JP7355335B2 - 小分子重炭酸イオンチャネルを用いた嚢胞性線維症の遺伝子型非依存性救済 - Google Patents

小分子重炭酸イオンチャネルを用いた嚢胞性線維症の遺伝子型非依存性救済 Download PDF

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JP7355335B2
JP7355335B2 JP2020517886A JP2020517886A JP7355335B2 JP 7355335 B2 JP7355335 B2 JP 7355335B2 JP 2020517886 A JP2020517886 A JP 2020517886A JP 2020517886 A JP2020517886 A JP 2020517886A JP 7355335 B2 JP7355335 B2 JP 7355335B2
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cholesterol
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JP2020536859A (ja
JP2020536859A5 (cg-RX-API-DMAC7.html
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ディー バーク，マーティン
エー ムラリア，カトリーナ
エス コールガード，ラジーヴ
ジェイ ウェルシュ，マイケル
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University of Iowa Research Foundation UIRF
University of Illinois System
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020517886A 2017-10-11 2018-10-11 小分子重炭酸イオンチャネルを用いた嚢胞性線維症の遺伝子型非依存性救済 Active JP7355335B2 (ja)

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JP2023111218A JP2023126932A (ja) 2017-10-11 2023-07-06 小分子重炭酸イオンチャネルを用いた嚢胞性線維症の遺伝子型非依存性救済

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US201762570795P 2017-10-11 2017-10-11
US62/570,795 2017-10-11
PCT/US2018/055435 WO2019075214A2 (en) 2017-10-11 2018-10-11 INDEPENDENT RESCUEING OF THE GENOTYPE OF CYSTIC FIBROSIS WITH BICARBONATE CHANNELS WITH SMALL MOLECULES

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JP2023111218A Division JP2023126932A (ja) 2017-10-11 2023-07-06 小分子重炭酸イオンチャネルを用いた嚢胞性線維症の遺伝子型非依存性救済

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JP2020536859A5 JP2020536859A5 (cg-RX-API-DMAC7.html) 2021-11-11
JP7355335B2 true JP7355335B2 (ja) 2023-10-03

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JP2023111218A Pending JP2023126932A (ja) 2017-10-11 2023-07-06 小分子重炭酸イオンチャネルを用いた嚢胞性線維症の遺伝子型非依存性救済

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EP (1) EP3694526B1 (cg-RX-API-DMAC7.html)
JP (2) JP7355335B2 (cg-RX-API-DMAC7.html)
AU (2) AU2018348214C1 (cg-RX-API-DMAC7.html)
CA (1) CA3076246A1 (cg-RX-API-DMAC7.html)
DK (1) DK3694526T3 (cg-RX-API-DMAC7.html)
ES (1) ES3009563T3 (cg-RX-API-DMAC7.html)
FI (1) FI3694526T3 (cg-RX-API-DMAC7.html)
PT (1) PT3694526T (cg-RX-API-DMAC7.html)
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AU2018348214C1 (en) 2017-10-11 2025-01-30 The Board Of Trustees Of The University Of Illinois Genotype-agnostic rescue of cystic fibrosis with small molecule bicarbonate channels
EP4496588A1 (en) 2022-03-21 2025-01-29 The Board Of Trustees Of The University Of Illinois Ion channel prosthetic compositions comprising lipid-coated crystals of amphotericin b
TW202519239A (zh) * 2023-07-19 2025-05-16 美國伊利諾大學理事會 利用遺失蛋白質（ｍｉｓｓｉｎｇ ｐｒｏｔｅｉｎｓ）之小分子模擬物恢復生理機能
WO2025064626A1 (en) * 2023-09-20 2025-03-27 The Board Of Trustees Of The University Of Illinois Additive effects for molecular prosthetcs and cftr modulators in cf epithelia

Citations (3)

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Publication number Priority date Publication date Assignee Title
JP2008501782A (ja) 2004-06-11 2008-01-24 ジテンドラ ナス ベルマ 塩水中のステロール濃縮混合層状アンフォテリシン（Ａｍｐｈｏｔｅｒｉｃｉｎ）挿入リポソーム及びその調製方法
WO2016073462A1 (en) 2014-11-04 2016-05-12 The Board Of Trustees Of The University Of Illinois Restoring physiology with small molecule mimics of missing proteins
JP7041961B2 (ja) 2016-04-08 2022-03-25 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイ ヒト嚢胞性線維症肺上皮における気道表面の生理機能の小分子介在性回復

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AU598958B2 (en) * 1987-11-12 1990-07-05 Vestar, Inc. Improved amphotericin b liposome preparation
CA2082951C (en) 1991-03-15 1999-12-21 Robert M. Platz Pulmonary administration of granulocyte colony stimulating factor
US5451569A (en) 1994-04-19 1995-09-19 Hong Kong University Of Science And Technology R & D Corporation Limited Pulmonary drug delivery system
KR101424980B1 (ko) * 2002-10-29 2014-08-01 인스메드 인코포레이티드 항감염제의 지속적인 방출
TWI249408B (en) 2003-12-10 2006-02-21 Ind Tech Res Inst New antifungal formulation and manufacturing method thereof
WO2011050311A1 (en) 2009-10-22 2011-04-28 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Use of endostatin peptides for the treatment of fibrosis
US8945605B2 (en) 2011-06-07 2015-02-03 Parion Sciences, Inc. Aerosol delivery systems, compositions and methods
US10960018B2 (en) * 2016-04-15 2021-03-30 The Uab Research Foundation Methods and compounds for stimulating read-through of premature termination codons
AU2018348214C1 (en) 2017-10-11 2025-01-30 The Board Of Trustees Of The University Of Illinois Genotype-agnostic rescue of cystic fibrosis with small molecule bicarbonate channels

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
JP2008501782A (ja) 2004-06-11 2008-01-24 ジテンドラ ナス ベルマ 塩水中のステロール濃縮混合層状アンフォテリシン（Ａｍｐｈｏｔｅｒｉｃｉｎ）挿入リポソーム及びその調製方法
WO2016073462A1 (en) 2014-11-04 2016-05-12 The Board Of Trustees Of The University Of Illinois Restoring physiology with small molecule mimics of missing proteins
JP7041961B2 (ja) 2016-04-08 2022-03-25 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイ ヒト嚢胞性線維症肺上皮における気道表面の生理機能の小分子介在性回復

Non-Patent Citations (4)

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Eur. Respi.r J.，2014年，Vol.44，pp.1308-1318
International Journal of Pediatrics，2010年，Article ID 376287，DOI: 10.1155/2010/376287
Journal of Chemotherapy，2015年，Vol.27，pp.307-311
Medical Mycology，2016年，Vol.54，pp.223-231

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Publication number Publication date
ES3009563T3 (en) 2025-03-27
FI3694526T3 (fi) 2025-02-06
US20250009775A1 (en) 2025-01-09
AU2018348214C1 (en) 2025-01-30
JP2020536859A (ja) 2020-12-17
WO2019075214A3 (en) 2020-04-02
EP3694526B1 (en) 2024-12-04
US12090164B2 (en) 2024-09-17
AU2018348214B2 (en) 2024-08-08
CA3076246A1 (en) 2019-04-18
AU2018348214A1 (en) 2020-04-23
WO2019075214A2 (en) 2019-04-18
JP2023126932A (ja) 2023-09-12
EP3694526A2 (en) 2020-08-19
US20250000886A1 (en) 2025-01-02
AU2024259758A1 (en) 2024-11-21
DK3694526T3 (da) 2025-02-03
US20200352970A1 (en) 2020-11-12
EP3694526A4 (en) 2021-06-09
PT3694526T (pt) 2025-01-20

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