JP7465886B2 - 治療剤を胃壁の中に送達するためのデバイス、システム、および方法 - Google Patents
治療剤を胃壁の中に送達するためのデバイス、システム、および方法 Download PDFInfo
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Description
本出願は、2019年3月1日に出願された米国仮特許出願第62/812,867号および2019年3月20日に出願された米国仮特許出願第62/821,250号に対する優先権およびその利益を主張し、両出願の完全な開示は参照によりあらゆる目的のために本明細書に組み込まれる。
本発明の実施形態は、嚥下可能な薬物送達デバイスに関する。より具体的には、本発明は、治療剤を胃洞または胃壁の他の部分の中に送達するための嚥下可能な薬物送達デバイスに関する。
Claims (20)
- 治療剤調製物を患者の胃の洞壁の中に送達するための嚥下可能なデバイスであって、前記デバイスは、
カプセル壁を有し、前記治療剤調製物が内部に収容された嚥下可能なカプセルと、
前記カプセルの内部にあり、前記治療剤調製物を前記カプセル壁を通り前記洞壁の中に前進させるように構成されたドライバと、
洞の蠕動収縮によって前記カプセル壁が圧搾されているときに感知する、前記カプセル壁に動作可能に結合されたセンサと、
前記センサおよび前記ドライバに動作可能に結合され、前記洞の前記蠕動収縮によって前記カプセルが圧搾されていることを前記センサが感知すると、前記ドライバに前記治療剤調製物を前記カプセル壁を通って前記洞壁の中に前進させ、前記カプセルの少なくとも一部分が前記洞の前記蠕動収縮によって圧搾されている間に、前記治療剤調製物が前記カプセル壁を通って前進させられるトリガと、を備える、嚥下可能なデバイス。 - 前記嚥下可能なカプセルの前記カプセル壁は、円筒形シェルを備える、請求項1に記載のデバイス。
- 前記カプセル壁の少なくとも一部分が、前記患者の腸管内で分解性である、請求項1に記載のデバイス。
- 前記カプセル壁の前記少なくとも一部分は、約6.5以上のpHで分解する、請求項3に記載のデバイス。
- 前記カプセル壁の少なくとも一部分が、前記患者の胃腸管内で非分解性である、請求項1に記載のデバイス。
- 前記ドライバは、推進剤を含む、請求項1に記載のデバイス。
- 前記推進剤は、ニトロセルロースを含む、請求項6に記載のデバイス。
- 前記ドライバは、バルーンを含む、請求項1に記載のデバイス。
- 前記ドライバは、圧縮ばねを含む、請求項1に記載のデバイス。
- 前記ドライバは、第1のドライバであって、前記デバイスは、第2のドライバをさらに含み、前記第1のドライバおよび前記第2のドライバは、それぞれ前記治療剤調製物を少なくとも2つの方向に送るように構成された、請求項1に記載のデバイス。
- 前記センサは、前記カプセル壁への外部の圧力を表す圧力信号を生成する電子トランスデューサを含む、請求項1に記載のデバイス。
- 前記トリガは、前記センサから前記圧力信号を受信し、前記圧力が所定の閾値を超えるとトリガ信号を生成する電子回路を含む、請求項11に記載のデバイス。
- 前記所定の閾値は、約300ダイン/cm2~約1100ダイン/cm2の範囲にある、請求項12に記載のデバイス。
- 前記センサは、閾値を上回る前記カプセル壁への外部圧力の変化に応答して状態を変化させる機械的または流体センサ要素を含む、請求項1に記載のデバイス。
- 前記閾値は、約300ダイン/cm2~約1100ダイン/cm2の範囲にある、請求項14に記載のデバイス。
- 前記治療剤調製物は、前記ドライバによって前記洞壁の中に前進させられるように構成された固体投与形態を含む、請求項1に記載のデバイス。
- 前記固体投与形態は、先細の、鋭利な、またはホーニングされた先端を有する細長い部材になるように、賦形剤または結合剤のうちの少なくとも1つと形成または混合された治療剤を含む、請求項16に記載のデバイス。
- 前記治療剤調製物は、前記ドライバによって中空針を通って前記洞壁の中に前進させられる液体投与形態を含む、請求項1に記載のデバイス。
- 治療剤調製物を患者の胃の洞壁の中に送達するための嚥下可能なデバイスであって、前記デバイスは、
前記患者の胃腸管を通過するようにサイズ決定され、対向した側部および対向した端部を含む壁を有し、前記壁の前記対向した側部の一方が前記洞壁に隣接するように、洞の蠕動収縮中に前記胃の洞内で長手方向に配向するように構成された細長い形状を有するカプセルと、
前記カプセルの内部にあり、治療剤を含み、組織貫通部材として成形されている、治療用調製物と、
前記カプセルの前記壁の側壁部に配置され、前記洞の前記蠕動収縮に対応する、前記カプセルに前記洞壁によって印加された力を感知し、前記力を感知すると出力を生成するように構成されたセンサと、
前記組織貫通部材および前記センサに動作可能に結合され、前記カプセルの少なくとも一部分が前記洞の前記蠕動収縮によって圧搾されている間に、前記センサからの前記出力に応答して、前記組織貫通部材を前記カプセルから洞壁組織の中に射出するように構成された射出手段と、を備える、嚥下可能なデバイス。 - 治療剤調製物を患者の胃腸(GI)管の壁であるGI壁の中に送達するための嚥下可能なデバイスであって、前記デバイスは、
カプセル壁を有し、前記治療剤調製物が内部に収容されている嚥下可能なカプセルと、
前記カプセルの内部にあり、前記治療剤調製物を前記カプセル壁を通って前記GI壁の中に前進させるように構成されたドライバと、
前記GI壁の蠕動収縮によって前記カプセルが圧搾されているときに感知する、前記カプセル壁に動作可能に結合されたセンサと、
前記センサおよび前記ドライバに動作可能に結合され、前記GI壁の前記蠕動収縮によって前記カプセルが圧搾されていることを前記センサが感知すると、前記ドライバに前記治療剤調製物を前記カプセル壁を通って前記GI壁の中に前進させ、前記カプセルの少なくとも一部分が前記GI壁の前記蠕動収縮によって圧搾されている間に、前記治療剤調製物は前記カプセル壁を通って前進させられるトリガと、を備える、嚥下可能なデバイス。
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Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9259386B2 (en) | 2010-12-23 | 2016-02-16 | Rani Therapeutics, Llc | Therapeutic preparation comprising somatostatin or somatostatin analogoue for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
US8734429B2 (en) | 2010-12-23 | 2014-05-27 | Rani Therapeutics, Llc | Device, system and methods for the oral delivery of therapeutic compounds |
US9402806B2 (en) | 2010-12-23 | 2016-08-02 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
US9415004B2 (en) | 2010-12-23 | 2016-08-16 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
US8809269B2 (en) | 2010-12-23 | 2014-08-19 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising insulin for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
US10689460B2 (en) | 2014-05-15 | 2020-06-23 | Incube Labs, Llc | PCSK9 antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
WO2019094521A1 (en) * | 2017-11-07 | 2019-05-16 | Rani Therapeutics, Llc | Clotting factor preparations for delivery into tissue of the intestinal tract using a swallowable drug delivery device |
AU2020233287A1 (en) | 2019-03-01 | 2021-09-23 | Rani Therapeutics, Llc | Devices, systems, and methods for delivering therapeutic agents into a stomach wall |
WO2022186403A1 (ko) * | 2021-03-05 | 2022-09-09 | 주식회사 레인보우솔루션 | 경구형 물질 전달 장치 |
CN113576374B (zh) * | 2021-08-31 | 2022-08-30 | 武汉大学 | 一种板簧驱动的磁控施药胶囊机器人 |
CN113576373B (zh) * | 2021-08-31 | 2022-08-30 | 武汉大学 | 一种磁控微针穿刺施药胶囊 |
DK181266B1 (en) * | 2021-10-28 | 2023-06-14 | Biograil ApS | Drug delivery device with offset acutator mechanism |
WO2023148623A2 (en) * | 2022-02-01 | 2023-08-10 | Abhinav Goyal | Devices, insertion apparatus, and methods for administering samples |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008534028A (ja) | 2005-01-18 | 2008-08-28 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 摂取されたカプセルの通過を制御するシステムおよび方法 |
JP2013515576A (ja) | 2009-12-24 | 2013-05-09 | インキューブ ラブズ, エルエルシー | 嚥下可能薬物送達デバイスおよび薬物送達方法 |
Family Cites Families (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4564363A (en) | 1983-07-13 | 1986-01-14 | Smithkline Beckman Corporation | Delayed action assembly |
TWI222370B (en) | 2001-12-14 | 2004-10-21 | Roche Diagnostics Gmbh | Needleless hypodermic injection device |
EP1594477A4 (en) | 2003-01-29 | 2009-07-15 | Pill Pharma Ltd E | ACTIVE MEDICATION CONTRIBUTION IN THE DIGESTIVE TUBE |
US9700450B2 (en) * | 2003-07-28 | 2017-07-11 | Baronova, Inc. | Devices and methods for gastrointestinal stimulation |
DE102005032369A1 (de) | 2005-07-08 | 2007-01-11 | Siemens Ag | Endoskopiekapsel |
US8591457B2 (en) | 2005-08-10 | 2013-11-26 | Alza Corporation | Method for making a needle-free jet injection drug delivery device |
US8597279B2 (en) * | 2006-10-31 | 2013-12-03 | Medimetrics Personalized Drug Delivery, Inc. | Swallowable multi-nozzle dosing device for releasing medicines in the gastrointestinal tract |
ATE505128T1 (de) | 2008-06-04 | 2011-04-15 | Olympus Medical Systems Corp | Kapselförmige medizinische vorrichtung |
US20100286628A1 (en) * | 2009-05-07 | 2010-11-11 | Rainbow Medical Ltd | Gastric anchor |
US8356634B2 (en) | 2009-07-21 | 2013-01-22 | Piranha Hose Products | System for controlling elongation of a conduit within which flowable material is conveyed |
US8682440B2 (en) | 2009-08-03 | 2014-03-25 | Incube Labs, Llc | Swallowable capsule and method for stimulating incretin production within the intestinal tract |
US8562589B2 (en) | 2009-12-24 | 2013-10-22 | Rani Therapeutics, Llc | Swallowable drug delivery device and method of delivery |
US8809271B2 (en) | 2010-12-23 | 2014-08-19 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising liraglutide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
US8846040B2 (en) | 2010-12-23 | 2014-09-30 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising etanercept for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
US9259386B2 (en) | 2010-12-23 | 2016-02-16 | Rani Therapeutics, Llc | Therapeutic preparation comprising somatostatin or somatostatin analogoue for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
US8809269B2 (en) | 2010-12-23 | 2014-08-19 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising insulin for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
US9149617B2 (en) | 2010-12-23 | 2015-10-06 | Rani Therapeutics, Llc | Device, system and methods for the oral delivery of therapeutic compounds |
US8734429B2 (en) | 2010-12-23 | 2014-05-27 | Rani Therapeutics, Llc | Device, system and methods for the oral delivery of therapeutic compounds |
US9861683B2 (en) | 2010-12-23 | 2018-01-09 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
US8764733B2 (en) | 2010-12-23 | 2014-07-01 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
US9629799B2 (en) | 2010-12-23 | 2017-04-25 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
US8969293B2 (en) | 2010-12-23 | 2015-03-03 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising exenatide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
US9402807B2 (en) | 2010-12-23 | 2016-08-02 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
US9284367B2 (en) | 2010-12-23 | 2016-03-15 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
US9402806B2 (en) | 2010-12-23 | 2016-08-02 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
US8980822B2 (en) | 2010-12-23 | 2015-03-17 | Rani Therapeutics, Llc | Therapeutic agent preparations comprising pramlintide for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
US9283179B2 (en) | 2010-12-23 | 2016-03-15 | Rani Therapeutics, Llc | GnRH preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
US9415004B2 (en) | 2010-12-23 | 2016-08-16 | Rani Therapeutics, Llc | Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
US20150064241A1 (en) * | 2013-09-05 | 2015-03-05 | Google Inc. | Delivery of Functionalized Particles |
CN105916541A (zh) | 2013-09-26 | 2016-08-31 | 医学量度个性化药物输送有限公司 | 具有阈值释放装置的传送胶囊 |
US10039810B2 (en) | 2014-05-15 | 2018-08-07 | Incube Labs, Llc | Pharmaceutical compositions and methods for fabrication of solid masses comprising anti-interleukin antibodies |
US11548940B2 (en) | 2014-05-15 | 2023-01-10 | Rani Therapeutics, Llc | Anti-interleukin antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
US10689460B2 (en) | 2014-05-15 | 2020-06-23 | Incube Labs, Llc | PCSK9 antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
US10300259B2 (en) * | 2014-10-22 | 2019-05-28 | Purdue Research Foundation | Smart capsule with GI-tract-location-specific payload release |
US10765361B2 (en) * | 2015-03-02 | 2020-09-08 | Verily Life Sciences Llc | Automated sequential injection and blood draw |
CA2983337A1 (en) | 2015-05-01 | 2016-11-10 | Incube Labs, Llc | Pharmaceutical compositions and methods for fabrication of solid masses comprising polypeptides and/or proteins |
CN109152796A (zh) | 2016-03-09 | 2019-01-04 | 因库博实验室有限责任公司 | 用于将活细胞递送至实体组织的方法和制品 |
US20170265598A1 (en) | 2016-03-15 | 2017-09-21 | Nike, Inc. | Method of making multi-colored objects |
US10286198B2 (en) | 2016-04-08 | 2019-05-14 | International Business Machines Corporation | Microchip medical substance delivery devices |
KR102391768B1 (ko) | 2017-05-17 | 2022-04-29 | 메사추세츠 인스티튜트 오브 테크놀로지 | 자가-직립 시스템, 방법, 및 관련 구성요소 |
WO2019094521A1 (en) | 2017-11-07 | 2019-05-16 | Rani Therapeutics, Llc | Clotting factor preparations for delivery into tissue of the intestinal tract using a swallowable drug delivery device |
CN108686292A (zh) | 2018-05-28 | 2018-10-23 | 重庆大学 | 一种释药胶囊 |
AU2020233287A1 (en) | 2019-03-01 | 2021-09-23 | Rani Therapeutics, Llc | Devices, systems, and methods for delivering therapeutic agents into a stomach wall |
-
2020
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- 2020-02-28 WO PCT/US2020/020544 patent/WO2020180746A1/en active Application Filing
- 2020-02-28 MX MX2021010442A patent/MX2021010442A/es unknown
- 2020-02-28 CN CN202310832179.6A patent/CN116870341A/zh active Pending
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- 2020-02-28 EP EP20766653.8A patent/EP3930688A4/en active Pending
- 2020-02-28 US US16/805,317 patent/US11565095B2/en active Active
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- 2020-02-28 JP JP2021550224A patent/JP2022523533A/ja active Pending
- 2020-02-28 AU AU2020232610A patent/AU2020232610A1/en active Pending
- 2020-02-28 EP EP20765802.2A patent/EP3930693A4/en active Pending
- 2020-02-28 CN CN202080028728.9A patent/CN113692275B/zh active Active
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- 2020-02-28 WO PCT/US2020/020540 patent/WO2020180745A1/en active Application Filing
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-
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-
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- 2023-10-31 US US18/499,078 patent/US20240139479A1/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008534028A (ja) | 2005-01-18 | 2008-08-28 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 摂取されたカプセルの通過を制御するシステムおよび方法 |
JP2013515576A (ja) | 2009-12-24 | 2013-05-09 | インキューブ ラブズ, エルエルシー | 嚥下可能薬物送達デバイスおよび薬物送達方法 |
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