JP2023105264A - Liquid concentrate processor, and operation method of liquid concentrate processor - Google Patents

Abstract

To provide a liquid concentrate processor capable of efficiently washing a channel, and an operation method of the liquid concentrate processor.SOLUTION: There is provided an operation method of a liquid concentrate processor which comprises: a filter 10 for filtering a liquid concentrate; and a concentrator 20 into which a filtrate filtered by the filter 10 is supplied, which concentrates the filtrate for forming concentrated liquid. The filter 10 comprises: a main body part 11 comprising an internal space 12h separated from a channel into which the liquid concentrate is supplied, by a filter member; a liquid concentrate supply port 11a and a washing fluid supply port 11b which are separated from the internal space 12h of the main body part 11 in a liquid-tight state, and are respectively connected to one/the other of both ends of the channel into which the liquid concentrate is supplied; and a filtrate discharge port 11c connected to the internal space 12h. In filtration and concentration work, in a state of closing the washing fluid supply port 11b, the liquid concentrate is supplied into the liquid concentrate supply port 11a, in washing work, the washing fluid supply port 11b is opened for flowing the washing fluid to a space between the liquid concentrate supply port 11a and the washing fluid supply port 11b.SELECTED DRAWING: Figure 1

Description

TECHNICAL FIELD The present invention relates to an undiluted solution processing apparatus and a method of operating the undiluted liquid processing apparatus. More specifically, a stock solution processing device that filters and concentrates a stock solution such as pleural and ascitic fluid that accumulates in the chest and abdomen of patients with carcinomatous pleural peritonitis, cirrhosis of the liver, and plasma waste fluid from plasmapheresis to obtain a treatment solution for intravenous drip infusion. The present invention relates to a method of operating a stock solution processing device.

In carcinomatous pleural peritonitis, liver cirrhosis, and the like, pleural effusion and ascites may accumulate in the thoracic and abdominal cavities. In such a state, pleural and ascitic effusion causes problems such as pressure on surrounding organs. In order to improve such problems, there are cases in which the pleural and ascitic fluid is removed by puncture.

On the other hand, pleural and ascitic fluid contains part or all of the plasma components leaked from the blood, and this plasma contains major proteins (eg, albumin, globulin, etc.). Although the above-mentioned symptoms can be improved by removing the pleural and ascitic fluid, the components useful for the human body, such as proteins, are lost along with the fluid. Therefore, it is necessary to replenish the lost components by intravenous administration of albumin preparations, globulin preparations, and the like.

However, intravenous administration of albumin preparations, globulin preparations, and the like makes it possible to replenish specific components, but the preparations are expensive and treatment costs increase.
Moreover, since only a limited amount of specific components can be supplied among the lost components, problems such as malnutrition and susceptibility to infection may occur.

Therefore, the so-called Cell-free and Concentrated Ascites Reinfusion Therapy (CART) has been developed, which is a therapeutic method in which a treated fluid obtained by treating pleural or ascites extracted from the thoracic or abdominal cavity is administered intravenously. there is In the case of such CART, most of the effective components other than the cellular components contained in the pleural effusion and ascites can be returned to the patient's body. can be supplied to the patient at Moreover, even if the concentrated liquid is administered, the deficient amount of the component can be supplemented by the formulation, so the amount of the albumin formulation or the like used can be reduced as much as possible, and the treatment cost can be suppressed.

In CART, the treatment fluid that is returned to the patient's body is produced by filtering and concentrating the pleural and ascites fluids. In a processing apparatus that generates such a treatment liquid, an undiluted liquid such as pleural effusion or ascites is supplied to a filter having a filtering member such as a hollow fiber membrane or a plate-like permeable membrane to obtain a liquid component (hereinafter sometimes referred to as a filtrate). ). By removing water from the filtrate by passing the separated filtrate through a concentrator, it is possible to obtain a concentrate obtained by concentrating the filtrate, that is, the above-described treated liquid (see Patent Documents 1 and 2).

By the way, in a filter, the undiluted liquid is filtered by the filtering member, but if the filtering member is defective, the undiluted liquid cannot be properly filtered, and there is a possibility that cells and the like, which should not be contained in the treated liquid, may be mixed into the filtrate. There is In order to prevent such cell fractions and the like from being included in the filtrate, it is necessary to check whether the filter member of the filter is damaged before processing the undiluted solution with the filter.

Since the filtering member of the filter used in CART is gas-impermeable, pressurized gas is supplied into the filter to check for damage to the filtering member (leak check). This leak check is performed as follows after the filter is attached to the processing equipment. First, one of the two ports (or the flow path communicating with the two ports) communicating with the flow path to which the undiluted solution is supplied in the filter is closed. In this state, pressurized gas is supplied from the other port, and the air pressure inside the flow path is measured through the port or the like. When the air pressure inside the channel reaches a predetermined pressure, the other port is also closed to check the fluctuation of the air pressure inside the channel. If the air pressure does not change for a certain period of time, it is determined that the filter member is not damaged, and if the air pressure fluctuates, it is determined that the filter member is damaged.

Japanese Patent No. 5062631 JP 2015-126763 A

In the processing equipment, the path from the bag containing the raw solution (raw solution bag) to the bag containing the processing solution (concentrated solution bag) must be kept closed from the outside so that it does not come into contact with air or the like. not. For this reason, after performing a leak check, when cleaning the flow path (hereinafter referred to as the circuit) in the processing apparatus where the undiluted solution flows, the air in the circuit, especially the undiluted solution, etc. is supplied to the filter. It is necessary to perform an operation to remove the air in the flow path (undiluted solution flow path).

However, since the undiluted solution channel of the filter is very narrow, it takes a long time to remove the air from the undiluted solution channel, and a large amount of cleaning liquid must be used to reliably remove the air.

Further, in the processing apparatus, there are cases where the filter member is washed after processing the undiluted solution. Backwashing is to wash the filter member and the like in the filter by flowing the washing liquid in the opposite direction to the flow of the solution during filtration or concentration.

In such backwashing, a large amount of washing liquid must be used for washing because the washing liquid must flow through the entire circuit or the entire channel in which the undiluted liquid or the like flows in the filter or the like. In addition, since the flow resistance of the raw solution flow path of the filter is high, and the washing liquid that has passed through the filtering member is supplied to the raw solution flow path of the filter, the washing liquid flowing through the raw liquid flow path of the filter can be prevented. The flow velocity and pressure are relatively small. As a result, there is a possibility that the undiluted solution flow channel of the filter cannot be sufficiently cleaned even if the cleaning liquid is passed through the undiluted solution flow channel of the filter.

SUMMARY OF THE INVENTION In view of such circumstances, it is an object of the present invention to provide an undiluted solution processing apparatus and a method of operating the undiluted liquid processing apparatus that can effectively clean a flow path.

(Washing 1)
A method of operating a concentrate processing apparatus according to a first aspect of the invention comprises a filter having a filter member for filtering the concentrate, and a concentrator supplied with a filtrate filtered by the filter and concentrating the filtrate to form a concentrate. and a method of operating a concentrate processing apparatus, wherein the filter includes a main body portion having an inner space isolated by a flow path to which the concentrate is supplied and the filtering member, and a raw liquid supply port and a cleaning liquid supply port that are liquid-tightly separated from an internal space and communicated with both ends of a flow path to which the raw liquid is supplied; and a filtered liquid discharge port that communicates with the internal space. During the filtration and concentration operation, the undiluted solution is supplied to the undiluted solution supply port with the cleaning fluid supply port closed, and during the cleaning operation, the undiluted solution supply port and the cleaning fluid are separated by opening the cleaning fluid supply port. It is characterized by flowing a cleaning liquid between it and the supply port.
A method for operating a concentrate processing apparatus of a second invention is characterized in that, in the first invention, the filtering device is a plurality of hollow fiber membranes in which the filtering members are bundled at one ends and at the other ends, and the body portion is a space for accommodating the hollow fiber membranes therein, communicated with both ends of the through-channels of the plurality of hollow fiber membranes, and liquid-tightly isolated from the internal space of the main body, A pair of header portions, which are spaces having a cross-sectional area larger than that of the through channel, are provided. Each header portion is provided with either the undiluted solution supply port or the cleaning liquid supply port. A channel communicating with the cleaning liquid supply port is provided with a negative pressure generating section for generating a negative pressure in the channel. It is characterized in that the negative pressure generating part is operated while the cleaning liquid is flowed between.
A method for operating a concentrate processing apparatus according to a third invention is characterized in that, in the first or second invention, the channel communicating with the concentrate supply port is provided with a negative pressure generating section for generating a negative pressure in the channel. The filter has a filtrate discharge port communicating with the internal space, and during cleaning work, the negative pressure generating unit is operated while the washing liquid is flowing through the filtrate discharge port. It is characterized by
(Washing 2)
A fourth aspect of the present invention provides a method of operating a liquid concentrate processing apparatus, comprising a filter having a filter member for filtering the liquid concentrate, and a concentrator supplied with a filtrate filtered by the filter and concentrating the filtrate to form a concentrate. and a method of operating a concentrate processing apparatus, wherein the filter includes a main body portion having an inner space isolated by a flow path to which the concentrate is supplied and the filtering member, and a raw liquid supply port and a cleaning liquid supply port that are liquid-tightly separated from an internal space and communicated with both ends of a flow path to which the raw liquid is supplied; and a filtered liquid discharge port that communicates with the internal space. , during the filtration and concentration operation, the undiluted solution is supplied to the undiluted solution supply port with the cleaning liquid supply port closed, and during the cleaning operation, the undiluted solution supply port or the undiluted solution supply port and the cleaning solution supply port are closed. The cleaning liquid is supplied to the inner space of the filter through the filtrate discharge port while both are open.
A method for operating a concentrate processing apparatus according to a fifth aspect of the present invention is characterized in that, in the method of the fourth aspect, the channel communicating with the concentrate supply port is provided with a negative pressure generating section for generating a negative pressure in the channel, During the cleaning operation, the negative pressure generating section is operated while the cleaning liquid is being supplied to the filtrate discharge port.
A method for operating the undiluted solution processing apparatus of the sixth invention is characterized in that, in the fourth or fifth invention, during the filtration and concentration operation, the liquid feed section provided in the flow path communicating with the filtrate discharge port is operated. It is characterized in that the filtrate is discharged from the filter to the concentrator, and the operation of the liquid feeding section provided in the flow path communicating with the filtrate discharge port is stopped during the cleaning operation.
(Washing 3)
A seventh aspect of the present invention provides a method for operating a liquid concentrate processing apparatus, comprising: a filter having a filter member for filtering the liquid concentrate; and a concentrator supplied with a filtrate filtered by the filter and concentrating the filtrate to form a concentrate. and a method of operating a concentrate processing apparatus, wherein the filter includes a main body portion having an inner space isolated by a flow path to which the concentrate is supplied and the filtering member, and a raw liquid supply port and a cleaning liquid supply port that are liquid-tightly separated from an internal space and communicated with both ends of a flow path to which the raw liquid is supplied; and a filtered liquid discharge port that communicates with the internal space. , the flow path communicated with the filtrate outlet is provided with a cleaning liquid feeding section for supplying cleaning liquid to the filtrate outlet and/or the filtrate outlet and the filtrate supply port of the concentrator are communicated with each other. A filtrate liquid feeding unit is provided in the filtrate supply channel, and during the filtration and concentration operation, the undiluted liquid is supplied to the undiluted liquid supply port with the cleaning liquid supply port closed, and the cleaning operation is performed. In some cases, the cleaning liquid is pushed into the internal space of the filter by the cleaning liquid feeding section through the filtered liquid discharge port or the filtered liquid feeding section.
An eighth aspect of the invention is directed to a method for operating a concentrate processing apparatus, wherein in the seventh aspect of the invention, the passage communicating with the undiluted solution supply port or the cleaning solution supply port includes a passage connected to the undiluted solution supply port or the cleaning solution supply port. When cleaning is performed, the cleaning liquid supply port and/or the undiluted solution supply port are opened, and the cleaning liquid is supplied from the undiluted solution supply port and/or the cleaning liquid supply port. It is characterized by actuating the liquid feeding part so as to flow out.
A method for operating the undiluted solution processing apparatus of the ninth invention is characterized in that, in the seventh or eighth invention, during the filtration and concentration operation, the filtrate supply flow communicating the filtrate discharge port and the filtrate supply port of the concentrator. Filtrate is discharged from the filter to the concentrator by operating a filtrate feeding section provided in the channel, and the filtrate supply channel is blocked by the filtrate feeding section during cleaning work. characterized by

(Undiluted solution processing device)
A method for operating a liquid concentrate processing apparatus according to a tenth aspect of the present invention is an apparatus for concentrating a liquid concentrate to form a concentrated liquid, which comprises a filter having a filter member for filtering the liquid concentrate, and a filtrate filtered by the filter. A concentrator for concentrating the filtrate to form the concentrate, a raw liquid supply unit for supplying the raw liquid to the filter, and a flow path to which the raw solution for the raw solution supply unit and the filter are supplied. a liquid feed channel that communicates with a raw liquid supply port that communicates with one end of a filter; a filtrate supply channel that communicates a filtrate discharge port of the filter and a filtrate supply port of the concentrator; and a concentrator. a concentrated liquid flow path connected to the concentrated liquid discharge port of the concentrator, a waste liquid flow path connected to the waste liquid discharge port for discharging the waste liquid separated from the concentrated liquid in the concentrator, and the filter in the filter A cleaning liquid supply channel connected to a filter cleaning liquid supply port communicating with the other end of the channel to which the undiluted solution is supplied, a cleaning liquid recovery channel communicating with the undiluted liquid supply port of the filter, and the filtered liquid supply. a connection channel communicating with the channel, wherein the cleaning liquid supply channel closes the cleaning liquid supply port during a filtration and concentration operation, and opens the cleaning liquid supply port during a cleaning operation. Alternatively, it has a clamping function for closing.
An eleventh aspect of the present invention is directed to a method of operating a concentrate processing apparatus according to the tenth aspect, wherein the liquid is sent to each of the filtrate supply channel, the concentrated liquid channel, the cleaning liquid supply channel, and the connection channel. A liquid feeding section is provided, and the connecting channel is connected between the liquid feeding section provided in the filtrate supply channel and the filter.
A method for operating a concentrate processing apparatus according to a twelfth invention is characterized in that, in the tenth invention, the filtrate supply channel, the concentrated liquid channel, and the cleaning liquid supply channel are provided with a liquid feeding unit for feeding liquid in each channel. It is characterized by being
A thirteenth aspect of the present invention is directed to a method for operating a concentrate processing apparatus according to the twelfth aspect, wherein the connection channel is connected between a liquid sending section provided in the filtrate supply channel and the concentrator. Characterized by
A method for operating a liquid concentrate processing apparatus according to a fourteenth aspect of the invention is characterized in that, in the tenth aspect of the invention, the liquid supply channel, the cleaning liquid recovery channel, the concentrated liquid channel, and the connecting channel are fed to each channel. A liquid part is provided.
A fifteenth aspect of the present invention is a method for operating a concentrate processing apparatus, in any one of the tenth to fourteenth aspects of the invention, wherein the filtering member is a hollow fiber membrane having a through-flow channel extending axially therethrough. .

(Washing 1)
According to the first invention, if the cleaning liquid is allowed to flow between the raw liquid supply port and the cleaning liquid supply port, the cleaning liquid can be directly supplied into the channel to which the raw liquid is supplied. can increase Moreover, the amount of cleaning liquid to be used can be reduced because it is only necessary to use an amount of cleaning liquid that can clean the channel to which the undiluted liquid is supplied.
According to the second invention, it becomes easier to remove large solids and the like accumulated in the header portion.
According to the third invention, the cleaning effect can be enhanced.
(Washing 2)
According to the fourth invention, if the cleaning liquid is allowed to flow through the filtered liquid discharge port into the internal space of the filter with the raw liquid supply port or both the raw liquid supply port and the cleaning liquid supply port opened, the direction of flow of the raw liquid is reversed. Since the cleaning liquid flows, clogging of the filtering member can be effectively eliminated.
According to the fifth and sixth inventions, the filter can be effectively washed.
(Washing 3)
According to the seventh invention, the cleaning liquid can be pushed into the internal space of the filter through the filtered liquid discharge port or the filtered liquid feeding section by the cleaning liquid feeding section. Clogging of the filtering member can be effectively eliminated.
According to the eighth and ninth inventions, the filter can be effectively washed.
(Undiluted solution processing device)
According to the tenth aspect of the present invention, the channels can be cleaned effectively by appropriately supplying the gas and the cleaning liquid to the channels arranged in each channel.
According to the eleventh invention, the undiluted solution can be supplied to the filter under negative pressure. Moreover, since the filter is washed under positive pressure, clogging of the flow path to which the stock solution is supplied can be effectively eliminated.
According to the twelfth and thirteenth inventions, the undiluted solution can be supplied to the filter under negative pressure. Moreover, it is possible to effectively wash the channel to which the undiluted solution is supplied in the filter.
According to the fourteenth invention, it is possible to effectively wash the inside of the flow path to which the undiluted solution is supplied in the filter.
According to the fifteenth invention, even if the filtering member is a hollow fiber membrane, the flow path can be effectively cleaned.

FIG. 2 is a schematic explanatory view of leak check work by the undiluted solution processing apparatus 1 of the present embodiment; It is a schematic explanatory drawing of preparation cleaning work of the undiluted-solution processing apparatus 1 of this embodiment. It is a schematic explanatory drawing of the filtration concentration work of the undiluted-solution processing apparatus 1 of this embodiment. FIG. 4 is a schematic explanatory diagram of the re-concentration work of the undiluted solution processing apparatus 1 of the present embodiment; 1 is a schematic explanatory diagram of a filter 10; FIG. FIG. 10 is a schematic explanatory diagram of preparatory cleaning work of the undiluted solution processing apparatus 1B of another embodiment. FIG. 10 is a schematic explanatory diagram of the filtration and concentration work of the undiluted solution processing apparatus 1B of another embodiment. FIG. 10 is a schematic explanatory diagram of a re-concentration operation of the undiluted solution processing apparatus 1B of another embodiment; It is a schematic explanatory drawing of 1 C of undiluted-liquid processing apparatuses of other embodiment. It is a schematic explanatory drawing of the leak check of 1 C of undiluted-liquid processing apparatuses of other embodiment. It is a schematic explanatory drawing of the leak check of 1 C of undiluted-liquid processing apparatuses of other embodiment. It is a schematic explanatory drawing of preparation washing|cleaning work of 1 C of undiluted-liquid processing apparatuses of other embodiment. It is a schematic explanatory drawing of the filtration concentration operation|work of 1 C of undiluted-liquid processing apparatuses of other embodiment. It is a schematic explanatory drawing of undiluted-solution processing apparatus 1D of other embodiment. It is a schematic explanatory drawing of the leak check of 1 C of undiluted-liquid processing apparatuses of other embodiment. It is a schematic explanatory drawing of another filter 10B.

The stock solution processing apparatus of the present invention is an apparatus for filtering and concentrating a stock solution such as pleural and ascitic fluid to obtain a processing solution that can be administered to a patient by a method such as intravenous drip infusion or intraperitoneal administration.

The raw liquid to be processed by the raw liquid processing apparatus of the present invention is not particularly limited, but examples thereof include pleural and ascitic fluid, blood plasma, and blood. Pleural and ascitic fluid is pleural or ascitic fluid that accumulates in the thoracic cavity or peritoneal cavity due to carcinomatous pleural peritonitis, liver cirrhosis, or the like. This pleural and ascitic fluid contains plasma components (proteins, hormones, sugars, lipids, electrolytes, vitamins, bilirubin, amino acids, etc.) leaked from blood vessels and organs, hemoglobin, cancer cells, macrophages, histiocytes, white blood cells, red blood cells, platelets, and bacteria. etc. are included. The undiluted solution processing apparatus of the present invention removes solids such as cancer cells, macrophages, histiocytes, white blood cells, red blood cells, platelets, and bacteria from the pleural and ascitic fluid, and concentrates the water and useful components contained in the pleural and ascitic fluid. can produce liquid.

Plasma includes waste plasma from plasma exchange therapy, and blood includes blood collected during surgery. In other words, reusable regenerated plasma can be produced by purifying waste plasma, blood collected during surgery, or the like using the undiluted solution processing apparatus of the present invention. In the undiluted solution processing apparatus of the present invention, in the case of waste plasma from plasma exchange therapy, a plasma component separator is used in place of the filter, and in the case of blood collected during surgery, the plasma separator is replaced with a plasma separator. You should use a device.

Moreover, the filter member used in the filter of the undiluted solution processing apparatus of the present invention is not particularly limited. A similar membrane may also be used to concentrate the filtrate in a concentrator. The filtration member used for such filtration and concentration permeates plasma, water, and the above-mentioned useful components contained in the pleural and ascitic fluid, but cancer cells, macrophages, histiocytes, leukocytes, erythrocytes, platelets, bacteria, etc. The material, size, and shape are not particularly limited as long as they are impermeable to cell components (that is, solid content) and impermeable to gas. For example, the shape of the filtering member may be a hollow fiber membrane, a flat membrane, a laminated membrane, or the like. Also, the filter member can be made of a material that exhibits a function of not permeating gas when wetted with a liquid. Of course, it is also possible to use a material formed of a material that exhibits a function of not permeating gas even in a state where it is not wetted with liquid. In this specification, the term "gas that does not permeate through the filtering member" means inert gas such as nitrogen, air, oxygen, etc., and means gas that is generally used for leak checks.

As one example, the hollow fiber membranes used in CART's ascites filter, plasma separator for plasmapheresis, plasma component separator for plasmapheresis, etc. may be used as filters and concentrators of the undiluted solution processing device of the present invention. be able to.

(Undiluted solution processing device 1 of the present embodiment)
Based on FIG. 3, the undiluted solution processing apparatus 1 of this embodiment will be described.

In addition, below, the case where the stock solution to be treated is pleural and ascitic fluid will be described as a representative.

Further, in the following description, each channel (liquid supply channel, filtrate supply channel, concentrated liquid channel, waste liquid channel, cleaning liquid supply channel, cleaning liquid recovery channel, connection channel) referred to in the scope of claims will be described. ) is formed of flexible tubes (liquid supply tube 2, filtrate supply tube 3, concentrated liquid tube 4, waste liquid tube 5, cleaning liquid supply tube 6, cleaning liquid recovery tube 7, connecting tube 9). Explain if there is However, each flow path may be formed of a flexible or inflexible pipe (for example, a hard plastic pipe, a steel pipe, a vinyl chloride pipe, etc.), a resin-molded integrated circuit, or the like.

Furthermore, in the following description, since each flow path is formed of a flexible tube, the description is based on the premise that a roller pump is used as the liquid feeding section of each flow path. However, the liquid sending unit may be any device that can send the liquid in each flow path, and may be appropriately selected according to the material of the pipes forming each flow path and the liquid flowing in the flow path. For example, an infusion pump, a diaphragm pump, or the like can also be used. In addition, since the roller pump exhibits a clamping function (a function that closes the flow path to prevent the flow of liquid) when the operation is stopped, the clamping function is not applied to the flow path provided with the liquid delivery part in the explanation below. No equipment is provided. However, when using a device that does not exhibit a clamping function even when the operation is stopped or a device that does not have a clamping function as the liquid feeding unit, a separate device with a clamping function should be installed in the flow path provided with the liquid feeding unit. (For example, a clamp, a clip, or the like) may be provided so that the instrument having the clamping function exhibits the clamping function when the operation of the liquid feeding section is stopped.

(Schematic configuration of undiluted solution processing apparatus 1 of the present embodiment)
First, a schematic configuration of the undiluted solution processing apparatus 1 of the present embodiment will be described.

In FIG. 3, reference numeral UB indicates a stock solution bag for containing the stock solution, that is, the pleural and ascitic fluid extracted from the chest or abdomen. Further, reference numeral CB indicates a concentrated solution bag containing a concentrated solution obtained by filtering and concentrating the stock solution. Furthermore, the symbol DB indicates a waste bag containing the waste liquid (that is, water) separated from the concentrate. Furthermore, reference numeral SB denotes a washing liquid bag containing washing liquid such as physiological saline and infusion (extracellular fluid), and reference numeral FB denotes a washing liquid recovery bag for collecting the washing liquid.

As shown in FIG. 3, in the undiluted solution processing apparatus 1 of this embodiment, the undiluted solution bag UB is connected to the filter 10 via the feed tube 2 . The liquid supply tube 2 is a tube that supplies the undiluted liquid in the undiluted liquid bag UB to the filter 10 . The liquid supply tube 2 is provided with a liquid supply tube liquid feeding portion 2p for feeding the liquid in the liquid supply tube 2 .

The filter 10 filters the undiluted liquid to produce filtrate. This filter 10 is connected to a concentrator 20 via a filtrate supply tube 3 . The filtrate supply tube 3 is a tube that supplies the filtrate produced by the filter 10 to the concentrator 20 . The filtrate supply tube 3 is provided with a flow rate adjusting means 3c such as a clamp or a clip for stopping and releasing the flow of the liquid in the filtrate supply tube 3 .

One end of a connecting tube 9 is connected to the filtrate supply tube 3 at a portion between the filter 10 and the flow rate adjusting means 3c. The connecting tube 9 is provided with a connecting tube liquid feeding section 9p for feeding the liquid in the connecting tube 9 .

A cleaning liquid bag SB is connected to the filter 10 via a cleaning liquid supply tube 6 . The cleaning liquid supply tube 6 is a tube that supplies the cleaning liquid from the cleaning liquid bag SB to the filter 10 . The cleaning liquid supply tube 6 is provided with flow rate adjusting means 6c such as a clamp or a clip for stopping and releasing the flow of the liquid in the cleaning liquid supply tube 6 .

Furthermore, the filter 10 is connected via a cleaning liquid recovery tube 7 to a cleaning liquid recovery bag FB that recovers the cleaning liquid used to clean the filter 10 . The cleaning liquid recovery tube 7 is provided with a cleaning liquid recovery tube liquid sending portion 7p for sending the liquid in the cleaning liquid recovery tube 7 .

The washing liquid collection tube 7 may be connected to the filter 10 via the liquid supply tube 2 or may be directly connected to the filter 10 .

The concentrator 20 produces a concentrate by concentrating the filtrate. This concentrator 20 is connected to a concentrated liquid bag CB via a concentrated liquid tube 4 . The concentrated liquid tube 4 is a tube that supplies the concentrated liquid concentrated by the concentrator 20 to the concentrated liquid bag CB. The concentrated liquid tube 4 is provided with a concentrated liquid tube liquid feeding section 4 p for feeding the liquid in the concentrated liquid tube 4 .

A waste liquid bag DB is connected to the concentrator 20 via a waste liquid tube 5 . The waste liquid tube 5 is a tube that supplies the waste liquid (moisture) separated from the concentrated liquid in the concentrator 20 to the waste liquid bag DB.

With the configuration as described above, in the undiluted solution processing apparatus 1 of the present embodiment, when the undiluted solution is supplied from the undiluted solution bag UB to the filter 10 through the supply tube 2, the undiluted solution is filtered by the filter 10 to obtain the filtrate. can be generated. Then, if the produced filtrate is supplied to the concentrator 20 through the filtrate supply tube 3, the concentrate can be produced by the concentrator 20, and the concentrate can be supplied through the concentrate tube 4. It can be collected in the bag CB.

On the other hand, if the cleaning liquid is supplied to the filter 10 from the cleaning liquid bag SB connected to the cleaning liquid supply tube 6, the filter 10 can be washed with the cleaning liquid. Further, by connecting a washing liquid bag SB to the concentrated liquid tube 4 instead of the concentrated liquid bag CB, the concentrator 20 can be washed with the washing liquid (see FIG. 2).

The work performed by the undiluted solution processing apparatus 1 of this embodiment will be described below.

(Preparatory cleaning work)
As shown in FIG. 2, in the preparatory cleaning operation of the undiluted solution processing apparatus 1 of the present embodiment, the cleaning solution bag SB is connected to the other end of the concentrated solution tube 4 instead of the concentrated solution bag CB, and the other end of the waste solution tube 5 is is connected to a washing liquid recovery bag FB instead of the waste liquid bag DB. The other end of the waste liquid tube 5 may remain connected to the waste liquid bag DB, or may be placed in a simple bucket or the like.
Also, a washing liquid collection bag FB is connected to the other end of the liquid supply tube 2 instead of the undiluted liquid bag UB. A waste liquid bag DB may be connected to the other end of the liquid supply tube 2, or may be placed in a simple bucket or the like.
Then, the other end of the connecting tube 9 is also connected to the washing liquid collection bag FB. A waste liquid bag DB may be connected to the other end of the connecting tube 9, or may be placed in a simple bucket or the like.

Next, the cleaning liquid is caused to flow through the filtrate supply tube 3 and the cleaning liquid supply tube 6 by the flow rate adjusting means 3c and the flow rate adjusting means 6c.

In the above state, the concentrated liquid tube liquid feed section 4p is operated so as to flow the washing liquid from the washing liquid bag SB connected to the concentrated liquid tube 4 to the concentrator 20. The connecting tube liquid feeding part 9p is operated so as to flow the cleaning liquid into the cleaning liquid collection bag FB connected to the 9. Then, the washing liquid is supplied to the concentrator 20 through the concentrated liquid tube 4 from the washing liquid bag SB connected to the concentrated liquid tube 4 . The supplied cleaning liquid passes through the concentrator 20 , passes through the filtrate supply tube 3 and the connecting tube 9 , and is collected in the cleaning liquid collection bag FB connected to the connecting tube 9 . Part of the washing liquid passes through the waste liquid tube 5 and is collected in the washing liquid collection bag FB connected to the other end of the waste liquid tube 5 .

In addition, the connection tube liquid feeding part 9p is operated so as to flow the washing liquid from the concentrator 20 to the washing liquid collection bag FB connected to the connection tube 9, and the washing liquid collection bag FB connected to the liquid supply tube 2 from the filter 10 is operated. The liquid supply tube liquid feeding section 2p is operated so as to flow the washing liquid to the . Then, the cleaning liquid is supplied to the filter 10 through the cleaning liquid supply tube 6 from the cleaning liquid bag SB connected to the cleaning liquid supply tube 6 . After passing through the filter 10, part of the supplied cleaning liquid passes through the filtrate supply tube 3 and the connecting tube 9, and is collected in the cleaning liquid collection bag FB connected to the connecting tube 9. It passes through the tube 2 and is collected in the washing liquid collection bag FB connected to the liquid supply tube 2 . Further, part of the cleaning liquid supplied to the filter 10 can also flow through the cleaning liquid recovery tube 7 by operating the cleaning liquid recovery tube liquid sending unit 7p.

Then, since the cleaning liquid can flow through the filter 10, the concentrator 20 and all the tubes, the entire undiluted solution processing apparatus 1 of the present embodiment can be cleaned.

In FIG. 2, the washing liquid is generated by operating the liquid supply tube liquid feeding section 2p and the cleaning liquid collection tube liquid feeding section 7p to suck out the cleaning liquid from the filter 10 and generate a flow of the cleaning liquid in the filter 10. The inside of the filter 10 is washed with. However, the inside of the filter 10 may be washed by pushing the cleaning liquid into the filter 10 to generate a flow of the cleaning liquid in the filter 10 .

For example, in FIG. 2, instead of the flow rate adjusting means 6c, the cleaning liquid supply tube 6 is provided with a cleaning liquid supply tube liquid sending portion 6p (see FIG. 6), and the cleaning liquid recovery tube 7 is provided instead of the cleaning liquid recovery tube liquid sending portion 7p to adjust the flow rate. Means 7c are provided. Then, the cleaning liquid collection tube 7 is opened by the flow rate adjusting means 7c, and the cleaning liquid supply tube liquid sending section 6p is operated so that the cleaning liquid flows through the cleaning liquid supply tube 6 from the cleaning liquid bag SB toward the filter 10. Then, the washing liquid can be pushed into the filter 10 and a flow of the washing liquid can be generated in the filter 10, so that the inside of the filter 10 can be washed with the washing liquid. In this case, the cleaning liquid may be supplied to the liquid supply tube 2 by operating the liquid supply tube liquid feeding portion 2p of the liquid supply tube 2 so as to suck out the cleaning liquid from the filter 10 . Alternatively, the cleaning liquid may flow only through the cleaning liquid collection tube 7 without operating the liquid supply tube liquid sending section 2p.

(Filtration concentration work)
After the preparatory cleaning work is completed, the filtration and concentration work is performed.

As shown in FIG. 3, in the filtration and concentration operation of the undiluted solution processing apparatus 1 of the present embodiment, the concentrated solution bag CB is connected to the concentrated solution tube 4 in place of the cleaning solution bag SB from the state of the preparatory cleaning operation, and the cleaning solution recovery bag is connected to the concentrated solution tube 4. A waste liquid bag DB is connected to the waste liquid tube 5 in place of the FB.
On the other hand, the undiluted solution bag UB is connected to the liquid supply tube 2 in place of the washing solution collection bag FB.
Further, the flow rate adjusting means 3c maintains a state in which the liquid can flow through the inside of the filtrate supply tube 3, while the flow rate adjusting means 6c closes the inside of the cleaning liquid supply tube 6 so that the liquid does not flow. In addition, the washing liquid collection tube liquid feeding section 7p and the connection tube liquid feeding section 9p are not operated, but are made to function as clamps.

In the above state, the feed tube liquid sending unit 2p is operated to flow the concentrate from the concentrate bag UB connected to the feed tube 2 to the filter 10, and the concentrator 20 is connected to the concentrate tube 4. The concentrated liquid tube liquid sending part 4p is operated so as to flow the concentrated liquid into the concentrated liquid bag CB.

Then, the stock solution is supplied from the stock solution bag UB to the filter 10 through the supply tube 2 . The supplied undiluted liquid is filtered by the filter 10 , and the produced filtrate is supplied to the concentrator 20 through the filtrate supply tube 3 . Then, the filtrate supplied to the concentrator 20 is concentrated by the concentrator 20, and the produced concentrated liquid is collected through the concentrated liquid tube 4 into the concentrated liquid bag CB. On the other hand, the water separated from the concentrated liquid is collected in the waste liquid bag DB through the waste liquid tube 5 .

(About filter cleaning)
In addition, during the filtration and concentration operation of the undiluted solution processing apparatus 1 of the present embodiment, the filtration member of the filter 10 (the plurality of hollow fiber membranes 16 of the hollow fiber membrane bundle 15 in FIG. 5, the filtration membrane 17b in FIG. 16) is removed. May be washed. Specifically, in FIG. 3, the inside of the filtrate supply tube 3 is blocked by the flow rate adjusting means 3c so that the liquid does not flow. In addition, the operation of the liquid supply tube liquid feeding section 2p is stopped to function as a clamp. On the other hand, the liquid can flow into the cleaning liquid supply tube 6 by the flow rate adjusting means 6c.

In the above state, if the cleaning liquid recovery tube liquid sending unit 7p is operated so as to flow the liquid from the filter 10 to the cleaning liquid recovery bag FB connected to the cleaning liquid recovery tube 7, the flow path (Fig. 5, the inside of the hollow fiber membrane 16, and the gap between the filtration membranes 17b in FIG. The inside of the passage can be washed.

In addition to the above state, if the connecting tube liquid feeding part 9p is operated so that the washing liquid flows from the washing liquid bag SB connected to the connecting tube 9 to the filter 10, the washing liquid bag SB connected to the connecting tube 9 is operated. The washing liquid is also supplied to the filter 10 from the Then, the cleaning liquid passes through the filter member in the direction opposite to the direction in which the filtrate passes through the filter member, so that the clogging of the filter member can be eliminated. In this case, since the cleaning liquid is supplied to the filter 10 from both the cleaning liquid bag SB connected to the cleaning liquid supply tube 6 and the cleaning liquid bag SB connected to the connecting tube 9, the cleaning liquid recovery tube is supplied to the cleaning liquid recovery tube by the cleaning liquid recovery tube liquid feeding unit 7p. The operation of the cleaning liquid collection tube liquid feeding section 7p and the connecting tube liquid feeding section 9p is adjusted so that the flow rate of the cleaning liquid flowing through the connecting tube liquid feeding section 9p is greater than the flow rate of the cleaning liquid flowing through the connecting tube 9 by the connecting tube liquid feeding section 9p. .

Note that the washing liquid collection tube liquid feeding section 7p and the connecting tube liquid feeding section 9p may be operated while the flow rate adjusting means 6c is closed. In this case, the cleaning liquid is supplied to the filtered liquid 10 only from the cleaning liquid bag SB connected to the connecting tube liquid feeding section 9p. In this case also, the washing liquid passes through the filtering member in the direction opposite to the direction in which the filtered liquid passes through the filtering member, so that clogging of the filtering member can be eliminated.

(Re-concentration work)
When further concentrating the concentrate obtained by the filtration concentration operation, a re-concentration operation is carried out.

As shown in FIG. 4, in the re-concentrating operation of the undiluted solution processing apparatus 1 of this embodiment, the other end of the connecting tube 9 is removed from the cleaning solution bag SB, and the other end of the connecting tube 9 is connected to the concentrated solution bag CB. be.
In addition, while maintaining the state in which the liquid can flow in the filtrate supply tube 3 by the flow rate adjusting means 3c, the liquid supply tube liquid feeding section 2p and the washing liquid collection tube liquid feeding section 7p are not operated and are made to function as clamps. . In addition, the inside of the cleaning liquid supply tube 6 is blocked by the flow rate adjusting means 6c so that the liquid does not flow. Then, the liquid does not flow through the filter 10 .

In the above state, the connecting tube liquid feeding part 9p is operated so that the concentrated liquid flows from the concentrated liquid bag CB through the connecting tube 9 to the concentrator 20, and from the concentrator 20 to the concentrated liquid bag CB through the concentrated liquid tube 4. The concentrated liquid tube liquid sending part 4p is operated so that the liquid flows.

Then, since the concentrated liquid is supplied from the concentrated liquid bag CB connected to the connecting tube 9 to the concentrator 20 through the connecting tube 9, the re-concentrated liquid further concentrated by the concentrator 20 passes through the concentrated liquid tube 4 to the concentrated liquid bag. Collected in CB. On the other hand, the water separated from the concentrated liquid is collected in the waste liquid bag DB through the waste liquid tube 5 . That is, it is possible to obtain a concentrated liquid (re-concentrated liquid) with an increased concentration ratio.

(Detailed Description of Filter 10)
In the undiluted solution processing apparatus 1 of the present embodiment, each bag, the filter 10 and the concentrator 20 are connected as described above. are connected as follows, cleaning and leak checking of the filter 10 can be effectively carried out.
The configuration of the filter 10, the connection of each tube to the filter 10, and the cleaning and leak check of the filter 10 will be described below.

(filter 10)
The filter 10 is, for example, an ascites filter used for CART, a plasma separator used for plasmapheresis, a plasma component separator, or the like. The filter 10 has a filtering member housed therein, and can filter the pleural and ascitic fluid with the filtering member to separate it into a filtrate and a separated liquid containing cells and the like.

The structure of the filter 10 when the filtering member is the hollow fiber membrane 16 will be described below with reference to FIG.

As shown in FIG. 5 , this filter 10 has a body portion 11 and a hollow fiber membrane bundle 15 arranged in this body portion 11 .

(Hollow fiber membrane bundle 15)
As shown in FIG. 5, the hollow fiber membrane bundle 15 is configured by bundling a plurality of hollow fiber membranes 16 .

The hollow fiber membrane 16 is a tubular member having a wall 16w with an annular cross section and a through channel 16h formed inside the wall 16w so as to penetrate the hollow fiber membrane 16 in the axial direction. The walls 16w of the hollow fiber membranes 16 have a function of impermeability of solids such as cells and gases but permeation of liquids.

The hollow fiber membrane bundle 15 is formed by bundling a plurality of hollow fiber membranes 16 at their one ends and at their other ends. In other words, the hollow fiber membrane bundle 15 is formed by bundling a plurality of hollow fiber membranes 16 such that the through-channel 16h of each hollow fiber membrane 16 penetrates between one end and the other end of the hollow fiber membrane bundle 15. ing.

The ends of the multiple hollow fiber membranes 16 do not necessarily have to be bundled together. In that case, both ends of the through-channels 16h of the plurality of hollow fiber membranes 16 are arranged to communicate with the pair of header portions 13 and 14 of the main body portion 11, respectively.

(Body part 11)
As shown in FIG. 5, the main body 11 includes a body 12 having an internal space 12h, which is a space airtight and liquid-tightly isolated from the outside. The internal space 12 of the body portion 12 is formed to communicate with the outside only through a port, which will be described later, and accommodates the hollow fiber membrane bundle 15 described above. The internal space 12 is airtightly separated from the through-channel 16h of the plurality of hollow fiber membranes 16 in a state in which the above-described hollow fiber membrane bundle 15 is housed inside, but liquid flows between them through the wall 16w. It is possible to pass through. In other words, the liquid inside the internal space 12 can be supplied to the through flow channel 16 h, and the liquid inside the through flow channel 16 h can be supplied to the internal space 12 .

Note that the size and shape of the internal space 12 are not particularly limited. In the state in which the hollow fiber membrane bundle 15 is accommodated, the liquid that has flowed into the internal space 12 through the port flows between the hollow fiber membrane bundle 15 and the inner surface of the body portion 12 (that is, the inner surface of the internal space 12) and a plurality of pipes. It is sufficient if the size is such that it can flow between the hollow fiber membranes 16 and flow through the walls 16w of the hollow fiber membranes 16 into the through channel 16h. In addition, the liquid that has flowed out from the through-channel 16h into the internal space 12 through the walls 16w of the hollow fiber membranes 16 flows between the plurality of hollow fiber membranes 16 and between the hollow fiber membrane bundle 15 and the inner surface of the internal space 12. It is sufficient if it is large enough to flow through and out of the port.

As shown in FIG. 5, the body portion 11 is provided with a pair of header portions 13 and 14 so as to sandwich the body portion 12, that is, to sandwich an internal space 12h. The pair of header portions 13 and 14 is a space airtight and liquid-tightly isolated from the inner space 12h of the body portion 12 and the outside, and is formed so as to communicate with the outside only through a port, which will be described later. ing. Each end of the hollow fiber membrane bundle 15 is connected to the pair of headers 13 and 14, respectively. Specifically, the hollow fiber membrane bundle 15 is arranged such that the openings at both ends of the through-channels 16h of the plurality of hollow fiber membranes 16 constituting the hollow fiber membrane bundle 15 communicate with the insides of the pair of header portions 13 and 14. are connected to a pair of header portions 13 and 14, respectively. Therefore, the pair of header portions 13 and 14 are in a state of being communicated with each other by the through passages 16 h of the plurality of hollow fiber membranes 16 forming the hollow fiber membrane bundle 15 .

(Each port 11a to 11c)
In addition, as described above, the body portion 11 is provided with ports 11a to 11c that communicate with the interior space 12h of the body portion 12 formed in the body portion 11 and the pair of header portions 13 and 14 and the outside. .

As shown in FIG. 5, one end of the body portion 11 is provided with a concentrate supply port 11a that communicates the header portion 13 with the outside. To this undiluted solution supply port 11a is connected one end of a liquid supply tube 2, the other end of which is connected to the liquid discharge port of the undiluted solution bag UB (see FIG. 3).

Further, a washing liquid recovery bag FB is communicated with the undiluted liquid supply port 11a via the liquid supply tube 2 or directly with the undiluted liquid supply port 11a. Specifically, one end of the cleaning liquid recovery tube 7, the other end of which is connected to the cleaning liquid recovery bag FB, is connected to the liquid supply tube 2 or the undiluted liquid supply port 11a (see FIG. 3).

A side surface of the body portion 12 of the body portion 11 is provided with a filtrate discharge port 11c that communicates between the internal space 12h and the outside. One end of the filtrate supply tube 3, the other end of which is connected to the filtrate supply port 20a of the concentrator 20, is connected to the filtrate discharge port 11c (see FIG. 3). Although two filtrate discharge ports 11c are provided in FIG. 5, the number of filtrate discharge ports 11c may be one.

A cleaning liquid supply port 11b is provided at the other end of the body portion 11 so as to communicate the header portion 14 with the outside. One end of a cleaning liquid supply tube 6, the other end of which is connected to the cleaning liquid bag SB, is connected to the cleaning liquid supply port 11b (see FIG. 3).

(Function of Filter 10)
The filter 10 has the structure described above, and the ports 11a to 11c of the main body 11 are connected to the undiluted solution bag UB and the washing solution bag SB through respective tubes as described above. For this reason, if the liquid supply tube liquid feeding part 2p is operated to supply the raw liquid from the raw liquid bag UB to the header section 13 of the main body 11 through the liquid supply tube 2 and the raw liquid supply port 11a, the hollow fiber membrane bundle 15 can be produced. Since the undiluted solution is supplied into the through channel 16 h of the hollow fiber membranes 16 , the undiluted solution is filtered by the hollow fiber membranes 16 . That is, the solid content contained in the stock solution cannot pass through the hollow fiber membranes 16 and remains in the through channel 16h. A filtrate can be obtained.

After the filtrate is discharged from the hollow fiber membrane 16 into the internal space 12h of the body portion 12 of the main body 11, it passes through the filtrate discharge port 11c, the filtrate supply tube 3, and the filtrate supply port 20a of the concentrator 20. and supplied to the concentrator 20 from the internal space 12h.

On the other hand, the filter 10 can be cleaned by operating the cleaning liquid collection tube liquid sending part 7p (or the liquid supply tube liquid sending part 2p) to suck out the liquid from the filter 10 . That is, since the cleaning liquid can be supplied from the cleaning liquid bag SB to the header section 14 of the main body 11 through the cleaning liquid supply tube 6 and the cleaning liquid supply port 11b, the flow path 16h through the hollow fiber membrane 16 from the header section 14 can flow into the flow path 16h. A cleaning liquid can be supplied (see FIG. 2). That is, since the cleaning liquid flows from the header portion 14 toward the header portion 13, the inside of the through channel 16h of the hollow fiber membrane 16, especially the inner surface of the through channel 16 (the inner surface of the wall 16w) is can be cleaned by a cleaning liquid flowing along the As a result, the solid content adhering to the inner wall of the through-flow channel 16h of the hollow fiber membrane 16 can be effectively flushed.

In particular, cleaning of the hollow fiber membrane 16 can be effectively carried out in the following manner.

First, the filtrate supply tube 3 and the connection tube 9 are closed by the flow rate adjusting means 3c provided in the filtrate supply tube 3 and the connection tube liquid feeding portion 9p provided in the connection tube 9 . On the other hand, the cleaning liquid supply tube 6 is opened by the flow rate adjusting means 6c. In this state, the cleaning liquid recovery tube liquid feeding part 7p of the cleaning liquid recovery tube 7 is operated.

As a result, a negative pressure is generated in the cleaning liquid recovery tube 7 upstream of the cleaning liquid recovery tube feeding section 7p, that is, in a portion on the filter 10 side. When such a negative pressure is generated, the cleaning liquid from the cleaning liquid bag SB flows through the cleaning liquid supply tube 6, the cleaning liquid supply port 11b, the header section 14, the through flow path 16h of the hollow fiber membrane 16, the header section 13, and the stock liquid supply. It flows into the washing liquid collection tube 7 through the port 11a.

At this time, since the filtrate supply tube 3 and the connecting tube 9 are closed, the washing liquid does not flow from the hollow fiber membranes 16 to the internal space 12h, but flows only through the through-channel 16h of the hollow fiber membranes 16. As a result, only the pair of header portions 13 and 14 and the inside of the through-channel 16h of the hollow fiber membranes 16 can be washed with the washing liquid, so that the amount of washing liquid used for washing the filter 10 can be reduced.

Moreover, since the internal space 12h is not washed, even when the filter 10 is washed after performing filtration and concentration, the filtrate can remain in the internal space 12h. Then, since it is possible to prevent the filtrate in the internal space 12h from being discharged together with the cleaning liquid, it is possible to prevent a decrease in the recovery rate of the filtrate.

When cleaning the filter 10, both the liquid supply tube liquid feeding section 2p of the liquid supply tube 2 and the cleaning liquid recovery tube liquid delivery section 7p of the cleaning liquid recovery tube 7 may be operated.
Further, when cleaning the filter 10, the supply liquid tube liquid delivery section 2p may be operated instead of the cleaning liquid collection tube liquid delivery section 7p. In this case, since the undiluted liquid in the through-channel 16h of the hollow fiber membrane 16 can also be recovered in the undiluted liquid bag UB together with the cleaning liquid, if the cleaning liquid containing the recovered undiluted liquid is supplied to the filter again, the recovery rate of the filtrate can be improved. can prevent a decline in

In addition, as described above, when both or one of the liquid supply tube liquid feeding section 2p and the washing liquid collection tube liquid feeding section 7p is operated, a negative pressure is also generated in the through channel 16h of the hollow fiber membrane 16. do. Then, even if the walls 16w of the hollow fiber membranes 16 are clogged with solids, the solids can be sucked out, so that clogging of the walls 16w of the hollow fiber membranes 16 can also be eliminated.

If the main purpose is to eliminate clogging of the walls 16w of the hollow fiber membranes 16, the cleaning solution bag SB is connected to the connection tube 9, and the cleaning solution flows from the cleaning solution bag SB toward the filter 10. You may operate the connection tube liquid-feeding part 9p like this. In this case, since the inner space 12h is substantially washed, the amount of washing liquid used is increased, but clogging of the walls 16w of the hollow fiber membranes 16 can be more easily eliminated. In other words, in addition to the above-described suction effect due to the negative pressure, the cleaning liquid is pushed in by the connection tube liquid feeding portion 9p.

Furthermore, if the cleaning operation is performed as described above, clogging of the header portion 13 to which the undiluted solution is supplied can be easily eliminated.

In the header portion 13 to which the undiluted solution is supplied, the solid content contained in the undiluted solution is supplied to the liquid supply tube 2 as it is. It may become clogged with. However, as described above, if a negative pressure is generated in the cleaning liquid recovery tube 7 on the filter 10 side rather than the cleaning liquid recovery tube liquid sending portion 7p, the solid content is removed from the header portion 13 by this negative pressure. Since it can be sucked out to the recovery tube 7, the clogging of the header portion 13 can be eliminated. Also in this case, the washing liquid bag SB may be connected to the connecting tube 9, and the connecting tube liquid feeding section 9p may be operated so that the washing liquid flows from the washing liquid bag SB toward the filter 10. FIG. Then, in addition to the effect of sucking out by the negative pressure described above, the effect of pushing the cleaning liquid by the connecting tube liquid feeding portion 9p also occurs, so that the clogging of the header portion 13 can be more easily eliminated. In the case of the above configuration, the cleaning liquid collecting tube liquid feeding section 7p corresponds to the negative pressure generating section recited in the claims.

(leak check)
Also, in the filter 10, if the plurality of hollow fiber membranes 16 of the hollow fiber membrane bundle 15 are broken, when the stock solution is supplied to the plurality of hollow fiber membranes 16 of the hollow fiber membrane bundle 15, the stock solution will not be filtered. There is a possibility that it will leak into the internal space 12h without being blocked. Similarly, if airtightness or liquidtightness is not maintained between the inner space 12h and the pair of header portions 13, 14, there is a possibility that the undiluted liquid will leak into the inner space 12h without being filtered. Therefore, it is necessary to check for leaks in the filter 10 (leak check) before processing the undiluted solution. In the case of the undiluted solution processing apparatus 1 of this embodiment, the leak check can be performed by the following method.

The leak check work is explained below.
When preparatory cleaning is performed, the leak check operation is performed before preparatory cleaning. Therefore, as shown in FIG. 1, the case where the leak check operation is performed while the undiluted solution processing apparatus 1 of the present embodiment is in the state immediately before preparatory cleaning will be described below.
Also, a case where a branch tube 9b communicating with the connecting tube 9 is provided in the connecting tube 9, and a pressurized gas supply section GS for supplying a pressurized gas in the leak check operation is provided in the branch tube 9b of the connecting tube 9 will be described. do. In this case, the branch tube 9b is provided with flow rate adjusting means 9c for closing and opening the branch tube 9b.

(first method)
First, as shown in FIG. 1 , a pressure gauge P1 for measuring the pressure inside the filtrate supply tube 3 is installed in the filtrate supply tube 3 . The pressure gauge P1 may be temporarily installed during the leak check work, or may be permanently installed during the filtration and concentration work. In the case of permanent installation, a pressure gauge P1 capable of measuring both air pressure and liquid pressure is used.

Then, the filtrate supply tube 3 is closed by the flow rate adjusting means 3c, the operation of the connecting tube liquid feeding portion 9p of the connecting tube 9 is stopped, and the branch tube 9b is closed by the flow rate adjusting means 9c. Then, the internal space 12h of the main body 11 is airtightly cut off from the outside.

On the other hand, the liquid supply tube liquid sending portion 2p connected to the liquid supply tube 2 and the cleaning liquid recovery tube liquid sending portion 7p connected to the cleaning liquid recovery tube 7 were not operated, and the cleaning liquid supply tube 6 was also closed by the flow rate adjusting means 6c. state. Then, both the pair of header portions 13 and 14 and the inside of the through passage 16h of the hollow fiber membranes 16 of the hollow fiber membrane bundle 15 are airtightly shut off from the outside.

In the above state, when the flow rate adjusting means 9c is opened and the pressurized gas is supplied from the pressurized gas supply portion GS to the branch tube 9b, the pressurized gas is introduced into the internal space 12h of the body portion 12 of the main body portion 11. The pressure inside the internal space 12h (in other words, the pressure inside the connecting tube 9 and the branch tube 9b) rises. Then, when the pressure in the internal space 12h measured by the pressure gauge P1 reaches or exceeds a certain pressure, the supply of the pressurized gas by the pressurized gas supply unit GS is stopped, and the branch tube 9b is closed by the flow rate adjusting means 9c. .

Here, if the plurality of hollow fiber membranes 16 of the hollow fiber membrane bundle 15 are broken, or if there is a defect in the airtightness or liquid tightness between the internal space 12h and the pair of header portions 13, 14, that The pressurized gas leaks into the through channel 16h of the hollow fiber membrane 16 or into the pair of header portions 13 and 14 from a location (defective location). As a result, the pressure in the internal space 12h is lowered, and leakage of the filter 10 can be confirmed by confirming the fluctuation of the air pressure measured by the pressure gauge P1.

Then, when the leak check is performed by the above method, gas does not enter the through channel 16h of the hollow fiber membrane 16 if there is no defective portion. In other words, since the leak check can be performed without introducing gas into the through-flow passage 16h of the hollow fiber membrane 16, the air removal operation after the leak check can be reliably performed in a short time.

In addition, when the leak check is performed by the above method, the through passages 16h of the plurality of hollow fiber membranes 16 of the hollow fiber membrane bundle 15 and the portions communicating with the through passages 16h (the pair of header portions 13, 14, the air pressure of the liquid supply tube 2, the cleaning liquid supply tube 6, and the cleaning liquid recovery tube 7) is preferably lowered. Then, when pressurized gas is supplied from the pressurized gas supply unit GS through the branch tube 9b, leakage from the defective portion is likely to occur. In this case, when the branch tube 9b is blocked by the flow rate adjusting means 9c, the air pressure fluctuates more quickly when there is a defect, so the leak check work time can be shortened. In addition, if the air pressure in the through passage 16h is low, even if pressurized gas is supplied, it takes a long time for the pressure in the internal space 12h to rise above a certain level due to leakage from the defective portion. . Then, by checking this time, it is possible to check the presence or absence of a defective portion.

In the above example, not only the internal space 12h, but also the pair of header portions 13 and 14 and the inside of the through passage 16h of the hollow fiber membranes 16 of the hollow fiber membrane bundle 15 are airtightly shut off from the outside. However, the pair of header portions 13 and 14 and the through passages 16h of the hollow fiber membranes 16 of the hollow fiber membrane bundle 15 may be communicated with the outside.

(Second method)
In the first method, the leak check was performed by measuring the pressure in the internal space 12h. may be implemented. That is, the leak may be confirmed not only by the pressure gauge P1 but also by the pressure gauge P2. For example, as shown in FIG. 1, a pressure gauge P2 is installed on the liquid supply tube 2 . In this case, if there is a defective portion and pressurized gas flows into the through passage 16h or the like, the pressure of the pressure gauge P1 decreases and the pressure of the pressure gauge P2 increases. Therefore, the leak can also be confirmed by the pressure of the pressure gauge P2.

When supplying pressurized air from the pressurized gas supply unit GS into the circuit, the cleaning liquid recovery tube liquid sending unit 7p and the liquid supply tube liquid sending unit 7p and the liquid supply tube liquid sending unit are arranged so that the pressure measured by the pressure gauge P2 is constant. 2p is preferably operated to draw air from within filter 10 . This is because, when liquid exists in the internal space 12h, the liquid is discharged to the through channel 16h of the hollow fiber membrane 16, and the pressure measured by the pressure gauge P2 is measured by the pressure gauge P1. This is because it may become higher than the pressure. Therefore, in order to reliably detect leakage from the internal space 12h to the hollow fiber membranes 16 and the like and realize a stable leak check, it is necessary to It is desirable to operate so that air is sucked from inside the filter 10 by the cleaning liquid collection tube liquid feeding section 7p and the liquid supply tube liquid feeding section 2p so that the pressure measured by the pressure gauge P2 is constant. For example, it is desirable to operate the cleaning liquid collection tube liquid feeding section 7p and the liquid supply tube liquid feeding section 2p so that the pressure measured by the pressure gauge P2 is lower than the pressure measured by the pressure gauge P1.

In particular, if the differential pressure between the pressure measured by the pressure gauge P1 and the pressure measured by the pressure gauge P2 is used, the leak check can be performed by comparing the pressure inside and outside the wall 16w of the hollow fiber membrane 16. Accuracy can be improved.

Also, when the leak check is performed by the second method, the pressure gauge P1 and the pressure gauge P2 may be temporarily installed during the leak check work, or permanently installed during the filtration and concentration work. It may be in a state where In the case of permanent installation, the pressure gauges P1 and P2 that can measure both air pressure and liquid pressure are used.

When the pressure of the pressure gauge P2 is used for the leak check, while the pressurized gas is not supplied from the pressurized gas supply unit GS, the cleaning liquid collection tube liquid sending unit 7p and the liquid supply tube liquid sending unit 2p, the through flow path 16h of the hollow fiber membrane 16 and the like are airtightly shut off from the outside by the flow rate adjusting means 6c. In addition, it is necessary to stop the operation of the filtrate supply tube liquid feed section 3p provided in the filtrate supply tube 3, the connection tube liquid feed section 9p provided in the connection tube 9, and the flow rate adjustment means 9c. be. While the gas is being supplied from the pressurized gas supply unit GS, the cleaning liquid collection tube liquid sending unit 7p and the liquid supply tube liquid sending unit 2p keep the pressure measured by the pressure gauge P2 constant as described above. It is desirable to drive for

(Detailed Description of Concentrator 20)
In the undiluted solution processing apparatus 1 of this embodiment, it is desirable that each tube to the concentrator 20 is connected as follows. The configuration of the concentrator 20 and the connection of each tube to the concentrator 20 will be described below.

The concentrator 20 is supplied with the filtrate from the filter 10 and concentrates the filtrate. The concentrator 20 has substantially the same structure as the filter 10 described above, and has the function of separating water from the filtrate to obtain a concentrated liquid. That is, the concentrator 20 has a structure in which a water separation member having a function of separating water from the filtrate is housed inside instead of the separation member of the filter 10 . For example, the concentrator 20 may be an ascitic fluid concentrator used for CART, a dialysis filter used for dialysis, or a membrane-type plasma component fractionator used for double-filtration plasma exchange therapy. can.

More specifically, the concentrator 20 has a filtrate supply port 20a that communicates with the filtrate discharge port 11c of the filter 10 through the filtrate supply tube 3. As shown in FIG. That is, the filtrate, which is the liquid to be concentrated, is supplied to the concentrator 20 from the filtrate supply port 20a.

The concentrator 20 also includes a waste liquid discharge port 20c for discharging the liquid (separated liquid) separated from the filtrate, that is, water and the like. The waste liquid discharge port 20c communicates with the waste liquid bag DB via the waste liquid tube 5. As shown in FIG. The concentrator 20 also has a concentrated liquid discharge port 20b through which the concentrated liquid is discharged. The concentrated liquid discharge port 20b communicates with the concentrated liquid bag CB via the concentrated liquid tube 4 .

And the concentrator 20 is equipped with a moisture separation member. This moisture separating member has a function of permeating moisture but not permeating useful components such as useful proteins contained in blood plasma.

Therefore, when the filtrate is supplied from the filtrate supply port 20 a into the concentrator 20 , the moisture is separated from the filtrate by the moisture separating member, and the separated moisture is discharged from the waste liquid discharge port 20 c through the waste liquid tube 5 . It is supplied to the waste liquid bag DB. On the other hand, the concentrated liquid from which part of the water has been removed is discharged from the concentrated liquid discharge port 20b, and the discharged concentrated liquid is supplied to the concentrated liquid bag CB through the concentrated liquid tube 4 (see FIG. 3). ).

(Undiluted solution processing device 1B of another embodiment)
In the above-described undiluted solution processing apparatus 1 of the present embodiment, the undiluted solution is supplied to the filter 10 in a manner of pushing the undiluted solution during filtration and concentration. It is good also as a structure which supplies.

That is, as shown in FIG. 7, the concentrate treatment apparatus 1B of the present embodiment is configured to supply the concentrate to the filter 10 by sucking the concentrate from the filter 10 . In other words, the filtrate supply tube 3 is provided with the filtrate supply tube liquid sending section 3p instead of the flow rate adjusting means 3c, and the liquid supply tube 2 is provided with the flow rate adjusting means 2c instead of the liquid supply tube liquid sending section 2p. is provided.

In the undiluted solution processing apparatus 1B, the filtrate supply tube liquid sending unit 3p is operated so that the liquid (filtrate) flows from the filter 10 to the concentrator 20 during filtration and concentration. When the filtrate supply tube liquid-sending portion 3p operates, the upstream side of the filtrate supply tube liquid-sending portion 3p in the filtrate supply tube 3, that is, the filter 10 side becomes negative pressure, and the inside of the filter 10 (for example, the main body The internal space 12h) of the body portion 12 of the portion 11 also becomes a negative pressure. Then, if the liquid supply tube 2 is put in a state where it can be fed by the flow rate adjusting means 2c, the undiluted liquid in the undiluted liquid bag UB is sucked into the filter 10 through the liquid supply tube 2, and the sucked undiluted liquid is transferred to the filtered liquid supply tube. 3 can be sucked.

Even in this undiluted solution processing apparatus 1B, by appropriately changing the bag connected to each tube and adjusting the operation of the flow rate adjusting means and the liquid feeding section provided in each tube, the preparatory washing work, the filtration concentration work and the re-concentration work can be performed. It can be performed.

(Preparatory cleaning work)
As shown in FIG. 6, a cleaning solution bag SB is connected to the other end of the concentrated solution tube 4 instead of the concentrated solution bag CB, and a cleaning solution recovery bag FB is connected to the other end of the waste solution tube 5 instead of the waste solution bag DB. do. The other end of the waste liquid tube 5 may remain connected to the waste liquid bag DB, or may be placed in a simple bucket or the like.
Also, a washing liquid collection bag FB is connected to the other end of the liquid supply tube 2 instead of the undiluted liquid bag UB. A waste liquid bag DB may be connected to the other end of the liquid supply tube 2, or may be placed in a simple bucket or the like.
Then, the other end of the connecting tube 9 is also connected to the washing liquid collection bag FB. A waste liquid bag DB may be connected to the other end of the connecting tube 9, or may be placed in a simple bucket or the like.
Further, a cleaning liquid recovery bag FB is connected to the other end of the cleaning liquid supply tube 6 instead of the cleaning liquid bag SB, and a cleaning liquid bag SB is connected to the other end of the cleaning liquid recovery tube 7 instead of the cleaning liquid recovery bag FB. A waste liquid bag DB may be connected to the other end of the cleaning liquid supply tube 6 and the other end of the cleaning liquid recovery tube 7, or may be placed in a simple bucket or the like.

Next, the washing liquid is caused to flow through the liquid supply tube 2 and the connecting tube 9 by the flow rate adjusting means 2c and the flow rate adjusting means 9c.

In the above state, the concentrated liquid tube liquid feed section 4p is operated so as to flow the washing liquid from the washing liquid bag SB connected to the concentrated liquid tube 4 to the concentrated liquid 20. The filtrate supply tube liquid sending part 3p is operated so as to flow the washing liquid into the washing liquid collection bag FB connected to the 9. Then, the washing liquid is supplied to the concentrator 20 through the concentrated liquid tube 4 from the washing liquid bag SB connected to the concentrated liquid tube 4 . The supplied cleaning liquid passes through the concentrator 20 , passes through the filtrate supply tube 3 and the connecting tube 9 , and is collected in the cleaning liquid collection bag FB connected to the connecting tube 9 . Part of the washing liquid passes through the waste liquid tube 5 and is collected in the washing liquid collection bag FB connected to the other end of the waste liquid tube 5 .

Further, the cleaning liquid recovery tube liquid sending part 7p is operated so as to flow the cleaning liquid from the cleaning liquid bag SB connected to the cleaning liquid recovery tube 7 to the filter 10 . Then, part of the cleaning liquid is supplied to the filter 10 through the cleaning liquid recovery tube 7 from the cleaning liquid bag SB connected to the cleaning liquid recovery tube 7 . After passing through the filter 10 , the cleaning liquid supplied to the filter 10 passes through the filtrate supply tube 3 and the connecting tube 9 and is collected in the cleaning liquid recovery bag FB connected to the connecting tube 9 . Also, by activating the cleaning liquid supply tube liquid sending unit 6 p , part of the cleaning liquid supplied to the filter 10 can also flow through the cleaning liquid supply tube 6 . Furthermore, part of the cleaning liquid passes through the cleaning liquid recovery tube 7 and the liquid supply tube 2 and is recovered in the cleaning liquid recovery bag FB connected to the liquid supply tube 2 .

Then, since the cleaning liquid can flow through the filter 10, the concentrator 20 and all the tubes, the entire undiluted solution processing apparatus 1B of the present embodiment can be cleaned.

(Filtration concentration work)
After the preparatory cleaning work is completed, the filtration and concentration work is performed.

As shown in FIG. 7, in the filtration and concentration operation of the undiluted solution processing apparatus 1B of the present embodiment, the concentrated solution bag CB is connected to the other end of the concentrated solution tube 4 in place of the cleaning solution bag SB from the state of the preparatory cleaning operation. A waste liquid bag DB is connected to the other end of the waste liquid tube 5 in place of the cleaning liquid recovery bag FB.
On the other hand, an undiluted solution bag UB is connected to the other end of the liquid supply tube 2 instead of the washing solution recovery bag FB.
Further, the flow rate adjusting means 2c maintains a state in which the liquid can flow through the liquid supply tube 2, while the flow rate adjusting means 9c blocks the inside of the connecting tube 9 so that the liquid does not flow. In addition, the washing liquid collection tube liquid feeding section 7p and the washing liquid supply tube liquid feeding section 6p are not operated, but are made to function as clamps.

In the above state, the filtrate supply tube liquid sending part 3p is operated so that the filtrate flows from the filter 10 to the concentrator 20, and the concentrated liquid tube flows so that the concentrated liquid flows from the concentrator 20 to the concentrated liquid bag CB. The liquid feeding part 4p is operated.

Then, the stock solution is supplied from the stock solution bag UB to the filter 10 through the supply tube 2 . The supplied undiluted liquid is filtered by the filter 10 and the produced filtrate is supplied to the concentrator 20 through the filtrate supply tube 3 . Then, the filtrate supplied to the concentrator 20 is concentrated by the concentrator 20, and the produced concentrated liquid is collected through the concentrated liquid tube 4 into the concentrated liquid bag CB. On the other hand, the water separated from the concentrated liquid is collected in the waste liquid bag DB through the waste liquid tube 5 .

(About filter cleaning)
A plurality of hollow fiber membranes 16 of the hollow fiber membrane bundle 15 of the filter 10 may be washed during the filtration and concentration operation of the undiluted solution processing apparatus 1B of the present embodiment. Specifically, in FIG. 7, the inside of the liquid supply tube 2 is blocked by the flow rate adjusting means 2c so that the liquid does not flow. In addition, the operation of the filtrate supply tube liquid-feeding section 3p and the concentrated liquid tube liquid-feeding section 4p is stopped to function as a clamp. Further, in the case of performing filter cleaning during the filtration and concentration work, after the preparatory cleaning work is completed, a cleaning liquid bag SB is connected to the other end of the cleaning liquid supply tube 6 in place of the cleaning liquid recovery bag FB, A cleaning liquid recovery bag FB is connected to the other end of the cleaning liquid recovery tube 7 instead of the cleaning liquid bag SB.

In the above state, the cleaning liquid supply tube liquid sending part 6p is operated so as to flow the cleaning liquid from the cleaning liquid bag SB connected to the cleaning liquid supply tube 6 to the filter 10, and the cleaning liquid recovery connected from the filter 10 to the cleaning liquid recovery tube 7 is operated. The washing liquid collection tube liquid sending part 7p is operated so as to flow the washing liquid into the bag FB. Then, the inside of the hollow fiber membranes 16 can be washed with the washing liquid because the washing liquid can flow in the direction opposite to the direction in which the undiluted solution flows during filtration and concentration.

Further, after the preparatory cleaning work is completed, the cleaning liquid bag SB is connected to the other end of the connecting tube 9 instead of the cleaning liquid collection bag FB. Then, if the liquid flows through the connecting tube 9 by the flow rate adjusting means 9c, the washing liquid can be supplied to the filter 10 from the washing liquid bag SB connected to the connecting tube 9 in addition to the above state. Then, the cleaning liquid supplied through the connecting tube 9 permeates the hollow fiber membranes 16 in the direction opposite to the direction in which the filtrate permeates the hollow fiber membranes 16, so that clogging of the hollow fiber membranes 16 can be eliminated. In this case, since the cleaning liquid is supplied to the filter 10 from both the cleaning liquid bag SB connected to the cleaning liquid supply tube 6 and the cleaning liquid bag SB connected to the connecting tube 9, the cleaning liquid recovery tube is supplied to the cleaning liquid recovery tube by the cleaning liquid recovery tube liquid feeding unit 7p. The flow rate of the cleaning liquid flowing through the cleaning liquid supply tube 6 is adjusted to be greater than the flow rate of the cleaning liquid flowing through the cleaning liquid supply tube 6 by the cleaning liquid supply tube liquid feeding section 6p.

When the liquid is caused to flow through the connecting tube 9 by the flow rate adjusting means 9c, the cleaning liquid collection tube liquid feeding section 7p may be operated while the cleaning liquid supply tube liquid feeding section 6p is stopped. In this case, the washing liquid is supplied to the filtered liquid 10 only from the washing liquid bag SB connected to the connecting tube 9 . In this case as well, the cleaning liquid passes through the hollow fiber membranes 16 in the direction opposite to the direction in which the filtrate passes through the hollow fiber membranes 16, so clogging of the hollow fiber membranes 16 can be eliminated.

(Re-concentration work)
When further concentrating the concentrate obtained by the filtration concentration operation, a re-concentration operation is carried out.

As shown in FIG. 8, in the re-concentrating operation of the undiluted solution processing apparatus 1B of the present embodiment, the other end of the connection tube 9 is removed from the cleaning solution bag SB, and the other end of the connection tube 9 is connected to the concentrated solution bag CB. be.
Further, while maintaining the state in which the liquid can flow in the connecting tube 9 by the flow rate adjusting means 9c, the cleaning liquid supply tube liquid feeding section 6p and the cleaning liquid recovery tube liquid feeding section 7p are not operated and function as clamps. In addition, the inside of the liquid supply tube 2 is blocked by the flow rate adjusting means 2c so that the liquid does not flow. Then, the filter 10 is brought into a state in which liquid does not flow.

In the above state, the filtrate supply tube liquid sending part 3p is operated so that the concentrated liquid flows from the concentrated liquid bag CB through the connecting tube 9 to the concentrator 20, and from the concentrator 20 through the concentrated liquid tube 4 The concentrated liquid tube liquid sending part 4p is operated so that the concentrated liquid flows into the concentrated liquid bag CB.

Then, since the concentrated liquid is supplied from the concentrated liquid bag CB connected to the connecting tube 9 to the concentrator 20 through the connecting tube 9, the re-concentrated liquid further concentrated by the concentrator 20 passes through the concentrated liquid tube 4 to the concentrated liquid bag. Collected in CB. On the other hand, the water separated from the concentrated liquid is collected in the waste liquid bag DB through the waste liquid tube 5 . That is, it is possible to obtain a concentrated liquid (re-concentrated liquid) with an increased concentration ratio.

(Undiluted solution processing device 1C of another embodiment)
In the above-described undiluted solution processing apparatus 1B of the present embodiment, when cleaning the filter 10, the cleaning solution is supplied from the cleaning solution bag SB connected to the connecting tube 9 while operating the cleaning solution recovery tube liquid feeding unit 7p, and the hollow Clogging of the thread membrane 16 is eliminated. In other words, the clogging of the hollow fiber membranes 16 is eliminated by using the negative pressure system to flow the washing liquid from the outside of the hollow fiber membranes 16 into the hollow fiber membranes 16 .

On the other hand, as shown in FIG. 9, the undiluted solution processing apparatus 1C of another embodiment (hereinafter sometimes simply referred to as the undiluted solution processing apparatus 1C) differs from the undiluted solution processing apparatus 1B in the following points.
In the undiluted solution processing apparatus 1C, the cleaning liquid recovery tube 7 is provided with a flow rate adjusting means 7c in place of the cleaning liquid recovery tube liquid transfer section 7p, while the connection tube 9 is provided with a connection tube liquid transfer section 9p. A waste liquid bag DB is connected to the other end of the cleaning liquid supply tube 6 instead of the cleaning liquid bag SB. Then, clogging of the hollow fiber membranes 16 is eliminated by pushing the cleaning liquid into the hollow fiber membranes 16 from outside the hollow fiber membranes 16 (positive pressure) by the connecting tube liquid feeding section 9p.

In addition, in the undiluted solution processing apparatus 1C, the inside of the hollow fiber membranes 16 is washed with the undiluted solution by operating the cleaning liquid supply tube liquid feeding portion 6p of the cleaning liquid supply tube 6 to flow the undiluted solution from the undiluted solution bag UB into the hollow fiber membranes 16. ing.

Further, in the undiluted solution processing apparatus 1C, in the filtrate supply tube 3, one end of the recirculation tube 8 is connected between the connection portion between the filtrate supply tube 3 and the connecting tube 9 and the filtrate supply tube liquid feed section 3p. It is The recirculation tube 8 is provided with flow rate adjusting means 8c.

A pressure gauge P1 for measuring the pressure in the internal space 12h of the main body 11 is installed in the filtered liquid discharge port 11c to which the filtered liquid supply tube 3 is not connected in the filter 10 .
Further, the cleaning liquid supply tube 6 is provided with a pressure gauge P2 for measuring the pressure in the through flow path 16h of the hollow fiber membrane 16 between the cleaning liquid supply tube liquid feeding portion 6p and the filter 10. As shown in FIG.
The pressure gauges P1 and P2 may be temporarily installed during the leak check work, or may be permanently installed during the filtration and concentration work. In the case of permanent installation, pressure gauges P1 and P2 that can measure both air pressure and liquid pressure are used.

Hereinafter, a processing operation by the undiluted solution processing apparatus 1C having the above configuration will be described.

(leak check)
A method of performing a leak check in the undiluted solution processing apparatus 1C will be described.
Also, in the leak check, the following points are changed from the state shown in FIG. 9, ie, the state in which filtration and cleaning work can be performed (see FIG. 10).

First, the pressurized gas supply unit GS is installed between the liquid supply unit 6p of the cleaning liquid supply tube and the filter 10 (near where the pressure gauge P2 is installed). The method of installing the pressurized gas supply unit GS in the cleaning liquid supply tube liquid sending unit 6p is not particularly limited. For example, a branch channel having a clamp or the like may be provided in advance in the liquid sending portion 6p of the cleaning liquid supply tube, and the pressurized gas supply portion GS may be installed in the branch channel.

First, a bag is connected to the end of each tube that is not connected to the filter 10 as follows.
A cleaning solution bag SB is connected to the other end of the solution supply tube 2 instead of the undiluted solution bag UB.
The cleaning liquid collection bag FB is connected to the other end of the cleaning liquid supply tube 6 instead of the waste liquid bag DB. The bag connected to the other end of the cleaning liquid supply tube 6 may be the waste liquid bag DB as it is, or may be arranged in a simple bucket or the like.
The bag connected to the other end of the cleaning liquid recovery tube 7 may remain the cleaning liquid recovery bag FB, may be replaced with the waste liquid bag DB, or may be placed in a simple bucket or the like.

When the bag is connected to each tube as described above, all the flow rate adjusting means provided on the tube are closed to stop the operation of all the tube liquid feeding parts. Then, all the tubes are closed.

Next, in the filtrate supply tube 3, the end connected to the filtrate supply port 20a of the concentrator 20 is removed from the filtrate supply port 20a and connected to the cleaning fluid recovery bag FB.
Also, the other end of the recirculation tube 8 is removed from the concentrated solution bag CB and connected to the cleaning solution collection bag FB to form an open end.
The other end of the filtrate supply tube 3 and the other end of the recirculation tube 8 may be connected to a waste liquid bag DB or placed in a simple bucket or the like.

In addition, the tube connected to the concentrator 20 may be configured as follows.
A washing liquid collection bag FB is connected to the other end of the concentrated liquid tube 4 instead of the concentrated liquid bag CB. A washing liquid collection bag FB is connected to the other end of the waste liquid tube 5 instead of the waste liquid bag DB. A waste liquid bag DB may be connected to the other end of the concentrated liquid tube 4, or may be placed in a simple bucket or the like. Also, the other end of the waste liquid tube 5 may be connected to a waste liquid bag DB, or may be placed in a simple bucket or the like.

<Liquid discharge>
When the above preparations are completed (see FIG. 10), liquid may exist inside the filter 10 (inside the through channel 16h of the hollow fiber membrane 16, inside the pair of header portions 13 and 14, and inside the internal space 12h). When there is, the liquid in the filter 10 is discharged as follows.

The flow rate adjusting means 7c provided in the cleaning liquid recovery tube 7 is opened, and air is supplied from the pressurized gas supply section GS to pressurize the inside of the circuit (that is, the inside of the filter 10 and each tube). Then, the liquid present in the hollow fiber membrane 16 and the pair of headers 13 and 14 of the filter 10 can be discharged through the undiluted liquid supply port 11a. It can be collected in a collection bag FB. When the liquid in the filter 10 is discharged, the flow rate adjusting means 7c is closed.

In addition, in the case of the above method, the liquid in the internal space 12h of the filter 10 cannot be recovered. Therefore, when the liquid inside the internal space 12h of the filter 10 is to be discharged, the liquid inside the internal space 12h can be recovered by performing the following operation before performing the above operation.

For example, while the filtrate discharge port 11c to which the pressure gauge P1 is connected is open to the atmosphere, the cleaning liquid supply tube liquid feeding portion 6p provided in the cleaning liquid supply tube 6 is operated to suck the liquid from the filter 10. do. Then, the liquid in the internal space 12 h of the filter 10 is also sucked by the suction force, and can be collected in the cleaning liquid recovery bag FB connected to the cleaning liquid supply tube 6 . In this case, together with the cleaning liquid supply tube 6, or before operating the cleaning liquid supply tube 6, the filtrate supply tube liquid feeding section 3p provided in the filtrate supply tube 3 is arranged so as to suck the liquid from the filter 10. may operate. Then, the liquid in the internal space 12h of the filter 10 can also be recovered in the washing liquid recovery bag FB connected to the filtrate supply tube 3.
Also, when the other end of the recirculation tube 8 is not connected to the cleaning liquid collection bag FB and is arranged in a bucket, that is, when the other end of the recirculation tube 8 is an open end, the same applies. In this way, the liquid in the internal space 12h of the filter 10 can be recovered in the cleaning liquid recovery bag FB connected to the cleaning liquid supply tube 6. FIG. That is, when the other end of the recirculation tube 8 is an open end, the flow rate adjusting means 8c is opened, and the cleaning liquid supply tube liquid feeding portion 6p provided in the cleaning liquid supply tube 6 is operated in the same manner as described above. . Then, the liquid in the internal space 12h of the filter 10 can be sucked into the cleaning liquid supply tube 6 by the suction force generated by the cleaning liquid supply tube liquid feeding unit 6p, so that the cleaning liquid recovery bag FB connected to the cleaning liquid supply tube 6 can be recovered.

Further, in the case of the following method, the liquid in the internal space 12h of the body portion 11 of the filter 10 can be recovered at the same time as the liquid in the hollow fiber membrane 16 and the pair of header portions 13 and 14 of the filter 10. can.

First, both the vicinity where the pressure gauge P2 is provided (that is, the cleaning liquid supply tube 6) and the filtered liquid discharge port 11c of the filter 10 are opened to the atmosphere. A space between the cleaning liquid supply tube liquid sending portion 6p in the cleaning liquid supply tube 6 and the cleaning liquid supply port 11b of the filter 10 is opened to the atmosphere by a method such as removing the pressurized gas supply section GS. In other words, the cleaning liquid supply port 11b of the filter 10 is opened to the atmosphere. Next, the filtrate discharge port 11c of the filter 10 is opened to the atmosphere. That is, the internal space 12h of the body portion 11 of the filter 10 is also open to the atmosphere. In this state, the filtrate supply tube liquid-feeding portion 3 p provided in the filtrate supply tube 3 is operated to suck the liquid from the filter 10 . Then, due to the suction force, the liquid present in the hollow fiber membrane 16 and the pair of header portions 13 and 14 of the filter 10 and the liquid in the internal space 12h is removed from the filter to which the filtrate supply tube 3 is connected. Since the liquid is sucked out through the filtrate discharge port 11c of the vessel 10, the liquid can be recovered in the washing liquid recovery bag FB to which the other end of the filtrate supply tube 3 is connected. In addition, when the liquid in the filter 10 is discharged, the operation of the filtrate supply tube liquid sending section 3p is stopped.

<Implementation of leak check>
After the liquid in the filter 10 has been discharged in the manner described above, a leak check is performed.

First, the flow rate adjusting means 8c is opened, and pressurized air is supplied from the pressurized gas supply section GS into the circuit. Then, pressurized air is supplied into the through-channels 16h of the hollow fiber membranes 16 of the filter 10, so that the pressure inside the through-channels 16h of the hollow fiber membranes 16 rises. Then, when it is confirmed by the pressure gauge P2 that the pressure in the through passage 16h of the hollow fiber membrane 16 of the filter 10 rises to a predetermined pressure, the gas supply from the pressurized gas supply section GS is stopped. After the gas supply is stopped, the flow rate adjusting means 8c may be closed or left open.

In addition, when the flow rate adjusting means 8c is not opened, when supplying pressurized air from the pressurized gas supply unit GS into the circuit, the pressure measured by the pressure gauge P1 is constant. It is desirable to operate so that air is sucked from inside the filter 10 by the liquid feeding part 3p. This is because, when liquid exists in the through-channel 16h of the hollow fiber membrane 16, the liquid is discharged into the internal space 12h of the main body 11 of the filter 10, resulting in the pressure measured by the pressure gauge P1. is higher than the pressure measured by the pressure gauge P2. Therefore, in order to reliably detect leakage from the hollow fiber membrane 16 or the like to the internal space 12h and realize a stable leak check, it is necessary to is preferably operated so that air is sucked from inside the filter 10 by the filtrate supply tube liquid sending portion 3p so that the pressure measured by the pressure gauge P1 becomes constant. For example, it is desirable to operate the filtrate supply tube liquid sending section 3p so that the pressure measured by the pressure gauge P1 is lower than the pressure measured by the pressure gauge P2.

Here, if the plurality of hollow fiber membranes 16 of the hollow fiber membrane bundle 15 are broken, or if there is a defect in the airtightness or liquid tightness between the internal space 12h and the pair of header portions 13, 14, that The pressurized gas leaks into the internal space 12h from the through passage 16h of the hollow fiber membrane 16 and the pair of header portions 13 and 14 from a location (defective location). As a result, the pressure in the hollow fiber membrane 16 is reduced, and leakage of the filter 10 can be confirmed by confirming the fluctuation of the air pressure measured by the pressure gauge P2.

Further, if there is a defective portion and pressurized gas flows into the internal space 12h, the pressure of the pressure gauge P2 decreases and the pressure of the pressure gauge P1 increases. Therefore, the leak can also be confirmed by the pressure of the pressure gauge P1.

In particular, if the differential pressure between the pressure measured by the pressure gauge P1 and the pressure measured by the pressure gauge P2 is used, the leak check can be performed by comparing the pressure inside and outside the wall 16w of the hollow fiber membrane 16. Accuracy can be improved.

In addition, when the pressure of the pressure gauge P1 is used for the leak check, while the pressurized gas is not supplied from the pressurized gas supply unit GS, the flow rate adjusting means 8c is closed and the filtrate is supplied. It is necessary to stop the operation of the filtrate supply tube liquid feeding section 3p provided on the tube 3 and the connecting tube liquid feeding section 9p provided on the connecting tube 9. FIG. While the gas is being supplied from the pressurized gas supply unit GS, it is desirable to drive the filtrate supply tube liquid sending unit 3p in order to keep the pressure measured by the pressure gauge P1 constant as described above. .

The locations where the pressure gauges P1 and P2 are provided are not limited to the locations described above. It should be installed in the appropriate place.

It should be noted that the inside of the hollow fiber membrane 16 of the filter 10 is in a pressurized state after the leak check is completed. Therefore, the pressure inside the hollow fiber membrane 16 is lowered after the leak check is completed in preparation for the preparatory cleaning for the next step. For example, the pressure in the hollow fiber membrane 16 can be reduced in a short time because the pressure can be released at once by opening the flow rate adjusting means 7c.

(Other leak check method 1)
Besides the method described above, the leak check can be performed by the following method.
As shown in FIG. 11, when the connection tube 9 is provided with the pressurized gas supply unit GS, the leak check is performed by the following method. When the leak check is performed by this method, gas does not enter the through channel 16h of the hollow fiber membrane 16 if there is no defective portion. In other words, since the leak check can be performed without introducing gas into the through-channel 16h of the hollow fiber membrane 16, there is an advantage that the air removal operation after the leak check can be performed reliably and in a short time.

As shown in FIG. 11, the connecting tube 9 is provided with a branch tube 9b communicating with the connecting tube 9, and the branch tube 9b of the connecting tube 9 is provided with a pressurized gas supply unit GS for supplying a pressurized gas in the leak check operation. prepare. The branch tube 9b is provided with a flow rate adjusting means 9c for closing and opening the branch tube 9b.

First, a bag is connected to the end of each tube that is not connected to the filter 10 as follows.
A cleaning solution bag SB is connected to the other end of the solution supply tube 2 instead of the undiluted solution bag UB.
The cleaning liquid collection bag FB is connected to the other end of the cleaning liquid supply tube 6 instead of the waste liquid bag DB. The bag connected to the other end of the cleaning liquid supply tube 6 may be the waste liquid bag DB as it is, or may be arranged in a simple bucket or the like.
The bag connected to the other end of the cleaning liquid recovery tube 7 may remain the cleaning liquid recovery bag FB, may be replaced with the waste liquid bag DB, or may be placed in a simple bucket or the like.

When the bag is connected to each tube as described above, all the flow rate adjusting means provided on the tube are closed to stop the operation of all the tube liquid feeding parts. Then, all the tubes are closed.

Next, in the filtrate supply tube 3, the end connected to the filtrate supply port 20a of the concentrator 20 is removed from the filtrate supply port 20a and connected to the cleaning fluid collection bag FB.
Also, the other end of the recirculation tube 8 is removed from the concentrated solution bag CB and connected to the cleaning solution collection bag FB to form an open end.
The other end of the filtrate supply tube 3 and the other end of the recirculation tube 8 may be connected to a waste liquid bag DB or placed in a simple bucket or the like.

In addition, the tube connected to the concentrator 20 may be configured as follows.
A washing liquid collection bag FB is connected to the other end of the concentrated liquid tube 4 instead of the concentrated liquid bag CB. A washing liquid collection bag FB is connected to the other end of the waste liquid tube 5 instead of the waste liquid bag DB. The other end of the concentrated liquid tube 4 may be connected to a waste liquid bag DB or placed in a simple bucket or the like. Also, the other end of the waste liquid tube 5 may be connected to a waste liquid bag DB, or may be placed in a simple bucket or the like.

<Liquid discharge>
When the above preparations are completed (see FIG. 11), if there is a possibility that liquid exists in the internal space 12h of the filter 10, the liquid in the internal space 12h of the filter 10 is discharged as follows. do.

First, the flow rate adjusting means 7c provided in the washing liquid recovery tube 7 is opened. In addition, the other flow rate adjusting means are maintained in a closed state, and the operation of all the tube liquid feeding parts is maintained in a stopped state. In this state, pressurized gas is supplied from the pressurized gas supply unit GS. Then, since the interior space 12h of the filter 10 is pressurized, the liquid in the interior space 12h of the main body 11 of the filter 10 is discharged into the hollow fiber membranes 16 and passed through the cleaning liquid recovery tube 7 to the cleaning liquid recovery tube. 7 is collected in the washing liquid collecting bag FB connected to the other end of the washing liquid collecting bag FB. When the liquid in the internal space 12h of the body portion 11 of the filter 10 is discharged, the pressurized gas supply portion GS stops supplying the pressurized gas, and the flow rate adjusting means 9c and the flow rate adjusting means 7c are closed. .

In addition, by activating the filtrate supply tube liquid sending unit 3p, not only the washing liquid collection bag FB connected to the other end of the washing liquid collection tube 7 but also the washing liquid collection bag connected to the other end of the filtrate supply tube 3 The liquid in the internal space 12h of the body portion 11 of the filter 10 may also be recovered in the FB.

<Implementation of leak check>
After the liquid in the internal space 12h of the main body 11 of the filter 10 is discharged by the method as described above, a leak check is performed.

First, the flow rate adjusting means 7c provided in the washing liquid recovery tube 7 is opened.
Next, the flow rate adjusting means 9c provided in the branch tube 9b is opened, and the pressurized gas is supplied to the branch tube 9b from the pressurized gas supply section GS. Then, the pressurized gas is supplied into the internal space 12h of the trunk portion 12 of the main body 11, and the pressure within the internal space 12h (in other words, the pressure within the connecting tube 9 and the branch tube 9b) increases. Then, when the pressure in the internal space 12h measured by the pressure gauge P1 reaches or exceeds a certain pressure, the supply of the pressurized gas by the pressurized gas supply unit GS is stopped, and the branch tube 9b is closed by the flow rate adjusting means 9c. .

Here, if the plurality of hollow fiber membranes 16 of the hollow fiber membrane bundle 15 are broken, or if there is a defect in the airtightness or liquid tightness between the internal space 12h and the pair of header portions 13, 14, that The pressurized gas leaks into the through channel 16h of the hollow fiber membrane 16 or into the pair of header portions 13 and 14 from a location (defective location). As a result, the pressure in the internal space 12h is lowered, and leakage of the filter 10 can be confirmed by confirming the fluctuation of the air pressure measured by the pressure gauge P1.

Then, when the leak check is performed by the above method, gas does not enter the through channel 16h of the hollow fiber membrane 16 if there is no defective portion. In other words, since the leak check can be performed without introducing gas into the through-flow passage 16h of the hollow fiber membrane 16, the air removal operation after the leak check can be reliably performed in a short time.

Further, if the pressure gauge P2 is installed, and pressurized gas flows into the through passage 16h or the like due to a defect, the pressure of the pressure gauge P1 decreases and the pressure of the pressure gauge P2 increases. Therefore, the leak can also be confirmed by the pressure of the pressure gauge P2.

In particular, if the differential pressure between the pressure measured by the pressure gauge P1 and the pressure measured by the pressure gauge P2 is used, the leak check can be performed by comparing the pressure inside and outside the wall 16w of the hollow fiber membrane 16. Accuracy can be improved.

The pressure gauge P1 and the pressure gauge P2 may be temporarily installed during the leak check work, or may be permanently installed during the filtration and concentration work. In the case of permanent installation, the pressure gauges P1 and P2 that can measure both air pressure and liquid pressure are used.

Further, when using the pressure of the pressure gauge P2 for leak check, after the pressure in the internal space 12h measured by the pressure gauge P1 reaches or exceeds a certain pressure, the flow rate adjusting means 7c is closed. , it is necessary to stop the operation of the cleaning liquid supply tube liquid sending portion 6p provided in the cleaning liquid supply tube 6.

Further, the locations where the pressure gauges P1 and P2 are provided are not limited to the locations described above. It may be provided at a communicating location.

(Other leak check method 2)
In the above example, the leak check is performed by removing the end of the filtrate supply tube 3 connected to the filtrate supply port 20a of the concentrator 20 from the filtrate supply port 20a. However, the leak check may be performed while the filtrate supply tube 3 is connected to the filtrate supply port 20 a of the concentrator 20 . In this case, preparatory cleaning can be performed immediately after the leak check is completed. Even in this case, the leak check can be performed in the same manner as in the above example.

Since the filtrate supply tube 3 is still connected to the filtrate supply port 20 a of the concentrator 20 , liquid cannot be discharged from the filtrate supply tube 3 or the recirculation tube 8 . Therefore, when the liquid in the internal space 12h of the filter 10 is to be discharged, the liquid can be discharged from the filtrate discharge port 11c to which the filtrate supply tube 3 is not connected. During this work, it is desirable to close the filtrate supply tube 3 by the filtrate supply tube liquid sending unit 3p and to close the recirculation tube 8 by the flow rate adjusting means 8c.

As shown in FIG. 15, a pressurized gas supply unit GS is installed between the cleaning liquid supply tube liquid supply unit 6p and the filter 10 (near where the pressure gauge P2 is installed). The method of installing the pressurized gas supply unit GS in the cleaning liquid supply tube 6 is not particularly limited. For example, the cleaning liquid supply tube 6 may be previously provided with a branched channel having a clamp or the like, and the pressurized gas supply section GS may be installed in the branched channel.

First, a bag is connected to the end of each tube that is not connected to the filter 10 as follows.
A cleaning solution bag SB is connected to the other end of the solution supply tube 2 instead of the undiluted solution bag UB.
The cleaning liquid collection bag FB is connected to the other end of the cleaning liquid supply tube 6 instead of the waste liquid bag DB. The bag connected to the other end of the cleaning liquid supply tube 6 may be the waste liquid bag DB as it is, or may be arranged in a simple bucket or the like.
The bag connected to the other end of the cleaning liquid recovery tube 7 may remain the cleaning liquid recovery bag FB, may be replaced with the waste liquid bag DB, or may be placed in a simple bucket or the like.

When the bag is connected to each tube as described above, all the flow rate adjusting means provided on the tube are closed to stop the operation of all the tube liquid feeding parts. Then, all the tubes are closed.

The other end of the recirculation tube 8 is then removed from the concentrate bag CB and connected to the wash collection bag FB as an open end. The other end of the recirculation tube 8 may be connected to a waste liquid bag DB or placed in a simple bucket or the like.

In addition, the tube connected to the concentrator 20 may be configured as follows.
A washing liquid collection bag FB is connected to the other end of the concentrated liquid tube 4 instead of the concentrated liquid bag CB. A washing liquid collection bag FB is connected to the other end of the waste liquid tube 5 instead of the waste liquid bag DB. The other end of the concentrated liquid tube 4 may be connected to a waste liquid bag DB or placed in a simple bucket or the like. Also, the other end of the waste liquid tube 5 may be connected to a waste liquid bag DB, or may be placed in a simple bucket or the like.

Further, the tube ap connecting the pressure gauge P1 and the filtrate discharge port 11c is provided with an outside air introduction portion Ai for supplying outside air or the like to the filtrate discharge port 11c through the tube. A flow rate adjusting means ac is installed in a tube connecting the outside air introduction part Ai and the tube ap.

<Liquid discharge>
When the above preparation is completed (see FIG. 15), there is a possibility that liquid may exist inside the filter 10 (inside the through channel 16h of the hollow fiber membrane 16, inside the pair of header portions 13 and 14, and inside the internal space 12h). When there is, the liquid in the filter 10 is discharged as follows.

The flow rate adjusting means 7c provided in the cleaning liquid recovery tube 7 is opened, a pressurized gas supply device or the like is connected in place of the pressure gauge P2, and air is supplied from the pressurized gas supply device or the like to the inside of the circuit (that is, pressurize the filter 10 and each tube). Then, the liquid present in the hollow fiber membrane 16 and the pair of headers 13 and 14 of the filter 10 can be discharged through the undiluted liquid supply port 11a. It can be collected in a collection bag FB. When the liquid in the filter 10 is discharged, the flow rate adjusting means 7c is closed. Also, the pressurized gas supply device and the like are removed and the pressure gauge P2 is attached again. 15, when the pressurized gas supply unit GS is connected to the cleaning liquid supply tube 6, even if the pressurized gas is supplied from the pressurized gas supply unit GS, the hollow fibers of the filter 10 are The liquid existing in the membrane 16 and the pair of header portions 13 and 14 can be recovered.

In addition, in the case of the above method, the liquid in the internal space 12h of the filter 10 cannot be recovered. Therefore, when the liquid inside the internal space 12h of the filter 10 is to be discharged, the liquid inside the internal space 12h can be recovered by performing the following operation before performing the above operation.

For example, the flow regulating means ac is opened so that air can be introduced from the filtrate discharge port 11c through the tube ap by the outside air introduction part Ai (or by removing the pressure gauge P1). In this state, the cleaning liquid supply tube liquid feeding portion 6p provided in the cleaning liquid supply tube 6 is operated to suck the liquid from the filter 10. As shown in FIG. Then, the liquid in the internal space 12 h of the filter 10 is also sucked by the suction force, and can be collected in the cleaning liquid recovery bag FB connected to the cleaning liquid supply tube 6 . In this case, the filtrate supply tube liquid-feeding part 3p provided in the filtrate supply tube 3 is removed from the filter 10 together with the cleaning liquid supply tube liquid-feeding part 6p or before the cleaning liquid supply tube liquid-feeding part 6p is operated. It may operate to aspirate liquids. Then, the liquid in the internal space 12 h of the filter 10 can be recovered in the cleaning liquid recovery bag FB connected to the filtrate supply tube 3 . When the liquid in the filter 10 is discharged, the flow rate adjusting means ac is closed (the pressure gauge P1 is attached again), and the cleaning liquid supply tube liquid feeding section 6p (and the filtrate supply tube liquid feeding section 3p) is activated. to stop.

Further, the liquid in the hollow fiber membrane 16 of the filter 10 can be discharged by operating as follows.

First, the cleaning liquid supply tube 6, that is, the cleaning liquid supply port 11b of the filter 10, is opened to the atmosphere by a method such as removing the pressure gauge P2. In this state, the filtrate supply tube liquid feeding section 3 p provided in the filtrate supply tube 3 is operated to suck the liquid from the filter 10 . Then, the suction force causes the liquid present in the hollow fiber membranes 16 and the pair of header portions 13 and 14 of the filter 10 and the liquid in the internal space 12h to be removed from the filter to which the filtrate supply tube 3 is connected. It is sucked out through the filtrate discharge port 11c of the vessel 10. Then, the sucked liquid can be collected in the cleaning liquid bag FB connected to the other end of the waste liquid tube 5 via the filtrate supply tube 3 , the concentrator 20 and the waste liquid tube 5 . Further, when the concentrated liquid supply tube liquid sending part 4p provided in the concentrated liquid tube 4 is operated so as to suck the liquid from the concentrator 20, the sucked liquid is connected to the other end of the concentrated liquid tube 4. can be collected in the washing liquid bag FB. When the liquid in the filter 10 is discharged, the pressure gauge P2 is attached again, and the operation of the filtrate supply tube liquid transfer section 3p (and the concentrated liquid supply tube liquid transfer section 4p) is stopped.

Further, even if the pressurized gas is supplied from the pressurized gas supply unit GS and the flow rate adjusting means 8c provided in the recirculation tube 8 is opened, the liquid in the hollow fiber membrane 16 of the filter 10 is as follows. can be discharged in the following manner. In other words, if the pressurized gas is supplied from the pressurized gas supply unit GS with the flow rate adjusting means 8c opened, the liquid in the hollow fiber membranes 16 of the filter 10 will flow into the internal space 12h of the main body 11 of the filter 10. can be discharged to

<Implementation of leak check>
After the liquid in the filter 10 has been discharged in the manner described above, a leak check is performed.

First, the flow rate adjusting means ac is opened, and the internal space 12h is opened to the atmosphere by the outside air introduction part Ai. In this state, pressurized air is supplied from the pressurized gas supply unit GS into the circuit. Then, pressurized air is supplied into the through-channels 16h of the hollow fiber membranes 16 of the filter 10, so that the pressure inside the through-channels 16h of the hollow fiber membranes 16 rises. Then, when it is confirmed by the pressure gauge P2 that the pressure in the through passage 16h of the hollow fiber membrane 16 of the filter 10 rises to a predetermined pressure, the gas supply from the pressurized gas supply section GS is stopped. After stopping the supply of the gas, the internal space 12h may remain open to the atmosphere, or may be airtightly shut off from the outside by the flow rate adjusting means ac and the outside air introducing portion Ai.

In addition, when the internal space 12h is not open to the atmosphere, the filtrate supply tube may It is desirable to operate so that air is sucked from inside the filter 10 by the liquid feeding part 3p. This is because, when liquid exists in the through-channel 16h of the hollow fiber membrane 16, the liquid is discharged into the internal space 12h of the main body 11 of the filter 10, resulting in the pressure measured by the pressure gauge P1. is higher than the pressure measured by the pressure gauge P2. Therefore, in order to reliably detect leakage from the hollow fiber membrane 16 or the like to the internal space 12h and realize a stable leak check, it is necessary to is preferably operated so that air is sucked from inside the filter 10 by the filtrate supply tube liquid sending portion 3p so that the pressure measured by the pressure gauge P1 becomes constant. For example, it is desirable to operate the filtrate supply tube liquid sending section 3p so that the pressure measured by the pressure gauge P1 is lower than the pressure measured by the pressure gauge P2.
Further, when the pressure of the pressure gauge P3 provided in the filtrate supply tube liquid sending portion 3p increases, air is sucked from the concentrator 20 by the concentrated liquid tube liquid sending portion 4p provided in the concentrated liquid tube 4. to operate.

Here, if the plurality of hollow fiber membranes 16 of the hollow fiber membrane bundle 15 are broken, or if there is a defect in the airtightness or liquid tightness between the internal space 12h and the pair of header portions 13, 14, that The pressurized gas leaks into the internal space 12h from the through passage 16h of the hollow fiber membrane 16 and the pair of header portions 13 and 14 from a location (defective location). As a result, the pressure in the hollow fiber membrane 16 is reduced, and leakage of the filter 10 can be confirmed by confirming the fluctuation of the air pressure measured by the pressure gauge P2.

Further, if there is a defective portion and pressurized gas flows into the internal space 12h, the pressure of the pressure gauge P2 decreases and the pressure of the pressure gauge P1 increases. Therefore, the leak can also be confirmed by the pressure of the pressure gauge P1.

In particular, if the differential pressure between the pressure measured by the pressure gauge P1 and the pressure measured by the pressure gauge P2 is used, the leak check can be performed by comparing the pressure inside and outside the wall 16w of the hollow fiber membrane 16. Accuracy can be improved.

In addition, when the pressure of the pressure gauge P1 is used for the leak check, while the pressurized gas is not supplied from the pressurized gas supply unit GS, the internal space 12h is It is in a state of being airtightly shut off from the outside. In addition, the flow rate adjusting means 8c is closed, and the operation of the filtrate supply tube liquid feed section 3p provided in the filtrate supply tube 3 and the connection tube liquid feed section 9p provided in the connection tube 9 is stopped. It is necessary to keep

The locations where the pressure gauges P1 and P2 are provided are not limited to the locations described above. It should be installed in the appropriate place.

It should be noted that the inside of the hollow fiber membrane 16 of the filter 10 is in a pressurized state after the leak check is completed. Therefore, the pressure inside the hollow fiber membrane 16 is lowered after the leak check is completed in preparation for the preparatory cleaning for the next step. For example, the pressure in the hollow fiber membrane 16 can be reduced in a short time because the pressure can be released at once by opening the flow rate adjusting means 7c.

(Preparatory cleaning work)
As shown in FIG. 12, after the leak check is completed, preparatory cleaning work is carried out.
Below, the case where preparatory cleaning is performed from the state of FIG. 11 will be described.

First, the filtrate supply tube 3 is connected to the filtrate supply port 20a of the concentrator 20, and then the washing liquid is caused to flow through the supply tube 2 by the flow rate adjusting means 2c. Then, the washing liquid is supplied to the filter 10 through the liquid supply tube 2 from the washing liquid bag SB connected to the liquid supply tube 2 .

In the above state, the cleaning liquid supply tube liquid sending portion 6 p provided in the cleaning liquid supply tube 6 is operated so that the cleaning liquid flows out from the filter 10 . Then, the cleaning liquid flows from the undiluted liquid supply port 11a to the cleaning liquid supply port 11b, and the insides of the through-channels 16h of the hollow fiber membranes 16 of the pair of header portions 13 and 14 and the hollow fiber membrane bundle 15 can be cleaned with the cleaning liquid. The cleaning liquid used to clean the pair of headers 13 and 14 is recovered in a cleaning liquid recovery bag FB connected to the cleaning liquid supply tube 6 .

In addition, the filtrate supply tube liquid sending unit 3p is operated so that the washing liquid flows from the filtrate supply tube 3 to the concentrator 20. FIG. Then, the washing liquid permeates the hollow fiber membrane 16 and fills the internal space 12h of the main body 12, and then flows into the filtrate supply tube 3 through the filtrate discharge port 11c to fill the filtrate supply tube 3. After the cleaning liquid filling the filtrate supply tube 3 flows into the concentrator 20 from the filtrate supply port 20a of the concentrator 20, it passes through the waste liquid discharge port 20c of the concentrator 20 and the waste liquid tube 5, and the cleaning liquid recovery bag FB is collected. to be recovered.

If the liquid in the internal space 12h of the main body 11 of the filter 10 has been discharged during the leak check, it is desirable to perform the following work in order to fill the internal space 12h with the cleaning liquid. . For example, the vicinity of the pressure gauge P1, that is, the filtrate discharge port 11c to which the filtrate supply tube 3 is not connected is opened to the atmosphere. Then, the air in the internal space 12h can be discharged through the filtrate discharge port 11c, and the internal space 12h can be filled with the cleaning liquid. When supplying the washing liquid from the liquid supply tube 2, the filter 10 is turned upside down and the filtrate discharge port 11c connected to the filtrate supply tube 3 is moved from the filtrate discharge port 11c connected to the pressure gauge P1. The internal space 12h can be filled with the cleaning liquid by laying the filter 10 so that the filtrate discharge port 11c faces upward.

After that, the concentrated liquid tube liquid feeding part 4 p provided in the concentrated liquid tube 4 is operated so as to suck out the liquid from the concentrator 20 . Then, the cleaning liquid in the concentrator 20 is discharged from the concentrated liquid discharge port 20b, fills the concentrated liquid tube 4, and is recovered in the cleaning liquid recovery bag FB.

By performing the above operation, the washing liquid can be flowed through the liquid supply tube 2, the filter 10, the filtrate supply tube 3, the concentrator 20, the concentrated liquid tube 4, and the liquid waste tube 5. FIG. That is, in the undiluted solution processing apparatus 1C of the present embodiment, the flow path through which the undiluted solution flows can be washed when the filtration and concentration work is performed, and the filter 10, the concentrator 20, and the above tubes can be filled with the washing liquid.

In addition, when the recirculation tube 8 and the connecting tube 9 are filled with the cleaning liquid, the following should be done.
For example, when the recirculation tube 8 and the connection tube 9 are filled, the flow rate adjusting means 8c provided in the recirculation tube 8 is opened, and the connection tube liquid feeding section 9p provided in the connection tube 9 is driven. . In this state, if the cleaning liquid is supplied from the cleaning liquid bag SB connected to the connecting tube 9 and collected in the cleaning liquid collection bag FB connected to the recirculation tube 8, the recirculation tube 8 and the connecting tube 9 are filled with the cleaning liquid. can meet.

The cleaning liquid recovery tube 7 is a path for recovering the cleaning liquid when the filter is cleaned during the filtration and concentration work. For this reason, even if air remains in the cleaning liquid collecting tube 7, the filter 10 does not normally enter the air during the filtration and concentration work, and does not affect the filtration and concentration work. There is no However, if air remains in the cleaning liquid recovery tube 7, the air in the cleaning liquid recovery tube 7 will be released into the liquid supply tube 2 when the undiluted solution bag UB becomes empty and the inside of the liquid supply tube 2 and the filter 10 becomes negative pressure. 2 and filter 10. Therefore, in order to reduce the possibility of air entering the filter 10, it is desirable to fill the cleaning liquid recovery tube 7 with the cleaning liquid as well.

If the cleaning liquid collecting tube 7 is to be filled with the cleaning liquid, the following should be done.
First, the cleaning liquid recovery bag FB connected to the cleaning liquid recovery tube 7 is arranged at a position lower than the cleaning liquid bag SB connected to the liquid supply tube 2 . In this state, the flow rate adjusting means 2c provided on the liquid supply tube 2 and the flow rate adjusting means 7c provided on the cleaning liquid recovery tube 7 are opened. Then, the cleaning liquid flows from the cleaning liquid bag SB connected to the liquid supply tube 2 to the cleaning liquid recovery tube 7 through the cleaning liquid supply tube 2. Therefore, if the cleaning liquid is recovered in the cleaning liquid recovery bag FB connected to the cleaning liquid recovery tube 7, the cleaning liquid The collection tube 7 can also be filled with washing liquid.

As described above, when the leak check is performed by disconnecting the filtrate supply tube 3 from the filtrate supply port 20a of the concentrator 20, the filtrate supply tube 3 is removed from the concentrator 20 before preparatory cleaning. It must be connected to the liquid supply port 20a. In this case, in order to prevent air from entering the concentrator 20, it is desirable to fill the filtrate supply tube 3 with washing liquid in advance. For example, before connecting the filtrate supply tube 3 to the filtrate supply port 20a of the concentrator 20, the flow rate adjusting means 2c provided in the supply tube 2 is opened and the The filtrate supply tube liquid sending unit 3p is driven. Then, the cleaning liquid can flow from the cleaning liquid bag SB connected to the liquid supply tube 2 to the filtrate supply tube 3 to fill the inside of the filtrate supply tube 3 with the cleaning liquid. Then, when the filtrate supply tube 3 and the filtrate supply port 20a of the concentrator 20 are connected, it is possible to prevent air from entering the concentrator 20 .

On the other hand, when filling the circuit with the cleaning liquid, if there is no cleaning liquid in the through passage 16h of the hollow fiber membrane 16 of the filter 10, the flow rate adjusting means 2c may be opened and the filtrate supply tube 3 may be operated. The washing liquid cannot be sucked into the filtrate supply tube 3.
Further, when the pressurized gas is supplied into the through passage 16h of the hollow fiber membrane 16 of the filter 10 to perform a leak check (that is, the pressure inside the through passage 16h of the hollow fiber membrane 16 of the filter 10 is gas exists), pressurized gas may flow back into the cleaning liquid bag SB when the flow rate adjusting means 2c is opened. Since the washing liquid bag SB is not normally supposed to be pressurized, it may be damaged by the pressure of the pressurized air.

Therefore, when there is no cleaning liquid in the through passage 16h of the hollow fiber membrane 16 of the filter 10, or when a leak check is performed by supplying pressurized gas into the through passage 16h of the hollow fiber membrane 16 of the filter 10 performs the following work before opening the flow rate adjusting means 2c. Specifically, the cleaning liquid supply tube liquid sending section 6p is driven while the flow rate adjusting means 2c is closed. Then, the pressurized gas in the through passage 16 h of the hollow fiber membrane 16 of the filter 10 is discharged to the cleaning liquid collection bag FB connected to the cleaning liquid supply tube 6 . At this time, the pressure of the pressure gauge P2 connected to the cleaning liquid supply tube 6 is measured, and it is confirmed that the inside of the through passage 16h of the hollow fiber membrane 16 of the filter 10 is sufficiently decompressed (near atmospheric pressure). After that, the flow rate adjusting means 2c is opened. Then, the work of filling the through passage 16h of the hollow fiber membrane 16 of the filter 10 can be performed without causing the pressurized gas to flow back into the cleaning liquid bag SB.

Further, the pressure inside the through passage 16h of the hollow fiber membrane 16 of the filter 10 may be reduced by the following method. The flow rate adjusting means 2c is closed, and the flow rate adjusting means 7c is opened while the washing liquid supply tube liquid feeding portion 6p is stopped. At this time, the pressure of the pressure gauge P2 connected to the cleaning liquid supply tube 6 is measured, and it is confirmed that the inside of the through passage 16h of the hollow fiber membrane 16 of the filter 10 is sufficiently decompressed (near atmospheric pressure). Then, the flow rate adjusting means 2c is opened (the flow rate adjusting means 7c is closed). Then, the work of filling the through passage 16h of the hollow fiber membrane 16 of the filter 10 can be performed without causing the pressurized gas to flow back into the cleaning liquid bag SB.

(Filtration concentration work)
After the preparatory cleaning work is completed, the filtration and concentration work is performed.

As shown in FIG. 13, in the filtration and concentration operation of the undiluted solution processing apparatus 1C of the present embodiment, the concentrated solution bag CB is connected to the concentrated solution tube 4 in place of the cleaning solution recovery bag FB from the state of the preparatory cleaning operation, and the cleaning solution is recovered. A waste liquid bag DB is connected to the waste liquid tube 5 instead of the bag FB.
The recirculation tube 8 is also connected to the concentrated liquid bag CB to which the concentrated liquid tube 4 is connected, and the recirculation tube 8 is closed by the flow rate adjusting means 8c.

On the other hand, the undiluted solution bag UB is connected to the liquid supply tube 2 instead of the cleaning solution bag SB. Moreover, while maintaining the state in which the liquid can flow through the liquid supply tube 2 by means of the flow rate adjusting means 2c, the operation of the cleaning liquid supply tube liquid feeding section 6p and the connection tube liquid feeding section 9p is stopped to The inside of the connecting tube 9 is closed so that the liquid does not flow. In addition, the washing liquid recovery tube 7 is closed by the flow rate adjusting means 7c.

In the above state, the filtrate supply tube liquid sending part 3p is operated so that the filtrate flows from the filter 10 to the concentrator 20, and the concentrated liquid tube flows so that the concentrated liquid flows from the concentrator 20 to the concentrated liquid bag CB. The liquid feeding part 4p is operated.

Then, the stock solution is supplied from the stock solution bag UB to the filter 10 through the supply tube 2 . The supplied undiluted liquid is filtered by the filter 10 and the produced filtrate is supplied to the concentrator 20 through the filtrate supply tube 3 . Then, the filtrate supplied to the concentrator 20 is concentrated by the concentrator 20, and the produced concentrated liquid is collected through the concentrated liquid tube 4 into the concentrated liquid bag CB. On the other hand, the water separated from the concentrated liquid is collected in the waste liquid bag DB through the waste liquid tube 5 .

(About filter cleaning)
A plurality of hollow fiber membranes 16 of the hollow fiber membrane bundle 15 of the filter 10 may be washed during the filtration and concentration operation of the undiluted solution processing apparatus 1C of the present embodiment. Specifically, in FIG. 13, the inside of the liquid supply tube 2 is blocked by the flow rate adjusting means 2c so that the liquid does not flow. In addition, the operation of the filtrate supply tube liquid-feeding section 3p and the concentrated liquid tube liquid-feeding section 4p is stopped to function as a clamp.

The connecting tube liquid feeding part 9p provided in the connecting tube 9 is operated so that the washing liquid flows from the washing liquid bag SB connected to the connecting tube 9 to the filtrate supply tube 3. Then, the cleaning liquid supplied to the filtrate supply tube 3 is supplied from the filtrate discharge port 11c to the internal space 12h of the main body 11 of the filter 10, and the cleaning liquid is fed to the hollow fiber membrane by the liquid feeding pressure of the connecting tube liquid feeding section 9p. It flows into 16 through channels 16h. Then, the washing liquid permeates the hollow fiber membranes 16 in the direction opposite to the direction in which the filtrate permeates the hollow fiber membranes 16 . Moreover, since the cleaning liquid is pushed into the through-channels 16h of the hollow fiber membranes 16 by the liquid feeding pressure of the connecting tube liquid feeding section 9p, clogging of the hollow fiber membranes 16 can be effectively eliminated.

At this time, the cleaning liquid supply tube liquid sending portion 6 p provided in the cleaning liquid supply tube 6 is operated so that the cleaning liquid flows out from the filter 10 . In addition, the cleaning liquid recovery tube 7 is opened by the flow rate adjusting means 7c provided in the cleaning liquid recovery tube 7 . Then, by adjusting the operation of the cleaning liquid supply tube liquid sending part 6p, part of the cleaning liquid pushed into the through channel 16h of the hollow fiber membrane 16 flows into the cleaning liquid collection bag FB provided in the cleaning liquid supply tube 6. , and the remainder flow into the cleaning liquid recovery bag FB provided in the cleaning liquid recovery tube 7 . As a result, the cleaning liquid pushed into the through channel 16h of the hollow fiber membrane 16 can flow through the through channel 16h of the hollow fiber membrane 16, and the cleaning liquid recovery provided in the cleaning liquid supply tube 6 and the cleaning liquid recovery tube 7 The washing liquid can be collected in the bag FB.

(Re-concentration work)
When further concentrating the concentrate obtained by the filtration concentration operation, a re-concentration operation is carried out.

In the re-concentration work, first, the liquid supply tube 2 is closed by the flow rate adjusting means 2c from the state of performing the concentration filtration work. At the same time, the operations of the filtrate supply tube liquid-feeding unit 3p and the concentrated liquid tube liquid-feeding unit 4p are stopped. The liquid flow in the device then stops.

When the flow of liquid stops, the flow control means 8c of the recirculation tube 8 allow liquid to flow through the recirculation tube 8. FIG.

In this state, the filtrate supply tube liquid sending part 3p is operated so that a flow toward the concentrator 20 is generated in the filtrate supply tube 3, and the concentrated liquid is caused to flow from the concentrator 20 to the concentrated liquid bag CB. The concentrated liquid tube liquid sending part 4p is operated.

Then, since the concentrated liquid is supplied from the concentrated liquid bag CB to the concentrator 20 through the recirculation tube 8 and the filtrate supply tube 3, the re-concentrated liquid further concentrated by the concentrator 20 flows through the concentrated liquid tube 4 into the concentrated liquid bag. Collected in CB. On the other hand, the water separated from the concentrated liquid is collected in the waste liquid bag DB through the waste liquid tube 5 . That is, it is possible to obtain a concentrated liquid (re-concentrated liquid) with an increased concentration ratio.

(Undiluted solution processing device 1D of another embodiment)
In the undiluted solution processing apparatus 1D of another embodiment, the connecting tube 9 is connected to the filtrate supply tube 3 from the undiluted liquid processing apparatus 1C by changing the position to connect the connecting tube 9 to the connecting tube 9 instead of the connecting tube liquid feeding section 9p. 9f is provided.

As shown in FIG. 14 , in the undiluted solution processing apparatus 1D, the connection tube 9 is connected between the filtrate supply tube liquid feed section 3p and the concentrator 20 in the filtrate supply tube 3 . With such a configuration, the cleaning liquid can be supplied to the filter 10 from the cleaning liquid bag SB connected to the connecting tube 9 by changing the operating direction of the liquid feeding portion 3p of the filtrate supply tube. Then, unlike the undiluted solution processing apparatus 1C, there is no need to provide a liquid feeding section (connecting tube liquid feeding section 9p) for supplying the cleaning liquid from the cleaning liquid bag SB connected to the connecting tube 9 to the filter 10. is obtained.

That is, in the undiluted solution processing apparatus 1C, as described above, it is necessary to operate the connecting tube liquid feeding section 9p in order to push the cleaning liquid supplied from the cleaning liquid bag SB connected to the connecting tube 9 into the hollow fiber membranes 16. there were. However, in the undiluted solution processing apparatus 1D, normally, the filtered liquid supply tube liquid feeding section 3p for feeding the filtrate from the filter 10 to the concentrator 20 is connected to the connecting tube 9 simply by reversing the operating direction. The cleaning liquid supplied from the cleaning liquid bag SB can be pushed into the hollow fiber membranes 16 .

In addition, in the undiluted solution processing apparatus 1D, a flow rate adjusting means 3c or a flow rate adjusting means 5c is provided between the position where the connection tube 9 is connected in the filtrate supply tube 3 and the concentrator 20 or in the waste liquid tube 5. Then, when one of the flow rate adjusting means 3c and the flow rate adjusting means 5c is blocked when switching from the filtration concentration process to the filter cleaning, the cleaning liquid supplied from the cleaning liquid bag SB connected to the connecting tube 9 will flow into the concentrator. 20 can be prevented.

Further, in the undiluted solution processing apparatus 1D, the cleaning liquid cannot be sent to the concentrator 20 from the cleaning liquid bag SB connected to the connecting tube 9 by the filtrate supply tube liquid sending section 3p. However, if the flow rate adjusting means 9f of the connecting tube 9 is opened and the concentrated liquid tube liquid feeding part 4p provided in the concentrated liquid tube 4 is operated so as to suck out the liquid from the concentrator 20, the concentrated liquid tube liquid feeding The negative pressure generated by the portion 4 p allows the cleaning liquid to be sent from the cleaning liquid bag SB connected to the other end of the connecting tube 9 to the concentrator 20 . Therefore, the cleaning of the concentrator 20 can be carried out even with the configuration of the undiluted solution processing apparatus 1D.

(Regarding another filter 10B)
In the above description, the case of using the filter 10 in which the filter member is the hollow fiber membrane 16 is described as a representative, but a filter member in which flat filter membranes are laminated may be used as the filter member. The structure of a filter member (laminated type) in which filter membranes are laminated will be described below with reference to FIG. 16 .

16, members having substantially the same structural functions as those of the filter 10 (see FIG. 5) described above are denoted by the same reference numerals as those of the filter 10. As shown in FIG. Further, description of portions having the same configuration and functions as those of the filter 10 will be omitted as appropriate.

As shown in FIG. 16, this filter 10B has substantially the same structure as a known filter (for example, a dialyzer used for dialysis) having a layered filter member. 11, and a filtration membrane 17b and a holding member 17a arranged in the body portion 11. As shown in FIG.

Like the hollow fiber membrane 16, the filtration membrane 17b has a function of not permeating solids such as cells and gas but permeating liquid.

The filtration membrane 17b is put into the main body part 11 in a state in which one sheet of rectangular membrane is folded many times in a bellows shape (repeating mountain folds and valley folds), and its four sides are the main body of the filter 10B. By being adhered inside the portion 11, the body portion 11 is separated into two spaces (a space 17f and a space 17h). The separated space 17f and space 17h in the main body 11 are liquid-tight and air-tightly separated by the filtration membrane 17b.

In addition, in FIG. 16, the filtration membrane 17b is folded in a bellows shape, but the filtration membrane 17b may be planar. In other words, the filter membrane 17b only needs to be able to separate the space inside the main body 11 into two liquid-tight and air-tight spaces, and its shape and arrangement are not particularly limited.

(Holding member 17a)
The holding member 17a is a member provided to prevent the filter membranes 17b from coming into contact with each other under the influence of pressure when the filter membranes 17b are folded into a bellows shape, thereby preventing a decrease in filtration efficiency. This holding member 17a is inserted between the folded filter membranes 17b. The holding member 17a may be provided so as to exhibit the above function, and its material and shape are not particularly limited. As for the position where the holding member 17a is inserted, it is arranged on the space 17f side in FIG. 16, but it may be arranged on either the space 17h side or the space 17f side. Also, the holding member 17a may be arranged on both the space 17h side and the space 17f side. The holding member 17a may be inserted at an appropriate position according to the conditions for using the filter 10B.

(each port)
The body portion 11 is provided with four ports on its outer surface. Of these four ports, two are provided on the surface with which the space 17h is in contact, and the remaining two are provided on the surface with which the space 17f is in contact. In other words, two ports (ports 11a and 11b in FIG. 16) communicate with space 17h, and the other two ports (ports 11c and 11c in FIG. 16) communicate with space 17f. Among the ports communicating with the space 17h, one side serves as the above-described undiluted liquid supply port 11a, and the other side serves as the cleaning liquid supply port 11b. Two ports communicating with the space 17f are the filtrate discharge ports 11c. Each of the ports 11a to 11c of the body portion 11 is connected to a tube, like the filter 10. FIG. For example, one end of the liquid supply tube 2 is connected to the raw liquid supply port 11a, one end of the filtrate supply tube 3 is connected to the filtrate discharge port 11c, and one end of the cleaning liquid supply tube 6 is connected to the cleaning liquid supply port 11b.

Therefore, if the filter 10B is installed instead of the filter 10, the undiluted solution can be filtered in the same manner as the filter 10, and the filtering member 17 can be washed and leak checked by the same method as the filter 10. can.

The method of operating the undiluted solution processing apparatus of the present invention includes an apparatus for obtaining a concentrated solution by filtering and concentrating pleural and ascitic fluid containing cells, blood during surgery and phlebotomy, and a method for purifying plasma such as waste plasma from plasmapheresis. It is suitable as a method for cleaning the filter, etc., in a device that is reused by

1 Undiluted solution processing device 2 Liquid supply tube 2c Flow rate adjustment means 2p Supply liquid tube liquid delivery section 3 Filtrate supply tube 3c Flow rate adjustment means 3p Filtrate supply tube liquid delivery section 4 Concentrated liquid tube 4p Concentrated liquid tube liquid delivery section 5 Waste liquid tube 5c flow rate adjusting means 6 cleaning liquid supply tube 6c flow rate adjusting means 6p cleaning liquid supply tube liquid sending section 7 cleaning liquid recovery tube 7c flow rate adjusting means 7p cleaning liquid recovery tube liquid sending section 8 recirculation tube 8c flow rate adjusting means 9 connecting tube 9c flow rate adjusting means 9f Flow rate adjusting means 9p Connection tube liquid sending section 10 Filter 10B Filter 11 Body section 11a Undiluted solution supply port 11b Cleaning liquid supply port 11c Filtrate discharge port 12 Body section 12h Internal space 13 Header section 14 Header section 15 Hollow fiber membrane bundle 16 Hollow Fiber membrane 16h Penetration channel 16w Wall 17a Holding member 17b Filter membrane 17h Space 17f Space 20 Concentrator 20a Filtrate supply port 20b Concentrated liquid outlet 20c Waste liquid outlet UB Undiluted liquid bag CB Concentrated liquid bag DB Waste liquid bag SB Cleaning liquid bag FB Cleaning liquid Collection bag P1 Pressure gauge P2 Pressure gauge P3 Pressure gauge GS Pressurized gas supply unit

Claims (15)

A method of operating a raw liquid treatment apparatus comprising: a filter having a filtering member for filtering a raw liquid; and a concentrator supplied with a filtrate filtered by the filter and concentrating the filtrate to form a concentrated liquid. and
The filter is
a body portion having an internal space isolated by a flow path to which the stock solution is supplied and the filtering member;
a stock solution supply port and a cleaning solution supply port that are liquid-tightly separated from the internal space of the main body and communicated with both ends of a channel to which the stock solution is supplied;
a filtrate outlet in communication with the internal space,
During the filtration and concentration operation, the undiluted solution is supplied to the undiluted solution supply port with the cleaning fluid supply port closed,
A method of operating an undiluted solution processing apparatus, wherein the cleaning liquid supply port is opened to allow the cleaning liquid to flow between the undiluted liquid supply port and the cleaning liquid supply port during cleaning work. The filter is
The filtering member is a plurality of hollow fiber membranes bundled at one end and at the other end,
The internal space of the main body is a space for accommodating the hollow fiber membrane therein,
a pair of header portions, which are spaces having a cross-sectional area larger than that of the through-flow channels, respectively communicated with both ends of the through-flow channels of the plurality of hollow fiber membranes and liquid-tightly isolated from the internal space of the main body; equipped with
Each header portion is provided with either the undiluted solution supply port or the cleaning solution supply port,
A channel communicating with the undiluted solution supply port or the cleaning solution supply port is provided with a negative pressure generating unit for generating a negative pressure in the channel,
2. The method of operating a raw solution processing apparatus according to claim 1, wherein during the cleaning operation, the negative pressure generating unit is operated while flowing the cleaning solution between the raw solution supply port and the cleaning solution supply port. A channel communicating with the undiluted solution supply port is provided with a negative pressure generating unit for generating a negative pressure in the channel,
The filter is
comprising a filtrate outlet communicating with the internal space;
3. The method of operating the undiluted solution processing apparatus according to claim 1, wherein during the cleaning work, the negative pressure generating section is operated while the cleaning liquid is flowing through the filtrate discharge port. A method of operating a raw liquid treatment apparatus comprising: a filter having a filtering member for filtering a raw liquid; and a concentrator supplied with a filtrate filtered by the filter and concentrating the filtrate to form a concentrated liquid. and
The filter is
a body portion having an internal space isolated by a flow path to which the stock solution is supplied and the filtering member;
a stock solution supply port and a cleaning solution supply port that are liquid-tightly separated from the internal space of the main body and communicated with both ends of a channel to which the stock solution is supplied;
a filtrate outlet in communication with the internal space,
During the filtration and concentration operation, the undiluted solution is supplied to the undiluted solution supply port with the cleaning fluid supply port closed,
During the cleaning operation, the cleaning liquid is supplied to the inner space of the filter through the filtered liquid discharge port in a state in which the raw liquid supply port or both the raw liquid supply port and the cleaning liquid supply port are opened. method of operating the undiluted solution processing equipment. A channel communicating with the undiluted solution supply port is provided with a negative pressure generating unit for generating a negative pressure in the channel,
5. The method of operating the undiluted solution processing apparatus according to claim 4, wherein during the cleaning operation, the negative pressure generating section is operated while supplying the cleaning liquid to the filtrate discharge port. During the filtration and concentration operation, the liquid feed unit provided in the flow path communicating with the filtrate discharge port is operated to discharge the filtrate from the filter to the concentrator,
6. The method of operating a liquid concentrate processing apparatus according to claim 4, wherein during the cleaning work, the operation of the liquid feeder provided in the flow path communicating with the filtrate outlet is stopped. A method of operating a raw liquid treatment apparatus comprising: a filter having a filtering member for filtering a raw liquid; and a concentrator supplied with a filtrate filtered by the filter and concentrating the filtrate to form a concentrated liquid. and
The filter is
a body portion having an internal space isolated by a flow path to which the stock solution is supplied and the filtering member;
a stock solution supply port and a cleaning solution supply port that are liquid-tightly separated from the internal space of the main body and communicated with both ends of a channel to which the stock solution is supplied;
a filtrate outlet in communication with the internal space,
The flow path communicated with the filtrate outlet includes a cleaning liquid feeding unit that supplies cleaning liquid to the filtrate outlet and/or a filter that communicates the filtrate outlet and the filtrate supply port of the concentrator. A filtrate liquid feeding unit provided in the liquid supply channel is provided,
During the filtration and concentration operation, the undiluted solution is supplied to the undiluted solution supply port with the cleaning fluid supply port closed,
1. A method of operating a raw liquid treatment apparatus, wherein the washing liquid is forced into the internal space of the filter through the filtrate discharge port or the filtrate liquid feeding section by the washing liquid feeding section during washing work. A flow path communicating with the raw liquid supply port or the cleaning liquid supply port is provided with a liquid feeding section for flowing out the cleaning liquid from the flow path connected to the raw liquid supply port or the cleaning liquid supply port,
During the cleaning operation, the cleaning liquid supply port and/or the raw liquid supply port are opened, and the liquid feeding section is operated so that the cleaning liquid flows out from the raw liquid supply port and/or the cleaning liquid supply port. The method of operating the undiluted solution processing apparatus according to claim 7. During the filtration and concentration operation, a filtrate liquid feeding unit provided in a filtrate supply flow path communicating between the filtrate discharge port and the filtrate supply port of the concentrator is operated to remove the concentration from the filter. Allow the filtrate to drain into the vessel,
9. The method of operating the undiluted solution processing apparatus according to claim 7, wherein the filtrate supply channel is blocked by the filtrate supply unit during cleaning work. An apparatus for concentrating a stock solution to form a concentrate, comprising:
a filter having a filter member for filtering the stock solution;
a concentrator supplied with a filtrate filtered by the filter and concentrating the filtrate to form the concentrate;
a stock solution supply unit that supplies the stock solution to the filter;
a liquid feed channel communicating between the liquid feed section and a liquid feed port communicating with one end of the liquid feed channel of the filter;
a filtrate supply channel communicating between the filtrate discharge port of the filter and the filtrate supply port of the concentrator;
a concentrate channel connected to a concentrate outlet of the concentrator;
a waste liquid channel connected to a waste liquid discharge port for discharging the waste liquid separated from the concentrated liquid in the concentrator;
a cleaning liquid supply channel connected to a filter cleaning liquid supply port communicating with the other end of the channel to which the undiluted solution of the filter is supplied in the filter;
a cleaning liquid recovery channel communicating with the undiluted liquid supply port of the filter;
a connecting channel communicating with the filtrate supply channel,
The cleaning liquid supply channel is
The undiluted solution processing apparatus has a clamping function for closing the cleaning liquid supply port during a filtration and concentration operation and for opening or closing the cleaning liquid supply port during a cleaning operation. The filtrate supply channel, the concentrated liquid channel, the cleaning liquid supply channel, and the connection channel are provided with a liquid delivery unit that carries out liquid delivery in each channel,
The connection channel is
11. The undiluted solution processing apparatus according to claim 10, wherein the undiluted solution processing apparatus is connected between the liquid feeding section provided in the filtrate supply channel and the filter. 11. The undiluted solution processing apparatus according to claim 10, wherein the filtrate supply channel, the concentrated liquid channel, and the cleaning liquid supply channel are provided with a liquid sending unit for sending the liquid in each channel. The connection channel is
13. The undiluted solution processing apparatus according to claim 12, wherein the undiluted solution processing apparatus is connected between the liquid feeding section provided in the filtrate supply channel and the concentrator. 11. The method according to claim 10, wherein the liquid supply channel, the cleaning liquid recovery channel, the concentrated liquid channel, and the connecting channel are provided with a liquid feeding section for feeding liquid in each channel. Undiluted solution processing equipment. The filtering member is
15. The undiluted solution treatment apparatus according to any one of claims 10 to 14, characterized in that it is a hollow fiber membrane in which a through channel is formed that penetrates in the axial direction.

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