JP7410856B2 - ドナー改変細胞の選択のための調節可能スイッチ - Google Patents

ドナー改変細胞の選択のための調節可能スイッチ Download PDF

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JP7410856B2
JP7410856B2 JP2020524723A JP2020524723A JP7410856B2 JP 7410856 B2 JP7410856 B2 JP 7410856B2 JP 2020524723 A JP2020524723 A JP 2020524723A JP 2020524723 A JP2020524723 A JP 2020524723A JP 7410856 B2 JP7410856 B2 JP 7410856B2
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クリストファー・ウォルター・アルマ
ジェフリー・バートレット
ルイス・ランドール・ブレトン
ジェフリー・フィリップ・シモンズ
ミン・ヤン
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シーエスエル・ベーリング・ジーン・セラピー・インコーポレイテッド
シーエスエル・ジーン・セラピー・プロプライエタリー・リミテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • C—CHEMISTRY; METALLURGY
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine

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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2020524723A 2017-07-18 2018-07-18 ドナー改変細胞の選択のための調節可能スイッチ Active JP7410856B2 (ja)

Applications Claiming Priority (3)

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US201762533707P 2017-07-18 2017-07-18
US62/533,707 2017-07-18
PCT/US2018/042630 WO2019018491A1 (en) 2017-07-18 2018-07-18 MODULAR SWITCH FOR SELECTING DONOR MODIFIED CELLS

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JP2020528455A JP2020528455A (ja) 2020-09-24
JP2020528455A5 JP2020528455A5 (cg-RX-API-DMAC10.html) 2021-08-26
JP7410856B2 true JP7410856B2 (ja) 2024-01-10

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US (3) US10426798B2 (cg-RX-API-DMAC10.html)
EP (2) EP3654994B1 (cg-RX-API-DMAC10.html)
JP (1) JP7410856B2 (cg-RX-API-DMAC10.html)
KR (1) KR20200125574A (cg-RX-API-DMAC10.html)
CN (1) CN111343996A (cg-RX-API-DMAC10.html)
AU (1) AU2018304222A1 (cg-RX-API-DMAC10.html)
BR (1) BR112020001132A2 (cg-RX-API-DMAC10.html)
CA (1) CA3070258A1 (cg-RX-API-DMAC10.html)
ES (2) ES3036762T3 (cg-RX-API-DMAC10.html)
SG (1) SG11202000428PA (cg-RX-API-DMAC10.html)
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US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
EP3654994B1 (en) * 2017-07-18 2022-12-28 CSL Behring Gene Therapy, Inc. A modulatable switch for selection of donor modified cells
CN114900773A (zh) 2017-12-14 2022-08-12 弗洛设计声能学公司 声泳系统及其操作方法、控制声换能器及声学系统的方法
EP3897831A1 (en) * 2018-12-23 2021-10-27 CSL Behring LLC Donor t-cells with kill switch
WO2021263070A1 (en) * 2020-06-26 2021-12-30 Csl Behring Llc Donor t-cells with kill switch
WO2022187496A1 (en) * 2021-03-04 2022-09-09 City Of Hope T-cells for anti-hiv car-t therapy and methods of use

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SG11202000428PA (en) 2020-02-27
EP3654994A1 (en) 2020-05-27
BR112020001132A2 (pt) 2020-07-21
ES3036762T3 (en) 2025-09-24
KR20200125574A (ko) 2020-11-04
EP3654994B1 (en) 2022-12-28
AU2018304222A1 (en) 2020-02-20
US20220072046A1 (en) 2022-03-10
JP2020528455A (ja) 2020-09-24
CN111343996A (zh) 2020-06-26
CA3070258A1 (en) 2019-01-24
US11213548B2 (en) 2022-01-04
WO2019018491A1 (en) 2019-01-24
US20200038444A1 (en) 2020-02-06
ES2940681T3 (es) 2023-05-10
US10426798B2 (en) 2019-10-01
EP4190339A1 (en) 2023-06-07
US20190054119A1 (en) 2019-02-21
EP4190339B1 (en) 2025-07-02

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