JP7422986B2 - Undiluted solution processing equipment and how to operate the undiluted solution processing equipment - Google Patents

Description

The present invention relates to a stock solution processing device and a method of operating the stock solution processing device. More specifically, we will introduce a stock solution processing device that filters and concentrates stock solutions such as pleural and ascitic fluid that accumulates in the chest and abdomen due to cancerous pleural peritonitis, liver cirrhosis, etc., and waste plasma from plasma exchange therapy to obtain a processed solution for intravenous infusion. The present invention relates to a method of operating a stock solution processing device.

In cases such as cancerous pleural peritonitis and liver cirrhosis, pleural effusion and ascites may accumulate in the thoracic and abdominal cavities, and when such pleural and ascitic effusion accumulates, problems arise such as the pleural and ascitic effusion presses on surrounding organs. In order to improve this problem, treatment to drain the thoracic and ascitic fluid through puncture may be performed.

On the other hand, pleural and ascitic fluid contains some or all of the plasma components leaked from the blood, and this plasma contains major proteins (eg, albumin, globulin, etc.). Although the above symptoms are improved by draining the pleural and ascitic fluid, components useful to the human body such as protein are lost along with water. Therefore, it is necessary to replenish the lost components by intravenously administering albumin preparations, globulin preparations, etc.

However, although it is possible to replenish specific components by intravenously administering albumin preparations, globulin preparations, etc., the preparations are expensive and treatment costs increase.
Moreover, since only a limited amount of a specific component among the lost components can be supplied, problems such as malnutrition and susceptibility to infection may occur.

Therefore, a treatment method in which pleural fluid or ascites (hereinafter referred to as undiluted fluid) that has been removed from the pleural cavity or abdominal cavity is treated and administered intravenously is the so-called Cell-free and Concentrated Ascites Reinfusion method. Therapy (CART) has been developed. In the case of CART, most of the effective components other than cellular components contained in pleural effusion and ascites can be returned to the patient's body, so it is not limited to specific components, and can effectively replace the components lost from the blood. can be supplied to patients. Furthermore, even if a concentrated solution is administered, the insufficient amount of components can be supplemented with a preparation, so the amount of albumin preparations and the like to be used can be minimized, and treatment costs can be kept down.

In CART, the treatment fluid returned to the patient's body is produced by filtering and concentrating pleural fluid and ascites fluid. In a treatment device that generates such a treatment liquid, the raw liquid such as pleural effusion or ascites is supplied to a filter having a filtration member such as a hollow fiber membrane or a plate-shaped permeable membrane to extract the liquid component (hereinafter sometimes referred to as filtrate). ) to separate. If water is removed from the filtrate by passing the separated filtrate through a concentrator, a concentrated solution obtained by concentrating the filtrate, that is, the above-mentioned treated solution can be obtained (see Patent Documents 1 and 2).

Patent No. 5062631 Japanese Patent Application Publication No. 2015-126763

As described above, in CART, the treated solution is returned to the patient's body after processing the undiluted solution extracted from the patient's body. Then, until the treatment liquid is returned, the patient's body will be in a state where necessary components are insufficient, so it is required to return the treatment liquid to the patient as soon as possible. In other words, in CART, it is very important to generate the processing liquid from the stock solution as quickly as possible.

In view of the above circumstances, it is an object of the present invention to provide a stock solution processing device and a method for operating the stock solution processing device, which can shorten the processing time of the stock solution extracted from the body of a patient and improve the workability of the operator. purpose.

<How to operate the stock solution processing device>
A method of operating a stock solution processing device according to a first aspect of the invention is a method of using the device for concentrating a stock solution to form a concentrated solution, the device comprising: a filter having a filter member for filtering the stock solution; a concentrator to which a filtered filtrate is supplied and which concentrates the filtrate to form the concentrate; a stock solution supply section that supplies the stock solution to the filter; a stock solution supply section and the stock solution in the filter; a filtrate supply flow path that communicates with a stock solution supply port that communicates with one end of the flow path through which the filtrate is supplied; and a filtrate supply flow that communicates between a filtrate discharge port of the filter and a filtrate supply port of the concentrator. a concentrate flow path connected to a concentrate discharge port of the concentrator; a waste liquid flow path connected to a waste liquid discharge port for discharging waste liquid separated from the concentrate in the concentrator; A supply liquid flow path liquid sending section provided in the liquid flow path, and a concentrated liquid flow path liquid sending section provided in the concentrate flow path or a waste liquid flow path liquid sending section provided in the waste liquid flow path. The amount of liquid to be fed through each flow path is adjusted based on the filter transmembrane differential pressure of the filter and/or the concentrator transmembrane differential pressure of the concentrator, and the concentrator transmembrane differential pressure is adjusted. If the pressure is lower than the set differential pressure of the concentrator, the amount of raw solution sent to the filter is increased until the concentrator transmembrane differential pressure reaches the set differential pressure , and the concentrator transmembrane differential is increased. If the pressure is within the set differential pressure of the concentrator, maintain the amount of raw solution sent to the filter, and if the concentrator transmembrane differential pressure is greater than the set differential pressure of the concentrator. The present invention is characterized in that the amount of the raw solution sent to the filter is reduced until the transmembrane pressure difference of the concentrator reaches a set pressure difference .
A method of operating a stock solution processing device according to a second aspect of the invention is a method of using a device for concentrating a stock solution to form a concentrated solution, the device comprising: a filter having a filter member for filtering the stock solution; a concentrator to which a filtered filtrate is supplied and which concentrates the filtrate to form the concentrate; a stock solution supply section that supplies the stock solution to the filter; a stock solution supply section and the stock solution in the filter; a filtrate supply flow path that communicates with a stock solution supply port that communicates with one end of the flow path through which the filtrate is supplied; and a filtrate supply flow that communicates between a filtrate discharge port of the filter and a filtrate supply port of the concentrator. a concentrate flow path connected to the concentrate discharge port of the concentrator; a waste liquid flow path connected to the waste liquid discharge port for discharging the waste liquid separated from the concentrate in the concentrator; and the filtration method. a filtrate supply flow path liquid sending section provided in the liquid supply flow path; a concentrate flow path liquid sending section provided in the concentrate flow path; or a waste liquid flow path liquid sending section provided in the waste liquid flow path; , which adjusts the amount of liquid to be sent through each channel based on the filter transmembrane differential pressure of the filter and/or the concentrator transmembrane differential pressure of the concentrator, and When the transmembrane pressure difference is smaller than the set differential pressure of the concentrator, the amount of filtrate sent to the concentrator is increased until the concentrator transmembrane differential pressure reaches the set differential pressure , and the concentrator When the transmembrane differential pressure is within the set differential pressure of the concentrator, the amount of filtrate sent to the concentrator is maintained, and the concentrator transmembrane differential pressure is within the set differential pressure of the concentrator. If the pressure is higher than the predetermined pressure, the amount of filtrate sent to the concentrator is reduced until the concentrator transmembrane differential pressure reaches a set differential pressure .
A method of operating a stock solution processing device according to a third aspect of the invention is a method of using the device for concentrating a stock solution to form a concentrated solution, the device comprising: a filter having a filter member for filtering the stock solution; a concentrator to which a filtered filtrate is supplied and which concentrates the filtrate to form the concentrate; a stock solution supply section that supplies the stock solution to the filter; a stock solution supply section and the stock solution in the filter; a filtrate supply flow path that communicates with a stock solution supply port that communicates with one end of the flow path through which the filtrate is supplied; and a filtrate supply flow that communicates between a filtrate discharge port of the filter and a filtrate supply port of the concentrator. a concentrate flow path connected to a concentrate discharge port of the concentrator; a waste liquid flow path connected to a waste liquid discharge port for discharging waste liquid separated from the concentrate in the concentrator; A supply liquid flow path liquid sending section provided in the liquid flow path, and a concentrated liquid flow path liquid sending section provided in the concentrate flow path or a waste liquid flow path liquid sending section provided in the waste liquid flow path. The amount of liquid to be fed through each flow path is adjusted based on the filter transmembrane differential pressure of the filter and/or the concentrator transmembrane differential pressure of the concentrator, and the concentrator transmembrane differential pressure is adjusted. If the pressure is lower than the set differential pressure of the concentrator, reduce the amount of concentrated liquid sent to the concentrate flow path or reduce the amount of concentrated liquid sent to the waste liquid flow path until the concentrator transmembrane differential pressure reaches the set differential pressure. When the amount of waste liquid to be fed is increased and the concentrator transmembrane pressure difference is within the range of the set differential pressure of the concentrator, the amount of concentrated liquid in the concentrate flow path or the liquid feed amount in the waste liquid flow path is increased. is maintained, and if the concentrator transmembrane differential pressure is greater than the set differential pressure of the concentrator, the concentrate is fed through the concentrate flow path until the concentrator transmembrane differential pressure reaches the set differential pressure. The present invention is characterized in that the amount of waste liquid is increased or the amount of waste liquid sent through the waste liquid flow path is decreased.
A method of operating a stock solution processing device according to a fourth aspect of the invention is a method of using the device for concentrating a stock solution to form a concentrated solution, the device comprising: a filter having a filter member for filtering the stock solution; a concentrator to which a filtered filtrate is supplied and which concentrates the filtrate to form the concentrate; a stock solution supply section that supplies the stock solution to the filter; a stock solution supply section and the stock solution in the filter; a filtrate supply flow path that communicates with a stock solution supply port that communicates with one end of the flow path through which the filtrate is supplied; and a filtrate supply flow that communicates between a filtrate discharge port of the filter and a filtrate supply port of the concentrator. a concentrate flow path connected to the concentrate discharge port of the concentrator; a waste liquid flow path connected to the waste liquid discharge port for discharging the waste liquid separated from the concentrate in the concentrator; and the filtration method. a filtrate supply flow path liquid sending section provided in the liquid supply flow path; a concentrate flow path liquid sending section provided in the concentrate flow path; or a waste liquid flow path liquid sending section provided in the waste liquid flow path; , which adjusts the amount of liquid to be sent through each channel based on the filter transmembrane differential pressure of the filter and/or the concentrator transmembrane differential pressure of the concentrator, and If the transmembrane pressure difference is smaller than the set differential pressure of the concentrator, reduce the amount of concentrated liquid sent through the concentrate flow path or reduce the amount of concentrated liquid sent to the waste liquid flow path until the concentrator transmembrane differential pressure reaches the set differential pressure. If the concentrator transmembrane differential pressure is within the range of the set differential pressure of the concentrator, the concentrated liquid in the concentrate channel or the waste liquid in the waste channel is increased. If the liquid volume is maintained and the concentrator transmembrane differential pressure is greater than the set differential pressure of the concentrator, the concentrate in the concentrate flow path is increased until the concentrator transmembrane differential pressure reaches the set differential pressure. The present invention is characterized in that the amount of liquid sent is increased or the amount of waste liquid sent through the waste liquid flow path is decreased.
A method of operating a stock solution processing device according to a fifth aspect of the invention is a method of using the device for concentrating a stock solution to form a concentrated solution, the device comprising: a filter having a filter member for filtering the stock solution; a concentrator to which a filtered filtrate is supplied and which concentrates the filtrate to form the concentrate; a stock solution supply section that supplies the stock solution to the filter; a stock solution supply section and the stock solution in the filter; a filtrate supply flow path that communicates with a stock solution supply port that communicates with one end of the flow path through which the filtrate is supplied; and a filtrate supply flow that communicates between a filtrate discharge port of the filter and a filtrate supply port of the concentrator. a concentrate flow path connected to a concentrate discharge port of the concentrator; a waste liquid flow path connected to a waste liquid discharge port for discharging waste liquid separated from the concentrate in the concentrator; It includes a concentrate flow path liquid sending section provided in the liquid flow path and a waste liquid flow path liquid sending section provided in the waste liquid flow path, and the filter membrane differential pressure and/or the filter transmembrane pressure of the filter is The amount of liquid sent through each channel is adjusted based on the concentrator transmembrane differential pressure of the concentrator, and when the concentrator transmembrane differential pressure is smaller than the set differential pressure of the concentrator, the The amount of concentrated liquid fed through the concentrate flow path is decreased and/or the amount of waste liquid fed through the waste liquid flow path is increased until the differential pressure between the concentrator membranes reaches the set differential pressure. When the pressure is within the range of the set differential pressure of the concentrator, the amount of concentrated liquid sent in the concentrated liquid flow path and/or the amount of waste liquid sent in the waste liquid flow path is maintained, and the amount of liquid sent to the concentrator is maintained. If the transmembrane pressure difference is larger than the set differential pressure of the concentrator, increase the amount of concentrated liquid sent through the concentrate flow path until the concentrator transmembrane differential pressure reaches the set differential pressure, and/or It is characterized by reducing the amount of waste liquid sent through the waste liquid channel.
A stock solution processing device according to a sixth aspect of the invention is a device for concentrating a stock solution to form a concentrated solution, and is provided with a filter having a filtration member for filtering the stock solution, and a filtrate filtered by the filter, a concentrator that concentrates the filtrate to form the concentrated solution; a stock solution supply section that supplies the stock solution to the filter; and an end of a flow path between the stock solution supply section and the filter to which the stock solution is supplied. a liquid supply channel that communicates with the connected stock solution supply ports; a filtrate supply channel that communicates the filtrate discharge port of the filter with the filtrate supply port of the concentrator; and a concentrated solution of the concentrator. A concentrate flow path connected to the discharge port, a waste liquid flow path connected to the waste liquid discharge port that discharges the waste liquid separated from the concentrate in the concentrator, and a liquid sending unit that sends liquid to each flow path. and a control unit that controls the liquid feeding unit, and the liquid feeding unit includes a liquid supply channel liquid feeding unit provided in the liquid supply channel and a control unit that controls the liquid feeding unit. a concentrated liquid flow path liquid sending section provided in the waste liquid flow path or a waste liquid flow path liquid sending section provided in the waste liquid flow path, and the control section controls the filter transmembrane differential pressure of the filter and/or the waste liquid flow path liquid sending section provided in the waste liquid flow path. Each liquid sending section is controlled based on the concentrator transmembrane differential pressure of the concentrator, and when the concentrator transmembrane differential pressure is smaller than the set differential pressure of the concentrator, the concentrator transmembrane differential pressure is controlled. The liquid supply channel liquid feeding section is controlled so that the amount of raw solution sent to the filter increases until the differential pressure reaches a set differential pressure, and the concentrator transmembrane differential pressure becomes equal to the set differential pressure of the concentrator. If the pressure is within the range, the feed liquid flow path liquid feeding section is controlled to maintain the amount of raw solution fed to the filter, and the concentrator transmembrane differential pressure is adjusted to the setting of the concentrator. If the differential pressure is higher than the differential pressure, the liquid supply flow path liquid sending section is controlled so that the amount of the raw solution sent to the filter is reduced until the concentrator transmembrane differential pressure reaches a set differential pressure. Features.
A stock solution processing device according to a seventh aspect of the invention is a device for concentrating a stock solution to form a concentrated solution, and is provided with a filter having a filtration member for filtering the stock solution, and a filtrate filtered by the filter, a concentrator that concentrates the filtrate to form the concentrated solution; a stock solution supply section that supplies the stock solution to the filter; and an end of a flow path between the stock solution supply section and the filter to which the stock solution is supplied. a liquid supply channel that communicates with the connected stock solution supply ports; a filtrate supply channel that communicates the filtrate discharge port of the filter with the filtrate supply port of the concentrator; and a concentrated solution of the concentrator. A concentrate flow path connected to the discharge port, a waste liquid flow path connected to the waste liquid discharge port that discharges the waste liquid separated from the concentrate in the concentrator, and a liquid sending unit that sends liquid to each flow path. and a control unit that controls the liquid sending unit, and the liquid sending unit includes a filtrate supply channel liquid sending unit provided in the filtrate supply channel, and a control unit that controls the liquid sending unit, and a control unit that controls the liquid sending unit. a concentrate flow path liquid sending section provided in the waste liquid flow path or a waste liquid flow path liquid sending section provided in the waste liquid flow path, and the control section controls the filter transmembrane differential pressure of the filter and/or the waste liquid flow path liquid sending section provided in the waste liquid flow path. Alternatively, each liquid feeding section is controlled based on the concentrator transmembrane differential pressure of the concentrator, and when the concentrator transmembrane differential pressure is smaller than the set differential pressure of the concentrator, the concentrator The filtrate supply channel liquid sending section is controlled so that the amount of filtrate sent to the concentrator is increased until the transmembrane pressure difference reaches a set pressure difference , and the concentrator transmembrane pressure difference reaches the concentration If the differential pressure is within the range of the set differential pressure of the concentrator, the filtrate supply flow channel is controlled to maintain the amount of filtrate sent to the concentrator, and the concentrator transmembrane differential pressure is increased. is larger than the set differential pressure of the concentrator, the feed liquid flow path is adjusted such that the amount of filtrate sent to the concentrator is reduced until the concentrator transmembrane differential pressure reaches the set differential pressure. It is characterized by controlling the liquid part.
The undiluted solution processing device of the eighth invention is an apparatus for concentrating a undiluted solution to form a concentrated solution, and is provided with a filter having a filter member for filtering the undiluted solution, and a filtrate filtered by the filter, a concentrator that concentrates the filtrate to form the concentrated solution; a stock solution supply section that supplies the stock solution to the filter; and an end of a flow path between the stock solution supply section and the filter to which the stock solution is supplied. a liquid supply channel that communicates with the connected stock solution supply ports; a filtrate supply channel that communicates the filtrate discharge port of the filter with the filtrate supply port of the concentrator; and a concentrated solution of the concentrator. A concentrate flow path connected to the discharge port, a waste liquid flow path connected to the waste liquid discharge port that discharges the waste liquid separated from the concentrate in the concentrator, and a liquid sending unit that sends liquid to each flow path. and a control unit that controls the liquid feeding unit, and the liquid feeding unit includes a liquid supply channel liquid feeding unit provided in the liquid supply channel and a control unit that controls the liquid feeding unit. a concentrated liquid flow path liquid sending section provided in the waste liquid flow path or a waste liquid flow path liquid sending section provided in the waste liquid flow path, and the control section controls the filter transmembrane differential pressure of the filter and/or the waste liquid flow path liquid sending section provided in the waste liquid flow path. Each liquid sending section is controlled based on the concentrator transmembrane differential pressure of the concentrator, and when the concentrator transmembrane differential pressure is smaller than the set differential pressure of the concentrator, the concentrator transmembrane differential pressure is controlled. The concentrate flow path liquid sending section or the waste liquid is configured such that the amount of concentrated liquid sent through the concentrate flow path is decreased or the amount of waste liquid sent through the waste liquid path is increased until the differential pressure reaches a set differential pressure. When the concentrator transmembrane differential pressure is within the range of the set differential pressure of the concentrator, the flow channel liquid sending section is controlled, and when the concentrator transmembrane differential pressure is within the range of the set differential pressure of the concentrator, the amount of concentrated solution sent in the concentrate channel or the waste liquid channel is controlled. controlling the concentrate flow path liquid sending section or the waste liquid flow path liquid sending section so as to maintain the amount of waste liquid fed, and when the concentrator transmembrane pressure difference is larger than the set differential pressure of the concentrator; The concentrate flow is controlled such that the amount of concentrated liquid sent through the concentrated liquid flow path increases or the amount of waste liquid sent through the waste liquid flow path decreases until the differential pressure between the membranes of the concentrator reaches a set differential pressure. The present invention is characterized in that the channel liquid feeding section or the waste liquid channel liquid feeding section is controlled.
The undiluted solution processing device of the ninth invention is an apparatus for concentrating a undiluted solution to form a concentrated solution, and is provided with a filter having a filter member for filtering the undiluted solution, and a filtrate filtered by the filter, a concentrator that concentrates the filtrate to form the concentrated solution; a stock solution supply section that supplies the stock solution to the filter; and an end of a flow path between the stock solution supply section and the filter to which the stock solution is supplied. a liquid supply channel that communicates with the connected stock solution supply ports; a filtrate supply channel that communicates the filtrate discharge port of the filter with the filtrate supply port of the concentrator; and a concentrated solution of the concentrator. A concentrate flow path connected to the discharge port, a waste liquid flow path connected to the waste liquid discharge port that discharges the waste liquid separated from the concentrate in the concentrator, and a liquid sending unit that sends liquid to each flow path. and a control unit that controls the liquid sending unit, and the liquid sending unit includes a filtrate supply channel liquid sending unit provided in the filtrate supply channel, and a control unit that controls the liquid sending unit, and a control unit that controls the liquid sending unit. a concentrate flow path liquid sending section provided in the waste liquid flow path or a waste liquid flow path liquid sending section provided in the waste liquid flow path, and the control section controls the filter transmembrane differential pressure of the filter and/or the waste liquid flow path liquid sending section provided in the waste liquid flow path. Alternatively, each liquid feeding section is controlled based on the concentrator transmembrane differential pressure of the concentrator, and when the concentrator transmembrane differential pressure is smaller than the set differential pressure of the concentrator, the concentrator The concentrate flow path liquid sending unit or The waste liquid flow path liquid sending section is controlled, and when the concentrator transmembrane pressure difference is within the range of the set differential pressure of the concentrator, the amount of concentrated liquid sent in the concentrate flow path or the waste liquid is controlled. The concentrate flow path liquid sending unit or the waste liquid flow path liquid sending unit is controlled to maintain the amount of waste liquid sent in the flow path, and the concentrator transmembrane pressure difference is greater than the set differential pressure of the concentrator. In this case, the concentration is performed such that the amount of concentrated liquid sent through the concentrate flow path increases or the amount of waste liquid sent through the waste liquid flow path decreases until the differential pressure between the membranes of the concentrator reaches a set pressure difference. The present invention is characterized in that the liquid flow path liquid sending section or the waste liquid flow path liquid sending section is controlled.
The undiluted solution processing device of the tenth invention is an apparatus for concentrating a undiluted solution to form a concentrated solution, and is provided with a filter having a filter member for filtering the undiluted solution, and a filtrate filtered by the filter, a concentrator that concentrates the filtrate to form the concentrated solution; a stock solution supply section that supplies the stock solution to the filter; and an end of a flow path between the stock solution supply section and the filter to which the stock solution is supplied. a liquid supply channel that communicates with the connected stock solution supply ports; a filtrate supply channel that communicates the filtrate discharge port of the filter with the filtrate supply port of the concentrator; and a concentrated solution of the concentrator. A concentrated liquid flow path connected to the discharge port, a waste liquid flow path connected to the waste liquid discharge port that discharges the waste liquid separated from the concentrated liquid in the concentrator, and a liquid sending unit that sends liquid to each flow path. and a control unit that controls the liquid sending unit, and the liquid sending unit includes a concentrate flow path liquid sending unit provided in the concentrate flow path and a control unit that controls the liquid sending unit. a waste liquid channel liquid sending section, and the control section controls each liquid sending section based on the filter transmembrane differential pressure of the filter and/or the concentrator transmembrane differential pressure of the concentrator. When the concentrator transmembrane differential pressure is smaller than the set differential pressure of the concentrator, the concentrate in the concentrate flow path is controlled until the concentrator transmembrane differential pressure reaches the set differential pressure. The concentrate flow path liquid sending unit and/or the waste liquid flow path liquid sending unit are controlled so that the amount of liquid sent through the waste liquid flow path is decreased and/or the amount of waste liquid sent through the waste liquid flow path is increased, When the differential pressure is within a set differential pressure of the concentrator, the amount of concentrated liquid sent through the concentrated liquid flow path and/or the amount of waste liquid sent through the waste liquid flow path is maintained. The concentrate flow path liquid sending section and/or the waste liquid flow path liquid sending section are controlled, and when the concentrator transmembrane differential pressure is larger than the set differential pressure of the concentrator, the concentrator transmembrane differential pressure is controlled. The concentrate flow path liquid sending unit and /or the concentrate flow path liquid sending portion and/or The present invention is characterized in that the waste liquid channel liquid sending section is controlled.

<Filtration concentration>
According to the first to tenth inventions, since the liquid feeding section is controlled based on the pressure difference between the membranes of the concentrator, the capacity of the filter and the concentrator can be effectively utilized, and furthermore, the time required to generate the concentrated liquid from the stock solution can be reduced. can be made shorter and the concentration efficiency can be improved.

It is a circuit diagram of the stock solution processing apparatus 1 of this embodiment, and is a schematic explanatory diagram of filtration concentration work. It is a circuit diagram of the stock solution processing apparatus 1 of this embodiment, and is a schematic explanatory diagram of preparatory cleaning work. It is a circuit diagram of the stock solution processing apparatus 1 of this embodiment, and is a schematic explanatory diagram of reconcentration work. It is a circuit diagram of the stock solution processing apparatus 1 of this embodiment, and is an example in which the waste solution tube 5 is provided with a waste solution tube liquid feeding section 5p. 1 is a schematic explanatory diagram of a filter 10. FIG. It is a circuit diagram of the stock solution processing apparatus 1B of 2nd Embodiment, and is a schematic explanatory drawing of the preparatory cleaning work. It is a circuit diagram of the stock solution processing apparatus 1B of 2nd Embodiment, and is a schematic explanatory drawing of filtration concentration work. It is a circuit diagram of the stock solution processing apparatus 1B of 2nd Embodiment, and is a schematic explanatory drawing of reconcentration work. It is a circuit diagram of the stock solution processing apparatus 1B of this embodiment, and is an example in which the waste solution tube 5 is provided with a waste solution tube liquid feeding section 5p. It is a circuit diagram of 1C of undiluted solution processing apparatuses of 3rd Embodiment, and is a schematic explanatory drawing of preparatory cleaning work. It is a circuit diagram of 1C of stock solution processing apparatuses of 3rd Embodiment, and is a schematic explanatory drawing of filtration concentration work. It is a circuit diagram of 1C of stock solution processing apparatuses of 3rd Embodiment, and is a schematic explanatory drawing of reconcentration work. It is a schematic explanatory view of the stock solution processing apparatus 1 of this embodiment, and is a schematic explanatory view in a state where the lid portions 112 of the roller pumps 110 and 120 are closed. It is a schematic explanatory view of the stock solution processing apparatus 1 of this embodiment, and is a schematic explanatory view in a state where the lid portions 112 of the roller pumps 110 and 120 are opened. FIG. 2 is a schematic explanatory diagram of the roller pump 110, in which (A) is a schematic perspective view with the lid 112 opened, and (B) is a schematic side view with the lid 112 opened. FIG. 3 is a schematic explanatory diagram of the tube positioning member 160 with the tube T attached, in which (A) is a schematic perspective view in a bent state, (B) is a schematic plan view in a bent state, and (C) is a schematic perspective view in a bent state. is a schematic rear view in a bent state. (A) is an exploded schematic explanatory diagram of the tube positioning member 160, and (B) is a schematic explanatory diagram of the tube positioning member 160 with the tube T attached. (A) is a schematic perspective view of the tube holder 150, and (B) is a schematic explanatory view of the tube holder 150 attached to a bucket. FIG. 1 is a schematic explanatory diagram of a stock solution processing apparatus 1 according to the present embodiment.

The stock solution processing device of the present invention is a device for filtering and concentrating a stock solution such as pleural and ascitic fluid to obtain a processing solution that can be administered to a patient by intravenous drip injection, intraperitoneal administration, or the like.

The stock solution to be processed by the stock solution processing device of the present invention is not particularly limited, but examples include pleural and ascitic fluid, plasma, and blood. Pleural and ascitic effusion refers to pleural effusion and ascites that accumulate in the pleural and abdominal cavities due to cancerous pleural peritonitis, liver cirrhosis, and the like. This pleural and ascitic fluid contains plasma components leaked from blood vessels and organs (proteins, hormones, sugars, lipids, electrolytes, vitamins, bilirubin, amino acids, etc.), hemoglobin, cancer cells, macrophages, histiocytes, white blood cells, red blood cells, platelets, and bacteria. etc. are included. The undiluted solution processing device of the present invention removes solid contents such as cancer cells, macrophages, histiocytes, white blood cells, red blood cells, platelets, and bacteria from this pleural and ascitic fluid, and concentrates water and useful components contained in the pleural and ascitic fluid. liquid can be produced.

Examples of plasma include waste plasma from plasma exchange therapy, and examples of blood include blood collected during surgery. That is, by purifying waste plasma, blood collected during surgery, etc. using the stock solution processing apparatus of the present invention, reusable regenerated plasma can be produced. In addition, in the stock solution processing device of the present invention, when processing waste plasma from plasma exchange therapy, a plasma component separator is installed instead of the filter, and when processing blood collected during surgery, a plasma component separator is installed in place of the filter. A plasma separator may be used instead.

Moreover, the filtration member used in the filter of the undiluted solution processing apparatus of the present invention is not particularly limited. Moreover, a similar filter member may be used for concentrating a filtrate in a concentrator. The filtration member used for such filtration and concentration allows plasma, water, and the above-mentioned useful components contained in pleural and ascitic fluid to pass through, but it does not allow cancer cells, macrophages, histiocytes, white blood cells, red blood cells, platelets, bacteria, etc. The cell component (that is, solid content) may be any material that does not permeate gas, and its material, size, and shape are not particularly limited. For example, the shape of the filtration member may be a hollow fiber membrane, a flat membrane, a laminated membrane, or the like. Furthermore, the filter member may be made of a material that does not allow gas to pass through when wetted with liquid. Of course, it is also possible to use a material made of a material that does not allow gas to pass through even when not wetted with liquid. Note that in this specification, the gas that does not pass through the filter member includes inert gases such as nitrogen, air, oxygen, etc., and refers to gases used for general leak checks.

As an example, hollow fiber membranes used in CART's ascites filter, plasma separator for plasma exchange, plasma component separator for plasma exchange, etc. can be used for the filter and concentrator of the stock solution processing device of the present invention. be able to.

<Stock solution processing device 1 of this embodiment>
The stock solution processing apparatus 1 of this embodiment will be explained based on FIGS. 13 to 19.
As shown in FIGS. 13, 14, and 19, the stock solution processing apparatus 1 of this embodiment includes a main body 100, a pair of roller pumps 110 and 120 provided in the main body 100, and a filter 10. A filter holding section 101 that holds the concentrator 20, a concentrator holding section 102 that holds the concentrator 20, and a pair of hanging sections 103, 103 from which the tube holder 150 and each bag B are hung.

In the undiluted solution processing apparatus 1 of this embodiment, when processing an undiluted solution, each bag B is suspended from a pair of hanging parts 103, 103, and the filtration is carried out in the filter holding part 101 and the concentrator holding part 102. The container 10 and the concentrator 20 are held. Then, each bag B, filter 10, and concentrator 20 are appropriately connected by a plurality of tubes T, and appropriate tubes T are set in a pair of roller pumps 110 and 120. In this state, by operating the pair of roller pumps 110 and 120, the stock solution in the stock solution bag UB can be filtered and concentrated to obtain a concentrated solution.

In addition, by changing the operating state of the pair of roller pumps 110, 120, changing each bag B connected to each tube T, changing the tube T through which the liquid flows, etc., it is possible to not only obtain a concentrated liquid, but also to obtain a concentrated liquid. re-concentration, cleaning of the filter 10 and concentrator 20, recovery of liquid present in the filter 10, concentrator 20, etc. can be carried out.

<Description of each configuration of the stock solution processing apparatus 1 of this embodiment>
Below, each part of the stock solution processing apparatus 1 of this embodiment will be explained.

<Main body part 100>
As shown in FIGS. 13, 14, and 19, the main body 100 includes a control section 106 in the center thereof. This control unit 106 has a function of controlling the operation of the pair of roller pumps 110, 120 and the entire device. The control unit 106 is also provided with a panel unit 106p that serves as an operation panel for operating the device and a display panel on which various displays are displayed. That is, by giving instructions to the control section 106 from the panel section 106p, the operator can instruct the processing to be performed on the stock solution processing apparatus 1 of this embodiment. Further, by checking numerical values, warnings, etc. displayed on the panel section 106p according to instructions from the control section 106, the operator can grasp the status of the stock solution processing apparatus 1 of this embodiment.

Note that the control unit 106 may include buttons for performing various operations in addition to the panel unit 106p.

<Roller pump 110, 120>
As shown in FIGS. 13, 14, and 19, a pair of roller pumps 110 and 120 are provided on both sides of the control section 106 of the main body section 100. Since the pair of roller pumps 110 and 120 have substantially the same structure, the roller pump 110 will be explained below.

Note that, in order to make the roller pump 110 easier to understand, FIG. 15 shows a state in which a portion functioning as the roller pump 110 is removed from the main body portion 100. The roller pump 110 will be described below based on FIG. 15.

As shown in FIG. 15, the roller pump 110 includes a frame 111 and a lid 112 attached to the frame 111 so as to be openable and closable. Specifically, the lid part 112 is provided so that when the lid part 112 is opened, a roller part 115, which will be described later, is exposed, and when the lid part 112 is closed, the roller part 115 can be covered with the lid part 112. The lid 112 is provided so that a space for accommodating the roller portion 115 is formed between the inner surface of the lid 112 and the upper surface of the frame 111 when the lid 112 is closed.

A roller section 115 including two rollers 116 is provided on the upper surface of the frame 111 (see FIG. 16). In this roller section 115, two rollers 116 are attached to one shaft 117, and this shaft 117 is rotated by a drive source 114 such as a motor. In other words, when the shaft 117 is rotated by the drive source 114, the two rollers 116 are rotated. Note that the number of rollers 116 provided in the roller section 115 is not limited to two, and may be one or three or more. It is only necessary to provide a number of rollers 116 suitable for the processing operation.

Further, a holder 113 is provided on the upper surface of the frame 111 at a position facing the roller section 115. This holder 113 is provided with a recessed surface 113a on the surface of the roller portion 115 facing the two rollers 116, which sandwiches the tube T between the two rollers 116. The holder 113 can move toward and away from the roller section 115 in conjunction with the opening and closing of the lid section 112 using a slider mechanism or the like. Specifically, when the lid part 112 is opened, the holder 113 is separated from the roller part 115 so that the space between the concave surface 113a of the holder 113 and the two rollers 116 is wider than the diameter of the tube T. It is supposed to move. Furthermore, when the lid part 112 is closed, the holder 113 approaches the roller part 115 and moves so that the gap between the concave surface 113a of the holder 113 and the two rollers 116 becomes narrower than the diameter of the tube T. It has become. In other words, when the lid part 112 is opened, the tube T can be placed between it and the roller part 115 and removed, and when the lid part 112 is closed, the tube T is sandwiched between the recessed surface 113a of the holder 113 and the two rollers 116. It is now possible to do so.

Therefore, if the lid part 112 is opened, the tube T is placed between the roller part 115 and the recessed surface 113a of the holder 113, and the lid part 112 is closed, the tube T can be clamped by the roller part 115 and the holder 113. There is. Furthermore, by operating the drive source 114 while the tube T is clamped by the roller portion 115 and the holder 113, the liquid within the tube T can be fed.

Note that the roller 116 only needs to have the same structure as a roller used in a general roller pump. For example, as shown in FIG. 16(C), the roller 116 may include a plurality of rollers 116b (for example, three rollers 116b) provided between a pair of cover plates 116a. When such a roller 116 is used, the tube T can be sandwiched between the plurality of rollers 116b and the recessed surface 113a of the holder 113, and when the roller 116 rotates, the roller 116b moves to handle the tube T. The liquid inside the tube T can be fed by using the tube T.

The size of the gap formed between the concave surface 113a of the holder 113 and the two rollers 116 when the lid part 112 is closed is set to be an appropriate gap according to the tube T placed on the roller 116. Just do it. An appropriate gap means a gap that can be clamped to prevent liquid from flowing inside the tube T when the roller 116 is not rotating, and that does not increase rotational resistance of the roller 116 so much when the roller 116 rotates. .
In addition, when a plurality of tubes T are arranged on the roller 116 and the diameters of the tubes T to be arranged are different, the gaps may be different depending on the position where each tube T is arranged. good. For example, if the recessed surface 113a of the holder 113 is provided with a step so that the distance from the recessed surface 113a of the holder 113 to the roller 116 is different, the distance from the recessed surface 113a of the holder 113 to the roller 116 can be changed depending on the position where each tube T is placed (that is, the roller 116 placed). You can change the gap by On the other hand, if a plurality of rollers 116 are provided and the diameters of the tubes T arranged by each roller 116 are different, the gap can be changed to match the tubes T by changing the diameter of the rollers 116.

<Control of roller pump 110>
Here, when the tube T is placed between the roller portion 115 and the recessed surface 113a of the holder 113, the tube T may not be placed at an appropriate position. When the drive source 114 is operated in such a state, the tube T may interfere with other parts of the roller 116 than the roller portion 115. If the tube T interferes with a portion of the roller 116 other than the roller portion 115, there is a risk that liquid feeding may not be possible or that the tube T or the roller 116 may be damaged.

Therefore, the control unit 106 may have a function of operating the drive source 114 to rotate the rollers 116 in the forward and reverse directions when detecting that the lid 112 is closed. By rotating the rollers 116 in the normal and reverse directions, the tube T can be moved to the proper position even if the arrangement of the tube T is slightly deviated from the proper position. Then, since there is no need to re-arrange the tube T, the working time can be shortened.

Further, even if the roller 116 is rotated in the normal or reverse direction, the tube T may not be placed in the proper position. Therefore, when the control unit 106 detects that the tube T cannot be placed in an appropriate position, it provides a safety function that prevents the drive source 114 from operating, and an alarm that alerts the operator that the tube T is not placed in an appropriate position. It is desirable to have the following functions. This can prevent damage to the device due to improper arrangement of the tubes T, and also allow the operator to quickly notice abnormalities in the arrangement of the tubes T.

For example, as an alarm function, when the control section 106 detects that the tube T is not placed in the proper position, the control section 106 displays an abnormality alarm on the panel section 106p, or emits an abnormality alarm sound. The following functions can be mentioned.

Further, as a method for detecting that the tube T is not placed at an appropriate position, for example, a method of detecting the driving force of the driving section 114 can be adopted. In this case, if the driving force of the drive unit 114 exceeds a certain level, the control unit 106 may determine that there is an abnormality in the arrangement of the tube T. If the drive unit 114 is a motor, the control unit 106 can determine that an abnormality has occurred in the arrangement of the tube T when the rotational resistance applied to its main shaft exceeds a predetermined value. The rotational resistance applied to the main shaft can be determined, for example, by detecting the current value supplied to the motor.

<Tube positioning member 160>
As a method for arranging the tube T at a proper position, the following tube positioning member 160 can be used. If the following tube positioning member 160 is used, when the tube T is wound around the roller 116, it will be easier to bring the tube T and roller 116 into close contact with each other, and the two tubes T can be attached to the two rollers 116, respectively. It becomes easier to wrap properly.

The configuration of the tube positioning member 160 will be explained below.
As shown in FIGS. 16 and 17, the tube positioning member 160 includes a pair of holding members 161, 161 and a connecting member 165.

<Pair of holding members 161, 161>
As shown in FIGS. 16 and 17, the pair of holding members 161, 161 hold two tubes T, and the two tubes T are spaced apart from each other along the axial direction (distance). (separated from each other). The pair of holding members 161, 161 have the same structure and are formed by combining a base member 162 and a guide member 163.

The base member 162 includes a base portion 162b that is a rectangular plate-like member. The base member 162 has a structure that holds the tube T such that the longitudinal direction of the base portion 162b and the axial direction of the tube T are perpendicular to each other. Specifically, a tube placement portion 162c extending from the base portion 162b is provided on the side of the base member 162 in the short axis direction. The tube placement portion 162c includes a pair of outer holding portions d, d standing upright from the surface of the tube placement portion 162c, and a pair of outer holding portions d, d located between the pair of outer holding portions d, d and the base portion 162b. Inner holding portions c, c are provided. The pair of inner holding parts c, c are arranged further inward in the longitudinal direction of the base part 162b than the pair of outer holding parts d, d. The pair of inner holding parts c and c include an upright part that stands up from the surface of the tube placement part 162c, and a bent part that is bent outward in the longitudinal direction of the base part 162b with respect to the upright part. have. Furthermore, the distance between the outer surface of the upright portion and the inner surface of the pair of outer holding portions d, d is equal to the diameter of the tube T in the longitudinal direction of the base portion 162b. are formed almost identically. Further, the distance between the lower surface of the bent portion and the surface of the base portion 162b of the pair of inner holding portions c, c is also formed to be approximately the same as the diameter of the tube T.

Then, when the base portion 162b is viewed from the minor axis direction, the inner surfaces of the pair of outer holding portions d, d, the outer surfaces of the standing portions and the lower surfaces of the bent portions of the pair of inner holding portions c, and the base Two holes (hereinafter referred to as virtual holes) are formed by the surface of the portion 162b.

On the other hand, the guide member 163 is disposed so as to overlap the surface of the base portion 162b of the base member 162. In this guide member 163, a pair of grooves 163g, 163g for accommodating the tube T are provided on the surface located on the surface side of the base portion 162b when stacked on the surface of the base portion 162b. The pair of grooves 163g, 163g are provided so that their axial directions are parallel to each other. Furthermore, when the guide member 163 is placed on the surface of the base portion 162b, the pair of grooves 163g, 163g and the two virtual holes are seen from the short axis direction of the base portion 162b. They are formed to overlap (preferably coincide).

Therefore, by arranging the two tubes T in the two virtual holes of the base member 162, the two tubes T can be arranged in the base member 162 so as to be parallel to each other. In this state, if the guide member 163 is stacked on the surface of the base part 162b, the two tubes T can be placed in the pair of grooves 163g, 163g, and the two tubes T can be placed in place so that the two tubes T do not come off. It can be held by the holding member 161.

The tube placement portion 162c of the base member 162 and the pair of grooves 163g, 163g of the guide member 163 described above correspond to "a plurality of tube holding portions" in the claims. Further, the long axis direction of the base portion 162b corresponds to the “direction in which the plurality of tube holding portions are lined up” in the claims. Further, the short axis direction of the base portion 162b corresponds to "the axial direction of the plurality of tubes held by the plurality of tube holding parts" in the claims.

<Connecting member 165>
As shown in FIGS. 16 and 17, the connecting member 165 connects the pair of tube holding parts 161, 161 described above. More specifically, the connecting member 165 connects the pair of tube holding parts 161, 161 between the pair of tube holding parts 161, 161 in order to maintain the pair of tube holding parts 161, 161 separated by a predetermined distance along the axial direction of the tube T. It is set in.

This connecting member 165 has a connecting structure connected to the pair of tube holding parts 161, 161 at both ends thereof, and can be detachably connected to the guide member 163 of the tube holding part 161 described above. Specifically, the guide member 163 is provided so that the end of the connecting member 165 is connected to a portion between the pair of grooves 163g, 163g. In other words, when the connecting member 165 is stretched out, it is positioned between the adjacent tubes T held by the tube holding part 161 when viewed from a direction intersecting the long axis direction and the short axis direction of the base part 162b. In addition, the connecting member 165 is connected to the guide member 163.

Moreover, the connecting member 165 is arranged in such a way that, when the connecting member 165 is extended, the connecting member 165 is located at a position that is biased toward the opposite side of the base portion 162b with respect to the central axis of the tube T held by the tube holding portion 161. It is connected to a guide member 163.

The connecting member 165 has a structure that can be bent between the pair of tube holding parts 161, 161 in a state where both ends are connected to the pair of tube holding parts 161, 161. More specifically, the connecting member 165 has a structure that can be bent between the pair of tube holding parts 161, 161 in a direction intersecting the long axis direction and the short axis direction of the base part 162b.

For example, the connecting member 165 is formed of a plate-shaped member made of plastic. Then, both ends of the connecting member 165 are connected to the guide members 163 of the pair of tube holding parts 161, 161 so that the width direction of the connecting member 165 is parallel to the longitudinal direction of the base part 162b. Then, the connecting member 165 can be bent between the pair of tube holding parts 161, 161 in a direction intersecting the long axis direction and the short axis direction of the base part 162b (FIG. 17).

When such tube positioning member 160 is attached to two tubes T, the following advantages can be obtained when these two tubes T are arranged in roller pump 110.

First, stopper members T1 and T2 are provided so that when the tube T is wound around the two 116 and 116 of the roller part 115 of the roller pump 110, the tube T is placed at a position separated by an appropriate length (Fig. 16). On the other hand, a pair of tube holding parts 161, 161 are arranged between stopper members T1, T2 so that the outer surfaces of the pair of tube holding parts 161, 161 are in contact with stopper members T1, T2, respectively. Then, when the tube T is stretched and the outer surfaces of the pair of tube holding parts 161 and 161 are in contact with the stopper members T1 and T2, respectively (hereinafter referred to as the proper arrangement state), the connecting member 165 is moved so that it is in the stretched state. is placed between the pair of tube holding parts 161, 161 (see FIG. 17(B)).
On the other hand, the roller pump 110 is provided with a pair of accommodating parts for accommodating the pair of tube holding parts 161, 161. Specifically, a pair of accommodating parts for accommodating the pair of tube holding parts 161, 161 are provided at positions sandwiching the surface of the roller part 115 that includes the rotating shaft 117. Moreover, the pair of housing parts is configured such that when the pair of tube holding parts 161, 161 are respectively stored in the pair of housing parts, the tube T can be wound around the two 116, 116 of the roller part 115 in an appropriate state. Set it in
Then, just by arranging the pair of tube holding parts 161, 161 in the pair of storage parts, the two tubes T can be properly wound around the two 116, 116 of the roller part 115 (see FIG. 15).

Furthermore, the connecting member 165 is connected to the guide member 163 such that the connecting member 165 is located on the opposite side of the base portion 162b with respect to the central axis of the tube T held by the tube holding portion 161. Then, if the tube T is wound around the roller 116 of the roller portion 115 so that the guide member 163 is positioned on the roller 116 side, the connecting member 165 will be positioned between the two tubes T with the center portion between both ends thereof being slightly bent. (See FIGS. 16(A) and 16(B)). Then, even if the two tubes T are arranged vertically side by side, the connecting member 165 can prevent the upper tube T from coming into contact with the lower tube T.

Note that the connecting member 165 does not necessarily have to be located on the side opposite to the base portion 162b with respect to the central axis of the tube T. However, with such a structure, the effects described above can be obtained.

Moreover, the tube holding part 161 does not have to be symmetrical with respect to the middle of the base part 162b in the longitudinal direction. In other words, the tube holding part 161 may be formed asymmetrically with respect to the middle of the two tubes T held by the tube holding part 161 in the longitudinal direction of the base part 162b. For example, as shown in FIG. 17, the guide member 163 may have different lengths at portions located outward from the pair of grooves 163g, 163g. In this way, when placing the pair of tube holding parts 161, 161 in the pair of storage parts, it is possible to prevent the pair of tube holding parts 161, 161 from being inserted incorrectly. In other words, even if an attempt is made to arrange the pair of tube holding parts 161, 161 in the pair of housing parts from the wrong direction, the pair of tube holding parts 161, 161 cannot be stored in the pair of housing parts. This can prevent operational errors when setting the tube T to the roller pump 110. For example, when setting the tube T on a roller pump, it is possible to prevent the tube T from being twisted or from setting two tubes on opposite rollers 116.

In addition, when it has a plurality of roller pumps, the size and shape of the tube holding part 161 may be changed depending on the roller pump to be set. This will prevent you from setting the tube in the wrong roller pump.

Further, a function may be provided that prevents the roller pump device from operating if the tube holding portion 161 is not properly set in the pair of storage portions. In this case, it is possible to prevent the tube T and roller 116 from being damaged even if the roller 116 is rotated by mistake when the tube T is not set properly. For example, if a button-type sensor or the like is provided in the pair of housing parts, which is pressed when an appropriate tube holding part 161 is placed, the above function can be achieved.

Furthermore, in the above example, the case where the tube positioning member 160 holds two tubes T has been described. However, the number of tubes T held by the tube positioning member 160 may be three or more, and is not particularly limited. In addition, when the tube positioning member 160 holds three or more tubes T, it is desirable that a connecting member 165 is provided between each adjacent tube T.

Further, the structure of the holding member 161 and the plurality of tube holding parts is not limited to the above structure. The holding member 161 and the plurality of tube holding parts only need to be able to hold a plurality of tubes parallel to each other and in a line. For example, a plurality of tube holding parts may be formed by simply forming through holes in a line in a plate-shaped holding member. Here, "in a row" refers to cases in which when multiple tubes are arranged in multiple tube holders, the central axes of the multiple tubes are aligned on almost the same plane, and tubes T held in multiple tube holders in the axial direction. This also includes a case where the central axis of the tube T is misaligned in the normal direction of the surface of the base member 162 when viewed from above. For example, when the tubes T held by a plurality of tube holding parts are viewed from the axial direction, even if the positions of the center axes of the tubes T are lined up in a staggered arrangement, the plurality of tubes mentioned above are arranged in a line. Included in the state of being held side by side.

<Filter holding section 101 and concentrator holding section 102>
As shown in FIGS. 13, 14, and 19, a filter holder 101 and a concentrator holder 102 are provided outside the pair of roller pumps 110 and 120, respectively. 13 and 14, the roller pump 110 provided on the left side of the control section 106 is equipped with the filter holding section 101, and the roller pump 120 provided on the right side of the control section 106 is provided with the concentrator holding section 101. 102.

The filter holding part 101 and the concentrator holding part 102 are provided with clamp parts 101c and 102c on their surfaces, and the filter 10 and the concentrator 20 can be detachably held by the clamp parts 101c and 102c. ing.

Further, the base ends of the filter holding section 101 and the concentrator holding section 102 are swingably connected to the frames of the pair of roller pumps 110 and 120. Specifically, the filter holding part 101 and the concentrator holding part 102 are moved so that when the filter holding part 101 and the concentrator holding part 102 are rocked outward, the clamp parts 101c and 102c are exposed. are connected to the frames of a pair of roller pumps 110 and 120. Conversely, if the filter holding part 101 and the concentrator holding part 102 are swung inward, the clamp parts 101c and 102c will be in a state facing the pair of rollers 116 and 116 of the pair of roller pumps 110 and 120. As such, the filter holding part 101 and the concentrator holding part 102 are connected to the frames of a pair of roller pumps 110 and 120. That is, when the work of processing the stock solution is not performed, the filter holding section 101 and the concentrator holding section 102 can be housed in the roller pumps 110 and 120. Note that the filter holding part 101 and the concentrator holding part 102 do not necessarily have to be swingably connected to the frames of the pair of roller pumps 110, 120, and are always exposed to the outside of the roller pumps 110, 120. You can leave it there. However, with the above configuration, there is an advantage that the undiluted solution processing apparatus 1 of this embodiment can be stored compactly when the undiluted solution processing apparatus 1 of this embodiment is not used.

Note that the stock solution processing apparatus 1 of this embodiment does not necessarily have the filter holding section 101 or the concentrator holding section 102. However, if the main body part 100 has the filter holding part 101 and the concentrator holding part 102, there is an advantage that there is no need to separately prepare a holder for holding the filter 10 and the concentrator 20.

<Pair of hanging parts 103, 103>
As shown in FIGS. 13, 14, and 19, a pair of hanging parts 103, 103 are provided on the back surface of the main body part 100. The pair of hanging parts 103, 103 are formed of shaft-shaped members, and the base ends of the shafts are removably attached to a pair of mounting parts 100h, 100h provided on the back surface of the main body part 100. . More specifically, the pair of hanging parts 103, 103 are attached so that when the base ends of the pair of hanging parts 103, 103 are attached to the pair of mounting parts 100h, 100h, the axial direction of the pair of hanging parts 103, 103 becomes almost vertical. Attachment portions 100h, 100h are provided.

The pair of hanging parts 103, 103 are provided with a hook part 103b like a general drip holder. The pair of hanging parts 103, 103 are such that each bag B can be hung from the hook part 103b.

Further, a hook portion 103f is provided on the pair of hanging portions 103, 103, and the tube holder 150 can be hung from the hook portion 103f.

Note that the pair of hanging parts 103, 103 do not necessarily have to be detachable from the main body part 100. However, if the pair of hanging parts 103, 103 are made removable, the undiluted solution processing apparatus 1 of this embodiment can be removed by removing the pair of hanging parts 103, 103 when the undiluted solution processing apparatus 1 of this embodiment is not in use. 1 can be stored compactly.

Moreover, the number of hanging parts 103 provided in the stock solution processing apparatus 1 of this embodiment is not limited to two, but may be one, or three or more. An appropriate number of hanging portions 103 may be provided in accordance with the number of bags B, the number of tubes T, etc. used in the processing performed by the stock solution processing apparatus 1 of this embodiment.

Moreover, the stock solution processing apparatus 1 of this embodiment does not necessarily have to have the pair of hanging parts 103, 103. In this case, a general drip holder for suspending the drip may be used. However, if the main body part 100 has the pair of hanging parts 103, 103, there is an advantage that there is no need to separately prepare a drip holder or the like.

<Tube holder 150>
As shown in FIG. 18, the tube holder 150 is a member for holding a plurality of tubes T. If this tube holder 150 holds a plurality of tubes T, the plurality of tubes T can be suspended from a pair of hanging parts 103, 103, as shown in FIG. ). Then, when setting a plurality of tubes T to the control unit 106 of the main body 100, the filter 10, the concentrator 20, or the pair of roller pumps 110, 120, only the necessary tubes T are removed from the tube holder 150. be able to work. That is, when setting a plurality of tubes T in the apparatus, the operator does not have to hold the tubes T that will not be used immediately, making it easier for the operator to perform the work.

<Main body part 151>
As shown in FIG. 18, the tube holder 150 includes a plate-shaped main body 151. As shown in FIG. The main body portion 151 is provided with a connecting portion 152 at its upper edge 151a. This connecting portion 152 has a through hole 152h that passes through the front and back sides, and if the hook portions 103f of the pair of hanging portions 103, 103 are passed through the through hole 152h, the tube holder 150 is held so that its upper edge 151a is upward. It can be hung from the hanging part 103 with the camera facing the direction of the camera.

In addition, in order to stably suspend the tube holder 150 from the pair of hanging parts 103, 103 with the upper end edge 151a facing upward, the through hole 152h and the hook part 103f of the pair of hanging parts 103, 103 are It is desirable that the shape be horizontally long. That is, it is desirable that the through hole 152h of the connecting portion 152 be a horizontally long hole that is long in the direction along the upper edge 151a. Further, it is desirable that the hook portions 103f of the pair of hanging portions 103, 103 also have a horizontally elongated shape that is long in the direction orthogonal to the axial direction of the pair of hanging portions 103, 103.

<Holding section 155>
A plurality of holding parts 155 that removably hold the tube T are provided on the surface 151c (first surface) of the main body part 151. This holding part 155 has a cylindrical structure having a through hole 155h passing through it in the vertical direction, and a slit-shaped opening 155s is formed in the front surface thereof. In this holding portion 155, the width of the opening 155s of the through hole 155h is smaller than the diameter of the tube T. That is, by pushing the tube T into the through hole 155h from the opening 155s, the tube T can be placed and held in the through hole 155h of the holding part 155, and by pulling the tube T, the tube T can be removed from the holding part 155. It looks like this.

The plurality of holding parts 155 are arranged in a line along the upper edge 151a of the main body part 151. Moreover, the plurality of holding parts 155 are provided so that the central axes of the through holes 155h are parallel to each other. Therefore, when the plurality of tubes T are held by the plurality of holding parts 155, the plurality of tubes T can be arranged so that their axial directions are parallel to each other and lined up in a line along the surface 151c of the main body part 155. Then, by attaching the plurality of tubes T to the plurality of holding parts 155 in a predetermined order, it is possible to prevent the operator from making a mistake such as mixing up the plurality of tubes T. For example, the plurality of tubes T are attached to the plurality of holding parts 155 so that the plurality of tubes T are lined up from left to right of the plurality of holding parts 155 in the order of connection to the device. Then, if the operator removes the tubes T in order from the left, he will not be able to connect the wrong tube T, thereby preventing work errors and reducing the work burden on the operator.

Note that "the plurality of holding parts 155 are lined up in a row along the upper edge 151a of the main body part 151" means that the plurality of holding parts 155 are arranged in a staggered manner, or when the plurality of holding parts 155 are aligned along the upper edge 151a of the main body part 151. This also includes cases where there is a slight deviation in the intersecting direction.

<Engagement member 153>
Further, the connecting portion 152 includes an engaging member 153 on the back surface 151d (that is, the second surface opposite to the front surface 151c) of the main body portion 151. This engagement member 153 is provided so as to protrude from the back surface 151d of the main body portion 151, and has an opening 153s at one end (upper end), and a gap 153h continuous with the opening 153s. ing.

By providing such an engaging member 153, the tube T held by the plurality of holding parts 155 of the main body part 151 can be turned downward at once, or the tube T can be maintained in a downward state. . For example, by inserting the edge of a bucket or the like into the gap 153h through the opening 153s, the tube holder 150 can be attached to the bucket or the like so that the upper edge 115a of the main body 151 faces downward. Then, if the plurality of tubes T are attached to the plurality of holding parts 155 with their tips facing the upper edge 115a side of the main body part 151 (upward when the main body part 151 is suspended from the hanging part 103), The tips of a plurality of tubes T can be arranged so as to face downward at the same time. That is, when draining liquid from a plurality of tubes T into a bucket or the like, it is possible to easily drain liquid from the plurality of tubes T by simply attaching the engaging member 153 to the edge of the bucket or the like.

Note that the shape of the connecting portion 152 is not limited to the above shape. Any shape may be used as long as the main body portion 151 can be connected to the pair of hanging portions 103, 103, etc.
Further, the shape of the engaging member 153 is not limited to the above-mentioned shape, but may be any shape as long as it has the above-mentioned functions. Furthermore, the engaging member 153 does not necessarily need to be provided.
Furthermore, in the above example, the case where the engaging member 153 is provided on the back surface 151d of the main body section 151 has been described, but the engaging member 153 may be provided on the surface 151c of the main body section 151, or and the back surface 151d.

<Filter 10 and concentrator 20>
Before explaining the circuit of the stock solution processing device 1 of this embodiment, an example of a filter and a concentrator used in the stock solution processing device 1 of this embodiment will be described. Note that although a filter and a concentrator using a hollow fiber membrane as a filtration member will be described below, the filter and concentrator used in the stock solution processing device 1 of this embodiment use a hollow fiber membrane as a filtration member. The present invention is not limited thereto, and filters and concentrators using known filtration members other than hollow fiber membranes can also be used.

<Filter 10>
The filter 10 is, for example, an ascites filter used in CART, a plasma separator used in plasma exchange, a plasma component separator, or the like. This filter 10 has a filtering member housed therein, and is capable of filtering pleural and ascitic fluid using the filtering member and separating it into a filtrate and a separated liquid containing cells and the like.

As shown in FIG. 5, the filter 10 includes a main body 11 and a hollow fiber membrane bundle 15 disposed within the main body 11.

<Hollow fiber membrane bundle 15>
As shown in FIG. 5, the hollow fiber membrane bundle 15 is constructed by bundling a plurality of hollow fiber membranes 16.

The hollow fiber membrane 16 is a tubular member having a wall 16w having an annular cross section and a through flow path 16h that penetrates the hollow fiber membrane 16 in the axial direction inside the wall 16w. The wall 16w of the hollow fiber membrane 16 has a function of not allowing solid matter such as cells or gas to pass therethrough, but allowing liquid to pass therethrough.

In the hollow fiber membrane bundle 15, one ends of the plurality of hollow fiber membranes 16 and the other ends thereof are bundled together. That is, the hollow fiber membrane bundle 15 is formed by bundling a plurality of hollow fiber membranes 16 such that the through flow path 16h of each hollow fiber membrane 16 passes between one end and the other end of the hollow fiber membrane bundle 15. ing.

Note that the plurality of hollow fiber membranes 16 do not necessarily have to be bundled at both ends. In that case, the plurality of hollow fiber membranes 16 are arranged such that both ends of the through passages 16h are communicated with the pair of header parts 13 and 14 of the main body part 11, respectively.

<Main body part 11>
As shown in FIG. 5, the main body 11 includes a body 12 having an internal space 12h that is airtightly and liquidtightly isolated from the outside. The internal space 12 of the body portion 12 is formed so as to communicate with the outside only through a port described later, and accommodates the hollow fiber membrane bundle 15 described above therein. This internal space 12 is airtightly separated from the passage channels 16h of the plurality of hollow fiber membranes 16 when the above-mentioned hollow fiber membrane bundle 15 is accommodated therein, but liquid can flow between them through the wall 16w. It is now possible to pass. In other words, the liquid in the internal space 12 can be supplied to the through passage 16h, and the liquid in the through passage 16h can be supplied to the internal space 12.

Note that the size and shape of the internal space 12 are not particularly limited. When the hollow fiber membrane bundle 15 is accommodated, liquid flowing into the internal space 12 through the port flows between the hollow fiber membrane bundle 15 and the inner surface of the body 12 (that is, the inner surface of the internal space 12) and between the plurality of It only needs to be large enough to flow between the hollow fiber membranes 16 and into the through channel 16h through the wall 16w of the hollow fiber membrane 16. In addition, the liquid that has flowed into the internal space 12 from the through channel 16h through the wall 16w of the hollow fiber membrane 16 flows between the plurality of hollow fiber membranes 16 and between the hollow fiber membrane bundle 15 and the inner surface of the internal space 12. It only needs to be large enough to flow through the port and flow out from the port.

As shown in FIG. 5, a pair of header parts 13 and 14 are provided in the main body part 11 so as to sandwich the body part 12, that is, to sandwich the internal space 12h. The pair of header sections 13 and 14 are airtightly and liquid-tightly isolated from the interior space 12h of the body section 12 described above and the outside, and have a space that communicates with the outside only through a port, which will be described later. is formed. Furthermore, each end of the hollow fiber membrane bundle 15 described above is connected to the pair of header parts 13 and 14, respectively. Specifically, the hollow fibers are arranged so that the openings at both ends of the through passages 16h of the plurality of hollow fiber membranes 16 constituting the hollow fiber membrane bundle 15 are communicated with the spaces inside the pair of header sections 13 and 14. Both ends of the membrane bundle 15 are connected to a pair of header parts 13 and 14, respectively. Therefore, the spaces inside the pair of header sections 13 and 14 are communicated with each other by the passage passages 16h of the plurality of hollow fiber membranes 16 constituting the hollow fiber membrane bundle 15.

<Each port 11a to 11c>
Further, as described above, the main body part 11 includes a port 11a that communicates between the internal space 12h of the body part 12 formed in the main body part 11 and the internal spaces of the pair of header parts 13 and 14, and the outside. -11c are provided.

As shown in FIG. 5, a stock solution supply port 11a is provided at one end of the main body 11 to communicate the header 13 with the outside. One end of the liquid supply tube 2, the other end of which is connected to the liquid outlet of the stock solution bag UB, is connected to the stock solution supply port 11a (see FIG. 1).

Further, a cleaning liquid recovery bag FB is connected to the stock solution supply port 11a via the solution supply tube 2 or directly to the stock solution supply port 11a. Specifically, one end of the cleaning liquid recovery tube 7, the other end of which is connected to the cleaning liquid collection bag FB, is connected to the liquid supply tube 2 or the stock solution supply port 11a (see FIG. 1).

A filtrate discharge port 11c is provided on the side surface of the trunk 12 of the main body 11 to communicate the internal space 12h with the outside. One end of the filtrate supply tube 3, the other end of which is connected to the filtrate supply port 20a of the concentrator 20, is connected to the filtrate discharge port 11c (see FIG. 1). In addition, although two filtrate discharge ports 11c are provided in FIG. 5, the number of filtrate discharge ports 11c may be one.

A cleaning liquid supply port 11b is provided at the other end of the main body 11 to communicate the header 14 with the outside. One end of the cleaning liquid supply tube 6, the other end of which is connected to the cleaning liquid bag SB, is connected to the cleaning liquid supply port 11b (see FIG. 1).

<Function of filter 10>
The filter 10 has the above configuration, and as described above, the stock solution bag UB and the cleaning solution bag SB are communicated with each port 11a to 11c of the main body 11 via each tube. Therefore, if the liquid supply tube liquid sending part 2p is operated to supply the liquid from the liquid bag UB to the header part 13 of the main body part 11 via the liquid supply tube 2 and the liquid liquid supply port 11a (see FIG. 1), the hollow Since the stock solution is supplied into the through channel 16h of the hollow fiber membranes 16 of the fiber membrane bundle 15, the stock solution is filtered by the hollow fiber membranes 16. In other words, the solid content contained in the stock solution cannot pass through the hollow fiber membrane 16 and remains in the through channel 16h, and only the liquid content, that is, the filtrate passes through the wall 16w of the hollow fiber membrane 16, so the stock solution is filtered. A filtrate can be obtained.

The filtrate is discharged from the hollow fiber membrane 16 into the internal space 12h of the body 12 of the main body 11, and then passes through the filtrate discharge port 11c, the filtrate supply tube 3, and the filtrate supply port 20a of the concentrator 20. The water is then supplied to the concentrator 20 from the internal space 12h.

On the other hand, the filter 10 can be cleaned by operating the cleaning liquid recovery tube liquid sending section 7p (or the liquid supply tube liquid sending section 2p) to suck out the liquid from the filter 10. That is, since the cleaning liquid can be supplied from the cleaning liquid bag SB to the header part 14 of the main body part 11 via the cleaning liquid supply tube 6 and the cleaning liquid supply port 11b, the cleaning liquid can be supplied from the header part 14 into the through passage 16h of the hollow fiber membrane 16. Cleaning liquid can be supplied (see Figure 5). That is, since the cleaning liquid flows from the header part 14 toward the header part 13, the inside of the through-flow path 16h of the hollow fiber membrane 16, especially the inner surface of the through-flow path 16 (the inner surface of the wall 16w), is can be cleaned by a cleaning liquid flowing along the Then, the solid matter adhering to the inner wall of the through-flow channel 16h of the hollow fiber membrane 16 can be effectively flushed away.

In particular, the hollow fiber membrane 16 can be effectively cleaned in the following manner.

First, the filtrate supply tube 3 and the connection tube 9 are closed by the flow rate adjusting means 3c provided in the filtrate supply tube 3 and the connection tube liquid feeding section 9p provided in the connection tube 9. On the other hand, the cleaning liquid supply tube 6 is opened by the flow rate adjusting means 6c. In this state, the cleaning liquid recovery tube liquid feeding section 7p of the cleaning liquid recovery tube 7 is operated.

Then, negative pressure is generated in the portion of the cleaning liquid recovery tube 7 on the upstream side of the cleaning liquid recovery tube liquid feeding section 7p, that is, on the filter 10 side. If such a negative pressure is generated, the cleaning liquid will flow from the cleaning liquid bag SB connected to the cleaning liquid supply tube 6 to the passage through the cleaning liquid supply tube 6, the cleaning liquid supply port 11b, the header part 14, and the hollow fiber membrane 16. 16h, the header section 13, and the stock solution supply port 11a to flow into the cleaning solution recovery tube 7.

At this time, since the filtrate supply tube 3 and the connection tube 9 are closed, the cleaning liquid does not flow from the hollow fiber membrane 16 to the internal space 12h, but flows only within the through passage 16h of the hollow fiber membrane 16. Then, only the pair of header parts 13 and 14 and the inside of the through flow path 16h of the hollow fiber membrane 16 can be cleaned with the cleaning liquid, so that the amount of cleaning liquid used for cleaning the filter 10 can be reduced.

Moreover, since the internal space 12h is not washed, even if the filter 10 is washed after performing filtration and concentration, the filtrate can remain in the internal space 12h. Then, it is possible to prevent the filtrate in the internal space 12h from being discharged together with the cleaning liquid, thereby preventing a decrease in the recovery rate of the filtrate.

In addition, when cleaning the filter 10, both the liquid supply tube liquid feeding part 2p of the liquid supply tube 2 and the cleaning liquid recovery tube liquid feeding part 7p of the cleaning liquid recovery tube 7 may be operated.
Moreover, when cleaning the filter 10, the liquid supply tube liquid feeding part 2p may be operated instead of the cleaning liquid recovery tube liquid feeding part 7p. In this case, the undiluted solution in the through-flow channel 16h of the hollow fiber membrane 16 can be collected together with the cleaning solution into the undiluted solution bag UB.If the cleaning solution containing the recovered undiluted solution is supplied to the filter 10 again, the filtrate can be recovered. This can prevent the rate from decreasing.

In addition, as described above, when both or one of the liquid supply tube liquid feeding section 2p and the cleaning liquid recovery tube liquid feeding section 7p is operated, negative pressure is also generated in the through passage 16h of the hollow fiber membrane 16. do. Then, even if the inside of the wall 16w of the hollow fiber membrane 16 is clogged with solid content, this solid content can be sucked out, so that the clogging of the wall 16w of the hollow fiber membrane 16 can also be eliminated.

Note that if the main purpose is also to eliminate clogging of the wall 16w of the hollow fiber membrane 16, a cleaning liquid bag SB is connected to the connecting tube 9, and the cleaning liquid flows from the cleaning liquid bag SB toward the filter 10. The connecting tube liquid feeding section 9p may be operated in this manner. In this case, since the internal space 12h is essentially cleaned, the amount of cleaning liquid used increases, but it becomes easier to eliminate clogging of the wall 16w of the hollow fiber membrane 16. That is, in addition to the suction effect due to the negative pressure described above, the cleaning liquid is pushed in by the connecting tube liquid feeding section 9p, so that clogging of the wall 16w of the hollow fiber membrane 16 can be more easily eliminated.

Furthermore, by carrying out the cleaning operation as described above, it becomes easier to eliminate clogging of the header section 13 to which the stock solution is supplied.

In the header section 13 to which the stock solution is supplied, the solid content contained in the stock solution is directly supplied to the liquid supply tube 2. Therefore, if the solid content is large, the opening of the through channel 16h of the hollow fiber membrane 16 will be closed to the solid content. There is a possibility that it will be blocked. However, as described above, if negative pressure is generated in the cleaning liquid recovery tube 7 on the side of the filter 10 rather than the cleaning liquid recovery tube liquid feeding part 7p, this negative pressure will cause solids to be removed from the header part 13 of the cleaning liquid. Since it can be sucked out into the recovery tube 7, clogging of the header section 13 can be eliminated. In this case as well, the cleaning liquid bag SB may be connected to the connecting tube 9, and the connecting tube liquid feeding section 9p may be operated so that the cleaning liquid flows from the cleaning liquid bag SB toward the filter 10. Then, in addition to the suction effect due to the negative pressure described above, the cleaning liquid is pushed in by the connecting tube liquid feeding section 9p, so that clogging of the header section 13 can be cleared even more easily. In the case of the above configuration, the cleaning liquid recovery tube liquid feeding section 7p corresponds to the negative pressure generating section in the claims.

<Detailed description of concentrator 20>
In the stock solution processing apparatus 1 of this embodiment, it is desirable that each tube to the concentrator 20 be connected as follows. The configuration of the concentrator 20 and the connection of each tube to the concentrator 20 will be described below.

The concentrator 20 is supplied with the filtrate from the filter 10 and concentrates the filtrate. This concentrator 20 has substantially the same structure as the filter 10 described above, and has a function of separating water from a filtrate to form a concentrated liquid. In other words, the concentrator 20 has a structure in which a water separation member having a function of separating water from the filtrate is housed in place of the separation member of the filter 10. For example, as the concentrator 20, an ascites concentrator used in CART, a dialysis filter used in dialysis, a membrane-type plasma component fractionator used in double filtration plasma exchange therapy, etc. can be used. can.

To specifically describe the concentrator 20, the concentrator 20 includes a filtrate supply port 20a that communicates with the filtrate discharge port 11c of the filter 10 through the filtrate supply tube 3. That is, the filtrate, which is the liquid to be concentrated, is supplied to the concentrator 20 from the filtrate supply port 20a.

Further, the concentrator 20 includes a waste liquid discharge port 20c for discharging liquid separated from the filtrate (separated liquid), that is, water and the like. This waste liquid outlet 20c is communicated with the waste liquid bag DB via the waste liquid tube 5. The concentrator 20 also includes a concentrated liquid outlet 20b through which the concentrated liquid is discharged. This concentrate outlet 20b is communicated with the concentrate bag CB via the concentrate tube 4.

The concentrator 20 is equipped with a water separation member. This water separation member has the function of allowing water to pass through it but not allowing useful components such as useful proteins contained in plasma to pass therethrough.

Therefore, when the filtrate is supplied into the concentrator 20 from the filtrate supply port 20a, water is separated from the filtrate by the water separation member, and the separated water is discharged from the waste liquid discharge port 20c and passes through the waste liquid tube 5. Supplied to waste liquid bag DB. On the other hand, the concentrated liquid from which part of the water has been removed is discharged from the concentrated liquid outlet 20b, and the discharged concentrated liquid is supplied to the concentrated liquid bag CB through the concentrated liquid tube 4 (see FIG. 1). ).

<Circuit configuration of stock solution processing device 1 of this embodiment>
Next, the circuit configuration of the stock solution processing apparatus 1 of this embodiment will be explained based on FIG.

In addition, below, the case where the stock solution to be processed is pleural and ascitic fluid will be described as a representative case.

In addition, in the following description, each flow path (liquid supply flow path, filtrate supply flow path, concentrated liquid flow path, waste liquid flow path, cleaning liquid supply flow path, cleaning liquid recovery flow path, connection flow path) in the claims will be used. ) is formed of flexible and pliable tubes (liquid supply tube 2, filtrate supply tube 3, concentrate tube 4, waste liquid tube 5, cleaning liquid supply tube 6, cleaning liquid recovery tube 7, connection tube 9). Explain when there is. However, each channel may be formed of a tube that does not have flexibility or pliability (for example, a hard plastic tube, a steel tube, a PVC tube, etc.), an integrated circuit molded with resin, or the like.

Furthermore, since the stock solution processing apparatus 1 of this embodiment has a pair of roller pumps 110 and 120, in the following description, each flow path is formed with a tube having flexibility or flexibility, and each flow path is The following explanation assumes that a roller pump is used as the liquid feeding section. However, in the stock solution processing apparatus 1 of the present embodiment, the liquid feeding section is not necessarily limited to a roller pump, and any device capable of feeding the liquid in each channel can be adopted. The liquid feeding section may be appropriately selected depending on the material of the pipes constituting each flow path and the liquid flowing in the flow path. For example, an infusion pump, a diaphragm pump, or the like may be used as the liquid feeding section. In addition, roller pumps perform a clamp function (a function that blocks the flow path to prevent liquid from flowing) when they stop operating, so in the following explanation, the clamp function is not applied to the flow path where the liquid feeding section is installed. No equipment is provided. However, when using a device that does not perform the clamping function even when the operation is stopped or a device that does not have the clamping function as the liquid feeding section, a separate device with a clamping function must be installed in the flow path where the liquid feeding section is installed. (For example, a clamp or a clip) may be provided to allow a device having a clamping function to perform the clamping function when the operation of the liquid feeding section is stopped.
Furthermore, since the operation of each liquid feeding section is controlled by the control section described above, the following description will be made on the premise that each liquid feeding section is controlled by the control section.

<Schematic configuration of stock solution processing device 1 of this embodiment>
First, the schematic configuration of the stock solution processing apparatus 1 of this embodiment will be explained.

In FIG. 1, the symbol UB indicates an undiluted solution bag that stores undiluted solution, that is, thoracic and ascitic fluid extracted from the chest or abdomen. Moreover, the code|symbol CB has shown the concentrate bag which accommodates the concentrate obtained by filtering and concentrating the stock solution. Further, the reference numeral DB indicates a waste liquid bag that stores waste liquid (that is, water) separated from the concentrated liquid. Further, the reference numeral SB indicates a washing liquid bag containing a washing liquid such as physiological saline or an infusion (extracellular fluid), and the reference numeral FB indicates a washing liquid collection bag for collecting the washing liquid.

As shown in FIG. 1, in the stock solution processing apparatus 1 of this embodiment, the stock solution bag UB is connected to a filter 10 via a liquid supply tube 2. The liquid supply tube 2 is a tube that supplies the stock solution in the stock solution bag UB to the filter 10. The liquid supply tube 2 is provided with a liquid supply tube liquid feeding section 2p that feeds the liquid within the liquid supply tube 2.

The filter 10 filters the stock solution to produce a filtrate. This filter 10 is connected to a concentrator 20 via a filtrate supply tube 3. The filtrate supply tube 3 is a tube that supplies the filtrate produced by the filter 10 to the concentrator 20. The filtrate supply tube 3 is provided with a flow rate adjusting means 3c, such as a clamp or a clip, for stopping and opening the flow of liquid within the filtrate supply tube 3.

One end of a connecting tube 9 is connected to the filtrate supply tube 3 at a portion between the filter 10 and the flow rate adjusting means 3c. This connecting tube 9 is provided with a connecting tube liquid feeding section 9p that feeds the liquid inside the connecting tube 9.

Further, a cleaning liquid bag SB is connected to the filter 10 via a cleaning liquid supply tube 6. The cleaning liquid supply tube 6 is a tube that supplies the cleaning liquid from the cleaning liquid bag SB to the filter 10. The cleaning liquid supply tube 6 is provided with a flow rate adjusting means 6c, such as a clamp or a clip, for stopping and opening the flow of liquid within the cleaning liquid supply tube 6.

Further, a cleaning liquid collection bag FB is connected to the filter 10 through a cleaning liquid collection tube 7 to recover the cleaning liquid that has been used to clean the filter 10 . The cleaning liquid recovery tube 7 is provided with a cleaning liquid recovery tube liquid feeding section 7p that feeds the liquid in the cleaning liquid recovery tube 7.

Note that the cleaning liquid recovery tube 7 may be connected to the filter 10 via the liquid supply tube 2 or directly to the filter 10.

The concentrator 20 is for producing a concentrated liquid by concentrating the filtrate. This concentrator 20 is connected to a concentrate bag CB via a concentrate tube 4. The concentrate tube 4 is a tube that supplies the concentrate concentrated in the concentrator 20 to the concentrate bag CB. This concentrated liquid tube 4 is provided with a concentrated liquid tube liquid feeding section 4p that feeds the liquid in the concentrated liquid tube 4. Note that instead of the concentrated liquid tube feeding part 4p, a waste liquid tube feeding part 5p may be provided in the waste liquid tube 5 (see FIG. 4). Even in this case, under the condition that the concentrate tube liquid sending section 4p increases the amount of concentrated liquid sent, the waste liquid tube feeding section 5p decreases the amount of waste liquid sent, and the concentrated liquid tube feeding section 4p increases the amount of concentrated liquid sent. If the waste liquid tube liquid sending part 5p increases the liquid sending amount of waste liquid under the condition that the amount of liquid sent is decreased, it can function in the same way as when the concentrated liquid tube 4 is provided with the concentrated liquid tube liquid sending part 4p. . Below, the case where the concentrate tube 4 is provided with the concentrate tube liquid feeding part 4p will be explained.

Further, a waste liquid bag DB is connected to the concentrator 20 via a waste liquid tube 5. The waste liquid tube 5 is a tube that supplies waste liquid (water) separated from the concentrated liquid by the concentrator 20 to the waste liquid bag DB.

With the above configuration, in the stock solution processing apparatus 1 of this embodiment, if the stock solution is supplied from the stock solution bag UB to the filter 10 via the liquid supply tube 2, the stock solution is filtered by the filter 10 and the filtrate is can be generated. Then, if the generated filtrate is supplied to the concentrator 20 via the filtrate supply tube 3, a concentrate can be generated by the concentrator 20, and this concentrate is passed through the concentrate tube 4 to the concentrator 20. It can be collected in bag CB.

On the other hand, if the cleaning liquid is supplied to the filter 10 from the cleaning liquid bag SB connected to the cleaning liquid supply tube 6, the filter 10 can be cleaned with the cleaning liquid. Furthermore, if a cleaning liquid bag SB is connected to the concentrated liquid tube 4 instead of the concentrated liquid bag CB, the concentrator 20 can be cleaned with the cleaning liquid (see FIG. 2).

Hereinafter, operations performed by the stock solution processing apparatus 1 of this embodiment will be explained.

<Preparation cleaning work>
As shown in FIG. 2, in the preparatory cleaning work of the stock solution processing device 1 of this embodiment, a cleaning solution bag SB is connected to the other end of the concentrate tube 4 instead of the concentrate bag CB, and the other end of the waste solution tube 5 is Connect a cleaning liquid collection bag FB instead of the waste liquid bag DB. Note that the other end of the waste liquid tube 5 may be connected to the waste liquid bag DB, or the other end of the waste liquid tube 5 may be placed in a simple bucket or the like.
Furthermore, a cleaning liquid collection bag FB is connected to the other end of the liquid supply tube 2 instead of the stock solution bag UB. Note that a waste liquid bag DB may be connected to the other end of the liquid supply tube 2, or the other end of the liquid supply tube 2 may be placed in a simple bucket or the like.
Then, the cleaning liquid collection bag FB is also connected to the other end of the connecting tube 9. Note that a waste liquid bag DB may be connected to the other end of the connecting tube 9, or the other end of the connecting tube 9 may be placed in a simple bucket or the like.

Then, the flow rate adjustment means 3c and the flow rate adjustment means 6c are opened to allow the cleaning liquid to flow through the filtrate supply tube 3 and the cleaning liquid supply tube 6.

In the above state, the concentrate tube liquid feeding section 4p is operated to flow the cleaning liquid from the cleaning liquid bag SB connected to the concentrate tube 4 to the concentrator 20, and from the concentrator 20 (that is, the filtrate supply tube 3) to the connecting tube The connecting tube liquid feeding section 9p is operated so that the cleaning liquid flows into the cleaning liquid collection bag FB connected to the cleaning liquid collection bag FB. Then, the cleaning liquid is supplied from the cleaning liquid bag SB connected to the concentrated liquid tube 4 to the concentrator 20 through the concentrated liquid tube 4. The supplied cleaning liquid passes through the concentrator 20 , passes through the filtrate supply tube 3 and the connecting tube 9 , and is collected into the cleaning liquid recovery bag FB connected to the connecting tube 9 . Note that a part of the cleaning liquid passes through the waste liquid tube 5 and is collected into the cleaning liquid collection bag FB connected to the other end of the waste liquid tube 5.

Further, the connecting tube liquid feeding section 9p is operated to flow the cleaning liquid from the concentrator 20 to the cleaning liquid collection bag FB connected to the connecting tube 9, and the cleaning liquid collection bag FB connected from the filter 10 to the liquid supply tube 2 is operated. The liquid supply tube liquid feeding section 2p is operated so that the cleaning liquid flows through the liquid supply tube. Then, the cleaning liquid is supplied from the cleaning liquid bag SB connected to the cleaning liquid supply tube 6 to the filter 10 through the cleaning liquid supply tube 6. After the supplied cleaning liquid passes through the filter 10, part of the supplied cleaning liquid passes through the filtrate supply tube 3 and the connecting tube 9 and is collected into the cleaning liquid recovery bag FB connected to the connecting tube 9, and a part of the supplied cleaning liquid passes through the filter 10. The liquid passes through the tube 2 and is collected into the cleaning liquid collection bag FB connected to the liquid supply tube 2. Further, by also operating the cleaning liquid recovery tube liquid feeding section 7p, a part of the cleaning liquid supplied to the filter 10 can also flow into the cleaning liquid recovery tube 7.

Then, since the cleaning liquid can be flowed through the filter 10, the concentrator 20, and all the tubes, the entire stock solution processing apparatus 1 of this embodiment can be cleaned.

In addition, in FIG. 2, the filter is operated by operating the liquid supply tube liquid sending part 2p and the cleaning liquid recovery tube liquid sending part 7p to suck out the cleaning liquid from the filter 10 and generate a flow of the cleaning liquid in the filter 10. Cleaning the inside of 10. However, the inside of the filter 10 may be cleaned by forcing the cleaning liquid into the filter 10 to generate a flow of the cleaning liquid within the filter 10.

For example, in FIG. 2, a cleaning liquid supply tube feeding section 6p is provided in the cleaning liquid supply tube 6 instead of the flow rate adjusting means 6c, and a flow rate adjusting means 7c is provided in the cleaning liquid recovery tube 7 in place of the cleaning liquid recovery tube feeding section 7p. Then, the cleaning liquid recovery tube 7 is opened by the flow rate adjusting means 7c, and the cleaning liquid supply tube liquid sending part 6p is operated so that the cleaning liquid flows in the cleaning liquid supply tube 6 from the cleaning liquid bag SB toward the filter 10. Then, since the cleaning liquid can be forced into the filter 10 and a flow of the cleaning liquid can be generated inside the filter 10, the inside of the filter 10 can also be cleaned with the cleaning liquid. In this case, the cleaning liquid may be caused to flow into the liquid supply tube 2 by operating the liquid supply tube liquid feeding section 2p of the liquid supply tube 2 so as to suck out the cleaning liquid from the filter 10. Alternatively, the cleaning liquid may be made to flow only into the cleaning liquid recovery tube 7 without operating the liquid supply tube liquid feeding section 2p.

(filtration concentration work)
After the preparatory cleaning work is completed, filtration and concentration work is carried out.

As shown in FIG. 1, in the filtration and concentration work of the stock solution processing apparatus 1 of this embodiment, from the preparatory cleaning work state (see FIG. 2), the concentrate bag CB is connected to the concentrate tube 4 instead of the washing liquid bag SB. A waste liquid bag DB is connected to the waste liquid tube 5 instead of the cleaning liquid collection bag FB.
On the other hand, an undiluted solution bag UB is connected to the solution supply tube 2 instead of the cleaning solution collection bag FB.
Further, while the flow rate adjustment means 3c maintains a state in which the liquid can flow in the filtrate supply tube 3, the flow rate adjustment means 6c closes the inside of the cleaning liquid supply tube 6 so that the liquid does not flow therein. In addition, the cleaning liquid recovery tube liquid feeding section 7p and the connecting tube liquid feeding section 9p are not operated and are made to function as a clamp.

In the above state, the liquid supply tube liquid feeding part 2p is operated so as to flow the liquid from the liquid bag UB connected to the liquid supply tube 2 to the filter 10, and the liquid supply tube 2p is operated to flow the liquid liquid from the liquid supply tube 2 to the concentrate tube 4. The concentrate tube liquid feeding section 4p is operated to flow the concentrate into the concentrate bag CB.

Then, the stock solution is supplied from the stock solution bag UB to the filter 10 through the liquid supply tube 2. The supplied stock solution is filtered by the filter 10, and the generated filtrate is supplied to the concentrator 20 through the filtrate supply tube 3. The filtrate supplied to the concentrator 20 is concentrated by the concentrator 20, and the generated concentrate is collected into the concentrate bag CB through the concentrate tube 4. On the other hand, the water separated from the concentrated liquid is collected through the waste liquid tube 5 into the waste liquid bag DB.

<About filtration concentration operation>
Here, in the filtration and concentration work, the operations of the liquid supply tube liquid feeding section 2p and the concentrated liquid tube liquid feeding section 4p are controlled so that the concentration ratio is within a predetermined range. However, as described below, the liquid supply tube liquid feeding section 2p and the concentrated liquid tube liquid feeding section 4p are operated by using the filter transmembrane pressure differential and the concentrator transmembrane differential pressure. The flow rate of the liquid in the portion 2p and the concentrated liquid tube feeding portion 4p may be controlled. Then, since the capacity of the filter 10 and the concentrator 20 can be effectively utilized to perform filtration and concentration, the time required to generate a concentrated liquid can be shortened and the efficiency of the concentration work can be increased.
In the following, a process of filtering and concentrating by controlling the operations of the liquid supply tube liquid feeding section 2p and the concentrated liquid tube liquid feeding section 4p using the filter transmembrane pressure differential and the concentrator transmembrane pressure differential will be described.

Note that the differential pressure between the membranes of the filter means the differential pressure between the liquid supply side and the drain side of the filtration member (hollow fiber membrane, etc.) of the filter 10.
Moreover, the concentrator membrane differential pressure means the differential pressure between the liquid supply side and the drain side of the water separation member (hollow fiber membrane, etc.) of the concentrator 20.

Note that the filter transmembrane pressure difference and the concentrator transmembrane pressure difference can be calculated by measuring the internal pressure of tubes connected to the filter 10 and the concentrator 20. For example, if pressure gauges are provided in the liquid supply tube 2 and the filtrate supply tube 3 and their signals are supplied to the control unit 106, the control unit 106 can calculate the filter transmembrane pressure. . Further, if pressure gauges are provided in the filtrate supply tube 3 and waste liquid tube 5 and their signals are supplied to the control unit 106, the control unit 106 can calculate the concentrator transmembrane pressure.

In addition, in the filter 10 or the concentrator 20, if either the liquid supply side or the drain side is in a state close to being open to the atmosphere, the liquid supply side or the drain side is in communication with the side that is not open to the atmosphere. The control unit 106 can calculate the filter transmembrane differential pressure and the concentrator transmembrane differential pressure by simply measuring the tube internal pressure. In other words, instead of using the filter transmembrane pressure differential or the concentrator transmembrane differential pressure, the control unit 106 operates the liquid feeding unit using only the internal pressure of the tube that is communicated with the side that is not open to the atmosphere. It can also be controlled. For example, if the tube connected to the filter 10 or concentrator 20 is connected to the bag and is not blocked by the liquid feeding section or flow rate adjustment means, the tube is considered to be in a state close to being open to the atmosphere. be able to. In the state shown in FIG. 1, of the tubes 2 and 3 connected to the filter 10, the liquid supply tube 2 connected to the stock solution bag UB can be considered to be open to the atmosphere. Further, among the tubes 3 and 5 connected to the concentrator 20, the drain tube 5 connected to the waste liquid bag DB can also be considered to be open to the atmosphere. Then, in the state shown in FIG. 1, the control section 106 can also control the operation of the liquid feeding section using only the tube internal pressure of the filter supply tube 3.

Further, the flow rate of the liquid flowing through the liquid supply tube 2 and the filtrate supply tube 3 may be estimated from the operation of the liquid supply tube liquid feeding section 2p and the concentrated liquid tube liquid feeding section 4p, or A flow meter may be provided in the section 2p and the concentrated liquid tube feeding section 4p to directly measure the flow rate.

<Explanation of filtration and concentration work using filter transmembrane pressure differential and concentrator transmembrane pressure differential pressure>
When performing filtration and concentration using the filter transmembrane pressure differential or the concentrator transmembrane differential pressure, an allowable differential pressure is set in advance. That is, depending on the filter 10 and the concentrator 20, the differential pressure (allowable differential pressure) that the filter 10 and the concentrator 20 can tolerate is set respectively. This allowable differential pressure may have a predetermined width or may be set to a specific value.

Note that when performing filtration and concentration using the filter transmembrane pressure differential or the concentrator transmembrane pressure differential, it is desirable to set an allowable flow rate in advance. In other words, it is desirable to set an allowable flow rate (allowable flow rate) of the stock solution in the liquid supply tube 2. This allowable flow rate may have a predetermined width or may be set to a specific value. Such an allowable flow rate does not necessarily have to be set. However, if the flow rate of the stock solution in the liquid supply tube 2 becomes too low, the time required for filtration and concentration becomes too long. Therefore, in order to prevent the processing time of the stock solution from increasing, it is desirable to set an allowable flow rate.
Further, when performing filtration and concentration using the filter transmembrane pressure differential or the concentrator transmembrane pressure differential, it is desirable to set an allowable concentration magnification in advance. That is, it is desirable to set the ratio of the flow rate of the concentrate flowing through the concentrate tube 4 to the flow rate of the stock solution in the liquid supply tube 2 (allowable concentration magnification). This allowable concentration factor may have a predetermined range or may be set to a specific value. Such an allowable concentration factor does not necessarily need to be set. However, if the concentration ratio, which is the ratio of the flow rate of the concentrate flowing through the concentrate tube 4 to the flow rate of the stock solution in the liquid supply tube 2, decreases too much, the reconcentration process will take time. Therefore, in order to prevent the concentration ratio from decreasing too much, it is desirable to set an allowable concentration ratio.

At the start of filtration and concentration, the liquid supply tube liquid feeding section 2p is operated to increase the amount of the raw solution fed to the filter 10. At this time, the concentrate tube liquid feeding section 4p is operated in accordance with the flow rate of the stock solution in the liquid supply tube 2 so that the concentrate reaches a predetermined concentration ratio. For example, when producing a concentrate with a concentration ratio of 10 times, the concentrate tube liquid feeding section 4p is configured such that the flow rate of the concentrate flowing through the concentrate tube 4 is 1/1/of the flow rate of the stock solution flowing inside the liquid supply tube 2. Its operation is adjusted so that it becomes 10. Further, the operation of the concentrate tube liquid feeding section 4p may be adjusted so that the concentrator transmembrane differential pressure becomes a set value. Incidentally, while the amount of the raw solution to be fed to the filter 10 is being increased, the operation of the concentrate tube liquid feeding section 4p is controlled so as to be in any of the above states.

As filtration and concentration proceed, the filter 10 and concentrator 20 gradually become clogged. Then, the filter transmembrane pressure difference and the concentrator transmembrane pressure difference increase. However, until the filter transmembrane pressure difference and the concentrator transmembrane pressure difference reach the allowable pressure difference, the liquid supply tube liquid feeding section 2p operates to increase the amount of the raw solution fed to the filter 10.

As will be described later, when the filter transmembrane pressure difference is within the range of the set pressure difference of the filter 10, the amount of filtrate sent to the concentrator 20, in other words, the amount of filtrate sent to the filter 10. The liquid supply tube liquid feeding section 2p is operated so that the amount of the stock solution to be fed is maintained. On the other hand, when the pressure difference between the membranes of the filter becomes larger than the set pressure difference of the filter 10, the liquid supply tube liquid sending part 2p is operated so that the amount of the raw solution sent to the filter 10 is reduced. Further, when the pressure difference between the membranes of the filter becomes smaller than the set pressure difference of the filter 10, the liquid supply tube liquid sending section 2p is operated so that the amount of the raw solution sent to the filter 10 is increased.

<First method>
The increase in the amount of the raw solution sent to the filter 10 is continued until the filter transmembrane pressure difference reaches the allowable pressure difference of the filter 10. When the pressure difference between the membranes of the filter reaches the allowable pressure difference of the filter 10, the flow rate of the stock solution in the liquid supply tube 2 is changed to the flow rate when the pressure difference between the filter membranes becomes the allowable pressure difference of the filter 10. The liquid supply tube liquid feeding section 2p is controlled so as to maintain the temperature. On the other hand, the concentrate tube liquid feeding section 4p is operated, and the flow rate of the concentrate flowing through the concentrate tube 4 is adjusted.

<Step 1>
First, when the concentrator transmembrane pressure difference is smaller than the set differential pressure of the concentrator 20, the concentrate tube liquid feeding section 4p operates to reduce the amount of concentrated liquid sent to the concentrate bag CB. be done. In other words, the operation of the concentrate tube liquid feeding section 4p is controlled so as to increase the concentration of the concentrate.

<Step 2>
Then, the amount of concentrated liquid sent to the concentrated liquid bag CB is reduced until the concentrator transmembrane pressure difference reaches the set differential pressure of the concentrator 20. When the concentrator transmembrane pressure difference reaches the set differential pressure of the concentrator 20, the flow rate of the concentrate in the concentrate tube 4 is maintained at the flow rate where the concentrator transmembrane pressure difference becomes the set differential pressure of the concentrator 20. The concentrated liquid tube liquid feeding section 4p is controlled so as to.

<Step 3>
Eventually, when the concentrator transmembrane pressure becomes larger than the set differential pressure of the concentrator 20 due to clogging of the concentrator 20, etc., the concentrate tube is transferred so that the amount of concentrate sent to the concentrate bag CB increases. The liquid part 4p is controlled. In addition, as the amount of concentrated liquid sent increases, the concentration ratio decreases, but the concentration ratio of the concentrated liquid tube feeding part 4p is adjusted so that the concentration ratio decreases while satisfying the allowable concentration ratio (so that the concentration of the concentrated liquid becomes low). Actuation is controlled.
In addition, if the concentration ratio becomes smaller than the allowable concentration ratio when increasing the amount of concentrated liquid fed in order to maintain the concentrator transmembrane pressure difference at the set pressure difference, use the following method (Second method). method).

As the amount of concentrate sent to the concentrate bag CB increases, the concentrator transmembrane differential pressure decreases, so when the concentrator transmembrane differential pressure becomes lower than the set differential pressure of the concentrator 20, the concentrate tube is again transferred. The liquid part 4p is operated so that the amount of concentrated liquid sent to the concentrated liquid bag CB is reduced.

That is, as long as the filter transmembrane pressure difference is within the allowable pressure difference of the filter 10, steps 1 to 3 are repeated. If this method is adopted, the filter 10 and concentration Depending on the membrane area of the filtration membrane of the container 20 and the state of clogging, and the state of the stock solution (concentration of substances that cause clogging of the filter or concentrator, concentration of useful substances to be recovered, viscosity of the liquid, etc.) , it becomes possible to ensure the maximum filtration flow rate and the maximum concentration ratio. In other words, by improving the filtration efficiency and concentration efficiency, it is possible to shorten the time it takes to generate a concentrated liquid from the stock solution, thereby making it possible to prevent reconcentration work and shorten the time required for reconcentration work.
Moreover, if the operation is performed as described above, the cleaning liquid filled in the filter 10, concentrator 20, and the circuit at the start of filtration and concentration, and the cleaning liquid in the filter 10 and the circuit immediately after cleaning the filter 10, can be transferred to the concentrator. It becomes possible to remove the liquid as waste liquid in a short time. In other words, it is possible to efficiently prevent dilution of the concentrated liquid by the cleaning liquid at the start and immediately after cleaning the filter as described above.

Note that the above method (first method) is preferably employed when the filter transmembrane pressure difference is larger than the concentrator transmembrane pressure difference, but the method is not limited to this condition. This method can also be adopted when the filter transmembrane pressure difference is smaller than the concentrator transmembrane pressure difference.
In addition, if the differential pressure between the filter membranes is larger than the allowable differential pressure, or if the differential pressure between the filter membranes is smaller than the allowable differential pressure, the amount of raw solution sent to the filter 10 may be lower than the allowable differential pressure. Even when the differential pressure is constant regardless of the differential pressure, the amount of concentrated liquid sent to the concentrator 20 may be adjusted by repeating steps 1 to 3 above.

<Second method>
In the first method, the flow rate of the concentrate in the concentrate tube 4 was adjusted based on the concentrator transmembrane pressure difference. It is also possible to adjust the flow rate.

<Step 1>
First, when the concentrator transmembrane pressure difference is smaller than the set differential pressure of the concentrator 20, the liquid supply tube liquid sending part 2p is operated so that the amount of the raw solution sent to the filter 10 is increased. . In other words, the operation of the liquid supply tube liquid sending section 2p is controlled so that the amount of filtrate produced to be sent to the concentrator 20 is increased.

<Step 2>
Then, the amount of filtrate produced to be sent to the concentrator 20 (in other words, the amount of raw solution sent to the filter 10) is increased until the concentrator transmembrane pressure difference reaches the set differential pressure of the concentrator 20. When the concentrator transmembrane pressure difference reaches the set pressure difference of the concentrator 20, the flow rate of the stock solution in the liquid supply tube 2 is changed to the flow rate when the concentrator transmembrane pressure difference becomes the set pressure difference of the concentrator 20. The operation of the liquid supply tube liquid feeding section 2p is controlled so as to maintain the liquid supply tube liquid feeding section 2p.

<Step 3>
Eventually, when the concentrator transmembrane pressure becomes larger than the set differential pressure of the concentrator 20 due to clogging of the concentrator 20, etc., the liquid supply tube liquid feeding section 2p is adjusted so that the flow rate of the stock solution in the liquid supply tube 2 decreases. operation is controlled. In other words, the operation of the liquid supply tube liquid sending section 2p is controlled so that the amount of filtrate produced to be sent to the concentrator 20 is reduced.

When the flow rate of the stock solution in the liquid supply tube 2 decreases, the concentrator transmembrane pressure difference decreases, so when the concentrator transmembrane pressure difference becomes lower than the set differential pressure of the concentrator 20, the liquid supply tube liquid feeding section 2p is operated so that the flow rate of the stock solution in the liquid supply tube 2 increases.

That is, as long as the filter transmembrane pressure difference is within the allowable pressure difference of the filter 10, steps 1 to 3 are repeated. If this method is adopted, the filter 10 and concentration Depending on the membrane area of the filtration membrane of the container 20 and the state of clogging, and the state of the stock solution (concentration of substances that cause clogging of the filter or concentrator, concentration of useful substances to be recovered, viscosity of the liquid, etc.) , it becomes possible to ensure the maximum filtration flow rate and the maximum concentration ratio. In other words, by improving the filtration efficiency and concentration efficiency, it is possible to shorten the time required to generate a concentrated liquid from the stock solution, thereby preventing reconcentration work and shortening the time required for reconcentration work.
Moreover, if the operation is performed as described above, the cleaning liquid filled in the filter 10, concentrator 20, and the circuit at the start of filtration and concentration, and the cleaning liquid in the filter 10 and the circuit immediately after cleaning the filter 10, can be transferred to the concentrator. It becomes possible to remove the liquid as waste liquid in a short time. In other words, it is possible to efficiently prevent dilution of the concentrated liquid by the cleaning liquid at the start and immediately after cleaning the filter as described above.

Note that the above method (second method) is preferably employed when the concentrator transmembrane pressure difference is larger than the filter transmembrane pressure difference, but the method is not limited to this condition. It can also be adopted when the concentrator transmembrane pressure difference is smaller than the filter transmembrane pressure difference.
In addition, if the differential pressure between the filter membranes is larger than the allowable differential pressure, or if the differential pressure between the filter membranes is smaller than the allowable differential pressure, the amount of raw solution sent to the filter 10 may be lower than the allowable differential pressure. Even when the differential pressure is constant regardless of the differential pressure, the amount of concentrated liquid sent to the concentrator 20 may be adjusted by repeating steps 1 to 3 above.

<About filter cleaning>
When the above-described filtration and concentration work is performed, the filter transmembrane pressure difference becomes larger than the allowable pressure difference of the filter 10 due to clogging of the filter 10 or the like. In this case, if the flow rate of the stock solution in the liquid supply tube 2 is reduced by controlling the operation of the liquid supply tube liquid sending section 2p, the filter membrane transmembrane pressure difference can be made smaller than the allowable pressure difference of the filter 10. However, when the filter 10 becomes severely clogged, the flow rate of the stock solution in the liquid supply tube 2 decreases in order to maintain the filter transmembrane pressure differential to the allowable differential pressure of the filter 10. The flow rate of the stock solution becomes smaller than the allowable flow rate. In such a state, the cleaning work of the filter 10 is performed during the filtration and concentration work of the stock solution processing apparatus 1 of this embodiment.

In the cleaning operation of the filter 10, the flow rate adjusting means 3c closes the inside of the filtrate supply tube 3 to prevent liquid from flowing therein. In addition, the operation of the liquid supply tube liquid feeding section 2p is stopped to function as a clamp. On the other hand, the flow rate adjustment means 6c allows the liquid to flow into the cleaning liquid supply tube 6.

In the above state, if the cleaning liquid recovery tube liquid feeding section 7p is operated to flow the liquid from the filter 10 to the cleaning liquid recovery bag FB connected to the cleaning liquid recovery tube 7, the flow path through which the undiluted solution in the filter 10 flows, Since the cleaning liquid can be flowed in the direction opposite to the direction in which the stock solution flows during filtration and concentration, the inside of the channel in the filter 10 through which the stock solution flows can be cleaned.

In addition to the above state, if the connecting tube liquid feeding section 9p is operated so that the cleaning liquid flows from the cleaning liquid bag SB connected to the connecting tube 9 to the filter 10, the cleaning liquid bag SB connected to the connecting tube 9 Washing liquid is also supplied to the filter 10 from the filter 10 . Then, this cleaning liquid passes through the filter member in the opposite direction to the direction in which the filtrate passes through the filter member, so that clogging of the filter member can be eliminated. In this case, since the cleaning liquid is supplied to the filter 10 from both the cleaning liquid bag SB connected to the cleaning liquid supply tube 6 and the cleaning liquid bag SB connected to the connecting tube 9, the cleaning liquid collection tube The operations of the cleaning liquid recovery tube liquid feeding section 7p and the connecting tube liquid feeding section 9p are adjusted so that the flow rate of the cleaning liquid flowing through the connecting tube liquid feeding section 7 is larger than the flow rate of the cleaning liquid flowing through the connecting tube 9 by the connecting tube liquid feeding section 9p. .

Note that the cleaning liquid recovery tube liquid feeding section 7p and the connecting tube liquid feeding section 9p may be operated with the flow rate adjusting means 6c closed. In this case, the cleaning liquid is supplied to the filtrate 10 only from the cleaning liquid bag SB connected to the connecting tube liquid feeding section 9p. Also in this case, since the cleaning liquid passes through the filter member in the opposite direction to the direction in which the filtrate passes through the filter member, clogging of the filter member can be eliminated.

<Filtrate recovery>
On the other hand, when the filter is cleaned using the above method, the filtrate remaining in the internal space 12h of the main body 11 of the filter 10 is mixed with the cleaning liquid and discharged. This will reduce the amount of active ingredient recovered by filtration and concentration.

Therefore, when cleaning the filter, it is preferable to send the filtrate existing in the internal space 12h of the main body 11 of the filter 10 to the concentrator 20 in advance, and then wash the filter.

As shown in FIG. 1, a cleaning liquid bag SB is connected to the port 11c of the main body 11 of the filter 10 via a tube. Then, the flow rate adjustment means 3c maintains the state in which the liquid flows in the filtrate supply tube 3, and stops the operation of the liquid supply tube liquid feeding section 2p while continuing the operation of the concentrated liquid tube liquid feeding section 4p. , to function as a clamp. In this state, if the cleaning liquid is supplied from the cleaning liquid bag SB to the filter 10 using the pump provided in the tube, the filtrate in the internal space 12h of the main body 11 of the filter 10 will be supplied to the concentrator 20 and replaced. The cleaning liquid is supplied from the cleaning liquid bag SB to the internal space 12h. Eventually, when all of the filtrate in the internal space 12h is replaced with the cleaning liquid, the flow rate adjusting means 3c closes the filtrate supply tube 3 and stops the operation of the concentrated liquid tube feeding section 4p. After this state is reached, if the filter 10 is washed in the manner described above, re-concentration of the filtrate discharged together with the washing liquid can be suppressed.

Note that the tube connected to the port 11c of the main body 11 of the filter 10 does not necessarily need to be provided with a pump. Even in this case, the filtrate in the internal space 12h of the main body 11 of the filter 10 can be replaced with the cleaning liquid by operating the concentrate tube liquid feeding section 4.

In addition, in the above description, the cleaning liquid bag SB is connected to the port 11c of the main body 11 of the filter 10 via the tube, but air is connected to the port 11c of the main body 11 of the filter 10 via the tube. May be supplied. Even in this case, the filtrate in the internal space 12h of the main body 11 of the filter 10 can be supplied to the concentrator 20 by air pressure. In this case, the interior space 12h of the main body 11 of the filter 10 is filled with air, so before cleaning, the interior space 12h is filled with a cleaning liquid. For example, if the cleaning liquid bag SB is connected to the port 11c of the main body 11 of the filter 10 and the cleaning liquid is supplied, the interior space 12h can be filled with the cleaning liquid.

Furthermore, in the above description, the stock solution is supplied into the through passage 16h of the plurality of hollow fiber membranes 16 of the hollow fiber membrane bundle 15 of the filter 10, and the filtrate is supplied to the body 12 of the main body 11 of the filter 10. The case where the liquid is discharged into the internal space 12h is explained. However, the stock solution is supplied from the filtrate discharge port 11c into the internal space 12h of the body 12 of the main body 11, and the filtered filtrate is passed through the flow path 16h of the plurality of hollow fiber membranes 16 of the hollow fiber membrane bundle 15. The liquid may be discharged into the interior and discharged to the outside from the stock solution supply port 11a. In this case, the filtrate supply tube 3 is connected to the stock solution supply port 11a, and the liquid supply tube 2 is connected to the filtrate discharge port 11c. When cleaning the filter in such a configuration, the filtrate present in the internal space 12h of the body 12 of the main body 11 of the filter 10 is sent to the concentrator 20 in advance in the same manner as described above. It is preferable to wash the filter and then wash the filter.

<Reconcentration work>
When further concentrating the concentrate obtained by the filtration and concentration operation, a reconcentration operation is performed.

As shown in FIG. 3, in the reconcentration work of the stock solution processing apparatus 1 of this embodiment, the other end of the connecting tube 9 is removed from the cleaning liquid bag SB, and the other end of the connecting tube 9 is connected to the concentrated liquid bag CB. Ru.
In addition, while maintaining the state in which the liquid can flow in the filtrate supply tube 3 by the flow rate adjustment means 3c, the liquid supply tube liquid feeding section 2p and the cleaning liquid recovery tube liquid feeding section 7p are not operated and are made to function as a clamp. . In addition, the inside of the cleaning liquid supply tube 6 is closed by the flow rate adjusting means 6c so that no liquid can flow therein. Then, the liquid will not flow into the filter 10.

In the above state, the connecting tube liquid sending part 9p is operated so that the concentrated liquid flows from the concentrate bag CB to the concentrator 20 through the connecting tube 9, and the concentrate is concentrated from the concentrator 20 to the concentrate bag CB through the concentrate tube 4. The concentrated liquid tube liquid feeding section 4p is operated so that the liquid flows.

Then, the concentrate is supplied from the concentrate bag CB connected to the connecting tube 9 to the concentrator 20 through the connecting tube 9, so that the reconcentrate further concentrated by the concentrator 20 passes through the concentrate tube 4 to the concentrate bag. Collected by CB. On the other hand, the water separated from the concentrated liquid is collected through the waste liquid tube 5 into the waste liquid bag DB. In other words, a concentrated liquid (reconcentrated liquid) with an increased concentration ratio can be obtained.

<Stock solution processing device 1B of second embodiment>
In the above-described undiluted solution processing apparatus 1 of the present embodiment, the undiluted solution is supplied to the filter 10 by being forced into it during filtration and concentration. It is also possible to have a configuration in which it is supplied.

That is, as shown in FIG. 7, the undiluted solution processing apparatus 1B of this embodiment is configured to supply the undiluted solution to the filter 10 by sucking out the undiluted solution from the filter 10. That is, the filtrate supply tube 3 is provided with a filtrate supply tube liquid sending section 3p instead of the flow rate adjustment means 3c, and the liquid supply tube 2 is provided with a flow rate adjustment means 2c instead of the liquid supply tube liquid sending section 2p. has been established.

In this stock solution processing apparatus 1B, the filtrate supply tube liquid sending section 3p is operated so that the liquid (filtrate) flows from the filter 10 to the concentrator 20 during filtration and concentration. When the filtrate supply tube liquid sending part 3p operates, negative pressure is created in the filtrate supply tube 3 upstream of the filtrate supply tube liquid sending part 3p, that is, on the filter 10 side, and the inside of the filter 10 (for example, the main body The internal space 12h) of the body 12 of the section 11 also becomes negative pressure. Then, if the liquid supply tube 2 is set in a state where the liquid can be fed by the flow rate adjustment means 2c, the liquid in the liquid bag UB is sucked into the filter 10 through the liquid feed tube 2, and the sucked liquid is transferred to the filtrate supply tube. Can be absorbed into 3.

Even with this stock solution processing apparatus 1B, if the bags connected to each tube are appropriately changed and the operation of the flow rate adjustment means and liquid feeding section provided in each tube is adjusted, preparatory cleaning work, filtration concentration work, and reconcentration work can be performed. It can be performed. In addition, in the stock solution processing apparatus 1B, a waste liquid tube liquid feeding part 5p may be provided in the waste liquid tube 5 instead of the concentrated liquid tube liquid feeding part 4p (see FIG. 9). Even in this case, under the condition that the concentrate tube liquid sending section 4p increases the amount of concentrated liquid sent, the waste liquid tube feeding section 5p decreases the amount of waste liquid sent, and the concentrated liquid tube feeding section 4p increases the amount of concentrated liquid sent. If the waste liquid tube liquid sending part 5p increases the liquid sending amount of waste liquid under the condition that the amount of liquid sent is decreased, it can function in the same way as when the concentrated liquid tube 4 is provided with the concentrated liquid tube liquid sending part 4p. . Below, the case where the concentrate tube 4 is provided with the concentrate tube liquid feeding part 4p will be explained.

<Preparation cleaning work>
As shown in FIG. 6, a washing liquid bag SB is connected to the other end of the concentrate tube 4 instead of the concentrate bag CB, and a washing liquid collection bag FB is connected to the other end of the waste liquid tube 5 instead of the waste liquid bag DB. do. Note that the other end of the waste liquid tube 5 may be connected to the waste liquid bag DB, or may be placed in a simple bucket or the like.
Furthermore, a cleaning liquid collection bag FB is connected to the other end of the liquid supply tube 2 instead of the stock solution bag UB. Note that a waste liquid bag DB may be connected to the other end of the liquid supply tube 2, or the other end of the liquid supply tube 2 may be placed in a simple bucket or the like.
Then, the cleaning liquid collection bag FB is also connected to the other end of the connecting tube 9. Note that a waste liquid bag DB may be connected to the other end of the connecting tube 9, or the other end of the connecting tube 9 may be placed in a simple bucket or the like.
Furthermore, a cleaning liquid collection bag FB is connected to the other end of the cleaning liquid supply tube 6 instead of the cleaning liquid bag SB, and a cleaning liquid bag SB is connected to the other end of the cleaning liquid collection tube 7 instead of the cleaning liquid collection bag FB. Note that a waste liquid bag DB may be connected to the other end of the cleaning liquid supply tube 6 and the other end of the cleaning liquid recovery tube 7, or the other end of the cleaning liquid supply tube 6 and the other end of the cleaning liquid recovery tube 7 may be connected to a simple bucket or the like. May be placed.

Next, the flow rate adjustment means 2c and the flow rate adjustment means 9c are opened to allow the cleaning liquid to flow through the liquid supply tube 2 and the connection tube 9.

In the above state, the concentrate tube liquid feeding section 4p is operated to flow the cleaning liquid from the cleaning liquid bag SB connected to the concentrate tube 4 to the concentrate 20, and the concentrator 20 (that is, the filtrate supply tube 3) is connected to the connecting tube. The filtrate supply tube liquid feeding section 3p is operated so that the cleaning liquid flows into the cleaning liquid collection bag FB connected to the filtrate supply tube 9. Then, the cleaning liquid is supplied from the cleaning liquid bag SB connected to the concentrated liquid tube 4 to the concentrator 20 through the concentrated liquid tube 4. The supplied cleaning liquid passes through the concentrator 20 , passes through the filtrate supply tube 3 and the connecting tube 9 , and is collected into the cleaning liquid recovery bag FB connected to the connecting tube 9 . Note that a part of the cleaning liquid passes through the waste liquid tube 5 and is collected into the cleaning liquid collection bag FB connected to the other end of the waste liquid tube 5.

Further, the cleaning liquid recovery tube liquid feeding section 7p is operated to flow the cleaning liquid from the cleaning liquid bag SB connected to the cleaning liquid recovery tube 7 to the filter 10. Then, a part of the cleaning liquid is supplied from the cleaning liquid bag SB connected to the cleaning liquid recovery tube 7 to the filter 10 through the cleaning liquid recovery tube 7. After passing through the filter 10, the cleaning liquid supplied to the filter 10 passes through the filtrate supply tube 3 and the connecting tube 9, and is collected in the cleaning liquid recovery bag FB connected to the connecting tube 9. Further, by also operating the cleaning liquid supply tube liquid sending section 6p, a part of the cleaning liquid supplied to the filter 10 can also flow into the cleaning liquid supply tube 6. Further, a part of the cleaning liquid passes through the liquid supply tube 2 from the cleaning liquid recovery tube 7 and is collected into the cleaning liquid recovery bag FB connected to the liquid supply tube 2.

Then, the cleaning liquid can be flowed through the filter 10, the concentrator 20, and all the tubes, so the entire stock solution processing apparatus 1B of this embodiment can be cleaned.

<Filtration and concentration work>
After the preparatory cleaning work is completed, filtration and concentration work is carried out.

As shown in FIG. 7, in the filtration and concentration work of the stock solution processing apparatus 1B of the present embodiment, from the preparatory cleaning work state (see FIG. 6), the concentrate bag CB is used in place of the washing liquid bag SB in addition to the concentrate tube 4. A waste liquid bag DB is connected to the other end of the waste liquid tube 5 instead of the cleaning liquid collection bag FB.
On the other hand, an undiluted solution bag UB is connected to the other end of the liquid supply tube 2 instead of the cleaning liquid collection bag FB.
Further, while the flow rate adjustment means 2c is opened to maintain a state in which the liquid can flow in the liquid supply tube 2, the flow rate adjustment means 9c closes the inside of the connecting tube 9 so that the liquid does not flow. In addition, the cleaning liquid recovery tube feeding section 7p and the cleaning liquid supply tube feeding section 6p are not operated and are made to function as a clamp.

In the above state, the filtrate supply tube liquid sending section 3p is operated to flow the filtrate from the filter 10 to the concentrator 20, and the concentrate tube is operated to flow the concentrate from the concentrator 20 to the concentrate bag CB. Activate the liquid feeding section 4p.

Then, the stock solution is supplied from the stock solution bag UB to the filter 10 through the liquid supply tube 2. The supplied stock solution is filtered by the filter 10, and the generated filtrate is supplied to the concentrator 20 through the filtrate supply tube 3. The filtrate supplied to the concentrator 20 is concentrated by the concentrator 20, and the generated concentrate is collected into the concentrate bag CB through the concentrate tube 4. On the other hand, the water separated from the concentrated liquid is collected through the waste liquid tube 5 into the waste liquid bag DB.

<About filtration concentration operation>
In the filtration and concentration work, the operations of the filtrate supply tube feeding section 3p and the concentrate tube feeding section 4p are controlled so that the concentration ratio falls within a predetermined range. However, as described below, the filtrate supply tube liquid sending part 3p and the concentrate tube liquid sending part 4p are operated by using the filter transmembrane pressure difference and the concentrator transmembrane pressure difference, that is, the filtrate supply tube 3 and concentrate tube 4 may be controlled. Then, since the capacity of the filter 10 and the concentrator 20 can be effectively utilized to perform filtration and concentration, the time required to generate a concentrated liquid can be shortened and the efficiency of the concentration work can be increased.
Below, we will explain the operation of controlling the operation of the filtrate supply tube liquid sending part 3p and the concentrate tube liquid sending part 4p to perform filtration and concentration using the filter transmembrane pressure difference and the concentrator transmembrane pressure difference. .

Note that the filter transmembrane pressure difference and the concentrator transmembrane pressure difference can be calculated by measuring the internal pressure of tubes connected to the filter 10 and the concentrator 20. For example, if pressure gauges are provided in the liquid supply tube 2 and the filtrate supply tube 3 and their signals are supplied to the control unit 106, the control unit 106 can calculate the filter transmembrane pressure. . Further, if pressure gauges are provided in the filtrate supply tube 3 and waste liquid tube 5 and their signals are supplied to the control unit 106, the control unit 106 can calculate the concentrator transmembrane pressure.

In addition, in the filter 10 or the concentrator 20, if either the liquid supply side or the drain side is in a state close to being open to the atmosphere, the liquid supply side or the drain side is in communication with the side that is not open to the atmosphere. The control unit 106 can calculate the filter transmembrane differential pressure and the concentrator transmembrane differential pressure by simply measuring the tube internal pressure. In other words, instead of using the filter transmembrane pressure differential or the concentrator transmembrane differential pressure, the control unit 106 operates the liquid feeding unit using only the internal pressure of the tube that is communicated with the side that is not open to the atmosphere. It can also be controlled. For example, if the tube connected to the filter 10 or concentrator 20 is connected to the bag and is not blocked by the liquid feeding section or flow rate adjustment means, the tube is considered to be in a state close to being open to the atmosphere. be able to. In the state shown in FIG. 7, of the tubes 2 and 3 connected to the filter 10, the liquid supply tube 2 connected to the stock solution bag UB can be considered to be open to the atmosphere. Further, among the tubes 3 and 5 connected to the concentrator 20, the drain tube 5 connected to the waste liquid bag DB can also be considered to be open to the atmosphere. Then, in the state shown in FIG. 7, the control section 106 can also control the operation of the liquid feeding section using only the tube internal pressure of the filter supply tube 3.

Further, the flow rate of the liquid flowing through the filtrate supply tube 3 and the concentrate tube 4 may be estimated from the operation of the filtrate supply tube liquid supply section 3p and the concentrate tube liquid supply section 4p, or 3, the filtrate supply tube feeding section 3p, the concentrate tube 4, and the concentrate tube 4p may be provided with flowmeters to directly measure the flow rate.

<Explanation of filtration and concentration work using filter transmembrane pressure differential and concentrator transmembrane pressure differential pressure>
When performing filtration and concentration using the filter transmembrane pressure differential or the concentrator transmembrane differential pressure, an allowable differential pressure is set in advance. That is, depending on the filter 10 and the concentrator 20, the differential pressure (allowable differential pressure) that the filter 10 and the concentrator 20 can tolerate is set respectively. This allowable differential pressure may have a predetermined width or may be set to a specific value.

Note that when performing filtration and concentration using the filter transmembrane pressure differential or the concentrator transmembrane pressure differential, it is desirable to set an allowable flow rate in advance. In other words, it is desirable to set an allowable flow rate (allowable flow rate) of the stock solution in the liquid supply tube 2. This allowable flow rate may have a predetermined width or may be set to a specific value. Such an allowable flow rate does not necessarily have to be set. However, if the flow rate of the stock solution in the liquid supply tube 2 becomes too low, the time required for filtration and concentration becomes too long. Therefore, in order to prevent the processing time of the stock solution from increasing, it is desirable to set an allowable flow rate.
Furthermore, when performing filtration and concentration work using the filter transmembrane pressure differential or the concentrator transmembrane pressure differential, it is desirable to set an allowable concentration magnification in advance. In other words, it is desirable to set the ratio of the flow rate of the concentrate flowing through the concentrate tube 4 to the flow rate of the stock solution in the liquid supply tube 2 (allowable concentration magnification). This allowable concentration factor may have a predetermined range or may be set to a specific value. Such an allowable concentration factor does not necessarily need to be set. However, if the concentration ratio, which is the ratio of the flow rate of the concentrate flowing through the concentrate tube 4 to the flow rate of the stock solution in the liquid supply tube 2, decreases too much (in other words, if the flow rate of the concentrate becomes too large), the reconcentration process will fail. It takes time. Therefore, in order to prevent the concentration ratio from decreasing too much, it is desirable to set an allowable concentration ratio.

At the start of filtration and concentration, the filtrate supply tube liquid feeding section 3p is operated so as to increase the amount of raw solution fed to the filter 10. At this time, the concentrate tube liquid feeding section 4p is operated in accordance with the flow rate of the filtrate in the filtrate supply tube 3 so that the concentrate has a predetermined concentration ratio. For example, when producing a concentrate with a concentration ratio of 10 times, the concentrate tube liquid feeding section 4p determines that the flow rate of the concentrate flowing through the concentrate tube 4 is equal to the flow rate of the filtrate flowing inside the filtrate supply tube 3. Its operation is adjusted so that it becomes 1/10. Further, the operation of the concentrate tube liquid feeding section 4p may be adjusted so that the concentrator transmembrane differential pressure becomes a set value. Note that while the amount of filtrate sent to the concentrator 20 is being increased, the operation of the concentrated liquid tube liquid feeding section 4p is controlled so as to be in any of the above states.

As filtration and concentration proceed, the filter 10 and concentrator 20 gradually become clogged. Then, the filter transmembrane pressure difference and the concentrator transmembrane pressure difference increase. However, until the filter transmembrane differential pressure and the concentrator transmembrane differential pressure reach the allowable differential pressure, the amount of filtrate sent to the concentrator 20 (in other words, the amount of raw solution sent to the filter 10) is reduced. The filtrate supply tube liquid sending section 3p operates to increase the amount of water.

As will be described later, when the filter transmembrane pressure difference is within the range of the set pressure difference of the filter 10, the amount of filtrate sent to the concentrator 20, in other words, the amount of filtrate sent to the filter 10. The filtrate supply tube liquid feeding section 3p is operated so that the amount of the stock solution to be fed is maintained. On the other hand, when the pressure difference between the membranes of the filter becomes larger than the set pressure difference of the filter 10, the filtrate supply tube liquid sending part 3p is operated so that the amount of the raw solution sent to the filter 10 is reduced. Further, when the pressure difference between the membranes of the filter becomes smaller than the set pressure difference of the filter 10, the filtrate supply tube liquid sending section 3p is operated so that the amount of the raw solution sent to the filter 10 is increased.

<First method>
The increase in the amount of filtrate sent to the concentrator 20 is continued until the filter transmembrane pressure difference reaches the allowable pressure difference of the filter 10. When the pressure difference between the filter membranes reaches the allowable pressure difference of the filter 10, the amount of filtrate sent to the concentrator 20 is reduced to the level where the pressure difference between the filter membranes reaches the allowable pressure difference of the filter 10. The filtrate supply tube liquid sending section 3p is controlled to maintain the flow rate. On the other hand, the concentrate tube liquid feeding section 4p is operated, and the flow rate of the concentrate flowing through the concentrate tube 4 is adjusted.

<Step 1>
First, when the concentrator transmembrane pressure difference is smaller than the set differential pressure of the concentrator 20, the concentrate tube liquid feeding section 4p operates to reduce the amount of concentrated liquid sent to the concentrate bag CB. be done. In other words, the operation of the concentrate tube liquid feeding section 4p is controlled so as to increase the concentration of the concentrate.

<Step 2>
Then, the amount of concentrated liquid sent to the concentrated liquid bag CB is reduced until the concentrator transmembrane pressure difference reaches the set differential pressure of the concentrator 20. When the concentrator transmembrane differential pressure reaches the set differential pressure of the concentrator 20, the flow rate of the concentrate in the concentrate tube 4 is maintained at the flow rate where the concentrator transmembrane differential pressure becomes the set differential pressure of the concentrator 20. The concentrated liquid tube liquid feeding section 4p is controlled so as to.

<Step 3>
Eventually, when the concentrator transmembrane pressure becomes larger than the set differential pressure of the concentrator 20 due to clogging of the concentrator 20, etc., the concentrate tube is transferred so that the amount of concentrate sent to the concentrate bag CB increases. The liquid part 4p is controlled. Note that as the amount of concentrated liquid fed increases, the concentration ratio decreases, but the concentration ratio of the concentrated liquid tube liquid feeding section 4p is adjusted so that the concentration ratio decreases while satisfying the allowable concentration ratio (so that the concentration of the concentrated liquid becomes low). Actuation is controlled.
In addition, if the concentration ratio becomes smaller than the allowable concentration ratio when increasing the amount of concentrated liquid sent in order to maintain the concentrator transmembrane pressure difference at the set pressure difference, use the following method (second method). method).

As the amount of concentrate sent to the concentrate bag CB increases, the concentrator transmembrane differential pressure decreases, so when the concentrator transmembrane differential pressure becomes lower than the set differential pressure of the concentrator 20, the concentrate tube is again transferred. The liquid part 4p is operated so that the amount of concentrated liquid sent to the concentrated liquid bag CB is reduced.

That is, as long as the filter transmembrane pressure difference is within the allowable pressure difference of the filter 10, steps 1 to 3 are repeated. If this method is adopted, the filter 10 and concentration Depending on the membrane area of the filtration membrane of the container 20 and the state of clogging, and the state of the stock solution (concentration of substances that cause clogging of the filter or concentrator, concentration of useful substances to be recovered, viscosity of the liquid, etc.) , it becomes possible to ensure the maximum filtration flow rate and the maximum concentration ratio. In other words, by improving the filtration efficiency and concentration efficiency, it is possible to shorten the time required to generate a concentrated liquid from the stock solution, thereby preventing reconcentration work and shortening the time required for reconcentration work.
Moreover, if the operation is performed as described above, the cleaning liquid filled in the filter 10, concentrator 20, and the circuit at the start of filtration and concentration, and the cleaning liquid in the filter 10 and the circuit immediately after cleaning the filter 10, can be transferred to the concentrator. It becomes possible to remove the liquid as waste liquid in a short time. In other words, it is possible to efficiently prevent dilution of the concentrated liquid by the cleaning liquid at the start and immediately after cleaning the filter as described above.

Note that the above method (first method) is preferably employed when the filter transmembrane pressure difference is larger than the concentrator transmembrane pressure difference, but the method is not limited to this condition. It can also be adopted when the filter transmembrane pressure difference is smaller than the concentrator transmembrane pressure difference.
In addition, if the differential pressure between the filter membranes is larger than the allowable differential pressure, or if the differential pressure between the filter membranes is smaller than the allowable differential pressure, the amount of raw solution sent to the filter 10 may be lower than the allowable differential pressure. Even when the differential pressure is constant regardless of the differential pressure, the amount of concentrated liquid sent to the concentrator 20 may be adjusted by repeating steps 1 to 3 above.

<Second method>
In the first method, the flow rate of the concentrate in the concentrate tube 4 was adjusted based on the concentrator transmembrane pressure difference, but as described below, the flow rate of the filtrate to the concentrator 20 is It is also possible to adjust the amount of liquid sent.

<Step 1>
First, when the concentrator transmembrane pressure difference is smaller than the set differential pressure of the concentrator 20, the filtrate supply tube liquid sending part 3p sends the amount of filtrate to the concentrator 20 (in other words, The pump is operated to increase the amount of stock solution sent to the pump. That is, the operation of the filtrate supply tube liquid sending section 3p is controlled so that the amount of filtrate produced to be sent to the concentrator 20 is increased.

<Step 2>
Then, the amount of filtrate produced to be sent to the concentrator 20 (in other words, the amount of raw solution sent to the filter 10) is increased until the concentrator transmembrane pressure difference reaches the set differential pressure of the concentrator 20. Then, when the concentrator transmembrane differential pressure reaches the set differential pressure of the concentrator 20, the amount of filtrate sent to the concentrator 20 is reduced to the level where the concentrator transmembrane differential pressure becomes the set differential pressure of the concentrator 20. The operation of the filtrate supply tube liquid sending section 3p is controlled to maintain the flow rate.

<Step 3>
Eventually, when the concentrator transmembrane pressure becomes larger than the set differential pressure of the concentrator 20 due to clogging of the concentrator 20, etc., the filtrate supply tube is routed so that the amount of filtrate sent to the concentrator 20 is reduced. The operation of the liquid part 3p is controlled. That is, the operation of the filtrate supply tube liquid sending section 3p is controlled so that the amount of filtrate produced to be sent to the concentrator 20 is reduced.

As the amount of filtrate sent to the concentrator 20 decreases, the concentrator transmembrane differential pressure becomes smaller, so when the concentrator transmembrane differential pressure becomes lower than the set differential pressure of the concentrator 20, the filtrate supply tube is again fed. The liquid part 3p is operated so that the flow rate of the stock solution in the liquid supply tube 2 increases.

That is, as long as the filter transmembrane pressure difference is within the allowable pressure difference of the filter 10, steps 1 to 3 are repeated. If this method is adopted, the filter 10 and concentration Depending on the membrane area of the filtration membrane of the container 20 and the state of clogging, and the state of the stock solution (concentration of substances that cause clogging of the filter or concentrator, concentration of useful substances to be recovered, viscosity of the liquid, etc.) , it becomes possible to ensure the maximum filtration flow rate and the maximum concentration ratio. In other words, by improving the filtration efficiency and concentration efficiency, it is possible to shorten the time it takes to generate a concentrated liquid from the stock solution, thereby making it possible to prevent reconcentration work and shorten the time required for reconcentration work.
Moreover, if the operation is performed as described above, the cleaning liquid filled in the filter 10, concentrator 20, and the circuit at the start of filtration and concentration, and the cleaning liquid in the filter 10 and the circuit immediately after cleaning the filter 10, can be transferred to the concentrator. It becomes possible to remove the liquid as waste liquid in a short time. In other words, it is possible to efficiently prevent dilution of the concentrated liquid by the cleaning liquid at the start and immediately after cleaning the filter as described above.

Note that the above method (second method) is preferably employed when the concentrator transmembrane pressure difference is larger than the filter transmembrane pressure difference, but the method is not limited to this condition. It can also be adopted when the concentrator transmembrane pressure difference is smaller than the filter transmembrane pressure difference.
In addition, if the differential pressure between the filter membranes is larger than the allowable differential pressure, or if the differential pressure between the filter membranes is smaller than the allowable differential pressure, the amount of raw solution sent to the filter 10 may be lower than the allowable differential pressure. Even when the differential pressure is constant regardless of the differential pressure, the amount of concentrated liquid sent to the concentrator 20 may be adjusted by repeating steps 1 to 3 above.

<About filter cleaning>
Also in the stock solution processing apparatus 1B of this embodiment, when the above-described filtration and concentration work is performed, the filter transmembrane pressure difference becomes larger than the allowable pressure difference of the filter 10 due to clogging of the filter 10, etc. . In this case, by reducing the flow rate of the stock solution in the liquid supply tube 2, the filter transmembrane pressure difference can be made smaller than the allowable pressure difference of the filter 10. However, when the filter 10 becomes severely clogged, the flow rate of the stock solution in the liquid supply tube 2 decreases in order to maintain the filter transmembrane pressure differential to the allowable differential pressure of the filter 10. The flow rate of the stock solution becomes smaller than the allowable flow rate. In such a state, the cleaning work of the filter 10 is performed during the filtration and concentration work of the stock solution processing apparatus 1 of this embodiment.

Specifically, in FIG. 7, the liquid supply tube 2 is closed by the flow rate adjusting means 2c so that the liquid does not flow. In addition, the operation of the filtrate supply tube liquid feeding section 3p and the concentrated liquid tube liquid feeding section 4p is stopped to function as a clamp. In addition, when cleaning the filter during the filtration and concentration work, after the preparatory cleaning work is completed, a cleaning liquid bag SB is connected to the other end of the cleaning liquid supply tube 6 instead of the cleaning liquid collection bag FB. A cleaning liquid recovery bag FB is connected to the other end of the cleaning liquid recovery tube 7 instead of the cleaning liquid bag SB.

In the above state, the cleaning liquid supply tube liquid feeding section 6p is operated to flow the cleaning liquid from the cleaning liquid bag SB connected to the cleaning liquid supply tube 6 to the filter 10, and the cleaning liquid recovery tube connected to the cleaning liquid recovery tube 7 from the filter 10 is operated. The cleaning liquid recovery tube liquid feeding section 7p is operated to flow the cleaning liquid into the bag FB. Then, since the cleaning liquid can flow inside the hollow fiber membrane 16 in the opposite direction to the direction in which the stock solution flows during filtration and concentration, the inside of the hollow fiber membrane 16 can be cleaned with the cleaning liquid.

Further, after the preparatory cleaning work is completed, a cleaning liquid bag SB is connected to the other end of the connecting tube 9 instead of the cleaning liquid collection bag FB. Then, if the liquid is made to flow in the connecting tube 9 by the flow rate adjusting means 9c, in addition to the above-mentioned state, the cleaning liquid can also be supplied to the filter 10 from the cleaning liquid bag SB connected to the connecting tube 9. Then, the cleaning liquid supplied through the connecting tube 9 passes through the hollow fiber membrane 16 in the opposite direction to the direction in which the filtrate passes through the hollow fiber membrane 16, so that clogging of the hollow fiber membrane 16 can be eliminated. In this case, since the cleaning liquid is supplied to the filter 10 from both the cleaning liquid bag SB connected to the cleaning liquid supply tube 6 and the cleaning liquid bag SB connected to the connecting tube 9, the cleaning liquid collection tube The flow rate of the cleaning liquid flowing through the cleaning liquid supply tube 7 is adjusted to be larger than the flow rate of the cleaning liquid flowing through the cleaning liquid supply tube 6 by the cleaning liquid supply tube liquid feeding section 6p.

In addition, when the liquid is made to flow in the connection tube 9 by the flow rate adjustment means 9c, the cleaning liquid recovery tube liquid feeding part 7p may be operated while the operation of the cleaning liquid supply tube liquid feeding part 6p is stopped. In this case, the cleaning liquid is supplied to the filtrate 10 only from the cleaning liquid bag SB connected to the connecting tube 9. Also in this case, the cleaning liquid passes through the hollow fiber membranes 16 in the opposite direction to the direction in which the filtrate passes through the hollow fiber membranes 16, so that clogging of the hollow fiber membranes 16 can be eliminated.

<Filtrate recovery>
On the other hand, when the filter is cleaned by the above method, the filtrate remaining in the internal space 12h of the main body 11 of the filter 10 is mixed with the cleaning liquid and discharged. This will reduce the amount of active ingredient recovered by filtration and concentration.

Therefore, when cleaning the filter, it is preferable to send the filtrate existing in the internal space 12h of the main body 11 of the filter 10 to the concentrator 20 in advance, and then wash the filter.

As shown in FIG. 7, the cleaning liquid bag SB is connected to the port 11c of the main body 11 of the filter 10 via a tube. Then, while maintaining the state in which the liquid flows from the filter 10 to the concentrator 20 by the filtrate supply tube liquid feeding section 3p and continuing the operation of the concentrated liquid tube liquid feeding section 4p, the liquid is supplied by the flow rate adjustment means 2c. Close tube 2. In this state, if the cleaning liquid is supplied from the cleaning liquid bag SB to the filter 10 using the pump provided in the tube, the filtrate in the internal space 12h of the main body 11 of the filter 10 will be supplied to the concentrator 20, and the filtrate will be replaced. The cleaning liquid is supplied from the cleaning liquid bag SB to the internal space 12h. Eventually, when all the filtrate in the internal space 12h is replaced with the cleaning liquid, the operation of the filtrate supply tube liquid feeding section 3p is stopped to close the filtrate supply tube 3, and the operation of the concentrated liquid tube liquid feeding section 4p is stopped. stop. After this state is reached, if the filter 10 is washed in the manner described above, re-concentration of the filtrate discharged together with the washing liquid can be suppressed.

Note that the tube connected to the port 11c of the main body 11 of the filter 10 does not necessarily need to be provided with a pump. Even in this case, by operating the filtrate supply tube liquid sending section 3p, the filtrate in the internal space 12h of the main body 11 of the filter 10 can be replaced with the cleaning liquid.

In addition, in the above description, the cleaning liquid bag SB is connected to the port 11c of the main body 11 of the filter 10 via the tube, but air is connected to the port 11c of the main body 11 of the filter 10 via the tube. May be supplied. Even in this case, the filtrate in the internal space 12h of the main body 11 of the filter 10 can be supplied to the concentrator 20 by air pressure. In this case, the interior space 12h of the main body 11 of the filter 10 is filled with air, so before cleaning, the interior space 12h is filled with a cleaning liquid. For example, if the cleaning liquid bag SB is connected to the port 11c of the main body 11 of the filter 10 and the cleaning liquid is supplied, the interior space 12h can be filled with the cleaning liquid.

Furthermore, in the above description, the stock solution is supplied into the through passage 16h of the plurality of hollow fiber membranes 16 of the hollow fiber membrane bundle 15 of the filter 10, and the filtrate is supplied to the body 12 of the main body 11 of the filter 10. The case where the liquid is discharged into the internal space 12h is explained. However, the stock solution is supplied from the filtrate discharge port 11c into the internal space 12h of the body 12 of the main body 11, and the filtered filtrate is passed through the flow path 16h of the plurality of hollow fiber membranes 16 of the hollow fiber membrane bundle 15. The liquid may be discharged into the interior and discharged to the outside from the stock solution supply port 11a. In this case, the filtrate supply tube 3 is connected to the stock solution supply port 11a, and the liquid supply tube 2 is connected to the filtrate discharge port 11c. When cleaning the filter in such a configuration, the filtrate present in the internal space 12h of the body 12 of the main body 11 of the filter 10 is sent to the concentrator 20 in advance in the same manner as described above. It is preferable to wash the filter and then wash the filter.

<Reconcentration work>
When further concentrating the concentrated liquid obtained by the filtration and concentration operation, a reconcentration operation is performed.

As shown in FIG. 8, in the reconcentration work of the stock solution processing apparatus 1B of this embodiment, the other end of the connecting tube 9 is removed from the cleaning liquid bag SB, and the concentrated liquid bag CB is connected to the other end of the connecting tube 9. Ru.
Further, while maintaining a state in which the liquid can flow in the connection tube 9 by the flow rate adjustment means 9c, the cleaning liquid supply tube liquid feeding section 6p and the cleaning liquid recovery tube liquid feeding section 7p are not operated and function as a clamp. In addition, the inside of the liquid supply tube 2 is closed by the flow rate adjusting means 2c so that liquid does not flow therein. Then, the state is such that no liquid flows into the filter 10.

In the above state, the filtrate supply tube liquid sending part 3p is operated to flow the concentrate from the concentrate bag CB through the connecting tube 9 to the concentrator 20, and the filtrate supply tube liquid sending part 3p is operated to flow the concentrate from the concentrator 20 through the concentrate tube 4. The concentrate tube liquid feeding section 4p is operated so that the concentrate flows into the concentrate bag CB.

Then, the concentrate is supplied from the concentrate bag CB connected to the connecting tube 9 to the concentrator 20 through the connecting tube 9, so that the reconcentrate further concentrated by the concentrator 20 passes through the concentrate tube 4 to the concentrate bag. Collected by CB. On the other hand, the water separated from the concentrated liquid is collected through the waste liquid tube 5 into the waste liquid bag DB. In other words, a concentrated liquid (re-concentrated liquid) with an increased concentration ratio can be obtained.

<Stock solution processing device 1C of third embodiment>
In the stock solution processing apparatus 1B of the present embodiment described above, the filtrate supply tube 3 is provided with a filtrate supply tube liquid feeding section 3p, so that the stock solution is sucked out from the filter 10 during filtration and concentration. In such a configuration, instead of providing the filtrate supply tube 3p with the filtrate supply tube 3p, the waste tube 5 can be provided with a wastewater tube 5p (see FIGS. 10 to 12).

In this stock solution processing apparatus 1C, during filtration and concentration, the concentrate tube liquid feeding section 4p and the waste liquid tube feeding section 5p are operated so that the liquid (filtrate) flows from the filter 10 to the concentrator 20. When the concentrate tube feeding section 4p and the waste liquid tube feeding section 5p operate, the filtrate supply tube 3 becomes a negative pressure, and the inside of the filter 10 (for example, the internal space 12h of the body 12 of the main body 11) also becomes negative. It becomes pressure. Then, if the liquid supply tube 2 is set in a state where the liquid can be fed by the flow rate adjustment means 2c, the liquid in the liquid bag UB is sucked into the filter 10 through the liquid feed tube 2, and the sucked liquid is transferred to the filtrate supply tube. Can be absorbed into 3.

Even with this stock solution processing apparatus 1C, if the bags connected to each tube are appropriately changed and the operation of the flow rate adjustment means and liquid feeding section provided in each tube is adjusted, preparatory cleaning work, filtration concentration work, and reconcentration work can be performed. It can be performed.

<Preparation cleaning work>
As shown in FIG. 10, a washing liquid bag SB is connected to the other end of the concentrate tube 4 instead of the concentrate bag CB, and a washing liquid collection bag FB is connected to the other end of the waste liquid tube 5 instead of the waste liquid bag DB. do. Note that the other end of the waste liquid tube 5 may be connected to the waste liquid bag DB, or may be placed in a simple bucket or the like.
Furthermore, a cleaning liquid collection bag FB is connected to the other end of the liquid supply tube 2 instead of the stock solution bag UB. Note that a waste liquid bag DB may be connected to the other end of the liquid supply tube 2, or the other end of the liquid supply tube 2 may be placed in a simple bucket or the like.
Then, the cleaning liquid collection bag FB is also connected to the other end of the connecting tube 9. Note that a waste liquid bag DB may be connected to the other end of the connecting tube 9, or the other end of the connecting tube 9 may be placed in a simple bucket or the like.
Furthermore, a cleaning liquid collection bag FB is connected to the other end of the cleaning liquid supply tube 6 instead of the cleaning liquid bag SB, and a cleaning liquid bag SB is connected to the other end of the cleaning liquid collection tube 7 instead of the cleaning liquid collection bag FB. Note that a waste liquid bag DB may be connected to the other end of the cleaning liquid supply tube 6, or the other end of the cleaning liquid supply tube 6 may be arranged in a simple bucket or the like.

Next, the cleaning liquid is made to flow through the liquid supply tube 2 and the connection tube 9 by the flow rate adjustment means 2c and the flow rate adjustment means 9c.

In the above state, the concentrated liquid tube liquid feeding section 4p is operated to flow the cleaning liquid from the cleaning liquid bag SB connected to the concentrated liquid tube 4 to the concentrated liquid 20. Then, the cleaning liquid is supplied from the cleaning liquid bag SB connected to the concentrated liquid tube 4 to the concentrator 20 through the concentrated liquid tube 4. The supplied cleaning liquid passes through the concentrator 20 , passes through the filtrate supply tube 3 and the connecting tube 9 , and is collected into the cleaning liquid recovery bag FB connected to the connecting tube 9 . Note that if the waste liquid tube feeding section 5p is operated so that the liquid flows from the concentrator 20 to the cleaning liquid collection bag FB, a part of the cleaning liquid will pass through the waste liquid tube 5 and be connected to the other end of the waste liquid tube 5. The cleaning liquid can be collected in the cleaning liquid collection bag FB.

Further, the cleaning liquid recovery tube liquid feeding section 7p is operated to flow the cleaning liquid from the cleaning liquid bag SB connected to the cleaning liquid recovery tube 7 to the filter 10. Then, a part of the cleaning liquid is supplied from the cleaning liquid bag SB connected to the cleaning liquid recovery tube 7 to the filter 10 through the cleaning liquid recovery tube 7. After passing through the filter 10, the cleaning liquid supplied to the filter 10 passes through the filtrate supply tube 3 and the connecting tube 9, and is collected in the cleaning liquid recovery bag FB connected to the connecting tube 9. Further, by also operating the cleaning liquid supply tube liquid sending section 6p, a part of the cleaning liquid supplied to the filter 10 can also flow into the cleaning liquid supply tube 6. Further, a part of the cleaning liquid passes through the liquid supply tube 2 from the cleaning liquid recovery tube 7 and is collected into the cleaning liquid recovery bag FB connected to the liquid supply tube 2.

Then, the cleaning liquid can be flowed through the filter 10, the concentrator 20, and all the tubes, so the entire stock solution processing apparatus 1C of this embodiment can be cleaned.

<Filtration and concentration work>
After the preparatory cleaning work is completed, filtration and concentration work is carried out.

As shown in FIG. 11, in the filtration and concentration work of the stock solution processing apparatus 1C of this embodiment, from the preparatory cleaning work state, a concentrate bag CB is connected to the other end of the concentrate tube 4 instead of the washing liquid bag SB, A waste liquid bag DB is connected to the other end of the waste liquid tube 5 instead of the cleaning liquid collection bag FB.
On the other hand, an undiluted solution bag UB is connected to the other end of the liquid supply tube 2 instead of the cleaning liquid collection bag FB.
Further, while the flow rate adjustment means 2c is opened to maintain a state in which the liquid can flow in the liquid supply tube 2, the flow rate adjustment means 9c closes the inside of the connecting tube 9 so that the liquid does not flow. In addition, the cleaning liquid recovery tube feeding section 7p and the cleaning liquid supply tube feeding section 6p are not operated and are made to function as a clamp.

In the above state, the concentrate tube liquid sending part 4p is operated to flow the concentrate from the concentrator 20 to the concentrate bag CB, and the waste liquid tube liquid sending part is operated to flow the waste liquid from the concentrator 20 to the waste liquid bag DB. Activate 5p.

Then, the stock solution is supplied from the stock solution bag UB to the filter 10 through the liquid supply tube 2. The supplied stock solution is filtered by the filter 10, and the generated filtrate is supplied to the concentrator 20 through the filtrate supply tube 3. The filtrate supplied to the concentrator 20 is concentrated by the concentrator 20, and the generated concentrate is collected into the concentrate bag CB through the concentrate tube 4. On the other hand, the water separated from the concentrated liquid is collected through the waste liquid tube 5 into the waste liquid bag DB.

<About filtration and concentration operations>
In the filtration and concentration work, the operations of the concentrated liquid tube feeding section 4p and the waste liquid tube feeding section 5p are controlled so that the concentration ratio falls within a predetermined range. However, as described below, by using the filter transmembrane pressure differential and the concentrator transmembrane differential pressure, the concentrate tube liquid feeding section 4p and the waste liquid tube feeding section 5p are activated, that is, the concentrated liquid tube 4 and the waste liquid The flow rate of the liquid within the tube 5 may be controlled. Then, since the capacity of the filter 10 and the concentrator 20 can be effectively utilized to perform filtration and concentration, the time required to generate a concentrated liquid can be shortened and the efficiency of the concentration work can be increased.
In the following, a process of filtering and concentrating by controlling the operations of the concentrate tube liquid sending section 4p and the waste liquid tube feeding section 5p using the filter transmembrane pressure differential and the concentrator transmembrane pressure differential will be described.

Note that the filter transmembrane pressure difference and the concentrator transmembrane pressure difference can be calculated by measuring the internal pressure of tubes connected to the filter 10 and the concentrator 20. For example, if pressure gauges are provided in the liquid supply tube 2 and the filtrate supply tube 3 and their signals are supplied to the control unit 106, the control unit 106 can calculate the filter transmembrane pressure. . Further, if pressure gauges are provided in the filtrate supply tube 3 and waste liquid tube 5 and their signals are supplied to the control unit 106, the control unit 106 can calculate the concentrator transmembrane pressure.

In addition, in the filter 10 or the concentrator 20, if either the liquid supply side or the drain side is in a state close to being open to the atmosphere, the liquid supply side or the drain side is in communication with the side that is not open to the atmosphere. The control unit 106 can calculate the filter transmembrane differential pressure and the concentrator transmembrane differential pressure by simply measuring the tube internal pressure. In other words, instead of using the filter transmembrane pressure differential or the concentrator transmembrane differential pressure, the control unit 106 can also control the operation of the liquid feeding unit using only the tube internal pressure that is not released to the atmosphere. . For example, if the tube connected to the filter 10 or concentrator 20 is connected to the bag and is not blocked by the liquid feeding section or flow rate adjustment means, the tube is considered to be in a state close to being open to the atmosphere. be able to. In the state shown in FIG. 12, of the tubes 2 and 3 connected to the filter 10, the liquid supply tube 2 connected to the stock solution bag UB can be considered to be open to the atmosphere. Further, among the tubes 3 and 5 connected to the concentrator 20, the drain tube 5 connected to the waste liquid bag DB can also be considered to be open to the atmosphere. Then, in the state shown in FIG. 12, the control section 106 can also control the operation of the liquid feeding section using only the tube internal pressure of the filter supply tube 3.

Further, the flow rate of the liquid flowing in the concentrate tube 4 and the waste liquid tube 5 may be estimated from the operation of the concentrate tube liquid feeding section 4p and the waste liquid tube feeding section 5p, or A flow meter may be provided in the liquid feeding section 4p, the waste liquid tube 5, or the waste liquid tube liquid feeding section 5p to directly measure the flow rate.

<Explanation of filtration and concentration work using filter transmembrane pressure differential and concentrator transmembrane pressure differential pressure>
When performing filtration and concentration using the filter transmembrane pressure differential or the concentrator transmembrane differential pressure, an allowable differential pressure is set in advance. That is, depending on the filter 10 and the concentrator 20, the differential pressure (allowable differential pressure) that the filter 10 and the concentrator 20 can tolerate is set respectively. This allowable differential pressure may have a predetermined width or may be set to a specific value.

Note that when performing filtration and concentration using the filter transmembrane pressure differential or the concentrator transmembrane pressure differential, it is desirable to set an allowable flow rate in advance. In other words, it is desirable to set an allowable flow rate (allowable flow rate) of the stock solution in the liquid supply tube 2. This allowable flow rate may have a predetermined width or may be set to a specific value. Such an allowable flow rate does not necessarily have to be set. However, if the flow rate of the stock solution in the liquid supply tube 2 becomes too low, the time required for filtration and concentration becomes too long. Therefore, in order to prevent the processing time of the stock solution from increasing, it is desirable to set an allowable flow rate.
Further, when performing filtration and concentration using the filter transmembrane pressure differential or the concentrator transmembrane pressure differential, it is desirable to set an allowable concentration magnification in advance. That is, it is desirable to set the ratio of the flow rate of the concentrate flowing through the concentrate tube 4 to the flow rate of the stock solution in the liquid supply tube 2 (allowable concentration magnification). This allowable concentration factor may have a predetermined range or may be set to a specific value. Such an allowable concentration factor does not necessarily need to be set. However, if the concentration ratio, which is the ratio of the flow rate of the concentrate flowing through the concentrate tube 4 to the flow rate of the stock solution in the liquid supply tube 2, decreases too much (in other words, if the flow rate of the concentrate becomes too large), the reconcentration process will fail. It takes time. Therefore, in order to prevent the concentration ratio from decreasing too much, it is desirable to set an allowable concentration ratio.

At the start of filtration and concentration, the concentrated liquid tube feeding section 4p and the waste liquid tube feeding section 5p are operated so as to increase the amount of raw solution fed to the filter 10. At this time, the concentrated liquid tube feeding section 4p and the waste liquid tube feeding section 5p are operated so that the concentrated liquid reaches a predetermined concentration ratio. For example, when producing a concentrate with a concentration ratio of 10 times, the flow rate of the concentrate flowing through the concentrate tube 4 and the flow rate of the waste liquid flowing through the waste liquid tube 5 are adjusted to be 1:10. Further, the operations of the concentrated liquid tube feeding section 4p and the waste liquid tube feeding section 5p may be adjusted so that the filter transmembrane pressure differential and the concentrator transmembrane differential pressure become set values. Note that while the amount of raw solution being sent to the filter 10 is being increased, the operations of the concentrate tube feeding section 4p and the waste liquid tube feeding section 5p are controlled so as to be in any of the above states. Ru.

As filtration and concentration proceed, the filter 10 and concentrator 20 gradually become clogged. Then, the filter transmembrane pressure difference and the concentrator transmembrane pressure difference increase. However, until the filter transmembrane differential pressure and the concentrator transmembrane differential pressure reach the allowable differential pressure, the concentrated liquid tube liquid feeding section 4p and the waste liquid tube feeding part 4p are operated to increase the amount of the raw solution fed to the filter 10. The liquid part 5p operates.

As will be described later, when the filter transmembrane pressure difference is within the range of the set pressure difference of the filter 10, the amount of filtrate sent to the concentrator 20, in other words, the amount of filtrate sent to the filter 10. The concentrated liquid tube liquid feeding section 4p and the waste liquid tube liquid feeding section 5p are operated so that the amount of the stock solution to be fed is maintained. On the other hand, when the pressure difference between the membranes of the filter becomes larger than the set pressure difference of the filter 10, the concentrated liquid tube liquid feeding section 4p and the waste liquid tube liquid feeding section 5p are arranged such that the amount of the raw solution sent to the filter 10 is reduced. is activated. Further, when the pressure difference between the membranes of the filter becomes smaller than the set pressure difference of the filter 10, the concentrated liquid tube liquid sending part 4p and the waste liquid tube liquid sending part 5p are operated so that the amount of the raw solution sent to the filter 10 increases. activated.

<First method>
Here, the increase in the amount of the raw solution sent to the filter 10 is continued until the filter transmembrane pressure difference reaches the allowable pressure difference of the filter 10. When the pressure difference between the membranes of the filter reaches the allowable pressure difference of the filter 10, the flow rate of the stock solution in the liquid supply tube 2 becomes the flow rate when the pressure difference between the filter membranes reaches the allowable pressure difference of the filter 10. The operations of the concentrated liquid tube feeding section 4p and the waste liquid tube feeding section 5p are controlled so as to maintain the concentration.

<Step 1>
First, when the concentrator transmembrane pressure difference is smaller than the set differential pressure of the concentrator 20, the concentrate tube liquid feeding section 4p operates to reduce the amount of concentrated liquid sent to the concentrate bag CB. be done. In other words, the operation of the concentrate tube liquid feeding section 4p is controlled so as to increase the concentration of the concentrate. At this time, the waste liquid tube liquid sending section 5p may maintain an operating state so that the amount of waste liquid flowing through the waste liquid tube 5 is maintained.
Conversely, when the concentrator transmembrane pressure difference is smaller than the set differential pressure of the concentrator 20, the operation of the waste liquid tube liquid sending section 5p is controlled so that the amount of waste liquid flowing through the waste liquid tube 5 is increased. The amount of concentrated liquid sent to the concentrator 20 may be maintained by doing so.

<Step 2>
Then, the amount of concentrated liquid sent to the concentrated liquid bag CB is reduced until the concentrator transmembrane pressure difference reaches the set differential pressure of the concentrator 20. When the concentrator transmembrane pressure difference reaches the set differential pressure of the concentrator 20, the flow rate of the concentrate in the concentrate tube 4 is changed to the flow rate when the concentrator transmembrane pressure becomes the set differential pressure of the concentrator 20. The concentrate tube liquid feeding section 4p is controlled so as to maintain the concentration. At this time, the operation of the waste liquid tube liquid sending section 5p may also be controlled so as to maintain the amount of waste liquid flowing through the waste liquid tube 5.

<Step 3>
Eventually, when the concentrator transmembrane pressure becomes larger than the set differential pressure of the concentrator 20 due to clogging of the concentrator 20, etc., the concentrate tube is transferred so that the amount of concentrate sent to the concentrate bag CB increases. The liquid part 4p is controlled. In addition, as the amount of concentrated liquid sent increases, the concentration ratio decreases, but the concentration ratio of the concentrated liquid tube feeding part 4p is adjusted so that the concentration ratio decreases while satisfying the allowable concentration ratio (so that the concentration of the concentrated liquid becomes low). Actuation is controlled. At this time, the waste liquid tube liquid sending section 5p may maintain an operating state so that the amount of waste liquid flowing through the waste liquid tube 5 is maintained.
Conversely, when the concentrator transmembrane pressure difference is larger than the set differential pressure of the concentrator 20, the operation of the waste liquid tube liquid sending section 5p is controlled so that the amount of waste liquid flowing in the waste liquid tube 5 is reduced. be done. Note that when the amount of waste liquid sent decreases, the concentration ratio decreases, but the operation of the waste liquid tube liquid sending part 5p is performed so that the concentration ratio decreases while satisfying the allowable concentration ratio (so that the concentration of the concentrated liquid becomes low). controlled.

When the amount of concentrated liquid sent to the concentrate bag CB increases (or when the amount of waste liquid sent through the waste liquid tube 5 decreases), the concentrator transmembrane pressure difference decreases, so the concentrator transmembrane pressure difference decreases. When the pressure difference becomes lower than the set differential pressure of the concentrator 20, the concentrate tube liquid sending part 4p is operated again so that the amount of concentrated liquid sent to the concentrate bag CB is reduced (or the amount of concentrated liquid flowing in the waste liquid tube 5 is reduced). (The operation of the waste liquid tube liquid sending section 5p is controlled so that the amount of waste liquid sent is increased.)

That is, as long as the filter transmembrane pressure difference is within the allowable pressure difference of the filter 10, steps 1 to 3 are repeated. If this method is adopted, the filter 10 and concentration Depending on the membrane area of the filtration membrane of the container 20 and the state of clogging, and the state of the stock solution (concentration of substances that cause clogging of the filter or concentrator, concentration of useful substances to be recovered, viscosity of the liquid, etc.) , it becomes possible to ensure the maximum filtration flow rate and the maximum concentration ratio. In other words, by improving the filtration efficiency and concentration efficiency, it is possible to shorten the time it takes to generate a concentrated liquid from the stock solution, thereby making it possible to prevent reconcentration work and shorten the time required for reconcentration work.
Moreover, if the operation is performed as described above, the cleaning liquid filled in the filter 10, concentrator 20, and the circuit at the start of filtration and concentration, and the cleaning liquid in the filter 10 and the circuit immediately after cleaning the filter 10, can be transferred to the concentrator. It becomes possible to remove the liquid as waste liquid in a short time. In other words, it is possible to efficiently prevent dilution of the concentrated liquid by the cleaning liquid at the start and immediately after cleaning the filter as described above.

In addition, in the above method (first method), when the filter transmembrane pressure difference is larger than the permissible pressure difference, or when the filter transmembrane pressure difference is smaller than the permissible pressure difference, the undiluted solution is not supplied to the filter 10. Even when the amount of liquid sent is constant regardless of the pressure difference between the membranes of the filter, the amount of concentrated liquid sent to the concentrator 20 may be adjusted by repeating steps 1 to 3 above.
Furthermore, the above method (first method) may be employed throughout the entire period of filtration and concentration, but it is employed only during a certain period, such as at the start of filtration and concentration or immediately after cleaning the filter, and during other periods when the concentration is set. It may be concentrated by a factor of two.

<About filter cleaning>
Also in the stock solution processing apparatus 1C of this embodiment, when the above-described filtration and concentration work is performed, the filter transmembrane pressure difference becomes larger than the allowable pressure difference of the filter 10 due to clogging of the filter 10, etc. . In this case, by reducing the flow rate of the stock solution in the liquid supply tube 2, the filter transmembrane pressure difference can be made smaller than the allowable pressure difference of the filter 10. However, if the filter 10 becomes severely clogged, the flow rate of the stock solution in the liquid supply tube 2 decreases in order to maintain the filter transmembrane pressure at the allowable differential pressure of the filter 10, and the flow rate of the stock solution in the liquid supply tube 2 decreases. The flow rate of the stock solution becomes smaller than the allowable flow rate. In such a state, the cleaning work of the filter 10 is performed during the filtration and concentration work of the stock solution processing apparatus 1 of this embodiment.

Specifically, in FIG. 11, the liquid supply tube 2 is closed by the flow rate adjusting means 2c so that the liquid does not flow. In addition, the operations of the concentrated liquid tube feeding section 4p and the waste liquid tube feeding section 5p are stopped to function as a clamp. In addition, when cleaning the filter during the filtration and concentration work, after the preparatory cleaning work is completed, a cleaning liquid bag SB is connected to the other end of the cleaning liquid supply tube 6 instead of the cleaning liquid collection bag FB. A cleaning liquid recovery bag FB is connected to the other end of the cleaning liquid recovery tube 7 instead of the cleaning liquid bag SB.

In the above state, the cleaning liquid supply tube liquid feeding section 6p is operated to flow the cleaning liquid from the cleaning liquid bag SB connected to the cleaning liquid supply tube 6 to the filter 10, and the cleaning liquid recovery tube connected to the cleaning liquid recovery tube 7 from the filter 10 is operated. The cleaning liquid recovery tube liquid feeding section 7p is operated to flow the cleaning liquid into the bag FB. Then, since the cleaning liquid can flow inside the hollow fiber membrane 16 in the opposite direction to the direction in which the stock solution flows during filtration and concentration, the inside of the hollow fiber membrane 16 can be cleaned with the cleaning liquid.

Further, after the preparatory cleaning work is completed, a cleaning liquid bag SB is connected to the other end of the connecting tube 9 instead of the cleaning liquid collection bag FB. Then, by opening the flow rate adjustment means 9c and allowing the liquid to flow through the connecting tube 9, in addition to the above state, the cleaning liquid can also be supplied to the filter 10 from the cleaning liquid bag SB connected to the connecting tube 9. Can be done. Then, the cleaning liquid supplied through the connecting tube 9 passes through the hollow fiber membrane 16 in the opposite direction to the direction in which the filtrate passes through the hollow fiber membrane 16, so that clogging of the hollow fiber membrane 16 can be eliminated. In this case, since the cleaning liquid is supplied to the filter 10 from both the cleaning liquid bag SB connected to the cleaning liquid supply tube 6 and the cleaning liquid bag SB connected to the connecting tube 9, the cleaning liquid collection tube The flow rate of the cleaning liquid flowing through the cleaning liquid supply tube 7 is adjusted to be larger than the flow rate of the cleaning liquid flowing through the cleaning liquid supply tube 6 by the cleaning liquid supply tube liquid feeding section 6p.

In addition, when the liquid is made to flow in the connection tube 9 by the flow rate adjustment means 9c, the cleaning liquid recovery tube liquid feeding part 7p may be operated while the operation of the cleaning liquid supply tube liquid feeding part 6p is stopped. In this case, the cleaning liquid is supplied to the filtrate 10 only from the cleaning liquid bag SB connected to the connecting tube 9. Also in this case, the cleaning liquid passes through the hollow fiber membranes 16 in the opposite direction to the direction in which the filtrate passes through the hollow fiber membranes 16, so that clogging of the hollow fiber membranes 16 can be eliminated.

<Filtrate recovery>
On the other hand, when the filter is cleaned by the above method, the filtrate remaining in the internal space 12h of the main body 11 of the filter 10 is mixed with the cleaning liquid and discharged. Then, in order to recover the components contained in the filtrate mixed with the cleaning liquid and discharged, re-concentration must be performed, so it takes time to generate the concentrated liquid.

Therefore, when cleaning the filter, it is preferable to send the filtrate existing in the internal space 12h of the main body 11 of the filter 10 to the concentrator 20 in advance, and then wash the filter.

As shown in FIG. 10, the cleaning liquid bag SB is connected to the port 11c of the main body 11 of the filter 10 via a tube. Then, while maintaining the state in which the liquid flows in the filtrate supply tube 3 by the flow rate adjustment means 3c, and while continuing the operation of the concentrate tube liquid supply section 4p or the waste liquid tube liquid supply section 5, the flow rate adjustment means 2c Close the liquid supply tube 2. In this state, if the cleaning liquid is supplied from the cleaning liquid bag SB to the filter 10 using the pump provided in the tube, the filtrate in the internal space 12h of the main body 11 of the filter 10 will be supplied to the concentrator 20 and replaced. The cleaning liquid is supplied from the cleaning liquid bag SB to the internal space 12h. Eventually, when all the filtrate in the internal space 12h is replaced with the cleaning liquid, the flow rate adjustment means 3c closes the filtrate supply tube 3 and stops the operation of the concentrate tube liquid feeding section 4p or the waste liquid tube feeding section 5. do. After this state is reached, if the filter 10 is washed in the manner described above, re-concentration of the filtrate discharged together with the washing liquid can be suppressed.

Note that the tube connected to the port 11c of the main body 11 of the filter 10 does not necessarily need to be provided with a pump. Even in this case, the filtrate in the internal space 12h of the main body 11 of the filter 10 can be replaced with the cleaning liquid by operating the concentrated liquid tube feeding section 4p or the waste liquid tube feeding section 5p.

In addition, in the above description, the cleaning liquid bag SB is connected to the port 11c of the main body 11 of the filter 10 via the tube, but air is connected to the port 11c of the main body 11 of the filter 10 via the tube. May be supplied. Even in this case, the filtrate in the internal space 12h of the main body 11 of the filter 10 can be supplied to the concentrator 20 by air pressure. In this case, the interior space 12h of the main body 11 of the filter 10 is filled with air, so before cleaning, the interior space 12h is filled with a cleaning liquid. For example, if the cleaning liquid bag SB is connected to the port 11c of the main body 11 of the filter 10 and the cleaning liquid is supplied, the interior space 12h can be filled with the cleaning liquid.

Furthermore, in the above description, the stock solution is supplied into the through passage 16h of the plurality of hollow fiber membranes 16 of the hollow fiber membrane bundle 15 of the filter 10, and the filtrate is supplied to the body 12 of the main body 11 of the filter 10. The case where the liquid is discharged into the internal space 12h is explained. However, the stock solution is supplied from the filtrate discharge port 11c into the internal space 12h of the body 12 of the main body 11, and the filtered filtrate is passed through the flow path 16h of the plurality of hollow fiber membranes 16 of the hollow fiber membrane bundle 15. The liquid may be discharged into the interior and discharged to the outside from the stock solution supply port 11a. In this case, the filtrate supply tube 3 is connected to the stock solution supply port 11a, and the liquid supply tube 2 is connected to the filtrate discharge port 11c. When cleaning the filter in such a configuration, the filtrate present in the internal space 12h of the body 12 of the main body 11 of the filter 10 is sent to the concentrator 20 in advance in the same manner as described above. It is preferable to wash the filter and then wash the filter.

(Reconcentration work)
When further concentrating the concentrate obtained by the filtration and concentration operation, a reconcentration operation is performed.

As shown in FIG. 12, in the reconcentration work of the stock solution processing apparatus 1C of this embodiment, the other end of the connecting tube 9 is removed from the cleaning liquid bag SB, and the concentrated liquid bag CB is connected to the other end of the connecting tube 9. Ru.
Further, while maintaining a state in which the liquid can flow in the connection tube 9 by the flow rate adjustment means 9c, the cleaning liquid supply tube liquid feeding section 6p and the cleaning liquid recovery tube liquid feeding section 7p are not operated and function as a clamp. In addition, the inside of the liquid supply tube 2 is closed by the flow rate adjusting means 2c so that liquid does not flow therein. Then, the state is such that no liquid flows into the filter 10.

In the above state, the filtrate supply tube liquid sending part 3p is operated to flow the concentrate from the concentrate bag CB through the connecting tube 9 to the concentrator 20, and the filtrate supply tube liquid sending part 3p is operated to flow the concentrate from the concentrator 20 through the concentrate tube 4. The concentrate tube liquid feeding section 4p is operated so that the concentrate flows into the concentrate bag CB.

Then, the concentrate is supplied from the concentrate bag CB connected to the connecting tube 9 to the concentrator 20 through the connecting tube 9, so that the reconcentrate further concentrated by the concentrator 20 passes through the concentrate tube 4 to the concentrate bag. Collected by CB. On the other hand, the water separated from the concentrated liquid is collected through the waste liquid tube 5 into the waste liquid bag DB. In other words, a concentrated liquid (reconcentrated liquid) with an increased concentration ratio can be obtained.

The stock solution processing device of the present invention is a device for obtaining a concentrated solution by filtering and concentrating pleural and ascitic fluid containing cells, blood during surgery or bloodletting, and for purifying and reusing plasma such as waste plasma from plasma exchange. It is suitable as a device for

1 Stock solution processing device 2 Liquid supply tube 2c Flow rate adjusting means 2p Liquid supply tube feeding section 3 Filtrate supply tube 3c Flow rate adjusting means 3p Filtrate supply tube feeding section 4 Concentrate tube 4p Concentrate tube feeding section 5 Waste liquid tube 5c Flow rate adjustment means 6 Cleaning liquid supply tube 6c Flow rate adjustment means 6p Cleaning liquid supply tube feeding part 7 Cleaning liquid recovery tube 7c Flow rate adjustment means 7p Cleaning liquid recovery tube feeding part 9 Connection tube 9c Flow rate adjustment means 9f Flow rate adjustment means 9p Connection tube liquid feeding Part 10 Filter 10B Filter 11 Main body 11a Stock solution supply port 11b Washing solution supply port 11c Filtrate discharge port 12 Body 12h Internal space 15 Hollow fiber membrane bundle 16 Hollow fiber membrane 16h Through channel 16w Wall 17a Holding member 17b Filtration membrane 17h Space 17f Space 20 Concentrator 20a Filtrate supply port 20b Concentrated liquid discharge port 20c Waste liquid discharge port 100 Main body portion 103 Hanging portion 106 Control portion 110 Roller pump 120 Roller pump 150 Tube holder 155 Holding portion 152 Connection portion 153 Engagement member 160 Tube positioning member 161 Holding member 165 Connection member UB Stock solution bag CB Concentrate solution bag DB Waste solution bag SB Washing solution bag FB Washing solution collection bag GB Concentrator washing solution collection bag P1 Pressure gauge P2 Pressure gauge

Claims (10)

A method of using an apparatus for concentrating a stock solution to form a concentrated solution, the method comprising:
The device is
a filter having a filter member that filters the stock solution;
a concentrator supplied with the filtrate filtered by the filter, and concentrating the filtrate to form the concentrate;
a stock solution supply unit that supplies the stock solution to the filter;
a liquid supply channel that communicates between the stock solution supply section and a stock solution supply port that communicates with one end of the channel through which the stock solution of the filter is supplied;
a filtrate supply channel that communicates a filtrate outlet of the filter with a filtrate supply port of the concentrator;
a concentrate flow path connected to a concentrate outlet of the concentrator;
a waste liquid flow path connected to a waste liquid outlet for discharging the waste liquid separated from the concentrated liquid in the concentrator;
a liquid supply channel liquid sending section provided in the liquid supply channel;
A concentrate flow path liquid sending section provided in the concentrate flow path or a waste liquid flow path liquid sending section provided in the waste liquid flow path ,
Adjusting the amount of liquid flowing through each channel based on the concentrator transmembrane pressure difference of the concentrator,
When the concentrator transmembrane differential pressure is smaller than the set differential pressure of the concentrator, increasing the amount of the raw solution sent to the filter until the concentrator transmembrane differential pressure reaches the set differential pressure,
When the concentrator transmembrane pressure difference is within the range of the set differential pressure of the concentrator, maintaining the amount of the raw solution sent to the filter,
When the concentrator transmembrane differential pressure is larger than the set differential pressure of the concentrator, reduce the amount of raw solution sent to the filter until the concentrator transmembrane differential pressure reaches the set differential pressure. Features: How to operate the undiluted solution processing equipment. A method of using an apparatus for concentrating a stock solution to form a concentrated solution, the method comprising:
The device is
a filter having a filter member that filters the stock solution;
a concentrator supplied with the filtrate filtered by the filter, and concentrating the filtrate to form the concentrate;
a stock solution supply unit that supplies the stock solution to the filter;
a liquid supply channel that communicates between the stock solution supply section and a stock solution supply port that communicates with one end of the channel through which the stock solution of the filter is supplied;
a filtrate supply channel that communicates a filtrate outlet of the filter with a filtrate supply port of the concentrator;
a concentrate flow path connected to a concentrate outlet of the concentrator;
a waste liquid flow path connected to a waste liquid outlet for discharging the waste liquid separated from the concentrated liquid in the concentrator;
a filtrate supply channel liquid sending section provided in the filtrate supply channel;
A concentrate flow path liquid sending section provided in the concentrate flow path or a waste liquid flow path liquid sending section provided in the waste liquid flow path ,
Adjusting the amount of liquid flowing through each channel based on the concentrator transmembrane pressure difference of the concentrator,
When the concentrator transmembrane differential pressure is smaller than the set differential pressure of the concentrator, the amount of filtrate sent to the concentrator is increased until the concentrator transmembrane differential pressure reaches the set differential pressure. ,
When the concentrator transmembrane pressure difference is within the range of the set differential pressure of the concentrator, maintaining the amount of filtrate sent to the concentrator,
When the concentrator transmembrane differential pressure is larger than the set differential pressure of the concentrator, reducing the amount of filtrate sent to the concentrator until the concentrator transmembrane differential pressure reaches the set differential pressure. A method of operating a stock solution processing device characterized by: A method of using an apparatus for concentrating a stock solution to form a concentrated solution, the method comprising:
The device is
a filter having a filter member that filters the stock solution;
a concentrator supplied with the filtrate filtered by the filter, and concentrating the filtrate to form the concentrate;
a stock solution supply unit that supplies the stock solution to the filter;
a liquid supply channel that communicates between the stock solution supply section and a stock solution supply port that communicates with one end of the channel through which the stock solution of the filter is supplied;
a filtrate supply channel that communicates a filtrate outlet of the filter with a filtrate supply port of the concentrator;
a concentrate flow path connected to a concentrate outlet of the concentrator;
a waste liquid flow path connected to a waste liquid outlet for discharging the waste liquid separated from the concentrated liquid in the concentrator;
a liquid supply channel liquid sending section provided in the liquid supply channel;
A concentrate flow path liquid sending section provided in the concentrate flow path or a waste liquid flow path liquid sending section provided in the waste liquid flow path ,
Adjusting the amount of liquid flowing through each channel based on the concentrator transmembrane pressure difference of the concentrator,
When the concentrator transmembrane differential pressure is smaller than the set differential pressure of the concentrator, reduce the amount of concentrated liquid sent through the concentrate flow path until the concentrator transmembrane differential pressure reaches the set differential pressure. or increasing the amount of waste liquid sent through the waste liquid flow path;
When the concentrator transmembrane pressure difference is within the range of the set differential pressure of the concentrator, maintaining the amount of concentrated liquid in the concentrated liquid flow path or the amount of liquid sent in the waste liquid flow path,
If the concentrator transmembrane differential pressure is larger than the set differential pressure of the concentrator, increase the amount of concentrated liquid sent through the concentrate flow path until the concentrator transmembrane differential pressure reaches the set differential pressure, or A method for operating a stock solution processing device, comprising reducing the amount of waste solution sent through the waste solution channel. A method of using an apparatus for concentrating a stock solution to form a concentrated solution, the method comprising:
The device is
a filter having a filter member that filters the stock solution;
a concentrator supplied with the filtrate filtered by the filter, and concentrating the filtrate to form the concentrate;
a stock solution supply unit that supplies the stock solution to the filter;
a liquid supply channel that communicates between the stock solution supply section and a stock solution supply port that communicates with one end of the channel through which the stock solution of the filter is supplied;
a filtrate supply channel that communicates a filtrate outlet of the filter with a filtrate supply port of the concentrator;
a concentrate flow path connected to a concentrate outlet of the concentrator;
a waste liquid flow path connected to a waste liquid outlet for discharging the waste liquid separated from the concentrated liquid in the concentrator;
a filtrate supply channel liquid sending section provided in the filtrate supply channel;
A concentrate flow path liquid sending section provided in the concentrate flow path or a waste liquid flow path liquid sending section provided in the waste liquid flow path ,
Adjusting the amount of liquid flowing through each channel based on the concentrator membrane differential pressure of the concentrator,
When the concentrator transmembrane differential pressure is smaller than the set differential pressure of the concentrator, reduce the amount of concentrated liquid sent through the concentrate flow path until the concentrator transmembrane differential pressure reaches the set differential pressure. or increasing the amount of waste liquid sent through the waste liquid flow path;
When the concentrator transmembrane pressure difference is within the range of the set differential pressure of the concentrator, maintaining the amount of concentrated liquid in the concentrated liquid flow path or the amount of liquid sent in the waste liquid flow path,
If the concentrator transmembrane differential pressure is larger than the set differential pressure of the concentrator, increase the amount of concentrated liquid sent through the concentrate flow path until the concentrator transmembrane differential pressure reaches the set differential pressure, or A method for operating a stock solution processing apparatus, characterized in that the amount of waste solution sent through the waste solution channel is reduced. A method of using an apparatus for concentrating a stock solution to form a concentrated solution, the method comprising:
The device is
a filter having a filter member that filters the stock solution;
a concentrator supplied with the filtrate filtered by the filter, and concentrating the filtrate to form the concentrate;
a stock solution supply unit that supplies the stock solution to the filter;
a liquid supply channel that communicates between the stock solution supply section and a stock solution supply port that communicates with one end of the channel through which the stock solution of the filter is supplied;
a filtrate supply channel that communicates a filtrate outlet of the filter with a filtrate supply port of the concentrator;
a concentrate flow path connected to a concentrate outlet of the concentrator;
a waste liquid flow path connected to a waste liquid outlet for discharging the waste liquid separated from the concentrated liquid in the concentrator;
a concentrate flow path liquid feeding section provided in the concentrate flow path;
A waste liquid flow path liquid sending section provided in the waste liquid flow path ,
Adjusting the amount of liquid flowing through each channel based on the concentrator transmembrane pressure difference of the concentrator,
When the concentrator transmembrane differential pressure is smaller than the set differential pressure of the concentrator, reduce the amount of concentrated liquid sent through the concentrate flow path until the concentrator transmembrane differential pressure reaches the set differential pressure. and/or increasing the amount of waste liquid sent through the waste liquid flow path;
When the concentrator transmembrane pressure difference is within the set differential pressure of the concentrator, the amount of concentrated liquid sent through the concentrated liquid flow path and/or the amount of waste liquid sent through the waste liquid flow path is adjusted. maintain,
If the concentrator transmembrane differential pressure is larger than the set differential pressure of the concentrator, increase the amount of concentrated liquid sent through the concentrate flow path until the concentrator transmembrane differential pressure reaches the set differential pressure, and A method for operating a stock solution processing apparatus, characterized in that:/or the amount of waste solution sent through the waste solution channel is reduced. An apparatus for concentrating a stock solution to form a concentrated solution, the device comprising:
a filter having a filter member that filters the stock solution;
a concentrator supplied with the filtrate filtered by the filter, and concentrating the filtrate to form the concentrate;
a stock solution supply unit that supplies the stock solution to the filter;
a liquid supply channel that communicates between the stock solution supply section and a stock solution supply port that communicates with one end of the channel through which the stock solution of the filter is supplied;
a filtrate supply channel that communicates a filtrate outlet of the filter with a filtrate supply port of the concentrator;
a concentrate flow path connected to a concentrate outlet of the concentrator;
a waste liquid flow path connected to a waste liquid outlet for discharging the waste liquid separated from the concentrated liquid in the concentrator;
A liquid sending unit that sends liquid to each flow path;
A control unit that controls the liquid feeding unit,
The liquid sending part is
a liquid supply channel liquid sending section provided in the liquid supply channel;
A concentrate flow path liquid sending section provided in the concentrate flow path or a waste liquid flow path liquid sending section provided in the waste liquid flow path,
The control unit includes :
Each liquid feeding section is controlled based on the concentrator transmembrane pressure difference of the concentrator,
When the concentrator transmembrane differential pressure is smaller than the set differential pressure of the concentrator, the amount of raw solution sent to the filter is increased until the concentrator transmembrane differential pressure reaches the set differential pressure. controlling the liquid supply flow path liquid sending section,
When the concentrator transmembrane pressure difference is within the range of the set differential pressure of the concentrator, the liquid supply flow path liquid sending section is controlled to maintain the amount of the raw solution sent to the filter. ,
When the concentrator transmembrane differential pressure is larger than the set differential pressure of the concentrator, the amount of the raw solution sent to the filter is reduced until the concentrator transmembrane differential pressure reaches the set differential pressure. A stock solution processing device, characterized in that the liquid supply flow path liquid sending section is controlled. An apparatus for concentrating a stock solution to form a concentrated solution, the device comprising:
a filter having a filter member that filters the stock solution;
a concentrator supplied with the filtrate filtered by the filter, and concentrating the filtrate to form the concentrate;
a stock solution supply unit that supplies the stock solution to the filter;
a liquid supply channel that communicates between the stock solution supply section and a stock solution supply port that communicates with one end of the channel through which the stock solution of the filter is supplied;
a filtrate supply channel that communicates a filtrate outlet of the filter with a filtrate supply port of the concentrator;
a concentrate flow path connected to a concentrate outlet of the concentrator;
a waste liquid flow path connected to a waste liquid outlet for discharging the waste liquid separated from the concentrated liquid in the concentrator;
A liquid sending unit that sends liquid to each flow path;
A control unit that controls the liquid feeding unit,
The liquid sending part is
a filtrate supply channel liquid sending section provided in the filtrate supply channel;
A concentrate flow path liquid sending section provided in the concentrate flow path or a waste liquid flow path liquid sending section provided in the waste liquid flow path,
The control unit includes :
Each liquid feeding section is controlled based on the concentrator transmembrane pressure difference of the concentrator,
When the concentrator transmembrane differential pressure is smaller than the set differential pressure of the concentrator, the amount of filtrate sent to the concentrator is increased until the concentrator transmembrane differential pressure reaches the set differential pressure. Controlling the filtrate supply flow path liquid sending section as follows,
When the concentrator transmembrane pressure difference is within the range of the set differential pressure of the concentrator, the filtrate supply channel liquid sending section is configured to maintain the amount of filtrate sent to the concentrator. control,
When the concentrator transmembrane differential pressure is larger than the set differential pressure of the concentrator, the amount of filtrate sent to the concentrator is reduced until the concentrator transmembrane differential pressure reaches the set differential pressure. A stock solution processing device, characterized in that the filtrate supply channel liquid sending section is controlled to: An apparatus for concentrating a stock solution to form a concentrated solution, the device comprising:
a filter having a filter member that filters the stock solution;
a concentrator supplied with the filtrate filtered by the filter, and concentrating the filtrate to form the concentrate;
a stock solution supply unit that supplies the stock solution to the filter;
a liquid supply channel that communicates between the stock solution supply section and a stock solution supply port that communicates with one end of the channel through which the stock solution of the filter is supplied;
a filtrate supply channel that communicates a filtrate outlet of the filter with a filtrate supply port of the concentrator;
a concentrate flow path connected to a concentrate outlet of the concentrator;
a waste liquid flow path connected to a waste liquid outlet for discharging the waste liquid separated from the concentrated liquid in the concentrator;
A liquid sending unit that sends liquid to each flow path;
A control unit that controls the liquid feeding unit,
The liquid sending part is
a liquid supply channel liquid sending section provided in the liquid supply channel;
A concentrate flow path liquid sending section provided in the concentrate flow path or a waste liquid flow path liquid sending section provided in the waste liquid flow path,
The control unit includes :
Each liquid feeding section is controlled based on the concentrator transmembrane pressure difference of the concentrator,
When the concentrator transmembrane differential pressure is smaller than the set differential pressure of the concentrator, the amount of concentrated liquid sent through the concentrate flow path is reduced until the concentrator transmembrane differential pressure reaches the set differential pressure. or controlling the concentrate flow path liquid sending section or the waste liquid flow path liquid sending section so that the amount of waste liquid sent through the waste liquid flow path is increased;
When the concentrator transmembrane pressure difference is within the set differential pressure of the concentrator, the amount of concentrated liquid sent through the concentrated liquid flow path or the amount of waste liquid sent through the waste liquid flow path is maintained. controlling the concentrate flow path liquid sending section or the waste liquid flow path liquid sending section,
When the concentrator transmembrane differential pressure is larger than the set differential pressure of the concentrator, the amount of concentrated liquid sent through the concentrate flow path is increased until the concentrator transmembrane differential pressure reaches the set differential pressure, or An undiluted solution processing device, characterized in that the concentrated solution channel liquid feeding section or the waste liquid channel liquid feeding section is controlled so that the amount of waste liquid fed through the waste liquid channel is reduced. An apparatus for concentrating a stock solution to form a concentrated solution, the device comprising:
a filter having a filter member that filters the stock solution;
a concentrator supplied with the filtrate filtered by the filter, and concentrating the filtrate to form the concentrate;
a stock solution supply unit that supplies the stock solution to the filter;
a liquid supply channel that communicates between the stock solution supply section and a stock solution supply port that communicates with one end of the channel through which the stock solution of the filter is supplied;
a filtrate supply channel that communicates a filtrate outlet of the filter with a filtrate supply port of the concentrator;
a concentrate flow path connected to a concentrate outlet of the concentrator;
a waste liquid flow path connected to a waste liquid outlet for discharging the waste liquid separated from the concentrated liquid in the concentrator;
A liquid sending unit that sends liquid to each flow path;
A control unit that controls the liquid feeding unit,
The liquid sending part is
a filtrate supply channel liquid sending section provided in the filtrate supply channel;
A concentrate flow path liquid sending section provided in the concentrate flow path or a waste liquid flow path liquid sending section provided in the waste liquid flow path,
The control unit includes :
Each liquid feeding section is controlled based on the concentrator transmembrane pressure difference of the concentrator,
When the concentrator transmembrane differential pressure is smaller than the set differential pressure of the concentrator, the amount of concentrated liquid sent through the concentrate flow path is reduced until the concentrator transmembrane differential pressure reaches the set differential pressure. or controlling the concentrate flow path liquid sending section or the waste liquid flow path liquid sending section so that the amount of waste liquid sent through the waste liquid flow path is increased;
When the concentrator transmembrane pressure difference is within the set differential pressure of the concentrator, the amount of concentrated liquid sent through the concentrated liquid flow path or the amount of waste liquid sent through the waste liquid flow path is maintained. controlling the concentrate flow path liquid sending section or the waste liquid flow path liquid sending section,
When the concentrator transmembrane differential pressure is larger than the set differential pressure of the concentrator, the amount of concentrated liquid sent through the concentrate flow path is increased until the concentrator transmembrane differential pressure reaches the set differential pressure, or A stock solution processing device characterized in that the concentrated solution channel liquid feeding section or the waste liquid channel liquid feeding section is controlled so that the amount of waste liquid fed through the waste liquid channel is reduced. An apparatus for concentrating a stock solution to form a concentrated solution, the device comprising:
a filter having a filter member that filters the stock solution;
a concentrator supplied with the filtrate filtered by the filter, and concentrating the filtrate to form the concentrate;
a stock solution supply unit that supplies the stock solution to the filter;
a liquid supply channel that communicates between the stock solution supply section and a stock solution supply port that communicates with one end of the channel through which the stock solution of the filter is supplied;
a filtrate supply channel that communicates a filtrate outlet of the filter with a filtrate supply port of the concentrator;
a concentrate flow path connected to a concentrate outlet of the concentrator;
a waste liquid flow path connected to a waste liquid outlet for discharging the waste liquid separated from the concentrated liquid in the concentrator;
A liquid sending unit that sends liquid to each flow path;
A control unit that controls the liquid feeding unit,
The liquid sending part is
a concentrate flow path liquid feeding section provided in the concentrate flow path;
and a waste liquid flow path liquid sending section provided in the waste liquid flow path,
The control unit includes :
Each liquid feeding section is controlled based on the concentrator transmembrane pressure difference of the concentrator,
When the concentrator transmembrane differential pressure is smaller than the set differential pressure of the concentrator, the amount of concentrated liquid sent through the concentrate flow path is reduced until the concentrator transmembrane differential pressure reaches the set differential pressure. and/or controlling the concentrate flow path liquid sending section and/or the waste liquid flow path liquid sending section so that the amount of waste liquid sent through the waste liquid flow path is increased;
When the concentrator transmembrane pressure difference is within the set differential pressure of the concentrator, the amount of concentrated liquid sent through the concentrated liquid flow path and/or the amount of waste liquid sent through the waste liquid flow path is adjusted. controlling the concentrate flow path liquid sending section and/or the waste liquid flow path liquid sending section so as to maintain the
When the concentrator transmembrane differential pressure is larger than the set differential pressure of the concentrator, the amount of concentrated liquid sent through the concentrate flow path is increased until the concentrator transmembrane differential pressure reaches the set differential pressure. A stock solution processing device characterized in that the concentrated liquid flow path liquid sending section and/or the waste liquid flow path liquid sending section are controlled so that the amount of waste liquid sent through the waste liquid flow path is decreased.

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