JP7431234B2 - カメラを有する医療用デバイス - Google Patents
カメラを有する医療用デバイス Download PDFInfo
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- JP7431234B2 JP7431234B2 JP2021528935A JP2021528935A JP7431234B2 JP 7431234 B2 JP7431234 B2 JP 7431234B2 JP 2021528935 A JP2021528935 A JP 2021528935A JP 2021528935 A JP2021528935 A JP 2021528935A JP 7431234 B2 JP7431234 B2 JP 7431234B2
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- Prior art keywords
- injection device
- drug
- electronic device
- food products
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- 238000013024 troubleshooting Methods 0.000 description 1
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- 229940007428 victoza Drugs 0.000 description 1
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Images
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
- G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
- A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/60—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
- A61M2205/52—General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/587—Lighting arrangements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/60—General characteristics of the apparatus with identification means
Description
Claims (11)
- 電子デバイスであって:
注射デバイスから薬剤を排出するための排出機構を含む注射デバイスと;
ディスプレイと;
立体カメラとを含み、電子デバイスは:
該立体カメラを使用して立体画像を取り込み;
取り込まれた立体画像が1つまたはそれ以上の食品を含むかどうかを判定し;
含むと判定された場合、取り込まれた立体画像に応じて、1つまたはそれ以上の食品の栄養素含有量の推定値を判定し;
栄養素含有量の推定値に関する情報を、ディスプレイを介して表示し、
立体カメラを使用して、処方箋に関連付けられた視覚的コードの画像を取り込み;
視覚的コードの取込み画像に応じて、注射デバイスの医薬品の投与方針を構成し;
排出機構によって注射デバイスから排出予定の薬剤の量を調整するように構成され、
排出機構によって注射デバイスから排出予定の薬剤の量は、1つまたはそれ以上の食品の推定された栄養素含有量と医薬品の投与方針に基づいて設定される、
前記電子デバイス。 - 注射デバイスの1つまたはそれ以上の設定を構成することは:
視覚的コードの取込み画像に応じて、注射デバイスをネットワークに接続すること;および
ネットワークを介して、注射デバイスにデータを転送すること
を含む、請求項1に記載の電子デバイス。 - 1つまたはそれ以上の設定は:
ユーザ識別情報;
ユーザ詳細情報;
医療従事者の識別情報;
医薬品バッチの登録番号;
医薬品の識別情報;
医薬品の投与方針;および/または
ユーザ履歴
のうちの少なくとも1つを含む、請求項2に記載の電子デバイス。 - 薬剤を含んだ薬剤カートリッジを含む、請求項1~3のいずれか1項に記載の電子デバイス。
- 薬剤に関連付けられた視覚的コードを取り込み;
取り込まれた視覚的コードに応じて、利用可能な薬剤の量を登録する
ようにさらに構成される、請求項1~4のいずれか1項に記載の電子デバイス。 - 取り込まれた立体画像が1つまたはそれ以上の食品を含むかどうかを判定することは、
立体画像を、該立体画像の視覚的および/または空間的な特性に基づいて、複数のセグメントに区分けすることを含む、請求項1~5のいずれか1項に記載の電子デバイス。 - 1つまたはそれ以上の食品の栄養素含有量の推定値を判定することは、食品のうちの1つまたはそれ以上を識別することを含む、請求項6に記載の電子デバイス。
- 食品のうちの1つまたはそれ以上を識別することは、画像認識アルゴリズムを使用することを含む、請求項7に記載の電子デバイス。
- 1つまたはそれ以上の食品の栄養素含有量の推定値を判定することは、1つまたはそれ以上の食品を識別するための選択可能な複数の選択肢を提供することを含む、請求項6~8のいずれか1項に記載の電子デバイス。
- 1つまたはそれ以上の食品の栄養素含有量の推定値を判定することは、ルックアップテーブルを使用することを含む、請求項6~9のいずれか1項に記載の電子デバイス。
- 栄養素情報は、1つまたはそれ以上の食品の炭水化物含有量の推定値を含む、請求項1~10のいずれか1項に記載の電子デバイス。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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EP18306559.8 | 2018-11-23 | ||
EP18306559 | 2018-11-23 | ||
PCT/EP2019/081296 WO2020104284A1 (en) | 2018-11-23 | 2019-11-14 | Medical device having camera |
Publications (2)
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JP2022507907A JP2022507907A (ja) | 2022-01-18 |
JP7431234B2 true JP7431234B2 (ja) | 2024-02-14 |
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JP2021528935A Active JP7431234B2 (ja) | 2018-11-23 | 2019-11-14 | カメラを有する医療用デバイス |
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US (1) | US20220013208A1 (ja) |
EP (1) | EP3884496A1 (ja) |
JP (1) | JP7431234B2 (ja) |
CN (1) | CN113168899A (ja) |
WO (1) | WO2020104284A1 (ja) |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005089833A1 (en) | 2004-03-18 | 2005-09-29 | Smiths Group Plc | Infusion apparatus and methods |
US20100249530A1 (en) | 2009-03-24 | 2010-09-30 | Medtronic Minimed, Inc. | Bolus Estimator with Image Capture Device |
US20120316405A1 (en) | 2009-03-09 | 2012-12-13 | Gloria Taylor | Portable Vital Statistics Monitoring and Medication Dispensing System |
JP2015187870A (ja) | 2015-04-30 | 2015-10-29 | 東芝テック株式会社 | 商品認識装置及び商品認識プログラム |
US20160063692A1 (en) | 2014-09-03 | 2016-03-03 | Sri International | Automated Food Recognition and Nutritional Estimation With a Personal Mobile Electronic Device |
JP2016512442A (ja) | 2013-02-05 | 2016-04-28 | デカ・プロダクツ・リミテッド・パートナーシップ | 医療デバイスの無線制御のためのデバイス、方法およびシステム |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080248455A1 (en) * | 2006-10-04 | 2008-10-09 | Bernhard Dohrmann | Apparatus, system, and method for remotely controlling a multiscreen display for delivery of instructional information |
EP2394217A4 (en) * | 2009-02-04 | 2016-05-04 | Abbott Diabetes Care Inc | MULTIFUNCTION ANALYTE TEST DEVICE AND METHODS |
CA3192699A1 (en) * | 2012-02-17 | 2013-08-22 | Good Measures, Llc | Systems and methods for user-specific modulation of nutrient intake |
EP3017423A1 (en) * | 2013-07-02 | 2016-05-11 | Roche Diagnostics GmbH | Estimation of food volume and carbs |
CA2966635C (en) * | 2014-11-21 | 2023-06-20 | Christopher M. Mutti | Imaging system for object recognition and assessment |
US9349297B1 (en) * | 2015-09-09 | 2016-05-24 | Fitly Inc. | System and method for nutrition analysis using food image recognition |
CN207216317U (zh) * | 2017-08-11 | 2018-04-10 | 陈颉燕 | 智能餐垫 |
CN107731278A (zh) * | 2017-09-04 | 2018-02-23 | 广东数相智能科技有限公司 | 一种食物识别方法、营养健康分析方法、系统及装置 |
-
2019
- 2019-11-14 JP JP2021528935A patent/JP7431234B2/ja active Active
- 2019-11-14 CN CN201980076606.4A patent/CN113168899A/zh active Pending
- 2019-11-14 EP EP19801568.7A patent/EP3884496A1/en active Pending
- 2019-11-14 US US17/293,731 patent/US20220013208A1/en active Pending
- 2019-11-14 WO PCT/EP2019/081296 patent/WO2020104284A1/en unknown
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005089833A1 (en) | 2004-03-18 | 2005-09-29 | Smiths Group Plc | Infusion apparatus and methods |
US20120316405A1 (en) | 2009-03-09 | 2012-12-13 | Gloria Taylor | Portable Vital Statistics Monitoring and Medication Dispensing System |
US20100249530A1 (en) | 2009-03-24 | 2010-09-30 | Medtronic Minimed, Inc. | Bolus Estimator with Image Capture Device |
JP2016512442A (ja) | 2013-02-05 | 2016-04-28 | デカ・プロダクツ・リミテッド・パートナーシップ | 医療デバイスの無線制御のためのデバイス、方法およびシステム |
US20160063692A1 (en) | 2014-09-03 | 2016-03-03 | Sri International | Automated Food Recognition and Nutritional Estimation With a Personal Mobile Electronic Device |
JP2015187870A (ja) | 2015-04-30 | 2015-10-29 | 東芝テック株式会社 | 商品認識装置及び商品認識プログラム |
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US20220013208A1 (en) | 2022-01-13 |
JP2022507907A (ja) | 2022-01-18 |
EP3884496A1 (en) | 2021-09-29 |
WO2020104284A1 (en) | 2020-05-28 |
CN113168899A (zh) | 2021-07-23 |
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