JP7421903B2 - Virus inactivator composition - Google Patents

Description

The present invention relates to a virus inactivator composition and a virus inactivation method.

Washing hands and the environment is considered to be one of the important preventive measures against viral infectious diseases such as influenza and colds. Among these, acute viral gastroenteritis and diarrhea are not only confirmed as mass infections in nursing homes, schools, hospitals, etc., but also mass infections caused by food poisoning through contaminated food in restaurants and cooking facilities. There have been many reports as well. Viruses that cause these include non-enveloped viruses such as norovirus, sapovirus, and rotavirus, and infection in children and the elderly may cause serious symptoms. Furthermore, the viruses that cause foot-and-mouth disease, which is a typical childhood infectious disease, and foot-and-mouth disease, which causes severe damage to livestock, are also classified as non-enveloped viruses, and hygiene measures for hands and the environment are extremely important as preventive measures against these viruses. be.

In particular, norovirus has been detected not only in Japan but also all over the world as a virus that causes non-bacterial food poisoning and acute gastroenteritis. Bacteria such as Staphylococcus aureus and Bacillus cereus have traditionally been known to cause food poisoning, but in recent years, food poisoning caused by norovirus, which causes acute gastroenteritis, accounts for about 25% of food poisoning cases and about 1,000 patients overall. It is the most common virus, accounting for half of the population, and is considered a problem as a virus that causes mass infections. It is well known that the route of infection is oral infection through eating raw oysters and other shellfish, but in homes and public facilities, infection can occur on the fingers or cooking utensils of people who have come into contact with contaminated food, or on patients' vomit or feces. There have also been many reports of secondary infections from viruses existing inside or in the patient's surrounding environment. In particular, such secondary infections lead to mass infections and spread of infection, and are a major cause of the increase in the number of patients.

Conventionally, various proposals have been made to inactivate viruses.
Patent Document 1 discloses a virucidal method in which a specific virucidal acid is brought into contact with a virus-containing region.
Patent Document 2 discloses an antibacterial composition that includes a proton donor and a surfactant and has a relaxation index, an antibacterial residual effectiveness index, and a 10-minute antiviral residual effectiveness index each within a predetermined range.
Patent Document 3 discloses an antibacterial composition containing an antibacterial active substance and an anionic surfactant mixture having an alkyl chain of a predetermined chain length.
US Pat. No. 5,001,203 discloses a method for inactivating viruses, comprising topically applying an antimicrobial composition comprising an organic acid and an anionic surfactant mixture having an alkyl chain of a predetermined chain length to the area requiring treatment. A method is disclosed.
Patent Document 5 describes a virus inactivating agent containing ethanol and an acid agent, the acid agent being at least two acids selected from the group consisting of citric acid, tartaric acid, and phosphoric acid, The virus inactivating agent has a pH of 1.0 to 6.0.
Patent Document 6 discloses that the antibacterial active substance, an anionic surfactant, a proton donor, and water are each contained in predetermined ranges, the pH is adjusted to about 3.0 to about 6.0, and the pH is greater than about 1.3. comprising a porous sheet or an absorbent sheet impregnated with an antimicrobial cleansing composition having a twice-wash instant bacterial reduction index and a mildness index greater than 0.3, including Gram-positive bacteria, Gram-negative bacteria, fungi, Antibacterial wipes are disclosed that are effective against yeast, mold and viruses.
Patent Document 7 discloses an inactivating agent for non-enveloped viruses that contains a specific quaternary ammonium salt as an active ingredient and has a pH in the range of 5 to 9.
Patent Document 8 discloses a decorative board having a substrate, a surface resin layer laminated on one or both surfaces of the substrate, and an organic antiviral agent disposed on the surface resin layer. The organic antiviral agent is described as an alkylbenzenesulfonic acid or a salt thereof.

Furthermore, it is thought that viruses become difficult to inactivate when they coexist with protein stains derived from foods, human body secretions, and the like. Patent Document 9 discloses a virus inactivator containing ethanol, a predetermined cation, a predetermined anion, and an acid agent. Patent Document 10 discloses a virus inactivating agent containing a virus inactivating component and a flocculant.

Japanese Unexamined Patent Publication No. 58-135802 Special Publication No. 2003-520809 Special Publication No. 2005-530857 Special Publication No. 2010-505964 Japanese Patent Application Publication No. 2018-199635 Special Publication No. 2002-541182 Japanese Patent Application Publication No. 2010-53091 JP2017-94544A Japanese Patent Application Publication No. 2018-197204 Japanese Patent Application Publication No. 2018-197205

To prevent food poisoning and infection caused by norovirus, prevent food poisoning from occurring on the floors and walls of large-scale cooking facilities and kitchen spaces such as group feeding facilities and restaurants, food processing equipment, cooking utensils, etc., as well as floors and walls at home, and toilets. Implement hygiene measures such as removing and inactivating viruses from toilets, cooking utensils, furniture, textile products, floors and walls of public facilities, equipment, medical equipment, etc., and washing hands. It is very important that these measures be implemented easily and with consideration for people and the environment. It is desired that such virus inactivation has a sufficient effect on viruses that coexist with protein stains.

The present invention provides a virus inactivator composition that can inactivate viruses such as norovirus that coexist with protein stains other than viruses by a simple method.

The present invention provides (a) an anionic surfactant having a hydrocarbon group having 10 to 24 carbon atoms [hereinafter referred to as component (a)] and (b) a pKa selected from organic acids and phosphoric acid of 1.8 or more. 5.0 or less [hereinafter referred to as component (b)] as an active ingredient, the pH at 20°C is 2.5 or more and 6.0 or less, and a virus that coexists with protein stains other than viruses. The present invention relates to a virus inactivating agent composition that inactivates viruses.

The present invention also relates to a cleaning composition containing the virus inactivator composition of the present invention.

The present invention also relates to a hard surface cleaning composition containing the virus inactivator composition of the present invention.

The present invention also relates to a method for inactivating viruses, which comprises bringing the virus inactivator composition of the present invention into contact with viruses that coexist with protein stains other than viruses.

The present invention also relates to a cleaning method in which the cleaning composition of the present invention is brought into contact with stains including viruses and protein stains other than viruses.

According to the present invention, there is provided a virus inactivator composition that can inactivate viruses such as norovirus that coexist with protein stains other than viruses by a simple method, and a method for inactivating viruses using the same. .

<Virus inactivator composition>
Component (a) is an anionic surfactant having a hydrocarbon group having 10 to 24 carbon atoms. The composition of the present invention contains component (a) as an effective ingredient for virus inactivation. One or more types of component (a) can be used.
Examples of the hydrocarbon group of component (a) include an alkyl group and an alkenyl group. The hydrocarbon group may be either straight chain or branched chain.
The hydrocarbon group of component (a) preferably has 10 or more carbon atoms, from the viewpoint of inactivating viruses that coexist with protein stains other than viruses (hereinafter also simply referred to as virus inactivation). is 18 or less, more preferably 14 or less.
In addition, in the case of a compound having a cyclic structure such as an aromatic hydrocarbon group, the hydrocarbon group of component (a) means a hydrocarbon group that replaces one of the hydrogen molecules of the cyclic structure. good.

Component (a) is selected from benzenesulfonic acid or its salt having a hydrocarbon group having 10 to 24 carbon atoms substituting on the benzene ring, and a sulfuric acid ester having a hydrocarbon group having 10 to 24 carbon atoms or a salt thereof. One or more selected anionic surfactants may be mentioned.

Examples of benzenesulfonic acids or salts thereof having a hydrocarbon group having 10 to 24 carbon atoms substituting on the benzene ring include alkylbenzenesulfonic acids having an alkyl group having 10 to 24 carbon atoms or salts thereof. From the viewpoint of virus inactivation, the alkyl group has at least 10 carbon atoms and at most 24 carbon atoms, preferably at most 18 carbon atoms, and more preferably at most 14 carbon atoms.

Examples of the sulfuric esters or salts thereof having a hydrocarbon group having 10 to 24 carbon atoms include alkyl sulfuric esters having an alkyl group having 10 to 24 carbon atoms or salts thereof. From the viewpoint of virus inactivation, the alkyl group has 10 or more carbon atoms and 24 or less carbon atoms, preferably 18 or more carbon atoms, and more preferably 14 carbon atoms or less.

In addition, as component (a) other than these, α-sulfo fatty acid ester or salt thereof whose fatty acid moiety has 10 to 24 carbon atoms, polyoxyalkylene (preferably) whose alkyl group has 10 to 24 carbon atoms is polyoxyethylene, the average number of added moles is 0.5 or more, preferably 1 or more, and 4 or less, preferably 3 or less)) an alkyl ether sulfate or a salt thereof, an olefin in which the number of carbon atoms in the olefin moiety is 10 to 24 Examples include sulfonic acids or salts thereof, alkanesulfonic acids or salts thereof in which the alkane moiety has 10 to 24 carbon atoms, and alkylsulfosuccinic acids or salts thereof in which the alkyl group has 10 to 24 carbon atoms.

Examples of the salt of component (a) include alkali metal salts such as sodium salts and potassium salts, and ammonium salts.

As component (a), from the viewpoint of virus inactivation, benzenesulfonic acid or a salt thereof having a hydrocarbon group having 10 to 24 carbon atoms to be substituted on the benzene ring, and a hydrocarbon group having 10 to 24 carbon atoms. Furthermore, preferred are alkylbenzenesulfonic acids or salts thereof having an alkyl group having 10 to 24 carbon atoms, and alkyl sulfate esters having an alkyl group having 10 to 24 carbon atoms or salts thereof.

In the virus inactivator composition of the present invention, component (a) is preferably 0.01% by mass or more, more preferably 0.03% by mass or more, still more preferably 0.01% by mass or more, from the viewpoint of virus inactivation. 05% by mass or more, even more preferably 0.1% by mass or more, and from the viewpoint of virus inactivation, preferably 5.0% by mass or less, more preferably 3.0% by mass or less, still more preferably 2.0% by mass or less. The content is 0% by mass or less, more preferably 1.0% by mass or less, even more preferably 0.9% by mass or less, even more preferably 0.6% by mass or less.

Component (b) is an acid agent selected from organic acids and phosphoric acid and having a pKa of 1.8 or more and 5.0 or less. The composition of the present invention contains component (b) as an effective ingredient for virus inactivation. One or more types of component (b) can be used.
From the viewpoint of virus inactivation, component (b) has a pKa of 1.8 or more, preferably 2.0 or more, more preferably 2.5 or more, even more preferably 3.0 or more, and 5.0 or more. It is preferably 4.5 or less, more preferably 4.2 or less. Among compounds having multiple pKas, it is preferable that the first pKa is within this range.
From the viewpoint of virus inactivation, component (b) is preferably an organic acid having 1 to 12 carbon atoms. The organic acid is preferably a carboxylic acid.
From the viewpoint of virus inactivation, component (b) is preferably an organic acid with a valence of 1 or more and 5 or less.
Component (b) is preferably a hydroxycarboxylic acid from the viewpoint of virus inactivation.

In addition, when producing the composition of the present invention, component (b) may be in the form of an acid or a salt. For example, the composition of the present invention may be manufactured using a salt of component (b).

In terms of virus inactivation, the components (b) include lactic acid (pKa=3.8), malic acid (pKa=3.4), succinic acid (pKa=4.2), and citric acid (pKa=3). .1), glycolic acid (pKa=3.8), tartaric acid (pKa=3.0), acetic acid (pKa=4.7), maleic acid (pKa=1.9), fumaric acid (pKa=3.0) ), phosphoric acid (pKa=2.1), preferably one or more organic acids selected from lactic acid, malic acid, succinic acid, and citric acid, and more preferably from the viewpoint of easy availability. It is malic acid.

In the virus inactivator composition of the present invention, (b)/(a), which is the mass ratio between the content of component (b) and the content of component (a), is determined at the time of virus inactivation and application. From the viewpoint of workability, the The following is more preferably 60 or less, even more preferably 20 or less, even more preferably 15 or less, even more preferably 10 or less, even more preferably 5 or less, even more preferably 3 or less, even more preferably 1.5 It is as follows. Note that the mass of component (b) of the present invention is based on a value converted to an acid type compound.

In the virus inactivator composition of the present invention, component (b) is preferably 0.01% by mass or more, more preferably 0.05% by mass or more, still more preferably 0.01% by mass or more, from the viewpoint of virus inactivation. 1% by mass or more, even more preferably 0.2% by mass or more, even more preferably 0.25% by mass or more, even more preferably 0.4% by mass or more, and from the economical point of view, preferably 5. 0% by mass or less, more preferably 3.0% by mass or less, even more preferably 2.0% by mass or less, even more preferably 1.0% by mass or less, even more preferably 0.95% by mass or less, even more preferably contains 0.9% by mass or less.

The virus inactivator composition of the present invention can contain water. If the composition is a liquid, water may be used as the balance of the composition.

The virus inactivator composition of the present invention contains (c) one or more surfactants selected from nonionic surfactants, cationic surfactants, and amphoteric surfactants [hereinafter referred to as ( (c) component].
Nonionic surfactants include (c1) alkyleneoxy groups such as glycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, polyethylene glycol fatty acid ester, sorbitan fatty acid ester, sucrose fatty acid ester, polyoxyethylene sorbitan fatty acid ester, etc. Polyhydric alcohol fatty acid ester that may contain, (c2) alkyl glycoside, (c3) polyoxyethylene alkyl ether, (c4) polyoxyethylene dialkyl ether, (c5) polyoxyethylene glycol, (c6) polyoxyethylene oxy Examples include propylene glycol, (c7) polyoxypropyleneoxyethyleneoxypropylene glycol, and the like.
Examples of cationic surfactants include quaternary ammonium salts having two alkyl groups having 8 to 24 carbon atoms, quaternary ammonium salts having one alkyl group having 8 to 24 carbon atoms, benzalkonium chloride, etc. can be mentioned.
Examples of amphoteric surfactants include alkylamine oxides and alkylbetaines.
The virus inactivator composition of the present invention contains, for example, component (c) preferably at least 0.01% by mass and preferably at most 0.5% by mass, within a range that does not impede the effects of the present invention. The content is preferably 0.3% by mass or less, more preferably 0.1% by mass or less.

The virus inactivator composition of the present invention can also contain components other than component (a), component (b), and optional component (c). For example, solvents, inorganic salts, inorganic acids, chelating agents, fragrances (natural fragrances, synthetic fragrances), thickeners, gelling agents, polymer compounds, humectants, preservatives, antioxidants, light stabilizers, preservatives. Components such as agents and buffers may be contained within the range that does not impair the effects of the present invention.

The virus inactivator composition of the present invention can be used, for example, in the form of a liquid, gel, or paste. Depending on the form of use thereof, the virus inactivator composition of the present invention, a solubilizing carrier such as water or alcohol, a gelling agent, etc. can be appropriately contained.

In the virus inactivator composition of the present invention, from the viewpoint of virus inactivation, the proportion of the content of component (a) in the total content of components other than water is preferably 3% by mass or more, and more preferably The content is preferably 5% by mass or more, more preferably 10% by mass or more, and preferably 95% by mass or less, more preferably 90% by mass or less, still more preferably 75% by mass or less, and even more preferably 60% by mass or less.

In the virus inactivator composition of the present invention, the ratio of the total content of component (a) and component (b) in the total content of components other than water is determined from the viewpoint of virus inactivation. , preferably 90% by mass or more, more preferably 93% by mass or more, more preferably 95% by mass or more, and preferably 100% by mass or less.

The virus inactivator composition of the present invention has a pH of 2.5 or more at 20°C as measured by a glass electrode method, from the viewpoint of sufficiently expressing the virus inactivation effect and from the viewpoint of preventing corrosion of equipment, etc. , preferably 2.8 or more, more preferably 3.0 or more, and 6.0 or less, more preferably 5.0 or less, still more preferably 4.5 or less. In addition, the pH at 20°C of the virus inactivator composition of the present invention is a value measured as is when the virus inactivator composition of the present invention is a liquid such as an aqueous solution, and is a value measured directly when the virus inactivator composition of the present invention is a liquid such as an aqueous solution. In this case, the value in the state of a 2% by mass aqueous solution or aqueous dispersion is applied as the solid content concentration. Further, the virus inactivator composition of the present invention may be used at a pH within the above range. That is, it may be brought into contact with the virus at a pH within the above range.

The virus inactivator composition of the present invention can be applied to various viruses. The virus is preferably a non-enveloped virus, that is, a non-enveloped single-stranded (+) RNA virus, a single-stranded (-) RNA virus, a double-stranded RNA virus, a single-stranded DNA virus, and a double-stranded RNA virus. Examples include double-stranded DNA viruses. Examples of such viruses include viruses belonging to Caliciviridae, Picornaviridae, Parvoviridae, Papillomaviridae, Polyomaviridae, and Adenoviridae. Among the above, the composition of the present invention has an excellent inactivating effect on Caliciviridae viruses (single-stranded (+) viruses), and among Caliciviridae viruses, Vesivirus, Norovirus, and Sapovirus genus. It has an excellent inactivating effect on viruses belonging to the genus Vesivirus and the genus Norovirus.

The virus inactivator composition of the present invention inactivates viruses that coexist with protein stains other than viruses. Protein stains other than viruses include protein stains derived from food, protein stains derived from the human body, protein stains derived from animals (excluding humans), protein stains derived from plants, and the like. Among these, it is preferable to apply it to viruses that coexist with human and animal excreta such as urine and feces, vomit, saliva, and protein stains such as foods, ingredients, and leftovers.

The amount of protein stains other than viruses is not necessarily limited depending on the contaminated equipment or articles and their conditions, but is preferably 0.001 μg/m ³ or more and 100000 μg/m ³ or less, for example. In addition, the ratio of the mass of virus to the mass of protein stains other than viruses is not necessarily limited by the contaminated equipment or objects and their condition, but is calculated as follows: (mass of protein stains other than viruses) / (mass of protein stains other than viruses) / (mass of protein stains other than viruses) The mass) is preferably, for example, 1/10 or more and 1,000,000/1 or less. If there is a significant amount of protein stains other than viruses, a portion of the stain may be removed in advance and then the virus inactivator composition of the present invention may be applied.

Although the mechanism of action of the effect of the virus inactivator composition of the present invention has not been clearly elucidated, it is believed that viruses are formed by adsorption of the components (a) and (b) of the present invention to viruses. It is thought that the virus is inactivated by changing the structure of the protein. When viruses coexist with protein stains, the components (a) and (b) of the present invention are also adsorbed to the proteins in the protein stains, changing the structure of the proteins in the protein stains. As a result, the structurally changed proteins in the protein stain will increase the pH of the applied virus inactivator composition, leaving the pH range effective for virus inactivation. Therefore, in the present invention, by using a specific organic acid as the component (b), by utilizing the buffering ability of the specific component (b), the pH fluctuation can be reduced and stabilized in the environment where the virus is affected. It is considered that the effect is being realized. Note that the present invention is not particularly limited to the above mechanism of action.

The virus inactivator composition of the present invention can be applied to (1) the body, such as human skin, fingers, hair, and the inside of the oral cavity, (2) foods, such as the surface of food materials such as vegetables, and (3) hard articles. (4) Textile products, such as textile materials such as cloth and thread, and products manufactured using these materials, can be targeted. Examples of hard articles include hard surfaces such as bathrooms, toilets, kitchens, floors, doorknobs, tableware, food processing equipment, desks, chairs, walls, and the like. These hard articles may be used at home or in public facilities or factories, such as swimming pools, bathhouses, cafeterias, hospitals, and the like.

<Virus inactivation method>
The present invention provides a method for inactivating viruses, which involves bringing the virus inactivator composition of the present invention into contact with viruses that coexist with protein stains other than viruses. In the present invention, component (a) and component (b) are brought into contact with a virus that coexists with a protein stain other than a virus at a pH of 2.5 or more and 6.0 or less. It was discovered that the ingredient functions as an effective ingredient for inactivating viruses. The virus inactivation method of the present invention uses (a) an anionic surfactant having a hydrocarbon group having 10 to 24 carbon atoms, and (b) an organic acid and phosphoric acid having a pKa of 1.8 to 5. The present invention may be a method for inactivating viruses, in which an acid agent having a pH of 0 or less is brought into contact with viruses coexisting with protein stains other than viruses under conditions where the pH is 2.5 or more and 6.0 or less. The virus may be present in the target mentioned in the virus inactivator composition of the present invention.

There are no particular limitations on the form in which the virus inactivator composition of the present invention is used when it is brought into contact with viruses. In the present invention, it is preferable to use the virus inactivator composition of the present invention under conditions where the components (a) and (b) come into contact with the virus at a pH of 2.5 or higher and 6.0 or lower.

When the virus inactivator composition of the present invention is in liquid form, it can be used particularly as a spray, lotion, etc. For example, it is possible to fill a known spray container such as a trigger spray container (direct pressure or pressure accumulation type) or a dispenser-type pump spray container, adjust the amount of spray, and spray it to a place where the virus is present or is thought to be present. Examples include those made as follows.
It can also be used as a wet wiping product (wet napkin, etc.). For example, the virus inactivating agent of the present invention may be applied to a substrate containing natural fibers, recycled fibers such as rayon, synthetic fibers such as polyethylene, polypropylene, polyester, or a woven or nonwoven web of a mixture of natural fibers and synthetic fibers. The composition, a solubilizing carrier, and, if necessary, various additives can be included for use. Specifically, it can be used for virus inactivation of skin conditioners, pet care products, surfaces of home kitchens, bathrooms, toilets, toilet seats, etc., surfaces of exercise equipment, etc.

When the virus inactivator composition of the present invention is made into a gel form using a water-soluble gel or an oil-based gel, or when it is made into a paste form, it can be used as a medical product by directly applying it to the human body, pets, etc. It can also be used as a filter for air purifiers by supporting it on paper, nonwoven fabric, or the like.

The amount of the virus inactivator composition of the present invention to be used is not particularly limited, but for example, the amount of component (a) per 1 m ² of the target object is preferably 0.0001 g or more, or more. The amount can be preferably 0.001 g or more, and preferably 0.1 g or less, and more preferably 0.05 g or less.
Although the amount of the virus inactivator composition of the present invention to be used is not particularly limited, for example, the total amount of component (a) and component (b) per unit area of 1 m ² of the object is preferably The amount can be 0.0002, more preferably 0.002 or more, and preferably 0.2 g or less, more preferably 0.1 g or less.

<Cleaning composition and cleaning method>
The virus inactivator composition of the present invention can be incorporated into a cleaning agent and used when cleaning stains containing viruses and non-virus protein stains.
The present invention provides a cleaning composition containing the virus inactivator composition of the present invention.
The present invention also provides a hard surface cleaning composition containing the virus inactivator composition of the present invention.
In the cleaning composition of the present invention, as well as the hard surface cleaning composition, components and compositions other than the virus inactivator composition of the present invention are selected from known embodiments, taking into consideration the intended use and usage. be able to.

The present invention provides a cleaning method in which a cleaning composition of the present invention, such as a hard surface cleaning composition, is brought into contact with soil including viruses and non-virus protein soils.

The cleaning method of the present invention can be applied to the targets mentioned in the virus inactivator composition of the present invention.

The virus inactivator composition shown in the table was prepared, and in the coexistence of beef extract, which is a protein stain other than viruses, feline calicivirus (family Caliciviridae, genus Vesivirus), which is also known as a substitute virus for norovirus, was detected. The inactivation effect was evaluated. In addition, the pH of the compositions in the table was adjusted to the values shown in the table using sodium hydroxide or hydrochloric acid, if necessary.

Virus inactivation evaluation is based on the "2015 Survey Report on Norovirus Inactivation Conditions" (National Institute of Health Sciences) and JIS L 1922, which are generally known as standard methods for virus inactivation evaluation. I went to
In an Eppendorf tube, add 900 μL of the virus inactivator composition and 100 μL of feline calicivirus solution (F-9 strain, ATCC VR-782) adjusted to 1.0×10 ⁷ PFU/mL for the total amount of these. Beef extract (Nacalai Tesque) was added in an amount corresponding to the ratio (mass%) shown in the table and mixed well. After 30 seconds, the reaction was stopped by diluting it 1/10 with quenching liquid (D/E Neutralizing Broth). As a blank, the same operation was performed using 900 μL of physiological saline instead of 900 μL of the virus inactivator composition. After stopping the reaction, the mixture was further diluted 1/10 with DMEM medium (Dulbecco's modified Eagle medium), and 0.5 mL of the mixture was added to CRFK cells (feline kidney-derived cell line) washed with PBS (phosphate buffered saline). (ATCC CCL-94), and after 1 hour, the medium was replaced with methylcellulose-containing medium. Two days later, the cells were stained with crystal violet, the number of plaques was counted, and the amount of logarithmic reduction was determined.
Logarithmic reduction = log (number of plaques on blank) - log (number of plaques on test sample)
In this specification, the logarithmic decrease amount is expressed as Δ4log, for example, when the logarithmic decrease amount=4. The criteria for evaluation were as follows, and the results are shown in the table.
Judgment criteria 〇: The amount of logarithmic decrease is greater than Δ4Log △: The amount of logarithm decrease is greater than Δ1Log and less than Δ4Log ×: The amount of logarithm decrease is less than Δ1Log

The ingredients in the table are as follows. Component (a') is a comparison component of component (a).
・LAS: Sodium dodecylbenzenesulfonate (Neoperex G-15 (Kao Corporation))
・SDS: Sodium lauryl sulfate (EMAL 0 (Kao Corporation))
・C8AS: Sodium n-octyl sulfate (Alfa Aesar)
・C8AGS: Sodium octylglyceryl sulfonate (synthetic product by Kao Corporation)
・AG: Lauryl glucoside (Mydol 12 (Kao Corporation))

Claims (6)

(a) one or more anionic surfactants selected from alkylbenzenesulfonic acids having an alkyl group having 10 to 24 carbon atoms and salts thereof [hereinafter referred to as component (a)]; and (b) malic acid [hereinafter referred to as (b) component] as an active ingredient;
pH at 20°C is 2.5 or more and 4.5 or less ,
Contains component (a) from 0.05% by mass to 3.0% by mass,
(b) Contains 0.1% by mass or more and 3.0% by mass or less of the component,
(b)/(a), which is the mass ratio between the content of component (b) and the content of component (a), is 0.02 or more and 100 or less,
The ratio of the total content of component (a) and content of component (b) in the total content of components other than water is 95% by mass or more,
A virus inactivator composition that inactivates viruses that coexist with protein stains other than viruses. The virus inactivator composition according to claim 1 , wherein the virus is non-enveloped. A cleaning composition comprising the virus inactivator composition according to claim 1 or 2 . A hard surface cleaning composition comprising the virus inactivator composition according to claim 1 or 2 . A method for inactivating viruses (excluding medical treatment for humans) , which comprises bringing the virus inactivator composition according to claim 1 or 2 into contact with viruses coexisting with protein stains other than viruses. A cleaning method comprising bringing the cleaning composition according to claim 3 into contact with stains containing viruses and non-virus protein stains.