JP7398135B2 - ユビキチン特異的プロテアーゼ阻害剤及びその製造方法と応用 - Google Patents
ユビキチン特異的プロテアーゼ阻害剤及びその製造方法と応用 Download PDFInfo
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Description
本発明は医薬分野に関し、具体的には、本発明は新しいユビキチン特異的プロテアーゼ阻害剤及びその製造方法と用途に関する。
細胞は、細胞内タンパク質の恒常性により正常に機能するが、この恒常性は、タンパク質の合成と分解の動的平衡により維持する。細胞は主にプロテアソームの分解によって、損傷したタンパク質やミッションを完了したタンパク質等、不要になったタンパク質を除去する。プロテアソームによって分解されたタンパク質は、一般的に、48位のリジンによって連結されたポリユビキチン鎖で標識される。タンパク質のポリユビキチン標識は、主にE1、E2及びE3を含む一連の酵素作用の結果である。E1は、それ自体のシステイン残基と、76個のアミノ酸からなるユビキチンのC末端カルボキシル基との間に高エネルギーのチオエステル結合を形成することによってユビキチンを活性化し、活性化されたユビキチンは、E2のシステイン残基に転移され(哺乳類には約50種類のE2カップリング酵素がある)、そして、E3リガーゼの作用下で(哺乳類の細胞には約500種類のE3がある)、E2カップリング酵素はユビキチンを標的タンパク質のリジン残基に転移する。実質的には、E3リガーゼは、単に、ユビキチンがE2から標的タンパク質に転移されるように、E2カップリング酵素と基質を集めるに過ぎない(Annu. Rev. Biochem. 2009, 78, 477 & 2018, 87, 697; J. Am. Soc. Nephrol. 2006, 17, 1807)。細胞の一連の活動において、ユビキチン介在性の、プロテアソームによるタンパク質分解は、必要な調節手段であり、例えば、細胞周期、アポトーシス(Front Cell. Dev. Biol. 2018, 6, 11; Cell Death Differ. 1999, 6, 303; J. Cell. Mol. Med. 2002, 6, 25)やDNA損傷チェックポイントの制御(DNA Repair 2010, 9, 1229; Biochim. Biophys. Acta 2014, 1843, 150; Cell Death Differ. 2010, 17, 78; ISRN Mol. Biol. 2012, 146748)等である。
従来技術における問題を改善し、USP28/USP25の阻害活性を有する新しい構造を提供するために、本発明は、下記の式Iに示される化合物及びそのラセミ体、立体異性体、互変異性体、同位体標識、窒素酸化物、溶媒和物、結晶多形体、代謝物、エステル、薬学的に許容可能な塩又はプロドラッグを提供する:
XはCR5又はNであり、
mは0、1、2、3、4、5又は6であり、
nは1又は2であり、
Yは
ZはNR10、O、S、CR11R12であり、破線の結合は、結合であっても、存在しなくてもよいことを示し、
pは1、2、3又は4であり、
qは1、2又は3であり、
wは0又は1であり、
vは1又は2であり、
R1、R2、R5は相同又は相異であってもよく、互いに独立して水素、ハロゲン、アミノ基及び任意選択的に非置換又は置換の(C1-C12)脂肪族ヒドロカルビル基から選ばれ、
R3は非置換又は置換の(C1-C12)脂肪族ヒドロカルビル基であり、
それぞれのR4、R6とR8は相同又は相異であってもよく、互いに独立して水素、ハロゲン、ヒドロキシル基、アミノ基及び任意選択的に非置換又は置換の(C1-C12)脂肪族ヒドロカルビル基から選ばれ、
R7とR9は水素、ハロゲン、ヒドロキシル基、アミノ基及び任意選択的に非置換又は置換の(C1-C12)脂肪族ヒドロカルビル基から選ばれ、制限条件として、それぞれのR6とR7は同時にHとはならず(例えば、R6がHである場合、R7はHではない)、
又は、R7とR9は、非置換の、若しくは任意選択的に1つ、2つ又はそれ以上のR13で置換された3-20員ヘテロ環基又は5-20員ヘテロアリール基から選ばれ、
R10は水素、非置換又は置換の(C1-C12)脂肪族ヒドロカルビル基から選ばれ、
R11、R12とR13は水素、ハロゲン、ヒドロキシル基、アミノ基及び任意選択的に非置換又は置換の(C1-C12)脂肪族ヒドロカルビル基から選ばれる。
中間体カルボン酸Aと中間体アミンBは、塩基性条件下でペプチドカップリング試薬の作用によりアミドを形成し、そして保護基を除去して目標化合物Iを得る:
試薬と反応条件:
a) アミドカップリング反応:カップリング試薬はEDCI-HOBt、BOP、HATUから選ばれ、塩基はDEA、TEA、EDCI又はDMAPから選ばれ、溶剤はDCM又はDMFから選ばれる;
b) 脱Tfac反応:塩基はK2CO3又はNaOMeから選ばれ、溶剤はMeOHから選ばれる;
c) 脱Boc反応:希塩酸-メタノール。
試薬と反応条件:a) DMF; b) NaOMe/DMF; c) (Tfac)2O/NaHCO3/CHCl3; d) NaH/DMF、R3-I; e) TFA/DCM。
本発明は、新しい構造のユビキチン特異的プロテアーゼ阻害剤を提供する。実験によると、本発明の化合物は、USP28及び/又はUSP25に対して良好な阻害活性を有し、従来技術の阻害剤の活性と比べて、5倍以上、例えば、10倍以上、ひいては15倍以上も向上できることが検証されている。
特に明記しない限り、本願の明細書及び特許請求の範囲に記載される基と用語の定義には、例としての定義、例示的な定義、好ましい定義、表に記載される定義、実施例における具体的な化合物の定義等が含まれ、互いに任意に組み合わせたり、結合したりすることができる。このような組み合わせ又は結合した後の基の定義及び化合物の構造は、本願に記載される範囲に含まれるべきである。
以下、具体的な実施例に合わせて本発明を更に説明する。本発明は以下の実施例を含むが、これらに限定されない。
中間体A-1(3-(N-メチル-N-トリフルオロアセチルアミノ)-チオフェン[2,3-b]ピリジニル-2-カルボン酸)の調製:
反応フラスコ(500 mL)にチオ酢酸カリウム(57.11 g、0.50 mol)と無水DMF(250 mL)を加え、r.t.で攪拌しながらブロモ酢酸tert-ブチル1a-1(97.53 g、0.50 mol)を滴下し、滴下完了後にr.t.で30 min反応を継続させる。反応液は80℃で減圧濃縮し、溶媒を除去し、冷却後に水(150 mL)を加えて溶解し、クロロホルム(150 mL)で2回抽出し、クロロホルム層は飽和NaCl溶液(100 mL)で2回洗浄し、無水Na2SO4で乾燥し、ろ過し、減圧濃縮し、オレンジレッドの液体1a-2(95.01g、収率99.9%)を得る。
適切な合成前駆体を使用し、上記の実施例1(中間体A-1)についての試薬と反応条件に基づいて下記の表1の実施例の中間体A-2~A-29を合成する。
中間体A-30(3-(N-メチル-N-トリフルオロアセチルアミノ-6-ヒドロキシメチルチオフェン[2,3-b]ピリジニル-2-カルボン酸)の調製:
反応フラスコ(250 mL)に2-tert-ブチルアセチルチオアセテート1a-2(10.64 g、56 mmol)、2-クロロ-3-シアノ-6-アセトキシメチルピリジン2a-1(10.53 g、50 mmol)と無水DMF(100 mL)を加え、0-5℃に冷却し、NaOMe(3.24 g、60 mmol)を段階的に加える。r.t.に昇温し、1 h反応を継続させる。攪拌しながら反応液を水(1.2 L)に注入し、大量の淡黄色の固体が析出し、吸引ろ過し、水で洗浄し、エタノール-水で再結晶し、3-アミノ-6-アセトキシメチルチエノ[2,3-b]ピリジニル-2-tert-ブチルホルメート2a-2(13.54 g、84%)を得る。
実施例3
中間体B-1(3-(4-(2-アミノエチル)フェニル)-3,8-ジアザビシクロ[3.2.1]オクチル-8-カルボン酸tert-ブチル)の調製:
反応フラスコ(250 mL)にp-ブロモフェネチルアミン1b-1(10.00 g、50 mmol)、KI(0.41 g、2.5 mmol)、K2CO3(16.58 g、120 mmol)とアセトニトリル(100 mL)を加え、還流まで昇温し、BnCl(20.89 g、165 mmol)を滴下する。滴下完了後、還流し2 h反応させる。反応液は無機塩をろ過して除去し、ろ液を減圧濃縮してアセトニトリルを除去し、濃縮物にクロロホルム(200 mL)を加え、飽和NaCl溶液(100 mL × 2)で洗浄し、無水Na2SO4で乾燥し、減圧濃縮して粗生成物を得る。粗生成物を減圧濃縮して過剰のBnClと副産物であるベンジルアルコールを除去し、1b-2(浅黄色の液体18.39 g、97%)を得る。
適切な合成前駆体を使用し、上記の実施例3(中間体B-1)についての試薬と反応条件に基づいて下記表2の実施例の中間体B-2~B-20を合成する。
中間体B-21(4-(4-アミノエチルフェニル)ピペリジル-1-カルボン酸tert-ブチル)の調製:
50 mLのマイクロ波管に1b-2(1.66 g、4.35 mmol)、4-(テトラメチル-1,3,2-ジオキサボロラン2-イル)-1,2,3,6-テトラヒドロピリジニル-1-tert-ブチルホルメート(2.69 g、8.70 mmol)、Pd(dppf)Cl2(0.32 g、0.44 mmol)、炭酸カリウム(1.20 g、8.68 mmol)、エタノール(10 mL)と水(2 mL)を加える。130℃でマイクロ波放射下で混合物を1 h加熱する。残留した固体をろ過して除去し、ろ液を減圧濃縮する。得られた粗生成物をシリカゲルカラムクロマトグラフィーにより精製し、EA-PEで勾配溶出し、黄色の固体2b-1(419 mg、20%)を得る。
適切な合成前駆体を使用し、上記で実施例4(中間体B-21)について概述したプロセスに基づいて下記の表3中の実施例の中間体B-22~B-24を合成する。
中間体B-25(3-(4-(1-アミノ-イソプロピル)フェニル)-3,8-ジアザビシクロ[3.2.1]オクチル-8-カルボン酸tert-ブチル)の調製:
100 mLの丸底フラスコにp-ブロモアセトフェノン3b-1(3.38 g、17.0 mmol)、3,8-ジアザビシクロ[3.2.1]オクチル-8-tert-ブチルホルメート(3.00 g、14.1 mmol)、炭酸カリウム(5.86 g、42.4mmol)とHMPA(30 mL)を加える。得られた溶液を70℃で油浴中で一晩撹拌し、その後、r.t.に冷却し、水(30 mL)で急冷する。得られた溶液をEA(30 mL)で3回抽出し、有機層を合併し、減圧濃縮した後にシリカゲルカラムクロマトグラフィーにより精製し(EA-PE 1: 5で溶出)、褐色の油状物3b-2(1.68 g、30%)を得る。ESI-MS: m/z 331 ([M+H]+)。
中間体B-26((S)-1-(4-ブロモフェニル)-2-アミノ-3-メトキシプロパン)の調製:
100 mLの丸底フラスコに4b-1(12.25 g、50 mmol)と無水アルコール(30 mL)を加え、0℃に冷却し、攪拌し、SOCl2(5.45 mL、75 mmol)を徐々に滴下し、滴下完了後にr.t.に昇温し、一晩攪拌する。反応完了後に減圧濃縮して溶媒を除去し、水(30 mL)を加え、EA(30 mL)で3回抽出し、有機層を合併し、減圧濃縮して4b-2(11.70 g、86%)を得る。
中間体B-27(3-(4-(2-アミノ-3-エトキシプロピル)フェニル)-3,8-ジアザビシクロ[3.2.1]オクチル-8-カルボン酸tert-ブチル)の調製:
ステップa及びbは、実施例6のa及びbと同様である。
中間体B-31とB-32(3-(3R-アミノクロマン-7-イル)-3,8-ジアザビシクロ[3.2.1]オクチル-8-カルボン酸tert-ブチルと3-(3S-アミノクロマン-7-イル)-3,8-ジアザビシクロ[3.2.1]オクチル-8-カルボン酸tert-ブチル)の調製:
反応フラスコ(100 mL)に4-臭素-2-ヒドロキシベンズアルデヒド(5a-1、3.02 g、15 mmol)、ジ-n-ブチルアミン塩酸塩(1.24 g、7.5 mmol)、2-ニトロエタノール(2.73 g、30 mmol)と酢酸アミル(15 mL)を加える。窒素ガス保護下で8 h加熱還流し、水分離器で水を除去する。反応完了後にr.t.に冷却し、ろ過し、暗色の固体を酢酸エチルで洗浄し、ろ液を減圧濃縮する。シリカゲルカラムクロマトグラフィーを経て(100 g、200-300メッシュ、石油エーテル-酢酸エチル20 : 1で溶出)、黄色の固体5a-2(1.92 g、収率50%)を得る。
化合物I-1(N-4-(3,8-ジアザビシクロ[3.2.1]オクチル-3-イル)フェネチル-6-メチル-3-メチルアミノチオフェン[2,3-b]ピリジニル-2-メチルアミン)及びその塩酸塩の調製:
I-1(237 mg)をMeOH(8 mL)で溶解し、r.t.で攪拌しながら36%塩酸(120 μL)を加え、大量のオレンジイエローの固体が析出する。吸引ろ過し、少量のMeOHで洗浄して遊離HClを除去し、I-1塩酸塩(253 mg、100%)を得る。ESI-MS: m/z 436 ([M+H]+); 1H NMR (400 MHz, DMSO-d6) δ 9.50-9.46 (m, 2H), 8.49 (d, J = 8.5 Hz, 1H), 7.87 (t, J = 4.9 Hz, 1H), 7.30 (d, J = 8.5 Hz, 1H), 7.09 (d, J = 8.6 Hz, 2H), 6.84 (d, J = 8.6 Hz, 2H), 6.53 (br s, 3H), 4.09 (br s, 2H), 3.55 (dd, J = 11.2, 1.6Hz, 2H), 3.36 (tt, J = 7.8, 4.8 Hz, 2H), 3.17 (s, 3H), 3.08 (d, J = 12.8 Hz, 2H), 2.72 (t, J = 7.8 Hz, 2H), 2.59 (s, 3H), 1.97 (m, 2H), 1.91 (m, 2H); 13C NMR (125 MHz, DMSO-d6) δ 164.7, 158.2, 157.6, 148.3, 146.8, 133.5, 130.1, 129.2, 124.4, 119.5, 114.6, 53.7, 50.6, 41.0, 34.4, 32.9, 25.4, 23.7.
適切な合成前駆体を使用し、前記の中間体A1~A30とB1~B36及び商業的に又は従来の合成方法により取得可能な前記B-I、上記の実施例9(化合物I-1)についての試薬と反応条件に基づいて下記の表6中の実施例の化合物I-2~I-92を合成する。
化合物I-93(N-4-(3,8-ジアザビシクロ[3.2.1]オクチル-3-イル)フェネチル-6-アミノ-3-メチルアミノチオフェン[2,3-b]ピリジニル-2-メチルアミン)の調製:
ステップa及びbは、実施例9のa及びcと同様である。
適切な合成前駆体を使用し、上記の実施例10(中間体I-93)についての試薬と反応条件に基づいて下記の表7の実施例の中間体I-94とI-95を合成する。
ユビキチン-ローダミン110法によりUSP28活性を測定する。
阻害%=1-[(被検化合物+基質の蛍光値-被検化合物(基質無し)の蛍光値)/DMSO対照群の平均蛍光値-被検化合物(基質無し)の蛍光値]
様々な濃度における被検化合物のUSP28に対する阻害率に基づいてそのIC50値を算出する。
ユビキチン-ローダミン110法によりUSP25の活性を測定する。
阻害%=1-[(被検化合物+基質の蛍光値-被検化合物(基質無し)の蛍光値)/DMSO対照群の平均蛍光値-被検化合物(基質無し)の蛍光値]
実施例11と同様に、様々な濃度における被検化合物のUSP25に対する阻害率に基づいてそのIC50値を算出する。
実施例11と実施例12を参照しながら、本発明に係る代表的な化合物及び関連する化合物に対してUSP28とUSP25の阻害活性(IC50)の試験を行い、本発明に係る化合物(E)の試験結果IC50(E)と関連する化合物(F)の試験結果IC50(F)とを比較する(IC50(F)/IC50(E)の比率を計算する)。その結果、本発明に係る化合物(E)の特徴となる3-メチルアミノの改善は、関連する3-アミノ化合物(F)と比べて、USP28とUSP25に対する阻害活性を効果的に向上可能であることが示されている。代表的な比較例は、下記の表9を参照する。
Claims (4)
- 下記の構造から選ばれる:
化合物及びそのラセミ体、立体異性体、互変異性体、同位体標識、窒素酸化物、溶媒和物、結晶多形体、又は薬学的に許容可能な塩。 - 請求項1に記載の化合物及びそのラセミ体、立体異性体、互変異性体、同位体標識、窒素酸化物、溶媒和物、結晶多形体、又は薬学的に許容可能な塩を含む、ことを特徴とする医薬組成物。
- USP28及び/又はUSP25関連の疾患又は障害の治療と阻害に用いられる医薬の製造における請求項1に記載の化合物及びそのラセミ体、立体異性体、互変異性体、同位体標識、窒素酸化物、溶媒和物、結晶多形体、又は薬学的に許容可能な塩、又は請求項2に記載の医薬組成物の使用。
- 前記USP28及び/又はUSP25関連の疾患又は障害は、がん、炎症、自己免疫疾患、ウイルス感染症及び細菌感染症を含む、ことを特徴とする請求項3に記載の使用。
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