JP7420558B2 - 自己不活性化ウイルスベクター - Google Patents
自己不活性化ウイルスベクター Download PDFInfo
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- JP7420558B2 JP7420558B2 JP2019560380A JP2019560380A JP7420558B2 JP 7420558 B2 JP7420558 B2 JP 7420558B2 JP 2019560380 A JP2019560380 A JP 2019560380A JP 2019560380 A JP2019560380 A JP 2019560380A JP 7420558 B2 JP7420558 B2 JP 7420558B2
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- A01K2217/00—Genetically modified animals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0393—Animal model comprising a reporter system for screening tests
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K38/00—Medicinal preparations containing peptides
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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- C07K2319/00—Fusion polypeptide
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- C07K2319/00—Fusion polypeptide
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- C07K2319/95—Fusion polypeptide containing a motif/fusion for degradation (ubiquitin fusions, PEST sequence)
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- C12N2760/00011—Details
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- C12N2760/20111—Lyssavirus, e.g. rabies virus
- C12N2760/20141—Use of virus, viral particle or viral elements as a vector
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- C12N2810/00—Vectors comprising a targeting moiety
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- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
- C12N2810/609—Vectors comprising as targeting moiety peptide derived from defined protein from viruses positive strand RNA viruses
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| GB1706945.1 | 2017-05-02 | ||
| PCT/GB2018/051166 WO2018203049A1 (en) | 2017-05-02 | 2018-05-02 | Self-inactivating viral vector |
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| JP2020518265A JP2020518265A (ja) | 2020-06-25 |
| JP2020518265A5 JP2020518265A5 (https=) | 2021-07-26 |
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| CA3208612A1 (en) * | 2021-02-19 | 2022-08-25 | Beam Therapeutics Inc. | Recombinant rabies viruses for gene therapy |
| AU2022264328A1 (en) * | 2021-04-27 | 2023-11-16 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Recombinant cedar virus chimeras |
| CN115704012A (zh) * | 2021-08-12 | 2023-02-17 | 中国科学院深圳先进技术研究院 | 一种含有降解决定子的重组病毒及其制备方法和应用 |
| CA3230629A1 (en) * | 2021-09-08 | 2023-03-16 | Beam Therapeutics Inc. | Viral guide rna delivery |
| CN116262911B (zh) * | 2021-12-14 | 2026-02-17 | 中国科学院深圳先进技术研究院 | 一种减毒、复制可控的顺向hsv示踪系统及其构建方法和应用 |
| CN114058641B (zh) * | 2022-01-17 | 2022-04-01 | 苏州大学 | 一种载体系统和应用及通过其降解目的蛋白的方法 |
| CN116676273A (zh) * | 2022-02-22 | 2023-09-01 | 中国科学院深圳先进技术研究院 | 一种蛋白水解靶向流感病毒及其制备方法和应用 |
| CN120366391A (zh) * | 2023-04-18 | 2025-07-25 | 上海本导基因技术有限公司 | 一种用于治疗亨廷顿疾病的慢病毒样颗粒 |
| CN117867029B (zh) * | 2023-12-29 | 2024-12-20 | 复百澳(苏州)生物医药科技有限公司 | 一种狂犬亚型假病毒的制备方法及应用 |
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| WO2017004022A2 (en) | 2015-06-29 | 2017-01-05 | The Board Of Trustees Of The Leland Stanford Junior University | Degron fusion constructs and methods for controlling protein production |
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| HUP0500722A2 (hu) * | 2001-07-20 | 2005-11-28 | The University of Georgia Research Foundation, Inc@Á | Attenuált veszettség vírus, a veszettség elleni vakcináláshoz és a központi idegrendszer génterápiájához egy nukleoprotein mutációval a foszforilezés helyén |
| US7608682B2 (en) | 2002-10-30 | 2009-10-27 | Meso Scale Technologies Llc | Substrates of N-end rule ubiquitylation and methods for measuring the ubiquitylation of these substrates |
| US9212359B2 (en) | 2011-06-23 | 2015-12-15 | Sanford Jay Silverman | Systems for induction of gene expression and protein depletion in yeast |
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| WO2016125364A1 (ja) | 2015-02-02 | 2016-08-11 | 株式会社Ｉｄファーマ | 改良されたマイナス鎖ｒｎａウイルスベクター |
| WO2017004022A2 (en) | 2015-06-29 | 2017-01-05 | The Board Of Trustees Of The Leland Stanford Junior University | Degron fusion constructs and methods for controlling protein production |
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| CN110914439A (zh) | 2020-03-24 |
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| AU2018262281B2 (en) | 2024-05-09 |
| JP2020518265A (ja) | 2020-06-25 |
| US20210115472A1 (en) | 2021-04-22 |
| BR112019023003A2 (pt) | 2020-05-19 |
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