JP7369819B2 - Method for producing sodium-adsorbing solid material and food composition for salt removal containing the solid material - Google Patents

Description

The present invention relates to a method for producing a sodium-adsorbing solid material with excellent sodium-adsorbing properties and texture, and a food composition for discharging salt containing the solid material.

Excessive sodium (salt) intake is known to affect hypertension and other related cardiovascular diseases in humans and non-human animals (eg, dogs and cats). BACKGROUND ART As a method for preventing or improving health problems caused by excessive intake of sodium, for example, reducing the amount of salt in meals is carried out, such as by reducing the amount of salt added as a seasoning. However, salty taste is important as a taste of foods, and reducing salt in meals also reduces the palatability of foods. Therefore, simply reducing the salt content in the diet is not necessarily easy from a sustainability perspective.

In order to maintain the palatability of foods and prevent or improve health disorders caused by excessive sodium intake, efforts are being made to develop components that promote the excretion of ingested sodium from the body. Alginates are known as components that promote the excretion of sodium (Patent Documents 1 to 3).

Japanese Unexamined Patent Publication No. 1983-130523 Japanese Unexamined Patent Publication No. 59-34853 Japanese Patent Application Publication No. 2019-125691

In order to prevent or ameliorate health disorders caused by excessive intake of sodium, there is a need for the development of ingredients with better sodium excretion ability. It is desirable that such ingredients be able to be administered orally. In this regard, if the taste and texture of orally administered ingredients are poor, humans and non-human animals may avoid ingesting such ingredients. Therefore, such ingredients are also required to have excellent taste and texture. In this regard, existing alginates sometimes have insufficient texture, such as being sticky in the mouth.

An object of the present invention is to provide a method for producing a sodium-adsorbing solid material that has excellent sodium adsorption properties and texture and is easy to administer orally, and a food composition for salt removal containing the solid material.

The method for producing a sodium adsorbent solid product of the present invention includes the steps of preparing a solution containing 0.1 to 5% by weight of potassium alginate or ammonium alginate, and preparing a solution containing 0.1 to 4% by weight of a calcium salt. and adding one of the potassium alginate-containing solution and the calcium salt-containing solution to the other.

The food composition for salt removal of the present invention contains a sodium adsorbent solid obtained by the method of the present invention.

The food composition for salt removal of the present invention has better sodium adsorption than existing alginates such as calcium alginate, and has better texture than existing alginates. Therefore, the salt excretion food composition of the present invention is easy to ingest, promotes sodium excretion, and can prevent or improve health disorders caused by excessive sodium intake. According to the method for producing a sodium adsorbent solid product of the present invention, a sodium adsorbent solid product having excellent sodium adsorption properties and texture can be obtained.

It is a graph showing the results of the salt reduction amount of the composition of the example. It is a graph showing a comparison of the amount of salt reduction between the composition of the example and other ingredients.

The method for producing a sodium-adsorbing solid material (hereinafter referred to as "this solid material") of the present invention (hereinafter referred to as "this method") contains 0.1 to 5% by weight of potassium alginate or ammonium alginate. The method includes the steps of preparing a solution, preparing a solution containing 0.1 to 4% by weight of a calcium salt, and adding one of the potassium alginate-containing solution and the calcium salt-containing solution to the other.

The above-mentioned potassium alginate and ammonium alginate are biodegradable polymeric polysaccharides in which two types of uronic acids, D-mannuronic acid and L-guluronic acid, are linearly polymerized. It is a salt obtained by ion exchange with potassium or ammonium. There is no particular limitation on the molecular weight of the potassium alginate and ammonium alginate. Further, the potassium alginate and ammonium alginate may have their chemical structures partially substituted or modified. The potassium alginate may be used alone, or two or more potassium alginates having partially different molecular weights or chemical structures may be used. Similarly, one type of ammonium alginate may be used alone, or two or more types of ammonium alginate having partially different molecular weights or chemical structures may be used.

The content of the potassium alginate or ammonium alginate in the solution containing potassium alginate or ammonium alginate is 0.1 to 5% by weight, preferably 0.2 to 4% by weight, more preferably 0.3 to 3% by weight, or more. Preferably it is 0.5 to 2% by weight. The above upper limit value and lower limit value can be combined as appropriate. In addition, when the potassium alginate or ammonium alginate-containing solution contains both potassium alginate and ammonium alginate, the content of either one may be within the above range, or the total content of both may be within the above range.

The solution containing potassium alginate or ammonium alginate may contain only one of potassium alginate and ammonium alginate, or may contain both potassium alginate and ammonium alginate. Compared to ammonium alginate, potassium alginate is thought to be less susceptible to drug interactions between cations released after administration and other components (e.g., the formation of ammonium chloride due to the interaction of ammonium ions and chloride ions). Therefore, the solution containing potassium alginate or ammonium alginate is preferably a solution containing only potassium alginate, or a solution in which the content of potassium alginate is higher than the content of ammonium alginate (for example, the mass ratio of potassium alginate and ammonium alginate is ( 2-10): 1) It is a solution.

The potassium alginate-containing solution may or may not further contain other alginates. One type of other alginate may be used alone, or two or more types may be included. Other alginates include, for example, sodium alginate. The content of the other alginates can be appropriately set as necessary. The content of the other alginates can be, for example, 0.01 to 5% by weight, 0.05 to 4% by weight, 0.1 to 3% by weight, and 0.5 to 2.5% by weight. . The above upper limit value and lower limit value can be combined as appropriate.

The calcium salt may be any salt that causes a solidification or gelation reaction when mixed with the potassium alginate-containing solution. The calcium salt may be either an inorganic calcium salt or an organic calcium salt. The organic calcium salt may be a salt with a monovalent carboxylic acid or a salt with a polyvalent carboxylic acid having a valence of two or more. Specific examples of organic calcium salts include calcium gluconate, calcium citrate, calcium lactate, calcium acetate, calcium benzoate, and calcium stearate. Specific examples of the inorganic calcium salt include calcium chloride and calcium carbonate. The calcium salt may be used alone or in combination of two or more.

The content of the calcium salt in the potassium alginate-containing solution is 0.1 to 4% by weight, preferably 0.2 to 3% by weight, and more preferably 0.3 to 2% by weight.

There are no particular limitations on the method for preparing the potassium alginate-containing solution. The potassium alginate-containing solution is usually dissolved by adding potassium alginate little by little in several portions while stirring the solvent. This is preferable because the dissolution of potassium alginate can be accelerated. The solvent is not particularly limited as long as it can prepare the potassium alginate-containing solution. Water (distilled water, sterile distilled water) is usually used as the solvent.

There are no particular limitations on the method for preparing the calcium salt-containing solution. The calcium salt-containing solution can be obtained, for example, by adding and dissolving a calcium salt in a solvent. The solvent is not particularly limited as long as it can prepare the calcium salt-containing solution. Water (distilled water, sterile distilled water) is usually used as the solvent.

There is no particular limitation on the specific embodiment of the step of adding one of the potassium alginate-containing solution and the calcium salt-containing solution to the other. Usually, the calcium salt-containing solution is added to the potassium alginate-containing solution, but the reverse is also possible. Further, the addition is usually performed by dropping one of the potassium alginate-containing solution and the calcium salt-containing solution while stirring the other.

The "solid material" includes all embodiments in which the fluidity of the potassium alginate-containing solution is reduced. The above-mentioned "solid substance" includes not only a completely solid substance but also a capsule-shaped substance containing a liquid substance in a film, or a jelly-like substance obtained by gelling the potassium alginate-containing solution. Note that "jelly-like" means that the viscosity is higher than that of water when measured under the same conditions.

(2) Food composition for salt removal The food composition for salt removal of the present invention (hereinafter referred to as "the present composition") contains an effective amount of the present solid material. The above explanation is valid for this solid material. Moreover, the effective amount means an amount that exhibits sodium adsorption ability, and as long as it exhibits sodium adsorption ability, the effective amount is not particularly limited and can be appropriately set by those skilled in the art. Further, the specific form of the composition is not particularly limited as long as it can be taken orally. The above-mentioned "food" also includes drinks.

The composition can be administered to either humans or non-human animals. There are no particular limitations on the type of non-human animal. Specific examples of the non-human animals include dogs, cats, mice, parakeets, guinea pigs, hamsters, rats, ferrets, monkeys, cows, pigs, goats, sheep, and chickens.

As mentioned above, the present composition has excellent sodium adsorption ability and can promote sodium excretion. Therefore, the present composition can be used to improve congestive heart disease. The above-mentioned "improvement of congestive heart disease" includes treatment, symptom relief, and prevention (suppression of deterioration) of congestive heart disease. Additionally, the present composition can be used to improve blood pressure and/or renal function. The above-mentioned "improvement of blood pressure and/or renal function" includes not only a change in condition but also maintenance of a normal condition. For example, improving blood pressure includes lowering blood pressure and maintaining normal blood pressure. Similarly, improving renal function includes improving renal dysfunction and maintaining normal renal function. The composition can also be used to improve congestive heart disease.

The present composition may be composed only of the present solid material, or may further contain other components. In addition to food and drink components (e.g., meat (cow, pig, etc.), seafood, fruits), the other ingredients may be conventionally contained in foods (including feed) and medicines for humans or non-human animals. Examples include known components (eg, saccharides, amino acids, pH adjusters, vitamins, antioxidants, pigments, preservatives, fragrances, etc.). The content of the other components can be appropriately set as necessary. For example, the content of the other components, particularly the food/drink components, can be 1 to 40% by weight, preferably 3 to 20% by weight, and more preferably 5 to 15% by weight.

On the other hand, the composition may not contain calcium alginate. The composition may be free of citric acid. The composition may be free of other heat-irreversible gel-forming water-soluble polymers (eg, pectin, CMC, and other polysaccharides such as gellan gum). In addition, "not containing" means not containing completely, but also containing a trace amount that does not affect the texture and sodium adsorption capacity (for example, 0.01% by weight or less, 0.005% by weight or less, 0.001% by weight) % or less and the lower limit exceeds 0).

<About impossible/impractical circumstances>
From the examples described later, this composition shows a superior Na removal effect than simple calcium alginate. This indicates that the present composition does not consist primarily of calcium alginate, which is formed simply by the reaction of potassium alginate and calcium. However, by investigating the chemical and physical changes in potassium alginate and calcium salts caused by this method, as well as the relationship between the structure and form after the change and the sodium removal effect, we have determined that this solid product can be used in specific terms in terms of structure and properties. It is either impossible or requires significant time, expense, and impractical to provide clarity. The inventor estimates that potassium alginate, for example, has many fishing hooks hanging at equal intervals along the middle of a long string, so when it comes into contact with sodium, it can get caught on some of the fishing hooks and be adsorbed. When calcium salts were added to potassium alginate, the calcium became a medium and gelled, and the independent fishing hook threads became so-called mesh-like, making it easier to adsorb sodium. (This is merely an estimate by the inventor, and is not intended to specify or define the claimed invention in any way.)

Hereinafter, the present invention will be specifically illustrated with reference to Examples. Note that the present invention is not limited to the embodiments shown in the examples. The embodiments of the present invention can be modified in various ways within the scope of the present invention depending on the purpose and use. It should be noted that all considerations regarding the results in the Examples are merely the opinions of the inventors, and are not intended to define or limit the present invention in any way.

(1) Synthesis of waste salt composition (I) - Granular form Flavor (1.0 g) was added to sterile distilled water (19 g) while stirring with a stirrer at 500 to 1200 rpm to prepare a 5% flavor solution. Next, while stirring at 1200 rpm, add potassium alginate (0.4 g) little by little to the solution and continue stirring for about 15 minutes. After confirming that the potassium alginate has dissolved, add the potassium alginate solution (20 ml). Prepared.

A 1% calcium gluconate solution was prepared by dissolving 5% calcium gluconate solution (5 ml) in 37.5 ml of tap water. The solution was stirred at 250 rpm using a stirrer, and the potassium alginate solution was added to the solution at a rate of 100 ml/h. The resulting granules were filtered, washed with water, and air-dried to obtain a composition in granular form.

(2) Synthesis of waste salt composition (II) - Jelly form 2.0 g of potassium alginate and 0.6 g of calcium citrate were mixed in a mortar until they were evenly mixed to obtain a mixture. Next, 20 g of ground chicken meat was mixed with distilled water (200 ml), and the mixture was added little by little to the mixture to dissolve it, thereby preparing a solution containing 1% potassium alginate. The solution is injected into a retort package, sterilized at 85°C to 120°C (according to the retort sterilization method), and left to stand at room temperature for 3 to 12 hours to obtain a jelly-like composition (retort package; 10g). / package) was obtained.

(3) Measurement of sodium adsorption amount The above salt removal composition (granular form; 50, 100, and 150 mg) was ground and added to 20 ml of medical saline (Na: 154 mEq/L). Thereafter, the concentration (%) of sodium chloride in the aqueous solution was measured using a salinity meter (manufactured by HORIBA). As a control, the above physiological saline was used. The results are shown in Table 1 and FIG. The adsorption rate (%) was calculated using the following formula.

(A) the above-mentioned waste salt composition (granular form), (B) ammonium alginate, (C) "Delsol" (manufactured by Toy Medical Co., Ltd.; contains calcium alginate and ammonium alginate as alginic acids, and does not contain potassium alginate. ) and (D) 120 mg of calcium alginate were each taken, ground and added to 20 ml of medical saline (Na: 154 mEq/L). As a control, the above physiological saline was used. Three samples each were prepared for the control and (A) to (D). Thereafter, the Na concentration (mEq/L) of the sample was measured using an animal blood measuring device "Drychem MX700" (manufactured by Fujifilm). The results are shown in Table 2 and FIG.

(4) Results From Table 1 and FIG. 1, by adding the compositions of Examples, a reduction in salt content of about 15 to 42% was observed.

In addition, from Table 2 and Figure 2, ammonium alginate, "Delsol" (contains calcium alginate and ammonium alginate as alginic acids, but does not contain potassium alginate), and calcium alginate all have a salt reduction of about 10%. On the other hand, the composition of the example showed a salt reduction of about 40%. In particular, this result showing superior salt reduction for the example compositions compared to calcium alginate indicates that the example compositions are different from just calcium alginate as a substance.

Claims (4)

Preparing a solution containing 0.1 to 5% by weight of potassium alginate or ammonium alginate;
Preparing a solution containing 0.1 to 4% by weight of calcium salt;
A method for producing a solid material for adsorbing sodium, comprising the step of adding one of the potassium alginate-containing solution and the calcium salt-containing solution to the other. The method for producing a solid material for adsorbing sodium according to claim 1, wherein the potassium alginate or ammonium alginate-containing solution further contains sodium alginate. The method for producing a solid material for adsorbing sodium according to claim 1 or 2, wherein the calcium salt is a calcium salt of an organic acid. A food composition for discharging salt, comprising an effective amount of a solid material for adsorbing sodium obtained by the method according to any one of claims 1 to 3.