸直腸がんを処置するためのｐｄ－１アンタゴニストおよびｌａｇ３アンタゴニストの組み合わせ - Google Patents

非マイクロサテライト高不安定性／ミスマッチ修復の良好な結腸直腸がんを処置するためのｐｄ－１アンタゴニストおよびｌａｇ３アンタゴニストの組み合わせ Download PDF

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JP7470105B2
JP7470105B2 JP2021513868A JP2021513868A JP7470105B2 JP 7470105 B2 JP7470105 B2 JP 7470105B2 JP 2021513868 A JP2021513868 A JP 2021513868A JP 2021513868 A JP2021513868 A JP 2021513868A JP 7470105 B2 JP7470105 B2 JP 7470105B2
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antagonist
lag3
antibody
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amino acid
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チャータッシュ，エリオット・ケー
マクラナハン，テリル・ケー
ヒーリー，ジェーン・アン
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メルク・シャープ・アンド・ドーム・エルエルシー
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • General Chemical & Material Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2021513868A 2018-09-13 2019-09-09 非マイクロサテライト高不安定性／ミスマッチ修復の良好な結腸直腸がんを処置するためのｐｄ－１アンタゴニストおよびｌａｇ３アンタゴニストの組み合わせ Active JP7470105B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862730772P 2018-09-13 2018-09-13
US62/730,772 2018-09-13
US201862755844P 2018-11-05 2018-11-05
US62/755,844 2018-11-05
PCT/US2019/050122 WO2020055702A1 (en) 2018-09-13 2019-09-09 Combination of pd-1 antagonist and lag3 antagonist for treating non-microsatellite instablity-high/proficient mismatch repair colorectal cancer

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JP2022500410A JP2022500410A (ja) 2022-01-04
JP2022500410A5 JP2022500410A5 (enExample) 2022-09-01
JP7470105B2 true JP7470105B2 (ja) 2024-04-17

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US (1) US20210317214A1 (enExample)
EP (1) EP3849606A4 (enExample)
JP (1) JP7470105B2 (enExample)
AU (1) AU2019337547A1 (enExample)
CA (1) CA3111066A1 (enExample)
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EP3880709A4 (en) * 2018-11-05 2022-07-27 Merck Sharp & Dohme Corp. DOSING REGIME OF ANTI-LAG3 ANTIBODIES AND COMBINATION THERAPY WITH ANTI-PD-1 ANTIBODIES FOR THE TREATMENT OF CANCER
EP4132932A4 (en) 2020-04-07 2024-04-17 Syndax Pharmaceuticals, Inc. COMBINATIONS OF MENIN INHIBITORS AND CYP3A4 INHIBITORS AND METHODS OF USE THEREOF
KR20230093282A (ko) 2020-10-23 2023-06-27 브리스톨-마이어스 스큅 컴퍼니 폐암에 대한 lag-3 길항제 요법
IL308476A (en) 2021-05-14 2024-01-01 Syndax Pharmaceuticals Inc Inhibitors of the menin-mil interaction
WO2023164638A1 (en) * 2022-02-25 2023-08-31 Bristol-Myers Squibb Company Combination therapy for colorectal carcinoma
US20250295661A1 (en) * 2022-05-09 2025-09-25 Syndax Pharmaceuticals, Inc. Menin-mll inhibitors for the treatment of cancer
WO2026035866A1 (en) 2024-08-07 2026-02-12 Iovance Biotherapeutics, Inc. Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with a lag-3 inhibitor and a pd-1 inhibitor

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CA3111066A1 (en) 2020-03-19
WO2020055702A1 (en) 2020-03-19
EP3849606A1 (en) 2021-07-21
AU2019337547A1 (en) 2021-03-18
JP2022500410A (ja) 2022-01-04
US20210317214A1 (en) 2021-10-14
EP3849606A4 (en) 2022-06-29

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