JP7387190B2 - Rpeメラニンレベルに基づいて網膜光線療法用の処置パラメータを調節するためのシステムおよびプロセス - Google Patents
Rpeメラニンレベルに基づいて網膜光線療法用の処置パラメータを調節するためのシステムおよびプロセス Download PDFInfo
- Publication number
- JP7387190B2 JP7387190B2 JP2021520162A JP2021520162A JP7387190B2 JP 7387190 B2 JP7387190 B2 JP 7387190B2 JP 2021520162 A JP2021520162 A JP 2021520162A JP 2021520162 A JP2021520162 A JP 2021520162A JP 7387190 B2 JP7387190 B2 JP 7387190B2
- Authority
- JP
- Japan
- Prior art keywords
- rpe
- retinal
- light
- melanin
- eye
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000011282 treatment Methods 0.000 title claims description 49
- 230000002207 retinal effect Effects 0.000 title claims description 47
- 238000001126 phototherapy Methods 0.000 title claims description 15
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 title description 238
- 238000000034 method Methods 0.000 title description 13
- 230000008569 process Effects 0.000 title description 7
- 210000003161 choroid Anatomy 0.000 claims description 74
- 230000036564 melanin content Effects 0.000 claims description 28
- 230000003287 optical effect Effects 0.000 claims description 22
- 210000003583 retinal pigment epithelium Anatomy 0.000 claims description 18
- 230000003247 decreasing effect Effects 0.000 claims description 6
- 210000000981 epithelium Anatomy 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 claims 1
- 210000002780 melanosome Anatomy 0.000 description 72
- 210000001508 eye Anatomy 0.000 description 60
- 238000010521 absorption reaction Methods 0.000 description 42
- 210000001525 retina Anatomy 0.000 description 21
- 230000006378 damage Effects 0.000 description 17
- 239000011159 matrix material Substances 0.000 description 14
- 230000005855 radiation Effects 0.000 description 14
- 230000008859 change Effects 0.000 description 13
- 230000002159 abnormal effect Effects 0.000 description 11
- 230000005540 biological transmission Effects 0.000 description 8
- 230000007423 decrease Effects 0.000 description 8
- 239000000049 pigment Substances 0.000 description 8
- 238000005259 measurement Methods 0.000 description 6
- 239000000178 monomer Substances 0.000 description 6
- 102000002812 Heat-Shock Proteins Human genes 0.000 description 5
- 108010004889 Heat-Shock Proteins Proteins 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 230000004913 activation Effects 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 230000000649 photocoagulation Effects 0.000 description 4
- 210000003786 sclera Anatomy 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 230000002457 bidirectional effect Effects 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 210000000695 crystalline len Anatomy 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 208000030533 eye disease Diseases 0.000 description 3
- 230000014509 gene expression Effects 0.000 description 3
- 238000012014 optical coherence tomography Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 206010025421 Macule Diseases 0.000 description 2
- 208000017442 Retinal disease Diseases 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 206010064930 age-related macular degeneration Diseases 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 210000003855 cell nucleus Anatomy 0.000 description 2
- 210000004087 cornea Anatomy 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000002647 laser therapy Methods 0.000 description 2
- 208000002780 macular degeneration Diseases 0.000 description 2
- 210000003470 mitochondria Anatomy 0.000 description 2
- 210000000933 neural crest Anatomy 0.000 description 2
- 210000001020 neural plate Anatomy 0.000 description 2
- 210000003463 organelle Anatomy 0.000 description 2
- 239000000790 retinal pigment Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 108010074864 Factor XI Proteins 0.000 description 1
- 241001274197 Scatophagus argus Species 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 210000003986 cell retinal photoreceptor Anatomy 0.000 description 1
- 230000004456 color vision Effects 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000003989 dielectric material Substances 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 238000005305 interferometry Methods 0.000 description 1
- 238000013532 laser treatment Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 238000006213 oxygenation reaction Methods 0.000 description 1
- 210000004694 pigment cell Anatomy 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 210000001747 pupil Anatomy 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000002310 reflectometry Methods 0.000 description 1
- 230000008263 repair mechanism Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/008—Methods or devices for eye surgery using laser
- A61F2009/00861—Methods or devices for eye surgery using laser adapted for treatment at a particular location
- A61F2009/00863—Retina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
- A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
- A61N2005/0645—Applicators worn by the patient
- A61N2005/0647—Applicators worn by the patient the applicator adapted to be worn on the head
- A61N2005/0648—Applicators worn by the patient the applicator adapted to be worn on the head the light being directed to the eyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0662—Visible light
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Radiology & Medical Imaging (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Pathology (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Radiation-Therapy Devices (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16/203,970 | 2018-11-29 | ||
| US16/203,970 US10952899B2 (en) | 2017-11-20 | 2018-11-29 | Process for adjusting treatment parameters for retina phototherapy based on RPE melanin levels |
| PCT/US2019/053553 WO2020112234A1 (en) | 2018-11-29 | 2019-09-27 | System and process for adjusting treatment parameters for retina phototherapy based on rpe melanin levels |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022514165A JP2022514165A (ja) | 2022-02-10 |
| JPWO2020112234A5 JPWO2020112234A5 (https=) | 2022-07-06 |
| JP2022514165A5 JP2022514165A5 (https=) | 2022-07-06 |
| JP7387190B2 true JP7387190B2 (ja) | 2023-11-28 |
Family
ID=70853111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021520162A Active JP7387190B2 (ja) | 2018-11-29 | 2019-09-27 | Rpeメラニンレベルに基づいて網膜光線療法用の処置パラメータを調節するためのシステムおよびプロセス |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP3880139B1 (https=) |
| JP (1) | JP7387190B2 (https=) |
| CN (1) | CN113365585A (https=) |
| AU (2) | AU2019386722B2 (https=) |
| BR (1) | BR112021009783A2 (https=) |
| CA (1) | CA3116687A1 (https=) |
| SG (1) | SG11202105023UA (https=) |
| WO (2) | WO2020112163A1 (https=) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009142597A (ja) | 2007-12-18 | 2009-07-02 | Kao Corp | メラニン分布可視化方法及びその装置 |
| JP2011510694A (ja) | 2008-01-18 | 2011-04-07 | ザ ジェネラル ホスピタル コーポレイション | 細胞増殖を誘導するための選択的光刺激 |
| US20160074221A1 (en) | 2010-06-14 | 2016-03-17 | Marie-Jose B. Tassignon | Femtosecond laser apparatus for plasma induced vitreous ablation in the eye |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5549596A (en) * | 1993-07-07 | 1996-08-27 | The General Hospital Corporation | Selective laser targeting of pigmented ocular cells |
| JP3688339B2 (ja) * | 1995-02-28 | 2005-08-24 | 株式会社ニデック | レ−ザ治療装置 |
| DE19954710C1 (de) * | 1999-11-17 | 2001-03-15 | Pulsion Medical Sys Ag | Vorrichtung zur Behandlung von wachsenden, erweiterten oder mißgebildeten Blutgefäßen |
| AU2003282798A1 (en) * | 2002-09-20 | 2004-04-08 | Iridex Corporation | Apparatus for real time measure/control of intra-operative effects during laser thermal treatments using light scattering |
| US20070213693A1 (en) * | 2004-08-27 | 2007-09-13 | Ellex Medical Pty Ltd | Selective ophthalmic laser treatment |
| US10398599B2 (en) * | 2007-10-05 | 2019-09-03 | Topcon Medical Laser Systems Inc. | Semi-automated ophthalmic photocoagulation method and apparatus |
| US7997732B2 (en) * | 2008-10-06 | 2011-08-16 | The Catholic University Of America | Lenslet array for retinal oximetry |
| US8968280B2 (en) * | 2009-01-23 | 2015-03-03 | The General Hospital Corporation | Dose determination for inducing microcavitation in retinal pigment epithelium (RPE) |
| JP6066595B2 (ja) * | 2011-07-29 | 2017-01-25 | キヤノン株式会社 | 眼底画像の画像処理装置、眼底画像の画像処理方法、及びプログラム |
| US10194798B1 (en) * | 2017-11-20 | 2019-02-05 | Ojai Retinal Technology, Llc | Measuring RPE and choroid melanin levels with reflectometer |
| US9962291B2 (en) * | 2012-05-25 | 2018-05-08 | Ojai Retinal Technology, Llc | System and process for neuroprotective therapy for glaucoma |
-
2019
- 2019-04-29 WO PCT/US2019/029636 patent/WO2020112163A1/en not_active Ceased
- 2019-09-27 CA CA3116687A patent/CA3116687A1/en active Pending
- 2019-09-27 AU AU2019386722A patent/AU2019386722B2/en not_active Ceased
- 2019-09-27 JP JP2021520162A patent/JP7387190B2/ja active Active
- 2019-09-27 WO PCT/US2019/053553 patent/WO2020112234A1/en not_active Ceased
- 2019-09-27 EP EP19889421.4A patent/EP3880139B1/en active Active
- 2019-09-27 CN CN201980090619.7A patent/CN113365585A/zh active Pending
- 2019-09-27 BR BR112021009783-0A patent/BR112021009783A2/pt not_active IP Right Cessation
- 2019-09-27 SG SG11202105023UA patent/SG11202105023UA/en unknown
-
2023
- 2023-10-06 AU AU2023241390A patent/AU2023241390A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009142597A (ja) | 2007-12-18 | 2009-07-02 | Kao Corp | メラニン分布可視化方法及びその装置 |
| JP2011510694A (ja) | 2008-01-18 | 2011-04-07 | ザ ジェネラル ホスピタル コーポレイション | 細胞増殖を誘導するための選択的光刺激 |
| US20160074221A1 (en) | 2010-06-14 | 2016-03-17 | Marie-Jose B. Tassignon | Femtosecond laser apparatus for plasma induced vitreous ablation in the eye |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2022514165A (ja) | 2022-02-10 |
| AU2019386722A1 (en) | 2021-06-17 |
| CA3116687A1 (en) | 2020-06-04 |
| WO2020112163A1 (en) | 2020-06-04 |
| CN113365585A (zh) | 2021-09-07 |
| EP3880139C0 (en) | 2024-07-03 |
| EP3880139B1 (en) | 2024-07-03 |
| BR112021009783A2 (pt) | 2021-08-17 |
| EP3880139A1 (en) | 2021-09-22 |
| AU2023241390A1 (en) | 2023-10-26 |
| AU2019386722B2 (en) | 2023-08-17 |
| WO2020112234A1 (en) | 2020-06-04 |
| SG11202105023UA (en) | 2021-06-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10194798B1 (en) | Measuring RPE and choroid melanin levels with reflectometer | |
| Regal et al. | Determination of optical parameters of the porcine eye and development of a simulated model | |
| Genina et al. | Optical clearing of the eye sclera in vivo caused by glucose | |
| US7465299B2 (en) | Monitoring of retinal temperature during laser therapy | |
| JP7387190B2 (ja) | Rpeメラニンレベルに基づいて網膜光線療法用の処置パラメータを調節するためのシステムおよびプロセス | |
| Jean et al. | Modeling of laser-induced thermal damage to the retina and the cornea | |
| US10952899B2 (en) | Process for adjusting treatment parameters for retina phototherapy based on RPE melanin levels | |
| van Bree et al. | Imaging of forward light-scatter by opacified posterior capsules isolated from pseudophakic donor eyes | |
| Du et al. | In vivo evaluation of laser-induced choroidal neovascularization in rats simultaneously using optical coherence tomography and photoacoustic microscopy | |
| JP7327832B2 (ja) | Rpeメラニンレベルの判定に基づいて網膜光線療法を安全に提供するためのプロセス | |
| Lund et al. | Spectral dependence of retinal thermal injury | |
| US11679272B2 (en) | Process for safely providing retinal phototherapy based on determination of RPE melanin levels | |
| Soleimani et al. | Effects of laser physical parameters on lesion size in retinal photocoagulation surgery: clinical OCT and experimental study | |
| Jiao et al. | Retinal damage thresholds from 100-millisecond laser radiation exposure at 1319 nm: a comparative study for rabbits with different ocular axial lengths | |
| Vogt et al. | Measurement and thermal dependence of biological tissue optical properties | |
| Jang et al. | Comparison of clinical outcomes between swept-source optical coherence tomography biometer and partial coherence interferometer | |
| Hunter | Diagnostic and therapeutic applications of visible and near-infrared light for the retina | |
| Różanowska et al. | Diagnostic and therapeutic applications of visible and near-infrared light for the retina | |
| van der Meulen | Straylight in anterior segment disorders of the eye | |
| Podol'tsev et al. | Heating of intraocular media by near IR laser radiation | |
| Lisenko et al. | An operative quantitative analysis of multispectral images of the eyeground | |
| Frish et al. | Research towards development of a dynamic reflectometer for control of laser-induced retinal photocoagulation | |
| Lisenko et al. | Method for calculating the optical diffuse reflection coefficient for the ocular fundus | |
| Ansari | The effects of tissue optical parameters and interface reflectivity on light diffusion in biological tissues |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220628 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20220629 |
|
| RD02 | Notification of acceptance of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7422 Effective date: 20230503 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20230503 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20230531 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20230810 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20231101 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20231108 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 7387190 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |