JP7451090B2 - Automatic analyzer, cap, and measurement method - Google Patents

Description

Embodiments of the present invention relate to an automatic analyzer, a cap, and a measurement method.

The automatic analyzer mixes biological samples (hereinafter referred to as samples) such as blood and urine with reagents corresponding to various test items in a cuvette (reaction container). The automatic analyzer determines the concentration, activity value, time required for change, etc. of the substance to be measured by shining light on the obtained mixed liquid and measuring the amount of transmitted light or scattered light.

By the way, in an automatic analyzer, a sample dispensing position where a sample is dispensed, a reagent dispensing position where a reagent is dispensed, etc. are set in advance. The reaction disk holds a plurality of cuvettes in an annular shape and rotates according to instructions from a control circuit to move the held cuvettes to a sample dispensing position, a reagent dispensing position, or the like. At this time, since the cuvette is repeatedly moved to a desired position and stopped at the desired position, sloshing occurs in the liquid mixture in the cuvette due to acceleration and deceleration of the reaction disk. This sloshing causes turbulence in the surface of the mixed liquid and unnecessary convection, which causes unstable measurement results.

Japanese Patent Application Publication No. 2018-48901

The problem to be solved by the invention is to stabilize measurement results.

According to an embodiment, the automatic analysis device comprises a reaction disk, a supply means and a photometric means. The reaction disk rotates while holding a reaction container containing a mixed solution of a sample and a reagent. The supply means supplies the suppressing member to the reaction vessel. The photometric means optically measures the mixed liquid whose movement is suppressed by the suppressing member.

FIG. 1 is a block diagram showing the functional configuration of an automatic analyzer according to the first embodiment. FIG. 2 is a diagram showing the configuration of the analysis mechanism shown in FIG. 1. FIG. 3 is a top view showing the structure of the cap supply mechanism shown in FIGS. 1 and 2. FIG. FIG. 4 is a side view showing the configuration of the cap supply mechanism shown in FIGS. 1 and 2. FIG. FIG. 5 is a perspective view of the cuvette shown in FIGS. 2-4. FIG. 6 is a top view of the cuvette shown in FIGS. 2-4. FIG. 7 is a side view of the cuvette shown in FIGS. 2-4. FIG. 8 is a perspective view of the cap shown in FIGS. 3 and 4. FIG. 9 is a top view of the cap shown in FIGS. 3 and 4. FIG. FIG. 10 is a side view of the cap shown in FIGS. 3 and 4. FIG. FIG. 11 is a bottom view of the cap shown in FIGS. 3 and 4. FIG. FIG. 12 is a flowchart showing the processing procedure of the control circuit when the automatic analyzer shown in FIG. 1 measures a predetermined test item. FIG. 13 is a side view showing the configuration of the cap supply mechanism when the pressing section shown in FIG. 4 pushes the cap into the cuvette. FIG. 14 is a perspective view showing the cap shown in FIGS. 8 to 11 inserted into a cuvette. FIG. 15 is a cross-sectional view showing the cap shown in FIGS. 8 to 11 inserted into a cuvette. FIG. 16 is a perspective view showing another example of the cap shown in FIGS. 3 and 4. FIG. 17 is a top view showing another example of the cap shown in FIGS. 3 and 4. FIG. 18 is a side view showing another example of the cap shown in FIGS. 3 and 4. FIG. 19 is a bottom view showing another example of the cap shown in FIGS. 3 and 4. FIG. FIG. 20 is a perspective view showing another example of the cap shown in FIGS. 3 and 4. FIG. 21 is a top view showing another example of the cap shown in FIGS. 3 and 4. FIG. FIG. 22 is a side view showing another example of the cap shown in FIGS. 3 and 4. FIG. 23 is a bottom view of another example of the cap shown in FIGS. 3 and 4. FIG. FIG. 24 is a perspective view showing another example of the cap shown in FIGS. 3 and 4. FIG. 25 is a top view showing another example of the cap shown in FIGS. 3 and 4. FIG. FIG. 26 is a side view showing another example of the cap shown in FIGS. 3 and 4. FIG. 27 is a bottom view of another example of the cap shown in FIGS. 3 and 4. FIG. FIG. 28 is a diagram showing another example of the lid portion of the cap shown in FIGS. 8 to 11. FIG. 29 is a block diagram showing the functional configuration of the automatic analyzer according to the second embodiment. FIG. 30 is a diagram showing the configuration of the oil supply mechanism shown in FIG. 29. FIG. 31 is a flowchart showing the processing procedure of the control circuit when the automatic analyzer shown in FIG. 29 measures a predetermined test item. FIG. 32 represents a cross-sectional view of the cuvette shown in FIGS. 5-7 with oil supplied thereto.

Hereinafter, embodiments will be described with reference to the drawings.

(First embodiment)
FIG. 1 is a block diagram showing an example of the functional configuration of an automatic analyzer 1 according to the first embodiment. The automatic analyzer 1 shown in FIG. 1 includes an analysis mechanism 2, an analysis circuit 3, a drive mechanism 4, an input interface 5, an output interface 6, a communication interface 7, a storage circuit 8, a control circuit 9, and a cap supply mechanism 10. .

The analysis mechanism 2 mixes a sample such as blood or urine with a reagent used in each test item. Further, depending on the test item, the analysis mechanism 2 mixes a standard solution diluted at a predetermined ratio with a reagent used in the test item. The analysis mechanism 2 measures optical property values of a sample or a mixture of a standard solution and a reagent. This measurement generates standard data expressed by transmitted light intensity or absorbance, scattered light intensity, etc., and test data.

The analysis circuit 3 is a processor that generates calibration data and analysis data by analyzing the standard data and test data generated by the analysis mechanism 2. For example, the analysis circuit 3 reads an analysis program from the storage circuit 8 and analyzes the standard data and test data according to the read analysis program. Note that the analysis circuit 3 may include a storage area for storing at least part of the data stored in the storage circuit 8.

The drive mechanism 4 drives the analysis mechanism 2 under the control of the control circuit 9. The drive mechanism 4 is realized by, for example, a gear, a stepping motor, a belt conveyor, a lead screw, or the like.

The input interface 5 receives, for example, settings such as analysis parameters for each test item related to a sample requested to be measured from an operator or via the hospital network NW. The input interface 5 is realized by, for example, a mouse, a keyboard, a touch pad on which instructions are input by touching the operation surface, and the like. The input interface 5 is connected to the control circuit 9 , converts an operation instruction input from an operator into an electrical signal, and outputs the electrical signal to the control circuit 9 . Note that in this specification, the input interface 5 is not limited to one that includes physical operation parts such as a mouse and a keyboard. For example, an electrical signal processing circuit that receives an electrical signal corresponding to an operation instruction input from an external input device provided separately from the automatic analyzer 1 and outputs this electrical signal to the control circuit 9 is also an input interface. Included in example 5.

The output interface 6 is connected to the control circuit 9 and outputs a signal supplied from the control circuit 9. The output interface 6 is realized by, for example, a display circuit, a printed circuit, an audio device, and the like. Display circuits include, for example, CRT displays, liquid crystal displays, organic EL displays, LED displays, plasma displays, and the like. Note that the display circuit also includes a processing circuit that converts data representing a display target into a video signal and outputs the video signal to the outside. The printed circuit includes, for example, a printer. Note that the printing circuit also includes an output circuit that outputs data representing the printing target to the outside. The audio device includes, for example, a speaker. Note that the audio device also includes an output circuit that outputs the audio signal to the outside.

The communication interface 7 is connected to, for example, a hospital network NW. The communication interface 7 performs data communication with an HIS (Hospital Information System) via the hospital network NW. Note that the communication interface 7 may perform data communication with the HIS via a laboratory information system (LIS) connected to the hospital network NW.

The storage circuit 8 includes a processor-readable storage medium such as a magnetic or optical storage medium or a semiconductor memory. Note that the memory circuit 8 does not necessarily need to be realized by a single memory device. For example, the memory circuit 8 may be realized by a plurality of memory devices.

The storage circuit 8 stores an analysis program executed by the analysis circuit 3 and a control program for realizing the functions provided in the control circuit 9. The storage circuit 8 stores the calibration data generated by the analysis circuit 3 for each inspection item. The storage circuit 8 stores the analysis data generated by the analysis circuit 3 for each sample. The storage circuit 8 stores a test order input by an operator or a test order received by the communication interface 7 via the hospital network NW.

The control circuit 9 is a processor that functions as the core of the automatic analyzer 1. The control circuit 9 executes a program stored in the storage circuit 8 to realize a function corresponding to the executed program. Note that the control circuit 9 may include a storage area that stores at least part of the data stored in the storage circuit 8.

FIG. 2 is a schematic diagram showing an example of the configuration of the analysis mechanism 2 shown in FIG. 1. The analysis mechanism 2 shown in FIG. 2 includes a reaction disk 201, a constant temperature section 202, a rack sampler 203, and a reagent storage 204.

The reaction disk 201 holds a plurality of cuvettes 2011 arranged in a ring. The reaction disk 201 transports the cuvette 2011 along a predetermined path. Specifically, the reaction disk 201 transports the cuvette 2011 by, for example, being alternately rotated and stopped at predetermined time intervals by the drive mechanism 4.

The constant temperature section 202 stores a heat medium set at a predetermined temperature, and raises the temperature of the liquid mixture contained in the cuvette 2011 by immersing the cuvette 2011 in the stored heat medium.

The rack sampler 203 movably supports a sample rack 2031 that can hold a plurality of sample containers containing samples requested to be measured. In the example shown in FIG. 2, a sample rack 2031 that can hold five sample containers in parallel is shown.

The rack sampler 203 is provided with a transport area for transporting the sample rack 2031 from a loading position where the sample rack 2031 is loaded to a collection position where the sample rack 2031 after measurement is collected. In the transport area, a plurality of sample racks 2031 aligned in the longitudinal direction are moved in the direction D1 by the drive mechanism 4.

Further, the rack sampler 203 is provided with a retraction area for pulling the sample rack 2031 from the transport area in order to move the sample container held by the sample rack 2031 to a predetermined sample suction position. The sample suction position is provided, for example, at a position where the rotation trajectory of the sample dispensing probe 207 and the movement trajectory of the opening of the sample container supported by the rack sampler 203 and held by the sample rack 2031 intersect. In the retraction area, the transported sample rack 2031 is moved in the direction D2 by the drive mechanism 4.

Furthermore, the rack sampler 203 is provided with a return area for returning the sample rack 2031 holding the sample container into which the sample has been aspirated to the transport area. In the return area, the sample rack 2031 is moved in the direction D3 by the drive mechanism 4.

The reagent storage 204 cools a plurality of reagent containers 100 that contain standard solutions and reagents used in each test item performed on a sample. A rotary table is rotatably provided in the reagent storage 204. The rotary table holds and holds a plurality of reagent containers 100 in an annular shape. Note that in this embodiment, although not shown in FIG. 2, the reagent storage 204 is covered with a reagent cover that is detachable.

The analysis mechanism 2 shown in FIG. 2 also includes a sample dispensing arm 206, a sample dispensing probe 207, a reagent dispensing arm 208, a reagent dispensing probe 209, and a photometry unit 211.

Sample dispensing arm 206 is provided between reaction disk 201 and rack sampler 203. The sample dispensing arm 206 is provided so as to be vertically movable and horizontally rotatable by the drive mechanism 4 . Sample dispensing arm 206 holds a sample dispensing probe 207 at one end.

The sample dispensing probe 207 rotates along an arcuate rotation trajectory as the sample dispensing arm 206 rotates. A sample suction position for sucking a sample from a sample container held by the sample rack 2031 on the rack sampler 203 is provided on this rotational orbit. Further, a sample discharge position for discharging the sample aspirated by the sample dispensing probe 207 to the cuvette 2011 is provided on the rotational trajectory of the sample dispensing probe 207 . The sample discharge position corresponds to, for example, the intersection of the rotational trajectory of the sample dispensing probe 207 and the movement trajectory of the cuvette 2011 held on the reaction disk 201.

The sample dispensing probe 207 is driven by the drive mechanism 4 and moves in the vertical direction at the sample suction position or the sample discharge position. Further, the sample dispensing probe 207 aspirates the sample from the sample container stopped at the sample suction position under the control of the control circuit 9. Further, the sample dispensing probe 207 discharges the aspirated sample into the cuvette 2011 stopped at the sample discharge position under the control of the control circuit 9.

Reagent dispensing arm 208 is provided between reaction disk 201 and reagent storage 204. The reagent dispensing arm 208 is provided so as to be vertically movable and horizontally rotatable by the drive mechanism 4 . Reagent dispensing arm 208 holds a reagent dispensing probe 209 at one end.

The reagent dispensing probe 209 rotates along an arcuate rotation trajectory as the reagent dispensing arm 208 rotates. A reagent suction position is provided on this rotating orbit. The reagent suction position is provided, for example, at a position where the rotational trajectory of the reagent dispensing probe 209 and the movement trajectory of the opening of the reagent container 100 placed annularly on the rotary table intersect. Furthermore, a reagent discharge position for discharging the reagent sucked by the reagent dispensing probe 209 into the cuvette 2011 is set on the rotational trajectory of the reagent dispensing probe 209 . The reagent discharge position corresponds to, for example, the intersection of the rotational trajectory of the reagent dispensing probe 209 and the movement trajectory of the cuvette 2011 held on the reaction disk 201.

The reagent dispensing probe 209 is driven by the drive mechanism 4 and moves in the vertical direction at a reagent suction position or a reagent discharge position on a rotating orbit. Further, the reagent dispensing probe 209 aspirates reagent from the reagent container stopped at the reagent suction position under the control of the control circuit 9. Further, the reagent dispensing probe 209 discharges the aspirated reagent into the cuvette 2011 stopped at the reagent discharge position under the control of the control circuit 9.

The photometry unit 211 is an example of a photometry means that measures optical property values in a mixed liquid of a sample and a reagent discharged into the cuvette 2011. Although one photometry unit 211 is illustrated in FIG. 2, a plurality of photometry units 211 may be provided. For example, the number of photometry units 211 is the same as the number of cuvettes 2011 that can be held by the reaction disk 201. Each photometry unit 211 has, for example, a light source on the annular center side (inner periphery side) of a cuvette 2011 held annularly by the reaction disk 201, and a photodetector (transparent) on the annular outside (outer periphery side) of the cuvette 2011. photodetector). Note that each photometry unit 211 may have a second photodetector (scattered light detector) on the side of the cuvette 2011 instead of the photodetector, or a photodetector and a second photodetector may be provided on the side of the cuvette 2011. It may also have a detector.

The light source is provided so as to irradiate light toward the outside of the ring in which cuvettes 2011 are arranged. Light emitted from the light source enters the cuvette 2011 through the first side wall and exits from the second side wall opposite to the first side wall.

The photodetector detects the light emitted from the cuvette 2011. Specifically, for example, the photodetector detects the light that has passed through the mixture of the standard solution and reagent in the cuvette 2011. A photodetector samples detected light at predetermined time intervals and generates standard data expressed as transmitted light intensity, absorbance, or the like. Further, the photodetector detects the light that has passed through the mixture of the sample and reagent in the cuvette 2011. The photodetector samples detected light at predetermined time intervals and generates test data expressed by transmitted light intensity, absorbance, or the like. The photodetector outputs the generated standard data and test data to the analysis circuit 3.

Note that the photodetector may output the intensity of the detected light to the analysis circuit 3 as a detection signal. At this time, the analysis circuit 3 samples the detection signal at predetermined time intervals and generates standard data and test data.

The cap supply mechanism 10 shown in FIGS. 1 and 2 is an example of a supply means for supplying the cap 20 to the analysis mechanism 2. Further, the cap supply mechanism 10 inserts the supplied cap 20 into the cuvette 2011 held by the reaction disk 201. The cap supply mechanism 10 is provided, for example, near the reagent discharge position. If the cap supply mechanism 10 is provided near the reagent discharge position, the time from when the reagent is discharged into the cuvette 2011 to when the cap 20 is inserted is shortened.

3 and 4 are schematic diagrams showing examples of the configuration of the cap supply mechanism 10 shown in FIGS. 1 and 2. The cap supply mechanism 10 shown in FIGS. 3 and 4 includes a supply unit 11, a transfer unit 12, a rotation unit 13, and an insertion unit 14.

Here, the shape of the cap 20 supplied by the cap supply mechanism 10 and the shape of the cuvette 2011 into which the cap 20 is inserted will be explained. 5 to 7 are diagrams showing examples of the shape of the cuvette 2011 shown in FIGS. 2 to 4. FIG. 5 represents an example of a perspective view of a cuvette 2011. FIG. 6 represents an example of a top view of cuvette 2011. FIG. 7 represents an example of a side view of cuvette 2011.

The cuvette 2011 shown in FIGS. 5 to 7 is a container that is capable of dispensing a sample and a reagent and is capable of accommodating the dispensed sample, reagent, or a mixture thereof. The cuvette 2011 is made of polypropylene (PP) or acrylic, for example, and is made by integral molding. The height of the cuvette 2011 is, for example, about 3 cm. The cuvette 2011 has, for example, a bottom portion 2011a, a body portion 2011b, a flange 2011c, a top portion 2011d, and an opening portion 2011e.

The body portion 2011b includes a cylindrical portion 2012b, an inclined portion 2013b, and a light transmitting portion 2014b. The cylindrical portion 2012b is formed, for example, so that the shape of a cross section perpendicular to the stretching direction is circular regardless of the distance from the bottom portion 2011a. Note that the cross-sectional shape is not limited to a circle, but may be a square or the like.

The light transmitting portion 2014b is a portion through which irradiated light, transmitted light, or scattered light is transmitted, and is provided at a position a predetermined distance away from the bottom portion 2011a. In the light transmitting portion 2014b, for example, first flat portions 20141b-1 to 20141b-4 are formed around the body portion 2011b at intervals of 90 degrees. The first plane parts 20141b-1 to 20141b-4 are formed along the extending direction of the body part 2011b and are orthogonal to each other. Note that the light transmitting portion 2014b may not have the first flat portions 20141b-1 to 20141b-4, and the shape of the cross section perpendicular to the stretching direction may be circular.

The inclined portion 2013b is provided between the cylindrical portion 2012b and the light transmitting portion 2014b, and is formed so that its shape in a cross section perpendicular to the stretching direction changes depending on the distance from the bottom portion 2011a. For example, second flat portions 20131b-1 to 20131b-4 are formed on the inclined portion 2013b. The second plane parts 20131b-1 to 20131b-4 are formed continuously with the first plane parts 20141b-1 to 20141b-4, respectively, and the width of the plane becomes narrower as the distance from the bottom part 2011a increases. Note that when the cross sections of the cylindrical portion 2012b and the light transmitting portion 2014b are approximately square, the inclined portion 2013b may not be provided.

The flange 2011c is an annular member provided in the opening 2015b of the body portion 2011b. The flange 2011c is formed to have an outer diameter larger than the outer diameter of the body portion 2011b. The thickness of the flange 2011c is, for example, a thickness that allows the flange 2011c to have sufficient strength to support the cuvette 2011.

The top portion 2011d is a rectangular cylindrical member extending in the direction of the opening 2011e on the flange 2011c. The top portion 2011d is formed to have a substantially square shape in a cross section perpendicular to the stretching direction. The top portion 2011d has, for example, side wall portions 2012d-1 to 2012d-4. The side wall portions 2012d-1 to 2012d-4 are formed parallel to the first plane portions 20141b-1 to 20141b-4, respectively. The distance between side wall portion 2012d-1 and side wall portion 2012d-3 opposing side wall portion 2012d-1 is approximately equal to the diameter of opening 2015b of body portion 2011b.

Note that the cross-sectional shape of the top portion 2011d is approximately rectangular in accordance with the formation direction of the first flat portions 20141b-1 to 20141b-4 of the light transmitting portion 2014b, but is not limited thereto. The cross-sectional shape of the top portion 2011d may be any shape such as a circle.

Next, the shape of the cap 20 will be explained. 8 to 11 are diagrams showing examples of the shape of the cap 20 shown in FIGS. 3 and 4. FIG. FIG. 8 shows an example of a perspective view of the cap 20. FIG. 9 represents an example of a top view of the cap 20. FIG. 10 represents an example of a side view of the cap 20. FIG. 11 shows an example of a bottom view of the cap 20.

The cap 20 shown in FIGS. 8 to 11 can be inserted into the cuvette 2011 and is formed to be able to suppress the movement of the liquid mixture contained in the cuvette 2011. The cap 20 is made of polyethylene (PE), for example, and is created by integral molding. The height of the cap 20 is about the same height as the cuvette 2011, for example, about 3 cm. The cap 20 has, for example, a lid portion 20a, a constriction portion 20b, a body portion 20c, a flange 20d, and a top portion 20e.

The lid portion 20a is a member formed to be able to physically restrict the liquid mixture contained in the cuvette 2011. Specifically, for example, as shown in FIG. 11, the lid portion 20a is formed so that its shape in a cross section perpendicular to the stretching direction is approximately the same shape as the cross section of the light transmitting portion 2014b. . Note that the shape of the lid part 20a is not limited to the shape shown in FIG. 11, and if the cross-sectional shape of the light transmitting part 2014b is circular, it is circular, and if it is square, it is square. The lid portion 20a is provided at a predetermined distance from the surface of the flange 20d on the lid portion 20a side, for example, so that it can be stopped inside the light transmitting portion 2014b. More specifically, the position in the light transmitting part 2014b is such that, for example, when the expected minimum amount of the mixed liquid is stored in the cuvette 2011, the lid part 20a of the cap 20 inserted into the cuvette 2011 is located at the liquid level. This is the position where it sinks into the mixed liquid by about several mm. This position corresponds to, for example, a position approximately 5 mm above the bottom 2011a of the cuvette 2011.

The lid portion 20a has cutout portions 21a-1 and 21a-2 as liquid drain portions. The notches 21a-1 and 21a-2 are formed, for example, at positions facing each other across the center of the lid 20a. The notches 21a-1 and 21a-2 are formed in a size large enough to allow the liquid mixture to pass through when the cap 20 is inserted and to suppress sloshing of the liquid mixture. Note that the notches 21a-1 and 21a-2 may be formed in any shape as long as the mixed liquid can pass therethrough when the cap 20 is inserted and sloshing of the mixed liquid can be suppressed. Moreover, the notches 21a-1 and 21a-2 may be holes. Moreover, two or more notches 21a-1 and 21a-2 may be formed as long as sloshing of the mixed liquid can be suppressed.

The constricted portion 20b is, for example, a columnar member provided between the lid portion 20a and the body portion 20c. When the cap 20 is inserted into the cuvette 2011, it is sandwiched between the outer wall of the constriction portion 20b, the surface of the lid portion 20a on the constriction portion 20b side, the surface of the body portion 20c on the constriction portion 20b side, and the lid portion 20a and the body portion 20c. A storage space is formed by the inner wall of the cuvette 2011. The capacity of the storage space is, for example, the maximum amount of the mixed liquid that is expected to be stored in the cuvette 2011, and the mixed liquid that passes through the notches 21a-1 and 21a-2 of the lid 20a and flows into the storage space. is set based on the amount of The height of the constricted portion 20b is set to allow formation of this accommodation space. The thickness and shape of the constricted portion 20b are set such that, for example, when the cap 20 is inserted into the cuvette 2011, it has enough strength to prevent buckling due to external force at the time of insertion.

The body portion 20c is a cylindrical member coaxially formed with a plurality of different outer diameters. Specifically, the body portion 20c is formed, for example, so that its outer diameter is approximately the same as the inner diameter of the body portion 2011b of the cuvette 2011. Further, the body portion 20c is configured such that the outer diameter of a portion corresponding to the top portion 2011d of the cuvette 2011, for example, a portion near the flange 20d, is approximately the same as the inner diameter of the opening 2015b of the body portion 2011b of the cuvette 2011. It is formed. Note that the body portion 20c may be a cylindrical member having a uniform outer diameter. The height of the body portion 20c is set based on, for example, the distance from the surface of the flange 20d on the lid portion 20a side to the lid portion 20a, and the height of the constriction portion 20b.

The body portion 20c has groove portions 21c-1 and 21c-2, which are formed along the axial direction and serve as air vent portions. The grooves 21c-1 and 21c-2 are formed, for example, at positions shifted by 90 degrees around the axis with respect to the notches 21a-1 and 21a-2. The width and cross-sectional shape of the grooves 21c-1 and 21c-2 may be any width and shape as long as the air inside the cuvette 2011 can be discharged.

The flange 20d is an annular member provided around the body portion 20c. The flange 20d is formed, for example, so that its outer diameter is approximately the same as that of the flange 2011c of the cuvette 2011. The thickness of the flange 20d is such that the flange 20d has enough strength to support the cap 20. The flange 20d has holes 21d-1 and 21d-2 at positions where the grooves 21c-1 and 21c-2 are provided in the body portion 20c. The size and shape of the holes 21d-1 and 21d-2 correspond, for example, to the width and shape of the grooves 21c-1 and 21c-2.

The top portion 20e is a columnar member extending on the flange 20d. The shape of the top portion 20e may be, for example, a cylindrical shape or a prismatic shape. The top portion 20e has grooves 21e-1 and 21e-2 at positions where the holes 21d-1 and 21d-2 are provided in the flange 20d. The width and shape of the grooves 21e-1 and 21e-2 correspond to the size and shape of the holes 21d-1 and 21d-2.

Returning to the description of the cap supply mechanism 10. The supply unit 11 shown in FIGS. 3 and 4, which is included in the cap supply mechanism 10, supplies the cap 20 to the transfer unit 12. Specifically, the supply unit 11 is provided above the transfer unit 12, for example, and has an input port, a storage section, and a discharge section. For example, the supply unit 11 stores the caps 20 that are inserted into the input port by the operator in a storage section. The supply unit 11 discharges the stored caps 20 one by one from the discharge section using gravity and supplies them to the transfer unit 12.

The transfer unit 12 transfers the cap 20 supplied by the supply unit 11 to the rotation unit 13 . Specifically, the transfer unit 12 includes, for example, rails 12a and 12b. The rails 12a and 12b are provided, for example, separated by a predetermined distance. The predetermined distance is larger than the outer diameter of the body portion 20c of the cap 20 and smaller than the diameter of the flange 20d. Thereby, in the cap 20, the surface of the flange 20d on the body portion 20c side comes into contact with the upper surface of the rails 12a, 12b, and the body portion 20c is accommodated in the space between the rails 12a, 12b. The rails 12a, 12b are provided with an inclination to such an extent that the cap 20 supporting the flange 20d on the upper surface can slide due to gravity.

The rotation unit 13 holds the cap 20 transferred by the transfer unit 12 and rotates the held cap 20 to an insertion position. The insertion position is a position for inserting the cap 20 into the cuvette 2011. Specifically, the rotation unit 13 includes, for example, holding parts 13a-1 and 13a-2 and a rotation shaft 13b. The holding parts 13a-1 and 13a-2 are provided, for example, at positions facing each other with the rotating shaft 13b interposed therebetween. The holding parts 13a-1 and 13a-2 are provided at substantially the same height as the ends of the rails 12a and 12b of the transfer unit 12. One of the holding parts 13a-1 and 13a-2 is provided at a position facing the space sandwiched between the rails 12a and 12b. The other of the holding parts 13a-1 and 13a-2 is provided at a position above the opening 2015b of the cuvette 2011 held by the stopped reaction disk 201. The holding parts 13a-1 and 13a-2 are formed to be able to hold the cap 20 in the vertical direction. The holding parts 13a-1 and 13a-2 rotate 180 degrees around the rotation axis 13b according to instructions from the control circuit 9, for example.

Note that the rotation unit 13 may include an adjustment section (not shown) for adjusting the attitude of the cap 20 to the attitude in which the cuvette 2011 is held.

The insertion unit 14 pushes the cap 20 held by the holding parts 13a-1 and 13a-2 of the rotation unit 13 into the cuvette 2011. Specifically, the insertion unit 14 includes, for example, a pressing section 14a and a driving section 14b. The pressing portion 14a is a rod-shaped member having a predetermined length. The predetermined length is determined, for example, depending on the distance by which the cap 20 held by the holding portion 13a-1 of the rotation unit 13 located directly above the cuvette 2011 is pushed toward the cuvette 2011. The pressing portion 14a is provided along the vertical direction directly above the holding portion 13a-1 of the rotation unit 13 located directly above the cuvette 2011. The pressing portion 14a is supported by the main body of the insertion unit 14. In the upper dead position, the pressing part 14a is supported such that its lower end is located slightly above the upper end of the cap 20 held by the holding part 13a-1. The pressing part 14a is driven in the vertical direction by the driving part 14b. The drive unit 14b lowers the pressing unit 14a to the stop position of the cap 20 inside the cuvette 2011, for example, in accordance with an instruction from the control circuit 9.

The control circuit 9 shown in FIG. 1 executes a control program stored in the storage circuit 8 to realize functions corresponding to the program. For example, the control circuit 9 has a system control function 91 by executing a control program. Note that in this embodiment, a case will be described in which the system control function 91 is realized by a single processor, but the present invention is not limited to this. For example, the system control function 91 may be realized by configuring a control circuit by combining a plurality of independent processors and having each processor execute a control program.

The system control function 91 is a function that centrally controls each section of the automatic analyzer 1 based on input information input from the input interface 5. For example, in the system control function 91, the control circuit 9 drives the drive mechanism 4 to perform measurements according to inspection items, and performs analysis to analyze standard data and test data generated by the analysis mechanism 2. Controls circuit 3.

Next, the operation of the automatic analyzer 1 configured as described above will be explained according to the processing procedure of the control circuit 9.
FIG. 12 is a flowchart showing an example of a processing procedure of the control circuit 9 when the automatic analyzer 1 shown in FIG. 1 measures a predetermined test item.
For example, the control circuit 9 reads the control program stored in the storage circuit 8 and implements the system control function 91 when a preset startup time comes or when a startup instruction is input from the operator. . In the system control function 91, the control circuit 9 centrally controls each section of the automatic analyzer 1.

Specifically, for example, the control circuit 9 controls the drive mechanism 4 to move the sample rack 2031 supported by the rack sampler 203 (step S121). The sample rack 2031 holds sample containers containing samples such as blood or urine. When the sample container held in the sample rack 2031 reaches the sample suction position, the control circuit 9 sends the inspection order stored in the storage circuit 8, indicating that the sample in the sample container that has arrived is the next inspection target. Refer to and confirm (step S122).

After confirming that the sample in the sample container is the next test target, the control circuit 9 rotates the sample dispensing arm 206 so that the sample dispensing probe 207 moves to the sample suction position. When the sample dispensing probe 207 reaches the sample suction position, the control circuit 9 lowers the sample dispensing probe 207 and aspirates the sample from the sample container located at the sample suction position (step S123).

When the sample is aspirated from the sample container, the control circuit 9 raises the sample dispensing probe 207 and rotates the sample dispensing arm 206 so that the sample dispensing probe 207 moves to the sample discharging position. When the sample dispensing probe 207 reaches the sample discharge position, the control circuit 9 lowers the sample dispensing probe 207 and discharges the sample into the empty cuvette 2011 located at the sample discharge position (step S124). Note that the control circuit 9 causes the drive mechanism 4 to rotate the reaction disk 201 and transfers the empty cuvette 2011 to the sample discharge position before the sample dispensing probe 207 is lowered. The sample discharged into the cuvette 2011 is heated to a predetermined temperature (for example, 37° C.) by the constant temperature section 202.

For example, in the background of the operation of dispensing a sample into the cuvette 2011, the control circuit 9 operates the reagent dispensing arm 208, the reagent dispensing probe 209, and the rotary table of the reagent storage 204, and performs the test indicated in the test order. A reagent corresponding to the item is aspirated from the reagent container 100 in the reagent storage 204 (step S125).

When the sample is ejected into the cuvette 2011, the control circuit 9 causes the drive mechanism 4 to rotate the reaction disk 201, and moves the cuvette 2011 into which the sample has been ejected to the reagent ejection position (step S126). When the cuvette 2011 reaches the reagent discharge position, the control circuit 9 operates the reagent dispensing arm 208 and the reagent dispensing probe 209 to discharge the reagent to the cuvette 2011 that has reached the reagent discharge position (step S127). At this time, the control circuit 9 ejects the reagent into the cuvette 2011 at a predetermined pressure, for example. By ejecting the reagent at a predetermined pressure, mixing of the reagent and sample within the cuvette 2011 is promoted.

When the reagent is discharged into the cuvette 2011, the control circuit 9 notifies the analysis circuit 3 that the reagent has been added to the blood sample, and causes the photometry unit 211 to start photometry of the liquid mixture held in the cuvette 2011 (step S128). . As a result, irradiation of light from the light source of the photometry unit 211 to the cuvette 2011 is started. Light irradiated from the light source enters into the cuvette 2011 from, for example, the first flat portion 20141b-1 of the cuvette 2011, which is disposed opposite to the light source. The light that has entered the cuvette 2011 passes through the liquid mixture in the cuvette 2011, and exits from the first plane section 20141b-3, which is provided opposite the first plane section 20141b-1. Furthermore, the light that has entered the cuvette 2011 is scattered by the liquid mixture in the cuvette 2011, and exits from, for example, the first plane section 20141b-2, which is orthogonal to the first plane section 20141b-1. The light emitted from the first planar section 20141b-3 and the light emitted from the first planar section 20141b-2 are detected by a transmitted light detector and a scattered light detector, respectively. The photodetector generates test data based on the detected light, and transmits the generated test data to the analysis circuit 3.

When the reagent is discharged into the cuvette 2011, that is, in parallel with the start of photometry of the liquid mixture in the cuvette 2011, the control circuit 9 operates the reaction disk 201 and the cap supply mechanism 10, and the cuvette 2011 from which the reagent has been discharged is operated. The cap 20 is inserted into the cap (step S129).

Specifically, for example, when the control circuit 9 discharges a reagent into the cuvette 2011 and raises the reagent dispensing probe 209, the drive mechanism 4 rotates the reaction disk 201, and the cuvette 2011 from which the reagent has been discharged is moved. Move it to the insertion position.

Furthermore, when the reagent is discharged into the cuvette 2011, the control circuit 9 controls the rotation unit 13 of the cap supply mechanism 10, and, for example, moves the holding part 13a-1 that holds the cap 20 transferred from the transfer unit 12 to the rotation axis. Rotate 180 degrees around 13b. Thereby, the cap 20 transferred from the transfer unit 12 will reach the insertion position before the cuvette 2011 reaches the insertion position.

When the cuvette 2011 reaches the insertion position, the control circuit 9 controls the drive section 14b of the insertion unit 14 to lower the pressing section 14a. As a result, the cap 20 held by the holding portion 13a-1 above the insertion position is pushed into the cuvette 2011 that is stopped at the insertion position. That is, cap 20 is inserted into cuvette 2011. FIG. 13 is a schematic diagram showing an example of the configuration of the cap supply mechanism 10 when the pressing part 14a shown in FIG. 4 pushes the cap 20 into the cuvette 2011.

When the cap 20 is inserted into the cuvette 2011, the air existing in the cuvette 2011 flows through the grooves 21c-1, 21c-2, the holes 21d-1, 21d-2, and the grooves 21e-1, 21e-2. It is exhausted to the outside of the cuvette 2011 via.

Furthermore, when the cap 20 is inserted into the cuvette 2011, the lid portion 20a comes into contact with the liquid surface of the mixed liquid contained in the cuvette 2011. After the liquid mixture and the lid 20a come into contact, the cap 20 is pushed further into the cuvette 2011. When the lid part 20a is pushed into the mixed liquid, the mixed liquid passes through the notches 21a-1 and 21a-2 to the surface of the lid part 20a on the constriction part 20b side and the constriction part 20b side of the body part 20c. The liquid flows into the space formed by the surface and the inner wall of the cylindrical portion 2012b. When the surface of the flange 20d of the cap 20 on the body portion 20c side contacts the top portion 2011d of the cuvette 2011, insertion of the cap 20 into the cuvette 2011 is completed.

14 and 15 are diagrams illustrating examples of the cap 20 and the cuvette 2011 in a state where the cap 20 is inserted into the cuvette 2011. FIG. 14 represents an example of a perspective view of the cap 20 and cuvette 2011. FIG. 15 represents an example of a cross-sectional view of the cap 20 and cuvette 2011.

In FIGS. 14 and 15, the lid part 20a of the cap 20 stops within the light transmitting part 2014b of the cuvette 2011. Since the shape of the lid part 20a is formed to be substantially the same as the inner shape of the light transmitting part 2014b, the outer peripheral surface of the lid part 20a contacts the inner wall of the light transmitting part 2014b. More specifically, the position where the lid part 20a stops within the light transmitting part 2014b is, for example, above the area through which the light passes and slightly below the liquid level of the expected minimum amount of the mixed liquid. . This position is, for example, a position at a height of about 5 mm from the bottom 2011a of the cuvette 2011.

Further, in FIGS. 14 and 15, for example, the outer wall of the body portion 20c of the cap 20 is in contact with the inner wall of the body portion 2011b of the cuvette 2011. This can be expressed in other words, for example, when the body 20c of the cap 20 is fitted into the body 2011b of the cuvette 2011. Thereby, the cap 20 is fixed within the cuvette 2011, so the posture of the cap 20 within the cuvette 2011 is maintained, and it is possible to prevent the lid portion 20a from shifting after the cap 20 is inserted.

When the control circuit 9 finishes measuring the liquid mixture in the cuvette 2011 in step S129, it refers to the stored test order and confirms whether there is a next measurement (step S1210). If there is no next measurement, the control circuit 9 ends the process. On the other hand, if there is a next measurement, the control circuit 9 moves the process to step S121.

As described above, the automatic analyzer 1 shown in the first embodiment uses the cap supply mechanism 10 as a supply means for supplying a suppressing member that forcibly suppresses the degree of freedom of movement of the liquid mixture in the cuvette 2011. Be prepared. The cap supply mechanism 10 supplies a cap 20 as a suppressing member, and inserts the supplied cap 20 into a cuvette 2011 held by a reaction disk 201 and into which a reagent has been discharged. Thereby, the mixed liquid contained in the cuvette 2011 is physically restrained by the cap 20, and it becomes possible to suppress the occurrence of sloshing of the mixed liquid caused by acceleration and deceleration of the reaction disk 201. Furthermore, by suppressing the occurrence of sloshing within the cuvette 2011, it is possible to reduce uneven distribution of concentration in the liquid, liquid level fluctuation noise, and the like.

Therefore, when the automatic analyzer 1 measures a blood coagulation reaction using the photometry unit 211, it is possible to suppress disturbance of blood coagulation due to sloshing. Furthermore, when the automatic analyzer 1 uses the photometry unit 211 to measure the amount of the component to be detected in the sample using the latex aggregation method, it is possible to suppress the inhibition of aggregation of latex particles due to sloshing. Become.

Further, when the reagent is ejected from the reagent dispensing probe 209 to the cuvette 2011 at a predetermined pressure, bubbles are generated in the mixed liquid. If these bubbles exist in a region near the optical path in the liquid mixture, there is a possibility that the intensity of light detected by the photometry unit 211 will be affected. When the cap 20 is inserted into the cuvette 2011, when the lid part 20a of the cap 20 suppresses the mixed liquid, bubbles in the mixed liquid move from the liquid drain part of the lid part 20a to the storage space. This reduces the amount of bubbles in the liquid mixture, making it possible to reduce the influence of the bubbles on measurement.

Further, in the automatic analyzer 1 shown in the first embodiment, the cap supply mechanism 10 is provided near the reagent discharge position for discharging the reagent into the cuvette 2011. This makes it possible to insert the cap 20 into the cuvette 2011 immediately after discharging the reagent into the cuvette 2011.

Further, the cap 20 shown in the first embodiment has a lid portion 20a, a body portion 20c, and a constriction portion 20b. The lid part 20a includes a liquid draining part and has a shape corresponding to the internal shape of the light transmitting part of the cuvette 2011. The body portion 20c has an outer diameter that is approximately the same as an inner diameter near the opening of the cuvette 2011. The constriction part 20b connects the lid part 20a and the body part 20c, and forms a space in the cuvette 2011 that can accommodate the mixed liquid that has passed through the liquid draining part of the lid part 20a. As a result, even if there is variation in the volume of the liquid mixture stored in the cuvette 2011, the lid part 20a of the cap 20 inserted into the cuvette 2011 can physically restrain the liquid mixture. .

Further, the body portion 20c of the cap 20 shown in the first embodiment has an air vent portion at a position shifted by a predetermined angle around the axis of the cap 20 with respect to the liquid vent portion. When inserting the cap 20 into the cuvette 2011, the liquid mixture contained in the cuvette 2011 may spout out from the liquid drain. By providing the air venting section offset from the liquid venting section, it is possible to prevent the liquid ejected from the liquid venting section from blocking the air venting section.

Note that the shape of the cap 20 shown in the first embodiment is not limited to the shapes shown in FIGS. 8 to 11. The cap 20 may have the shapes shown in, for example, FIGS. 16 to 19, FIGS. 20 to 23, and FIGS. 24 to 27.

For example, the cap 20 shown in FIGS. 16 to 19 has a prismatic member 20f having a shape similar to the inside shape of the top portion 2011d of the cuvette 2011 on the surface of the flange 20d on the lid portion 20a side. The prismatic member 20f is an example of an adjustment member. By adjusting the direction of the cap 20 based on the direction of the prismatic member 20f, it is possible to align the direction of the lid portion 20a with the direction of the light transmitting portion 2014b of the cuvette 2011.

Further, for example, in the cap 20 shown in FIGS. 20 to 23, the shape of the flange 20d corresponds to the shape of the top portion 2011d of the cuvette 2011. That is, in the examples shown in FIGS. 20 to 23, the flange 20d has a substantially square shape. The flange 20d is an example of an adjustment member. By adjusting the direction of the cap 20 based on the direction of the flange 20d, it is possible to align the direction of the lid portion 20a with the direction of the light transmitting portion 2014b of the cuvette 2011.

Further, for example, in the cap 20 shown in FIGS. 24 to 27, the shape of the top portion 20e is similar to the shape of the top portion 2011d of the cuvette 2011. The top portion 20e is an example of an adjustment member. By adjusting the direction of the cap 20 based on the direction of the top portion 20e, it is possible to align the direction of the lid portion 20a with the direction of the light transmitting portion 2014b of the cuvette 2011. Further, the configuration used in the mechanism for holding the cuvette 2011 on the reaction disk 201 can also be used in the cap supply mechanism 10.

Further, in the first embodiment, the case where the surface on the bottom portion 2011a side of the lid portion 20a of the cap 20 is flat has been described as an example. The surface of the lid 20a on the bottom 2011a side does not have to be flat. FIG. 28 is a schematic diagram showing another example of the lid portion 20a of the cap 20 shown in FIGS. 8 to 11. The lid portion 20a shown in FIG. 28 is used, for example, with a cuvette 2011 having a square cross-sectional shape. The lid portion 20a is provided with approximately semicircular grooves that are orthogonal to each other.

Furthermore, in the first embodiment, the case where the cap 20 is inserted into the cuvette 2011 used in the automatic analyzer 1 has been described as an example. However, the container into which the cap 20 is inserted is not limited to the cuvette 2011 of the automatic analyzer 1. The container may be of any size as long as it is used in a device that optically measures components in a contained liquid.

(Second embodiment)
In the first embodiment, the case where the mixed liquid contained in the cuvette 2011 is physically restrained by inserting the cap 20 into the cuvette 2011 has been described as an example. In the second embodiment, a case will be described in which a liquid mixture contained in the cuvette 2011 is physically restrained by supplying oil to the cuvette 2011.

FIG. 29 is a block diagram showing an example of the functional configuration of the automatic analyzer 1a according to the second embodiment. The automatic analyzer 1a shown in FIG. 29 includes an analysis mechanism 2, an analysis circuit 3, a drive mechanism 4, an input interface 5, an output interface 6, a communication interface 7, a storage circuit 8, a control circuit 9, and an oil supply mechanism 15. .

The oil supply mechanism 15 shown in FIG. 29 is an example of a supply means that supplies oil to the cuvette 2011 held by the reaction disk 201. The oil supply mechanism 15 is provided, for example, near the reagent discharge position. When the oil supply mechanism 15 is provided near the reagent discharge position, the time from when the reagent is discharged to the cuvette 2011 until when the oil is supplied is shortened.

FIG. 30 is a schematic diagram showing an example of the configuration of the oil supply mechanism 15 shown in FIG. 29. The oil supply mechanism 15 shown in FIG. 30 includes an oil supply probe 151 and a drive section 152. The oil supply probe 151 is driven by a drive unit 152 and moves in the vertical direction. Further, the oil supply probe 151 supplies oil to the stopped cuvette 2011 under the control of the control circuit 9.

The oil supplied by the oil supply probe 151 is, for example, silicone oil or vegetable oil. In order to suppress the movement of the liquid mixture contained in the cuvette 2011, it is desirable that the viscosity of the oil be high. On the other hand, if it is possible to supply oil with a weight that can suppress the movement of the mixed liquid, it is possible to select an oil with a viscosity comparable to that of the mixed liquid.

FIG. 31 is a flowchart showing an example of the processing procedure of the control circuit 9 when the automatic analyzer 1a shown in FIG. 29 measures a predetermined test item.
When the reagent is discharged into the cuvette 2011 in step S127, the control circuit 9 operates, for example, the reaction disk 201 and the oil supply mechanism 15 to supply oil to the cuvette 2011 into which the reagent has been discharged (step S311).

Specifically, for example, when the control circuit 9 discharges a reagent into the cuvette 2011 and raises the reagent dispensing probe 209, the drive mechanism 4 rotates the reaction disk 201, and the cuvette 2011 from which the reagent has been discharged is moved. Move to oil supply position.

When the cuvette 2011 reaches the oil supply position, the control circuit 9 controls the drive section 152 to lower the oil supply probe 151. When the oil supply probe 151 is lowered to a predetermined position within the cuvette 2011, the control circuit 9 causes the oil supply probe 151 to supply a preset amount of oil into the cuvette 2011.

When oil is supplied to the cuvette 2011, the oil is stored so as to cover the upper layer of the liquid mixture contained in the cuvette 2011. FIG. 32 shows an example of a cross-sectional view of the cuvette 2011 in a state where the cuvette 2011 is supplied with oil.

As described above, the automatic analyzer 1a shown in the second embodiment includes the oil supply mechanism 15 as a supply means for supplying a suppressing member that forcibly suppresses the degree of freedom of movement of the liquid mixture in the cuvette 2011. Be prepared. The oil supply mechanism 15 supplies oil as a suppressing member to the cuvette 2011 held by the reaction disk 201 and into which the reagent has been discharged. As a result, the liquid mixture contained in the cuvette 2011 is physically restrained by the oil, making it possible to suppress the occurrence of sloshing of the liquid mixture caused by acceleration and deceleration of the reaction disk 201. Furthermore, by suppressing the occurrence of sloshing within the cuvette 2011, it is possible to reduce uneven distribution of concentration in the liquid, liquid level fluctuation noise, and the like.

According to at least one embodiment described above, the automatic analyzers 1 and 1a can stabilize the measurement results, and can realize more accurate measurements.

The term "processor" used in the description of the embodiments refers to, for example, a CPU (central processing unit), a GPU (Graphics Processing Unit), an application specific integrated circuit (ASIC), or a programmable logic device. (For example, it refers to circuits such as Simple Programmable Logic Device (SPLD), Complex Programmable Logic Device (CPLD), and Field Programmable Gate Array (FPGA)). A processor realizes its functions by reading and executing a program stored in a memory circuit. Note that instead of storing the program in the memory circuit, the program may be directly incorporated into the circuit of the processor. In this case, the processor realizes its functions by reading and executing a program built into the circuit. Note that each processor in each of the above embodiments is not limited to being configured as a single circuit for each processor, but may be configured as a single processor by combining a plurality of independent circuits to realize its functions. Good too. Furthermore, a plurality of components in each of the above embodiments may be integrated into one processor to realize its functions.

Although several embodiments of the invention have been described, these embodiments are presented by way of example and are not intended to limit the scope of the invention. These embodiments can be implemented in various other forms, and various omissions, substitutions, and changes can be made without departing from the gist of the invention. These embodiments and their modifications are included within the scope and gist of the invention as well as within the scope of the invention described in the claims and its equivalents.

1, 1a...Automatic analyzer 2...Analysis mechanism 201...Reaction disk 202...Thermostat section 203...Rack sampler 204...Reagent storage 100...Reagent container 206...Sample dispensing arm 207...Sample dispensing probe 208...Reagent dispensing arm 209 ...Reagent dispensing probe 211...Photometry unit 2011...Cuvette 2011a...Bottom part 2011b...Body part 2012b...Cylinder part 2013b...Slope part 20131b-1 to 20131b-4...Second flat part 2014b...Light transmission part 20141b-1 to 20141b- 4...First plane part 2015b...Opening part 2011c...Flange 2011d...Top part 2012d-1 to 2012d-4...Side wall part 2011e...Opening part 2031...Sample rack 4...Drive mechanism 5...Input interface 6...Output interface 7...Communication interface 8...Storage circuit 9...Control circuit 91...System control function 10...Cap supply mechanism 11...Supply unit 12...Transfer unit 12a, 12b...Rail 13...Rotation unit 13a-1, 13a-2...Holding section 13b...Rotation shaft 14 …Insertion unit 14a…Press portion 14b…Drive portion 15…Oil supply mechanism 151…Oil supply probe 152…Drive portion 20…Cap 20a…Lid portions 21a-1, 21a-2…Notch portion 20b…Narrow portion 20c…Body Parts 21c-1, 21c-2... Groove 20d... Flange 21d-1, 21d-2... Hole 20e... Top 21e-1, 21e-2... Groove 20f... Square column member

Claims (6)

a reaction disk that rotates while holding a reaction container containing a mixed solution of a sample and a reagent;
Supply means for supplying a suppressing member to the reaction vessel;
and photometry means for optically measuring the mixed liquid whose movement is suppressed by the suppressing member,
The supply means supplies a cap as the suppressing member, inserts the supplied cap into the reaction container,
The automatic analyzer, wherein the cap has a lid portion that comes into contact with the mixed liquid by being inserted into the reaction container. further comprising a reagent dispensing probe that discharges the reagent into a reaction container containing the sample,
The automatic analyzer according to claim 1, wherein the supply means is provided near a reagent discharge position where the reagent is discharged. The lid portion includes a liquid draining portion and has a shape corresponding to an internal shape of a portion of the container to be inserted through which light passes;
The cap is
a body portion having an outer diameter that is approximately the same as an inner diameter near the opening of the container;
a constriction connecting the lid part and the body part and forming a space capable of accommodating the liquid that has passed through the liquid draining part by the lid part, the body part, and the inner wall of the reaction container;
An automatic analyzer according to claim 1 or claim 2. 4. The automatic analyzer according to claim 3, wherein the body section has an air vent section at a position shifted by a predetermined angle around the axis of the cap with respect to the liquid vent section. The automatic analysis device according to claim 3 or 4, wherein the cap further includes an adjustment member for adjusting the insertion direction. Dispense the reagent into the reaction container,
moving a reaction container into which the reagent is discharged and which contains the mixed liquid to a supply position;
Supplying a cap as a suppressing member to the reaction vessel that has reached the supply position,
inserting the supplied cap into the reaction vessel;
bringing a lid portion of the cap into contact with the mixed liquid;
A measurement method for optically measuring a liquid mixture in the reaction container whose movement is suppressed by the lid .